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Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
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Figure 1

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
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Figure 2

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 1 FEV1 (L).
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Analysis 1.1

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 1 FEV1 (L).

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 2 FEV1 (% pred).
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Analysis 1.2

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 2 FEV1 (% pred).

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 3 FVC (L).
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Analysis 1.3

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 3 FVC (L).

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 4 FVC (% pred).
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Analysis 1.4

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 4 FVC (% pred).

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 5 Perceived efficacy (mm).
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Analysis 1.5

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 5 Perceived efficacy (mm).

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 6 Tolerability (mm).
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Analysis 1.6

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 6 Tolerability (mm).

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 7 Satisfaction (mm).
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Analysis 1.7

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 7 Satisfaction (mm).

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 8 Dyspnoea.
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Analysis 1.8

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 8 Dyspnoea.

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 9 Sputum wet weight.
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Analysis 1.9

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 9 Sputum wet weight.

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 1 FEV1 (L).
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Analysis 2.1

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 1 FEV1 (L).

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 2 FEV1 (% pred).
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Analysis 2.2

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 2 FEV1 (% pred).

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 3 FVC (L).
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Analysis 2.3

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 3 FVC (L).

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 4 FVC (% pred).
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Analysis 2.4

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 4 FVC (% pred).

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 5 Perceived efficacy (mm).
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Analysis 2.5

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 5 Perceived efficacy (mm).

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 6 Tolerability (mm).
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Analysis 2.6

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 6 Tolerability (mm).

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 7 Satisfaction (mm).
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Analysis 2.7

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 7 Satisfaction (mm).

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 1 FEV1 (L).
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Analysis 3.1

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 1 FEV1 (L).

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 2 FEV1 (% pred).
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Analysis 3.2

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 2 FEV1 (% pred).

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 3 FVC (L).
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Analysis 3.3

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 3 FVC (L).

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 4 FVC (% pred).
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Analysis 3.4

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 4 FVC (% pred).

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 5 Perceived efficacy (mm).
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Analysis 3.5

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 5 Perceived efficacy (mm).

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 6 Tolerability (mm).
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Analysis 3.6

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 6 Tolerability (mm).

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 7 Satisfaction (mm).
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Analysis 3.7

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 7 Satisfaction (mm).

Comparison 1. Inhalation before versus during airway clearance techniques

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 FEV1 (L) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

2 FEV1 (% pred) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

3 FVC (L) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

4 FVC (% pred) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

5 Perceived efficacy (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

6 Tolerability (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

7 Satisfaction (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

8 Dyspnoea Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

9 Sputum wet weight Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 1. Inhalation before versus during airway clearance techniques
Comparison 2. Inhalation before versus after airway clearance techniques

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 FEV1 (L) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

2 FEV1 (% pred) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

3 FVC (L) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

4 FVC (% pred) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

5 Perceived efficacy (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

6 Tolerability (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

7 Satisfaction (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

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Comparison 2. Inhalation before versus after airway clearance techniques
Comparison 3. Inhalation during versus after airway clearance techniques

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 FEV1 (L) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

2 FEV1 (% pred) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

3 FVC (L) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

4 FVC (% pred) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

5 Perceived efficacy (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

6 Tolerability (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

7 Satisfaction (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

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Comparison 3. Inhalation during versus after airway clearance techniques