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Cochrane Database of Systematic Reviews

Timing of hypertonic saline inhalation for cystic fibrosis

Esta versión no es la más reciente

Información

DOI:
https://doi.org/10.1002/14651858.CD008816.pub3Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 22 diciembre 2016see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:
  1. Grupo Cochrane de Fibrosis quística y enfermedades genéticas

Copyright:
  1. Copyright © 2016 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Cifras del artículo

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Citado por:

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Contraer

Autores

  • Mark Elkins

    Correspondencia a: Sydney Medical School, University of Sydney, Sydney, Australia

    [email protected]

  • Ruth Dentice

    Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, Australia

Contributions of authors

RD and ME contributed to: the writing of the protocol; the conduct of the searches, the review of the search results; and the writing of the final review.

Sources of support

Internal sources

  • No sources of support supplied

External sources

  • National Institute for Health Research, UK.

    This systematic review was supported by the National Institute for Health Research, via Cochrane infrastructure funding to the Cochrane Cystic Fibrosis and Genetic Disorders Group.

Declarations of interest

Both review authors are authors on the Dentice trial, therefore data extraction for this trial was also carried out at the editorial base (Dentice 2012).

Acknowledgements

We wish to thank Tracey Remmington and Nikki Jahnke for their assistance in the preparation of this review.

Version history

Published

Title

Stage

Authors

Version

2020 Feb 28

Timing of hypertonic saline inhalation for cystic fibrosis

Review

Mark Elkins, Ruth Dentice

https://doi.org/10.1002/14651858.CD008816.pub4

2016 Dec 22

Timing of hypertonic saline inhalation for cystic fibrosis

Review

Mark Elkins, Ruth Dentice

https://doi.org/10.1002/14651858.CD008816.pub3

2012 Feb 15

Timing of hypertonic saline inhalation for cystic fibrosis

Review

Mark Elkins, Ruth Dentice

https://doi.org/10.1002/14651858.CD008816.pub2

2010 Nov 10

Timing of hypertonic saline inhalation for cystic fibrosis

Protocol

Mark Elkins, Ruth Dentice

https://doi.org/10.1002/14651858.CD008816

Keywords

MeSH

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
Figuras y tablas -
Figure 1

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Figuras y tablas -
Figure 2

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 1 FEV1 (L).
Figuras y tablas -
Analysis 1.1

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 1 FEV1 (L).

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 2 FEV1 (% pred).
Figuras y tablas -
Analysis 1.2

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 2 FEV1 (% pred).

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 3 FVC (L).
Figuras y tablas -
Analysis 1.3

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 3 FVC (L).

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 4 FVC (% pred).
Figuras y tablas -
Analysis 1.4

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 4 FVC (% pred).

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 5 Perceived efficacy (mm).
Figuras y tablas -
Analysis 1.5

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 5 Perceived efficacy (mm).

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 6 Tolerability (mm).
Figuras y tablas -
Analysis 1.6

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 6 Tolerability (mm).

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 7 Satisfaction (mm).
Figuras y tablas -
Analysis 1.7

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 7 Satisfaction (mm).

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 8 Dyspnoea.
Figuras y tablas -
Analysis 1.8

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 8 Dyspnoea.

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 9 Sputum wet weight.
Figuras y tablas -
Analysis 1.9

Comparison 1 Inhalation before versus during airway clearance techniques, Outcome 9 Sputum wet weight.

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 1 FEV1 (L).
Figuras y tablas -
Analysis 2.1

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 1 FEV1 (L).

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 2 FEV1 (% pred).
Figuras y tablas -
Analysis 2.2

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 2 FEV1 (% pred).

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 3 FVC (L).
Figuras y tablas -
Analysis 2.3

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 3 FVC (L).

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 4 FVC (% pred).
Figuras y tablas -
Analysis 2.4

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 4 FVC (% pred).

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 5 Perceived efficacy (mm).
Figuras y tablas -
Analysis 2.5

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 5 Perceived efficacy (mm).

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 6 Tolerability (mm).
Figuras y tablas -
Analysis 2.6

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 6 Tolerability (mm).

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 7 Satisfaction (mm).
Figuras y tablas -
Analysis 2.7

Comparison 2 Inhalation before versus after airway clearance techniques, Outcome 7 Satisfaction (mm).

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 1 FEV1 (L).
Figuras y tablas -
Analysis 3.1

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 1 FEV1 (L).

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 2 FEV1 (% pred).
Figuras y tablas -
Analysis 3.2

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 2 FEV1 (% pred).

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 3 FVC (L).
Figuras y tablas -
Analysis 3.3

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 3 FVC (L).

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 4 FVC (% pred).
Figuras y tablas -
Analysis 3.4

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 4 FVC (% pred).

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 5 Perceived efficacy (mm).
Figuras y tablas -
Analysis 3.5

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 5 Perceived efficacy (mm).

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 6 Tolerability (mm).
Figuras y tablas -
Analysis 3.6

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 6 Tolerability (mm).

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 7 Satisfaction (mm).
Figuras y tablas -
Analysis 3.7

Comparison 3 Inhalation during versus after airway clearance techniques, Outcome 7 Satisfaction (mm).

Comparison 1. Inhalation before versus during airway clearance techniques

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 FEV1 (L) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

2 FEV1 (% pred) Show forest plot

1

Mean Difference (Fixed, 95% CI)

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3 FVC (L) Show forest plot

1

Mean Difference (Fixed, 95% CI)

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4 FVC (% pred) Show forest plot

1

Mean Difference (Fixed, 95% CI)

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5 Perceived efficacy (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

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6 Tolerability (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

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7 Satisfaction (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

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8 Dyspnoea Show forest plot

1

Mean Difference (Fixed, 95% CI)

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9 Sputum wet weight Show forest plot

1

Mean Difference (Fixed, 95% CI)

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Figuras y tablas -
Comparison 1. Inhalation before versus during airway clearance techniques
Comparison 2. Inhalation before versus after airway clearance techniques

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 FEV1 (L) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

2 FEV1 (% pred) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

3 FVC (L) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

4 FVC (% pred) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

5 Perceived efficacy (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

6 Tolerability (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

7 Satisfaction (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 2. Inhalation before versus after airway clearance techniques
Comparison 3. Inhalation during versus after airway clearance techniques

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 FEV1 (L) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

2 FEV1 (% pred) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

3 FVC (L) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

4 FVC (% pred) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

5 Perceived efficacy (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

6 Tolerability (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

7 Satisfaction (mm) Show forest plot

1

Mean Difference (Fixed, 95% CI)

Totals not selected

Figuras y tablas -
Comparison 3. Inhalation during versus after airway clearance techniques