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Referencias

References to studies included in this review

Adsit 2014 {published data only}

Adsit RT, Fox BM, Tsiolis T, Ogland C, Simerson M, Vind LM, et al. Using the electronic health record to connect primary care patients to evidence‐based telephonic tobacco quitline services: a closed‐loop demonstration project. Translational Behavioral Medicine 2014 Sep;4(3):324‐32. [DOI: 10.1007/s13142‐014‐0259‐y]

Bentz 2002 {published data only (unpublished sought but not used)}

Bentz CJ, Davis N, Bayley B. The feasibility of paper‐based Tracking Codes and electronic medical record systems to monitor tobacco‐use assessment and intervention in an Individual Practice Association (IPA) Model health maintenance organization (HMO). Nicotine & Tobacco Research 2002;4(Suppl 1):S9‐17.

Bentz 2007 {published data only}

Bentz CJ, Bayley KB, Bonin KE, Fleming L, Hollis JF, Hunt JS, et al. Provider feedback to improve 5A's tobacco cessation in primary care: a cluster randomized clinical trial. Nicotine & Tobacco Research 2007;9(3):341‐9.

Frank 2004 {published data only}

Frank O, Litt J, Beilby J. Opportunistic electronic reminders. Improving performance of preventive care in general practice. Australian Family Physician 2004;33:87‐90.

Koplan 2008 {published data only}

Koplan KE, Regan S, Goldszer RC, Schneider LI, Rigotti NA. A computerized aid to support smoking cessation treatment for hospital patients. Journal of General Internal Medicine 2008;23(8):1214‐7.

Linder 2009 {published data only}

Linder JA, Rigotti NA, Schneider LI, Kelley JH, Brawarsky P, Haas JS. An electronic health record‐based intervention to improve tobacco treatment in primary care: a cluster‐randomized controlled trial. Archives of Internal Medicine 2009;169(8):781‐7.
Linder JA, Rigotti NA, Schneider LI, Kelley JH, Brawarsky P, Schnipper JL, et al. Clinician characteristics and use of novel electronic health record functionality in primary care. Journal of the American Medical Informatics Association : JAMIA 2011;18 Suppl 1:i87‐90. [CENTRAL: 841364; CRS: 9400123000015269; PUBMED: 21900702]

Lindholm 2010 {published data only}

Lindholm C, Adsit R, Bain P, Reber PM, Brein T, Redmond L, et al. A demonstration project for using the electronic health record to identify and treat tobacco users. WMJ 2010;109(6):335‐40.

Mathias 2012 {published data only}

Mathias JS, Didwania AK, Baker DW. Impact of an electronic alert and order set on smoking cessation medication prescription. Nicotine & Tobacco Research 2012;14(6):674‐81. [CRS: 9400123000016464; PUBMED: 22180576]

McCullough 2009 {published data only}

McCullough A, Fisher M, Goldstein AO, Kramer KD, Ripley‐Moffitt C. Smoking as a vital sign: prompts to ask and assess increase cessation counseling. Journal of the American Board of Family Medicine: JABFM 2009;22(6):625‐32.

Ragucci 2009 {published data only}

Ragucci KR, Shrader SP. A method for educating patients and documenting smoking status in an electronic medical record. Annals of Pharmacotherapy 2009;43(10):1616‐20.

Rindal 2013 {published data only}

Rindal DB, Rush WA, Schleyer TK, Kirshner M, Boyle RG, Thoele MJ, et al. Computer‐assisted guidance for dental office tobacco‐cessation counseling: a randomized controlled trial. American Journal of Preventive Medicine 2013;44(3):260‐4. [CENTRAL: 853436; CRS: 9400123000018009; EMBASE: 2013118212; PUBMED: 23415123]

Sherman 2008 {published data only (unpublished sought but not used)}

Sherman SE, Takahashi N, Kalra P, Gifford E, Finney JW, Canfield J, et al. Care coordination to increase referrals to smoking cessation telephone counseling: a demonstration project. American Journal of Managed Care 2008;14(3):141‐8.

Spencer 1999 {published data only}

Spencer E, Swanson T, Hueston WJ, Edberg DL. Tools to improve documentation of smoking status. Continuous quality improvement and electronic medical records. Archives of Family Medicine 1999;8(1):18‐22.

Szpunar 2006 {published data only}

Szpunar SM, Williams PD, Dagroso D, Enberg RN, Chesney JD. Effects of the tobacco use cessation automated clinical practice guideline. American Journal of Managed Care 2006;12(11):665‐73.

Vidrine 2013 {published data only}

Vidrine JI, Shete S, Cao Y, Greisinger A, Harmonson P, Sharp B, et al. Ask‐Advise‐Connect: A new approach to smoking treatment delivery in health care settings. JAMA Internal Medicine 2013;173(6):458‐64. [CENTRAL: 870587; CRS: 9400107000000013; EMBASE: 2013215566; PUBMED: 23440173]

Vidrine 2013a {published data only}

Vidrine JI, Shete S, Li Y, Cao Y, Alford MH, Michelle Galindo‐Talton R, et al. The ask‐advise‐connect approach for smokers in a safety net healthcare system: A group‐randomized trial. American Journal of Preventive Medicine 2013;45(6):737‐41. [CENTRAL: 915204; CRS: 9400129000000250; EMBASE: 2013729163]

References to studies excluded from this review

Bunik 2013 {published data only}

Bunik M, Cavanaugh KL, Herrick D, Mehner L, Venugopalakrishnan J, Crane LA, et al. The ONE step initiative: quality improvement in a pediatric clinic for secondhand smoke reduction. Pediatrics 2013;132(2):e502‐11. [CRS: 9400126000000028; PUBMED: 23858424]

Greenwood 2012 {published data only}

Greenwood DA, Parise CA, MacAller TA, Hankins AI, Harms KR, Pratt LS, et al. Utilizing clinical support staff and electronic health records to increase tobacco use documentation and referrals to a state quitline. Journal of Vascular Nursing 2012;30(4):107‐11. [CRS: 9400126000000506; PUBMED: 23127426]

Herrin 2012 {published data only}

Herrin J, da Graca B, Nicewander D, Fullerton C, Aponte P, Stanek G, et al. The effectiveness of implementing an electronic health record on diabetes care and outcomes. Health Services Research 2012;47(4):1522‐40. [CRS: 9400123000016383; PUBMED: 22250953]

Herrin 2014 {published data only}

Herrin J, da Graca B, Aponte P, Stanek HG, Cowling T, Fullerton C, et al. Impact of an EHR‐Based Diabetes Management Form on Quality and Outcomes of Diabetes Care in Primary Care Practices. American Journal of Medical Quality 2014;January; epub ahead of print.

Kruse 2013 {published data only}

Kruse GR, Chang Y, Kelley JH, Linder JA, Einbinder JS, Rigotti NA. Healthcare system effects of pay‐for‐performance for smoking status documentation. American Journal of Managed Care 2013;19(7):554‐61. [CRS: 9400129000002774; PUBMED: 239194195]

Levine 2013 {published data only}

Levine L, Chang J, Merkatz IR, Bernstein PS. enhamced physician prompts in prenatal electronic medical records impact documentation on smoking cessation. Open J Obstet Gynecol 2013;3(10):717‐721.

Mundra 2012 {published data only}

Mundra V, Shadi Yaghoubian S, Nguyen V, Sider D, Jose Muniz J, Villabona CV. Impact of the Use of an Electronic Template on CliniciansAdherence to Follow Guidelines for Diabetes Care. Eur J Biomed Informatics 2012;8(1):20‐33.

Onders 2014 {published data only}

Onders R, Spillane J, Reilley B, Leston J. Use of electronic clinical reminders to increase preventive screenings in a primary care setting: blueprint from a successful process in Kodiak, Alaska. Journal of Primary Care & Community Health 2014;5(1):50‐4. [CRS: 9400129000002776; PUBMED: 24327588]

Wang 2013 {published data only}

Wang JJ, Sebek KM, McCullough CM, Amirfar SJ, Parsons AS, Singer J, et al. Sustained improvement in clinical preventive service delivery among independent primary care practices after implementing electronic health record systems. Preventing Chronic Disease 2013;10:E130.

Warren 2013 {published data only}

Warren GW, Marshall JR, Cummings KM, Zevon MA, Reed R, Hysert P, Mahoney MC, Hyland AJ, Nwogu C, Demmy T, Dexter E, Kelly M, O'Connor RJ, Houstin T, Jenkins D, Germain P, Singh AK, Epstein J, Dobson Amato KA, Reid ME. Automated tobacco assessment and cessation support for cancer patients. Cancer 2014;120(4):562‐9.

Agaku 2014

Agaku IT, Ayo‐Yusuf OA, Vardavas CI. A comparison of cessation counseling received by current smokers at US dental and physician offices during 2010‐2011. American Journal of Public Health 2014;104(8):e67‐75.

Campbell 2000

Campbell MJ. Cluster randomized trials in general (family) practice research. Statistical Methods for Medical Research 2000;9(2):81‐94.

Fiore 1991

Fiore MC. The New Vital Sign. JAMA 1991;266:3183‐84.

Fiore 2008

Fiore MC, Jaén CR, Baker TB, Bailey WC, Benowitz NL, Curry SJ, et al. Treating Tobacco Use and Dependence: 2008 Update U.S. Public Health Service Clinical Practice Guideline. Treating Tobacco Use and Dependence: 2008 Update Clinical Practice Guideline. Rockville, MD: US Department of Health and Human Services, 2008.

Hesse 2010

Hesse BW. Time to reboot: resetting healthcare to support tobacco dependency treatment services. American Journal of Preventive Medicine 2010;39(6S1):S85‐S87.

Higgins 2011

Higgins JPT, Green S [eds]. Cochrane Handbook for Systematic Reviews of Interventions, 5.1.0. [updated March 2011]. The Cochrane Collaboration, 2011.

Ng 2014

Ng M, Freeman MK, Fleming TD, Robinson M, Dwyer‐lindgren L, Thomson B, et al. Smoking prevalence and cigarette consumption in 187 countries, 1980‐2112. JAMA 2014;311:183‐192.

NHS 2011

National Institute for Health and Clinical Excellence (NICE). Brief interventions and referral for smoking cessation in primary care and other settings. http://www.nice.org.uk/guidance/PH1March 2006. [website accessed May 2011]

Stead 2013

Stead LF, Buitrago D, Preciado N, Sanchez G, Hartmann‐Boyce J, Lancaster T. Physician advice for smoking cessation. Cochrane Database of Systematic Reviews 2013, Issue 5. [DOI: 10.1002/14651858.CD000165.pub4]

The PLOS Medicine Editors 2014

The PLOS Medicine Editors. Observational Studies: Getting Clear about Transparency. PloS Med 2014;11(8):e1001711.

WHO 2002

WHO. The Tobacco Atlas. 1st Edition. Geneva, Switzerland: WHO, 2002.

WHO 2009

WHO. WHO Report on the Global Tobacco Epidemic. Geneva, Switzerland: WHO, 2009.

References to other published versions of this review

Boyle 2010

Boyle R, Solberg L, Fiore M. Use of electronic health records to support smoking cessation. Cochrane Database of Systematic Reviews 2011, Issue 12. [DOI: 10.1002/14651858.CD008743.pub2]

Boyle 2011

Boyle R, Solberg L, Fiore M. Use of electronic health records to support smoking cessation. Cochrane Database of Systematic Reviews 2011, Issue 12. [DOI: 10.1002/14651858.CD008743.pub2]

Characteristics of studies

Characteristics of included studies [ordered by study ID]

Adsit 2014

Methods

Country: USA

Setting: Madison, Wisconsin

Design: 18 month before and after study measuring change in referral to a telephone quitline.

Participants

Two clinics within a healthcare system: Primary care clinic with 7 physicians; Pulmonary care clinic with 6 physicians.

Interventions

EHR was modified to prompt clinic staff to offer a quitline referral. Secure link was established between patient record and quitline.

Outcomes

Proportion of patients who smoke referred to quitline; acceptance rate by the patient. Data obtained from medical and administrative records.

Notes

Designed as a case study without empirical testing.

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

High risk

No control group

Allocation concealment (selection bias)

High risk

As above

Blinding of participants and personnel (performance bias)
All outcomes

Low risk

Personnel not blind to change in EHR by design, risk of bias judged low

Blinding of outcome assessment (detection bias)
All outcomes

Low risk

Objective data obtained from medical and administrative records using an automated reporting system.

Incomplete outcome data (attrition bias)
All outcomes

Low risk

Data were based on electronic records for all patients with a visit.

Bentz 2002

Methods

Country: USA

Setting: Portland, Oregon

Design: Tracking codes to measure and report tobacco cessation guideline provider activities were introduced in two primary care clinics. One clinic was using an electronic health record and the comparison clinic a paper chart.

Participants

2 Primary care clinics, one using an internally developed, web‐based electronic health record and another using a paper medical record.

Interventions

The EHR clinic was prompted to ask patients about smoking, give advice to quit, and to document these actions in the EHR. A tracking form was attached to the paper chart in the non‐EHR clinic.

Outcomes

Documentation of tobacco use was collected from a sample of 50 patient charts. Billing and claims databases were used to measure code utilization.

Notes

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

High risk

Clinics not randomly allocated

Allocation concealment (selection bias)

High risk

As above

Blinding of participants and personnel (performance bias)
All outcomes

Low risk

Personnel not blind to change in EHR by design, risk of bias judged low

Blinding of outcome assessment (detection bias)
All outcomes

Low risk

Objective data extracted by research staff based on a random sample of clinic patients

Incomplete outcome data (attrition bias)
All outcomes

Low risk

EMR data included all charts; the comparison clinic was based on a random sample.

Bentz 2007

Methods

Country: USA

Setting: Primary care clinics, Portland, Oregon

Design: Cluster randomized controlled trial. Clinics were grouped by business affiliation, payer mix, and baseline rate of recorded smoking status (ask rate); then randomized into intervention and control. A case‐mix score was calculated to control for age and illness diagnosis. Regression analysis was performed using generalized estimating equations. Intra‐cluster correlation coefficients (ICC) were calculated for the analysis.

Participants

19 Primary care clinics (n=10 intervention) using a common electronic health record within one health system.

Interventions

Intervention group clinics received written reports showing individual provider, and clinic performance on tobacco clinical guideline actions: ask, advise, assess, assist, arrange. Written reports were provided monthly to the clinic manager.

Control clinics used same EHR without feedback

Outcomes

Outcomes were obtained from electronic files and included estimates of asking about tobacco use, advising to quit, assessing interest in quitting, and assistance with referral to the telephone quitline.

 

Notes

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

Low risk

Group randomized, clinics were grouped by pre‐determined criteria prior to randomization

Allocation concealment (selection bias)

Low risk

Clinics assigned at baseline, defined patient populations, no risk of differential patient recruitment

Blinding of participants and personnel (performance bias)
All outcomes

Low risk

Intervention personnel not blind to change in EHR by design, risk of bias judged low

Blinding of outcome assessment (detection bias)
All outcomes

Low risk

Outcome data were extracted from the EMR on a monthly basis based on all patient visits

Incomplete outcome data (attrition bias)
All outcomes

Low risk

Data were collected at the patient level and included all patients

Frank 2004

Methods

Country: Australia

Setting: Urban general practice clinic of 10 physicians; Adelaide

Design: Patient randomized study. Data were analysed with regression using generalized estimating equations.

Participants

Intervention sample n=5118; Control sample n=5389; 56% female

Interventions

Reminders for preventive activities including recording smoking status appeared as a field in the electronic health record.

Outcomes

Documentation of smoking status in the electronic health record.

Notes

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

Low risk

Patients were randomized by family medical record number. 'The baseline characteristics of the patients allocated to the two experimental groups were similar'. Judged at low risk of selection bias.

Allocation concealment (selection bias)

Low risk

No opportunity to change allocation, all clinic patients included, no potential for selection bias

Blinding of participants and personnel (performance bias)
All outcomes

High risk

All physicians in a single clinic were included. 'The GPs were not blinded to the allocation of patients to the intervention or control groups.' The risk is that all patients could be treated the same regardless of study assignment

Blinding of outcome assessment (detection bias)
All outcomes

Low risk

'Automatic recording of preventive care opportunities and their uptake'

Incomplete outcome data (attrition bias)
All outcomes

Low risk

Data collected electronically for all patients.

Koplan 2008

Methods

Country: USA

Setting: Boston, Massachusetts

Design: Uncontrolled before‐and‐after study. Pre‐intervention period (4 months) was compared to post‐intervention (4 months).

Participants

Admitted hospital patients in a large multi‐specialty hospital affiliated with a University. Records for 17,530 admissions were examined.

Interventions

A series of check boxes (tobacco order set) was added to admission screens of the hospital computerized order‐entry system. The assessment included smoking/nonsmoking, cessation materials, cessation consultation, and orders for nicotine replacement medications or bupropion.

Outcomes

Referral to smoking cessation counselling and ordering cessation medications.

Notes

Effects on smoking status identification could not be assessed as available only in the postintervention period; previously these data were not electronically collected.

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

High risk

No control group

Allocation concealment (selection bias)

High risk

As above

Blinding of participants and personnel (performance bias)
All outcomes

Low risk

Personnel not blind to change in EHR by design, risk of bias judged low

Blinding of outcome assessment (detection bias)
All outcomes

Low risk

'NRT orders were obtained from hospital pharmacy records. Smoking counselor consults were obtained from the electronic database kept by hospital smoking counselors.'

Incomplete outcome data (attrition bias)
All outcomes

Low risk

Same methods of data collection pre and postintervention

Linder 2009

Methods

Country: USA

Setting: Boston, Massachusetts

Design: Cluster randomized controlled trial. Clinics were matched based on size (number of annual visits) and practice type (hospital based, community based, or community health centre) then randomly assigned to intervention or usual care. Intra‐cluster correlation coefficients (ICC) were calculated for the analysis. A generalized linear model controlled for the clusters and possible interactions.

Participants

Documented smokers (n=9589) in 26 Primary care clinics (n=12 intervention) using an internally developed, web‐based electronic health record.

Interventions

Intervention group clinicians experienced three changes to the electronic health record: a cigarette icon on the top of the health record was either black when smoking status was missing or scarlet for current smokers; tobacco treatment reminders were listed in the patient record; and treatment order forms for cessation medication and telephone Quitline referral were added.

Outcomes

Primary outcome was documented smoking cessation counselling (smoking counsellor reached a patient by telephone, or a patient attended a program, or the Quitline reached a patient by telephone).

Secondary outcomes included documentation of smoking status, prescribing cessation medication, and referral to cessation treatment, and smokers subsequently documented as non smokers.

Notes

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

Low risk

Group randomized; clinics were matched on pre‐determined criteria then randomized

Allocation concealment (selection bias)

Low risk

Clinics assigned at baseline, defined patient populations, no risk of differential patient recruitment

Blinding of participants and personnel (performance bias)
All outcomes

Low risk

Intervention personnel not blind to change in EHR by design, risk of bias judged low

Blinding of outcome assessment (detection bias)
All outcomes

Low risk

Same methods of data collection from electronic records for intervention and control clinics

Incomplete outcome data (attrition bias)
All outcomes

Low risk

Methods of data collection makes differential attrition unlikely

Lindholm 2010

Methods

Country: USA

Setting: Madison, Wisconsin

Design: Uncontrolled before‐and‐after study. Pre‐intervention period (12 months) was compared to post‐intervention (12 months). Chi² tests were performed.

Participants

Primary care patients attending 18 general internal medicine and family medicine clinics. About 250,000 patient visits were examined pre and post intervention.

Interventions

A tobacco use box was added to the vital signs patient window; if a tobacco user was identified, the patient was asked if they were willing to talk to the doctor about quitting: if yes, a three question paper survey asked about past cessation medication use, cigarettes used per day, and a possible quit date. This survey was left for the physician to review during the visit.

Outcomes

Assessment of smoking status pre‐post from the electronic health record; proportion provided medication (post intervention only), clinician documentation of smoking cessation counselling (post intervention only).

Notes

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

High risk

No control group

Allocation concealment (selection bias)

High risk

As above

Blinding of participants and personnel (performance bias)
All outcomes

Low risk

Personnel not blind to change in EHR by design, risk of bias judged low

Blinding of outcome assessment (detection bias)
All outcomes

Low risk

Data automatically generated from EHR

Incomplete outcome data (attrition bias)
All outcomes

Low risk

Data collected electronically.

Mathias 2012

Methods

Country: USA

Setting: Chicago, Illinois

Design: before and after study involving cohort and cross sectional smokers.

Participants

Single urban primary care practice; 37 attending and 78 resident physicians. 1,349 documented smokers in preintervention cohort, 1,346 in postintervention cohort. 764 included in both cohorts

Interventions

A smoking cessation alert was added to the EHR. The alert prompted physician actions including a medication order set.

Outcomes

Change in orders of prescription for cessation medications; change in referral to cessation counselling.

Notes

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

High risk

No control group

Allocation concealment (selection bias)

High risk

As above

Blinding of participants and personnel (performance bias)
All outcomes

Low risk

Personnel not blind to change in EHR, risk of bias judged low

Blinding of outcome assessment (detection bias)
All outcomes

Low risk

Objective data extracted from EHR, although assessors not blind to whether pre‐ or post‐intervention

Incomplete outcome data (attrition bias)
All outcomes

Low risk

Same methods of data extraction pre and postintervention

McCullough 2009

Methods

Country: USA

Setting: Chapel Hill, North Carolina

Design: Uncontrolled before‐and‐after study. Pre‐intervention period (4 months) was compared to post‐intervention (8 months). Chi² tests were performed.

Participants

Primary care patients attending 3 family medicine clinics (n=899)

Interventions

Two questions were added to the patient vital signs in the electronic health record – “Current smoker?” and “Plan to quit?”

Outcomes

Documented smoking status, assessment of quit plan, and smoking cessation counselling recorded in the electronic health record.

Notes

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

High risk

No control group

Allocation concealment (selection bias)

High risk

As above

Blinding of participants and personnel (performance bias)
All outcomes

Low risk

Personnel not blind to change in EHR, risk of bias judged low

Blinding of outcome assessment (detection bias)
All outcomes

Low risk

Researchers extracted objective data from randomly selected medical records

Incomplete outcome data (attrition bias)
All outcomes

Low risk

Same methods of data collection pre and postintervention

Ragucci 2009

Methods

Country: USA

Setting: Columbia, South Carolina

Design: Uncontrolled before‐and‐after study. Pre‐intervention period (4 months) was compared to post‐intervention (8 months). Pharmacist delivered intervention during drug therapy management.

Participants

Anticoagulation patients or diabetes patients who were current smokers (n=90) attending 3 University‐based primary care clinics.

Interventions

A smoking template was added to the pharmacy‐related progress notes within the electronic health record. The template queried on smoking status, type of tobacco, amount of tobacco, years of tobacco use, past quit attempts, desire to quit, and assessment of nicotine addiction. Based on smoking status, pharmacist provided a message on the benefits of smoking cessation and education on cessation medications.

Outcomes

Smoking cessation and readiness to quit smoking if not quit.

Notes

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

High risk

Uncontrolled study

Allocation concealment (selection bias)

High risk

As above

Blinding of participants and personnel (performance bias)
All outcomes

Low risk

Personnel not blind to change in EHR by design, risk of bias judged low

Blinding of outcome assessment (detection bias)
All outcomes

High risk

Patients reported their smoking status without validation

Incomplete outcome data (attrition bias)
All outcomes

Unclear risk

Unclear whether any smokers identified at baseline were not followed up

Rindal 2013

Methods

Country: USA

Setting: Minneapolis, Minnesota

Design: A two‐arm group randomized trial with dental clinics assigned to an enhanced dental record intervention or usual care control.

Participants

15 dental clinics. Prior to randomizations, clinics were stratified by size, proportion smoking, and public vs private insurance.

Interventions

In the enhanced condition, the EDR was modified to prompt providers to ask and discuss smoking and interest in quitting.

Outcomes

Change in provider actions ‐‐ ask, discuss quitting, refer to quitline.

Notes

No follow‐up as patients were called a few days after their visit.

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

Low risk

Stratified and group randomization of all clinics in a dental system

Allocation concealment (selection bias)

Low risk

Clinics assigned at baseline, defined patient populations, no risk of differential patient recruitment

Blinding of participants and personnel (performance bias)
All outcomes

Unclear risk

Personnel not blind to change in EHR by design, dentists only worked at a single clinic, risk of bias judged low

Blinding of outcome assessment (detection bias)
All outcomes

Unclear risk

Patient reported outcomes. Unclear whether patients or assessors blind to EDR condition

Incomplete outcome data (attrition bias)
All outcomes

Low risk

Similar proportion of patients of intervention and control clinics reached

Sherman 2008

Methods

Country: USA

Setting: Los Angeles, California and Palo Alto, California

Design: group randomized clinical trial. Regression analysis performed; no assessment of group correlation.

Participants

18 Primary care clinics (n=10 intervention) affiliated with the Veterans Health Administration (VA).

Interventions

A simplified method was added to an existing electronic health record for referral to telephone‐based cessation counselling. Electronic mail reminders were sent to providers. Project staff promoted the referral tool during visits to the intervention clinics.

Outcomes

Primary outcome was provider self reported referrals to telephone‐based cessation counselling.

Notes

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

Low risk

Randomly assigned, stratified by region (Northern vs Southern California) and size (large vs small)

Allocation concealment (selection bias)

Low risk

Clinics assigned at baseline, defined patient populations, no risk of differential patient recruitment

Blinding of participants and personnel (performance bias)
All outcomes

High risk

The change to the electronic record could not be restricted in control clinics so access to the intervention was incompletely controlled.

Blinding of outcome assessment (detection bias)
All outcomes

High risk

Self reported outcome from providers surveyed about their referral patterns

Incomplete outcome data (attrition bias)
All outcomes

High risk

Not all providers responded to surveys.

Selective reporting (reporting bias)

High risk

Referral rate was reported for intervention but not control clinics

Spencer 1999

Methods

Country: USA

Setting: Eau Claire, Wisconsin

Design: Uncontrolled before‐and‐after study. Pre‐intervention period (9 months) was compared to post‐intervention (19 months).

Participants

Primary care patients attending a single family medicine clinic affiliated with a university.

Interventions

Smoking status was documented in a single location – the major problem list in the electronic health record. Medical Assistants were assigned the role of documenting smoking status and providing cessation education.

Outcomes

Documentation of smoking status and cessation counselling by clinicians.

Notes

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

High risk

No control group

Allocation concealment (selection bias)

High risk

As above

Blinding of participants and personnel (performance bias)
All outcomes

Low risk

Personnel not blind to change in EHR by design, risk of bias judged low

Blinding of outcome assessment (detection bias)
All outcomes

Unclear risk

Different source of data before and after the EHR change

Szpunar 2006

Methods

Country: USA

Setting: Detroit, Michigan

Design: Controlled before‐and‐after study. Pre‐intervention data collection (9 weeks) and post intervention data collection (14 weeks). Two intervention clinics were compared to 4 control clinics. Regression analysis controlled for baseline demographics and co‐morbidities. Patient surveys were completed at baseline and 2 weeks following a visit in the post‐intervention period.

Participants

Primary care patients attending 6 primary care clinics (2 intervention, 2 vital sign check in screen only, 2 control). These clinics form part of a large healthcare system. Clinics were selected based on convenience and size.

Interventions

Screens were added to the electronic health record. A vital sign entry recorded smoking status and willingness to quit. Further screens were automated to provide information to the provider, suggested dialogue to use, and encouraged referral to a smoking cessation program.

Outcomes

Documentation of clinician actions – ask, advise, assess, assist, arrange based on patient surveys.

Notes

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

High risk

Non randomized. Clinics were selected on ability to participate; there were baseline differences in patient characteristics

Allocation concealment (selection bias)

Low risk

Clinics assigned at baseline, defined patient populations, no risk of differential patient recruitment

Blinding of participants and personnel (performance bias)
All outcomes

Unclear risk

No information

Blinding of outcome assessment (detection bias)
All outcomes

Unclear risk

Patients interviewed by telephone after clinic visits, unclear whether they or interviewers were blind to clinic condition

Incomplete outcome data (attrition bias)
All outcomes

Unclear risk

No details about proportion of clinic attenders who were successfully contacted

Vidrine 2013

Methods

Country: USA

Setting: Houston, Texas

Design: pair‐matched two‐arm group randomized trial

Participants

10 community health clinics (described as safety net clinics) matched on patient volume, age, gender, race/ethnicity, and SES.

Interventions

Intervention clinics trained nursing staff to assess quitting interest and connect interested smokers to the quitline. The quitline then called smokers. Control clinics gave smokers a quitline referral card.

Outcomes

Proportion of smokers enrolled in treatment with the quitline.

Notes

Clinic selection not reported.

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

Low risk

Randomized after pairing on patient volume, smoking prevalence, mean age and sex distribution

Allocation concealment (selection bias)

Low risk

Clinics assigned at baseline, defined patient populations, no risk of differential patient recruitment

Blinding of participants and personnel (performance bias)
All outcomes

Low risk

Personnel not blind to change in EHR by design, risk of bias judged low

Blinding of outcome assessment (detection bias)
All outcomes

Low risk

Objective outcomes using data supplied by quitline

Incomplete outcome data (attrition bias)
All outcomes

Unclear risk

Control clinics patient outcomes relied on names of quitline referrals being correctly matched to quitline callers.

Vidrine 2013a

Methods

Country: USA

Setting: Houston, Texas

Design: Pair‐matched two arm group randomized trial

Participants

10 family practice clinics from a large network of clinics.

Interventions

Intervention clinics linked interested smokers through the EHR to the quitline. The quitline proactively called the smokers.

Outcomes

Proportion of smokers enrolled in treatment with the quitline.

Notes

Clinic selection not reported

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

Low risk

Randomized after pairing on patient volume, smoking prevalence, mean age and sex distribution

Allocation concealment (selection bias)

Low risk

Clinics assigned at baseline, defined patient populations, no risk of differential patient recruitment

Blinding of participants and personnel (performance bias)
All outcomes

Low risk

Personnel not blind to change in EHR by design, risk of bias judged low

Blinding of outcome assessment (detection bias)
All outcomes

Low risk

Objective outcomes using data supplied by quitline

Incomplete outcome data (attrition bias)
All outcomes

Low risk

Control clinics patient outcomes relied on names of quitline referrals being correctly matched to quitline callers.

Characteristics of excluded studies [ordered by study ID]

Study

Reason for exclusion

Bunik 2013

Single clinic with non random surveys of patients

Greenwood 2012

The EHR effect was confounded by staff training effect

Herrin 2012

Outcome measure not well defined; limited to documentation of smoking

Herrin 2014

Observational study with significant selection bias and without a focus on smoking

Kruse 2013

EHR changes could not be separated from pay for performance changes

Levine 2013

Single site pilot study with selection bias

Mundra 2012

Single site, observational study with no useful data on smoking intervention

Onders 2014

EHR improvements coincided with staffing changes and patient volume changes

Wang 2013

Study was a test of performance feedback with the EHR as the source of the feedback

Warren 2013

This was a feasability study that did not test EHR changes

Data and analyses

Open in table viewer
Comparison 1. Study results

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 All outcomes Show forest plot

Other data

No numeric data

Analysis 1.1

Study

Smoking cessation

Guideline recommended actions

Randomized controlled trials

Bentz 2007

Guideline actions increased within the intervention clinics for smoking status (94.5% vs 88.1% p<0.05), advised to quit (71.6% vs 52.7%, p<0.001), assessed interest in quitting 65.5% vs 40.1% p<0.001), and provided assistance (20.1% vs 10.5%, p < 0.001).

Quitline referral increased in the intervention clinics (adjusted OR 1.53)

Linder 2009

Significantly more smokers in the intervention clinics were subsequently documented as nonsmokers compared to smokers in the control clinics (5.3% vs 1.9%, p < 0.001)

Significantly more smokers were referred to cessation counselling in the intervention clinics (4.5% vs 0.4% in control clinics, p<0.001), and significantly more smokers from intervention clinics made contact with a cessation counsellor (3.9% vs 0.3% in control clinics, p<0.001). No difference in the proportion of documented smokers from control or intervention clinics prescribed any cessation medication (2.0% vs 2.0%).

Rindal 2013

Significantly more smoking patients from intervention clinics versus control clinic patients reported dental provider actions: discussed interest in quitting (87% vs 70%); discussed quitting (47% vs 26%); and referral to quitline (37% vs 17%).

Sherman 2008

The average number of smokers per month referred to telephone counselling increased from 1.0 to 15.6 (p< 0.001) among intervention clinic providers, and from 0.2 to 0.7 (p<0.04) among control clinic providers.

Vidrine 2013

Patients from intervention clinics were more likely to enroll in quitline treatment compared to control clinics (15% vs 0.5%).

Vidrine 2013a

Patients from intervention clinics were more likely to enroll in quitline treatment compared to control clinics (8% vs 0.6%).

Controlled trials

Bentz 2002

Documentation of tobacco use was unchanged in the paper chart clinic, but increased from 79% to 88% in the enhanced EHR clinic.

Frank 2004

Assessment of smoking status was unchanged between intervention and control patient visits (2.0% vs 1.8%, RR 1.12 , 95% CI 0.90 to 1.39).

Szpunar 2006

Asking about tobacco use increased in the intervention clinics from 88.4% to 92.8%.

Uncontrolled trials

Adsit 2014

The proportion of patients referred to the quitline increased from <1% to 14%. 5% enrolled in quitline treatment.

Koplan 2008

The proportion of smoking patients referred to cessation counselling increased from 0.8% to 2.1% (p < 0.001); medication ordered increased from 1.6% to 2.5% (p < 0.001).

Lindholm 2010

Tobacco use status in the EHR increased from 71.6% to 78.4% (p < 0.001).

Mathias 2012

The percentage of documented smokers with a change in smoking status from active to quit during the pre‐ or postintervention period increased from 17.1% in the preintervention cohort to 20.5% in the postintervention cohort (p = .06)

In the post enhancement period, cessation medication prescribing did not change (14.4% vs. 13.4%, p = .5), but quitline referral increased from 2% to 7% (p < 0.001).

McCullough 2009

Tobacco use status increased from 71% to 84% (p < 0.001). Assessement of plan to quit increased from 25.% to 51% (p < 0.005), and smokers assessed for a plan to quit were more likely to receive cessation counselling (46% vs 14% among smokers not assessed, p < 0.001).

Ragucci 2009

Of 90 smokers in the study, 29 were quit at 6 months (32%)

Spencer 1999

Recording of tobacco use status increased from 18.4% to 80.3%.



Comparison 1 Study results, Outcome 1 All outcomes.

1.1 Randomized controlled trials

Other data

No numeric data

1.2 Controlled trials

Other data

No numeric data

1.3 Uncontrolled trials

Other data

No numeric data

Study flow diagram for update 2014
Figuras y tablas -
Figure 1

Study flow diagram for update 2014

Study

Smoking cessation

Guideline recommended actions

Randomized controlled trials

Bentz 2007

Guideline actions increased within the intervention clinics for smoking status (94.5% vs 88.1% p<0.05), advised to quit (71.6% vs 52.7%, p<0.001), assessed interest in quitting 65.5% vs 40.1% p<0.001), and provided assistance (20.1% vs 10.5%, p < 0.001).

Quitline referral increased in the intervention clinics (adjusted OR 1.53)

Linder 2009

Significantly more smokers in the intervention clinics were subsequently documented as nonsmokers compared to smokers in the control clinics (5.3% vs 1.9%, p < 0.001)

Significantly more smokers were referred to cessation counselling in the intervention clinics (4.5% vs 0.4% in control clinics, p<0.001), and significantly more smokers from intervention clinics made contact with a cessation counsellor (3.9% vs 0.3% in control clinics, p<0.001). No difference in the proportion of documented smokers from control or intervention clinics prescribed any cessation medication (2.0% vs 2.0%).

Rindal 2013

Significantly more smoking patients from intervention clinics versus control clinic patients reported dental provider actions: discussed interest in quitting (87% vs 70%); discussed quitting (47% vs 26%); and referral to quitline (37% vs 17%).

Sherman 2008

The average number of smokers per month referred to telephone counselling increased from 1.0 to 15.6 (p< 0.001) among intervention clinic providers, and from 0.2 to 0.7 (p<0.04) among control clinic providers.

Vidrine 2013

Patients from intervention clinics were more likely to enroll in quitline treatment compared to control clinics (15% vs 0.5%).

Vidrine 2013a

Patients from intervention clinics were more likely to enroll in quitline treatment compared to control clinics (8% vs 0.6%).

Controlled trials

Bentz 2002

Documentation of tobacco use was unchanged in the paper chart clinic, but increased from 79% to 88% in the enhanced EHR clinic.

Frank 2004

Assessment of smoking status was unchanged between intervention and control patient visits (2.0% vs 1.8%, RR 1.12 , 95% CI 0.90 to 1.39).

Szpunar 2006

Asking about tobacco use increased in the intervention clinics from 88.4% to 92.8%.

Uncontrolled trials

Adsit 2014

The proportion of patients referred to the quitline increased from <1% to 14%. 5% enrolled in quitline treatment.

Koplan 2008

The proportion of smoking patients referred to cessation counselling increased from 0.8% to 2.1% (p < 0.001); medication ordered increased from 1.6% to 2.5% (p < 0.001).

Lindholm 2010

Tobacco use status in the EHR increased from 71.6% to 78.4% (p < 0.001).

Mathias 2012

The percentage of documented smokers with a change in smoking status from active to quit during the pre‐ or postintervention period increased from 17.1% in the preintervention cohort to 20.5% in the postintervention cohort (p = .06)

In the post enhancement period, cessation medication prescribing did not change (14.4% vs. 13.4%, p = .5), but quitline referral increased from 2% to 7% (p < 0.001).

McCullough 2009

Tobacco use status increased from 71% to 84% (p < 0.001). Assessement of plan to quit increased from 25.% to 51% (p < 0.005), and smokers assessed for a plan to quit were more likely to receive cessation counselling (46% vs 14% among smokers not assessed, p < 0.001).

Ragucci 2009

Of 90 smokers in the study, 29 were quit at 6 months (32%)

Spencer 1999

Recording of tobacco use status increased from 18.4% to 80.3%.

Figuras y tablas -
Analysis 1.1

Comparison 1 Study results, Outcome 1 All outcomes.

Use of electronic health records to support smoking cessation

Patient or population: People who smoke

Settings: Healthcare clinics

Intervention: Any use of an Electronic Health Record (EHR) to improve smoking status documentation or cessation assistance for patients who use tobacco, either by direct action or by feedback of clinical performance measures.

Comparison: No EHR, or EHR without support for smoking cessation intervention

Outcomes

Effect

No of Participants
(studies)

Quality of the evidence
(GRADE)

Comments

Smoking cessation

More intervention clinic than control clinic smokers quit (5.3% vs 1.9%, p < 0.001)

1 cluster RCT, 26 clinics

⊕⊝⊝⊝

very low1

Indirect measurement based on EHR documentation of smoking status

Guideline recommended actions

Studies typically showed positive effects on outcomes including documenting smoking status, giving advice to quit, assessing interest in quitting, and providing assistance including referral.

6 cluster RCTs, 98 clinics

⊕⊕⊕⊝

Moderate2

Studies did not all assess the same outcomes. Non randomized and uncontrolled studies also showed positive effects

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1 Only one study reported the outcome, and did not use direct patient report of cessation

2 Heterogeneity in the interventions and targeted behaviours

Figuras y tablas -
Comparison 1. Study results

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 All outcomes Show forest plot

Other data

No numeric data

1.1 Randomized controlled trials

Other data

No numeric data

1.2 Controlled trials

Other data

No numeric data

1.3 Uncontrolled trials

Other data

No numeric data

Figuras y tablas -
Comparison 1. Study results