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Incentivos para la prevención del hábito de fumar en niños y adolescentes

Appendices

Appendix 1. Specialized Register search strategy

The register search combined the following topic specific terms in title, abstract or keyword fields: (motivation OR reinforcement OR reward* OR 'token economy' OR punishment OR incentive* OR competition* OR contest* OR lotter* OR raffle* OR prize* OR voucher* OR gift* OR inducement* OR 'contingent payment' OR 'deposit contract') AND (adolescen* OR young OR child* or minor* OR juvenile OR girl* or boy*).

Appendix 2. MEDLINE search strategy

1 RANDOMIZED‐CONTROLLED‐TRIAL.pt.
2 CONTROLLED‐CLINICAL‐TRIAL.pt.
3 CLINICAL‐TRIAL.pt.
4 Meta analysis.pt.
5 exp Clinical Trial/
6 Random‐Allocation/
7 randomized‐controlled trials/
8 double‐blind‐method/
9 single‐blind‐method/
10 placebos/
11 Research‐Design/
12 ((clin$ adj5 trial$) or placebo$ or random$).ti,ab.
13 ((singl$ or doubl$ or trebl$ or tripl$) adj5 (blind$ or mask$)).ti,ab.
14 (volunteer$ or prospective$).ti,ab.
15 exp Follow‐Up‐Studies/
16 exp Retrospective‐Studies/
17 exp Prospective‐Studies/
18 exp Evaluation‐Studies/ or Program‐Evaluation.mp.
19 exp Cross‐Sectional‐Studies/
20 exp Behavior‐therapy/
21 exp Health‐Promotion/
22 exp Community‐Health‐Services/
23 exp Health‐Education/
24 exp Health‐Behavior/
25 or/1‐24
26 ((Smok$ or cigar$ or tobacco$) adj7 (prevent$ or uptake or initiation)).ti,ab.
27 exp Smoking/pc [Prevention & Control]
28 26 or 27 [Smoking prevention terms]
29 token economy/ or motivation/ or "aspirations(psychology)"/ or goals/ or intention/
30 "reinforcement psychology"/ or punishment/ or reinforcement schedule/ or reward/
31 (reinforcement or punishment).tw.
32 (incentive$ or competition$ or contest$ or lotter$ or raffl$ or reward$ or prize$).mp.
33 (voucher$ or gift$ or inducement$ or contingent payment$ or deposit contract$).mp.
34 or/29‐33 [Intervention terms]
35 child/ or minors/
36 (young people or minor$1).tw.
37 (child$ or juvenile$ or girl$ or boy$ or teen$ or adolescent$).ti,ab.
38 school$.tw.
39 or/35‐38 [Age specific terms]
40 25 and 28 and 34 and 39

Appendix 3. EMBASE search strategy

1 random$.ti,ab.
2 factorial$.ti,ab.
3 (cross over$ or crossover$ or cross‐over$).ti,ab.
4 placebo$.ti,ab.
5 (double$ adj blind$).ti,ab.
6 (single$ adj blind$).ti,ab.
7 assign$.ti,ab.
8 allocat$.ti,ab.
9 volunteer$.ti,ab.
10 CROSSOVER PROCEDURE.sh.
11 DOUBLE‐BLIND PROCEDURE.sh.
12 RANDOMIZED CONTROLLED TRIAL.sh.
13 SINGLE‐BLIND PROCEDURE.sh.
14 or/1‐13
15 ((smok$ or cigar$ or tobacco$) adj7 (prevent$ or uptake)).ti,ab.
16 Smoking/pc
17 "smoking and smoking related phenomena"/
18 adolescent smoking/
19 (abstin$ adj3 smok$).mp.
20 (prevent$ adj smok$).mp.
21 or/15‐20
22 motivation/ or reinforcement/ or reward/
23 (token economy or reward or reinforcement or punishment or incentive$ or competition$ or contest$ of lotter$ or raffle$ or prize$ or voucher$ or gift$ or inducement$).ti,ab.
24 contingent payment$.ti,ab.
25 deposit contract$.ti,ab.
26 22 or 23 or 24 or 25
27 exp child/ or exp adolescent/
28 (young people or minors or minor or child$ or teen$ or girl$ or boy$ or juvenile$ or adolescent$ or school$).ti,ab. (960983)
29 27 or 28
30 14 and 21 and 26 and 29

Appendix 4. CINAHL search strategy

S36 S17 and S25 and S31 and S35

S35 S32 or S33 or S34

S34   young people or ( minor or minors or child* or juvenil* or girl* or boy* or teen* or adolescen* or school* )

S33   (MH "Adolescence") OR (MH "Minors (Legal)")

S32   (MH "Child+")

S31   S26 or S27 or S28 or S29 or S30

S30   ( reinforcement* or punishment* or incentive* or competition* or contest* or lotter* or raffle* or reward* or prize* or voucher* or gift* or inducement* ) or contingent payment* or deposit contract*

S29   (MH "Reinforcement (Psychology)+")

S28   MH "Goals and Objectives+")

S27   (MH "Motivation") OR (MH "Intention")

S26   token economy

S25   S18 or S19 or S20 or S21 or S22 or S23 or S24

S24   (MH "Smoking/PC")

S23   tobacco* N7 uptake*

S22   cigar* N7 uptake*

S21   smok* N7 uptake*

S20   tobacco* N7 prevent*

S19   cigar* N7 prevent*

S18   smok* N7 prevent*

S17   S1 or S2 or S3 or S4 or S5 or S6 or S7 or S8 or S9 or S10 or S11 or S12 or S13 or S14 or S15 or S16

S16   (MH "Health Behavior+")

S15   (MH "Health Education")

S14   (MH "Community Health Services+")

S13   (MH "Health Promotion")

S12   (MH "Behavior Therapy")

S11   (MH "Cross Sectional Studies")

S10   (MH "Evaluation Research+")

S9     (MH "Retrospective Design")

S8     (MH "Experimental Studies+") OR (MH "Quasi‐Experimental Studies+")

S7     (MH "Placebos")

S6     (MH "Random Sample+")

S5     (MH "Clinical Trials+")

S4     (MH "Prospective Studies+")

S3     placebo* or random*

S2     clin* n5 trial*

S1     ((((((ZT "clinical trial")) or ((ZT "systematic review"))) or ((ZT "meta analysis") or (ZT         "protocol"))) or ((ZT "protocol"))) or ((ZT "proceedings"))) or ((ZT "systematic review"))

Appendix 5. PsycINFO search strategy

1 tobacco‐smoking/
2 (smok$ or tobacco$ or cigar$).mp.
3 Prevention/
4 (1 or 2) and 3
5 ((Smok$ or cigar$ or tobacco$) adj7 (prevent$ or uptake or initiation)).ti,ab.
6 4 or 5 [smoking prevention terms]
7 (incentive$ or competition$ or contest$ or lotter$ or raffl$ or reward$ or prize$).mp.
8 (voucher$ or gift$ or inducement$ or contingent payment$ or deposit contract$).mp.
9 7 or 8 [intervention terms]
10 (young people or minor$1 or child$ or juvenile$ or girl$ or boy$ or teen$ or adolescent$).tw.
11 school$.mp.
12 10 or 1 [Age specific limits]
13 6 and 9 and 12

Appendix 6. CSA search strategy

This strategy was used for ASSIA, ERIC, Sociological Abstracts and PAIS

(Keyword includes title, abstract and descriptors)

KW=(Incentive* or competition* or contest* or lotter* or raffle* or reward* or prize* or voucher* or gift* or inducement* or ‘contingent payment*’ or ‘deposit contract*’ or reinforcement or punishment)) and (KW=(smok* or tobacco or cigarette*)) and (KW=(adolescen* or minor or minors or child* or juvenile* or girl* or boy* or teen* or adolescent* or youth or young people))

PRISMA study flow diagram of search results
Figuras y tablas -
Figure 1

PRISMA study flow diagram of search results

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies
Figuras y tablas -
Figure 2

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies

Risk of bias summary: review authors' judgements about each risk of bias item for each included study
Figuras y tablas -
Figure 3

Risk of bias summary: review authors' judgements about each risk of bias item for each included study

Comparison 1 Incentive versus control. Randomized and non‐randomized controlled studies (adjusted for clustering), Outcome 1 Smoking uptake at longest follow‐up (RR).
Figuras y tablas -
Analysis 1.1

Comparison 1 Incentive versus control. Randomized and non‐randomized controlled studies (adjusted for clustering), Outcome 1 Smoking uptake at longest follow‐up (RR).

Study

Number of non‐smokers at baseline

Number of smokers at endpoint who reported not smoking at baseline

Time point

Outcome

Biological criterion

Results

Secondary outcomes (dose response, cost, harms)

Crone 2003

556 intervention; 420 control (data from authors)

112 intervention; 88 control

 

 

19 months

Smoking = current smoking, including daily/weekly/experimental

Not biochemically verified

Not reported at 19 months in published paper.

Our reanalysis: RR 0.92 (95% CI 0.53 to 1.61)

Not reported

Isensee 2012a

430 never‐ smokers in intervention; 610 never‐smokers in control (data from authors)

136 intervention; 184 control

19 months

Smoking = ever smoking, even just a puff

Not biochemically verified

From published paper: Authors reported that no group differences were found in the frequency of smoking initiation but data not presented in paper.

Our reanalysis:  RR 1.05 (95% CI 0.80 to 1.38)

Bullying (Hanewinkel 2010):  "When compared with control classrooms on all three dependent variables – being victimised, active bullying or being isolated – the adjusted ORs indicated no significant differences at post‐test for any of the IGs [Intervention Groups]".

Schulze 2006

591 never‐smokers in intervention; 449 never‐smokers in control

224 intervention; 173 control

24 months

Smoking = current smoking, including irregular (less than weekly) smoking

Not biochemically verified

From published paper: 62.1% remained ‘never smoker’ in intervention group at follow‐up versus 61.4% in control group: OR 1.02 (0.83 to 1.24) adjusted for age, sex and school type.

 

Our reanalysis:  RR 0.98 (95% CI 0.77 to 1.24)

Not reported

Figuras y tablas -
Analysis 2.1

Comparison 2 Results of included studies, Outcome 1 Results table: RCTs.

Study

Number of non‐smokers at baseline

Number of smokers at endpoint who reported not smoking at baseline

Time point

Outcome

Biological criterion

Results

Secondary outcomes (dose response, cost, harms)

Comment

Burke 1992

Not reported

Not reported

18 months

Mean (SD) score of 5‐category self‐definition of smoking and 10‐category self‐reported frequency

Salivary thiocyanate (TCN)

From published paper:  Mean TCN at follow‐up of pre‐intervention never‐smokers higher (560 mcg/mL, SD 403) versus control (514 mcg/mL, SD 424).

Primary outcome for this review not available.

Not reported

Kairouz 2009

664 intervention; 915 control

93 intervention; 165 control

10 ‐ 18 months

Smoking = ever smoking, even just a puff

Not biochemically verified

From published paper: OR 0.8 (0.5 to 1.1), adjusted for age, gender, school location, social deprivation index.

Our reanalysis: 

RR 0.81 (95% CI 0.55 to1.20)

Intervention participants more likely than control participants to report that people “should not hang out with smokers” (14% versus 11%) and that they, themselves would “not want to be friends with a classmate who smokes” (28% versus 25%)

Concerns about misreporting of smoking status.  Note large numbers of ever‐smokers at baseline then denying ever smoking at follow‐up.  Stat sig more in intervention vs control (24% vs 16%)

Stucki 2014

544 intervention, 378 control

39 intervention,

24 control

About 7 months

Smoking = any smoking in last 6 months, even just a puff and smoking during the previous month

Not biochemically verified

From published and additional data from authors. OR for decreased smoking prevalence 0.7, CI 0.5 to 1.0

Increased smoking‐related knowledge b ‐1.0, P < 0.01

Vartiainen 1996

Not reported and not available from authors

Not reported and not available from authors

18 months

Smoking = daily smoking

Not biochemically verified

Reports only on the increase in prevalence of smoking from baseline to follow‐up. From baseline to longest follow‐up, increase by 10.8% points in Intervention group vs 11.2% points in control group: OR 1.25 (P = 0.15).

Primary outcome for this review not available.

Not reported.  Except in discussion – authors report "The social pressure created by the competition process was not greatly criticised in the pupils’ answers."

Wiborg 2002

1215 intervention group; 502 control

(data from authors)

207 intervention; 107 control

12 months

Smoking = 4 week prevalence of smoking

Not biochemically verified

From published paper: OR 1.36 (1.04 to 1.76), adjusted for age, sex, smoking status at baseline

Our reanalysis: 

RR 0.81 (95% CI 0.53 to 1.23)

Cost benefit (Hoeflymayr 2008). Cost benefit ratio: economic modelling based on estimates of reduced smoking prevalence in Intervention group and models of assumed future smoking behaviour and cessation. Not based on prevention of initiation

Figuras y tablas -
Analysis 2.2

Comparison 2 Results of included studies, Outcome 2 Results table: non‐randomized CTs.

Smokefree Class Competitions (SFC) for preventing smoking uptake

Patient or population: Children and adolescents aged 5 ‐ 18 years who were non‐smokers at baseline

Settings: Schools in Germany, the Netherlands, Finland, Switzerland, Canada and the United States

Intervention: Participation in SFC

Comparison: No participation in SFC

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of Participants

Actual number/

effective number2
(studies)

Quality of the evidence
(GRADE)

Assumed risk1

Corresponding risk

Smoking uptake at longest follow‐up (RCTS)

317 per 1000

320 per 1000

RR 1.00 (0.84 to 1.19)

3056/1108

(3)

Low3, 4

Smoking uptake at longest follow‐up

(Non‐RCTs)

158 per 1000

132 per 1000

RR 0.82 (0.63 to 1.08)

4219/1377

(3)

Very low3, 5, 6

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval; RR: Risk Ratio; RCT: Randomised Controlled Trial

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1'Assumed risk' calculated as risk in control groups.
2Adjusted for clustering.
3Downgraded one level due to imprecision. All studies included had a wide confidence interval.
4Downgraded one level due to risk of bias. 2/3 studies judged to be at high risk of attrition bias.
5Downgraded one level due to observational (non‐RCT) study type.
6Downgraded one level due to risk of bias. 2/3 studies judged to be at high risk of selection bias, most other bias risks unclear.

Figuras y tablas -
Comparison 1. Incentive versus control. Randomized and non‐randomized controlled studies (adjusted for clustering)

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Smoking uptake at longest follow‐up (RR) Show forest plot

6

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

1.1 RCTs

3

1108

Risk Ratio (M‐H, Fixed, 95% CI)

1.00 [0.84, 1.19]

1.2 Non‐randomized CTs

3

1377

Risk Ratio (M‐H, Fixed, 95% CI)

0.82 [0.63, 1.08]

Figuras y tablas -
Comparison 1. Incentive versus control. Randomized and non‐randomized controlled studies (adjusted for clustering)
Comparison 2. Results of included studies

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Results table: RCTs Show forest plot

Other data

No numeric data

2 Results table: non‐randomized CTs Show forest plot

Other data

No numeric data

Figuras y tablas -
Comparison 2. Results of included studies