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Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
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Figure 1

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

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Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
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Figure 2

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

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Table 1. Search results

Source of the search

Number of records

CHBG Controlled Trial Register

51

Cochrane Central Register of Controlled Trials

78

MEDLINE (Ovid)

116

EMBASE (Ovid)

518

Science Citation Index EXPANDED

91

Total number of references identified

851

Number of duplicates excluded

198

Number of references in final list

653
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Table 1. Search results
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Table 2. Baseline and after treatment laboratory variables in Nelson et al trial

 

Statin (n = 10)

Placebo  (n = 6)

Before treatment

After treatment

Mean decrease

Before treatment

After treatment

Mean decrease

ALT (U/L)

70.4

49.5

20.9

66.8

75.3

‐8.5

AST (U/L)

43.3

36.5

6.8

42.8

49.3

‐6.5

ALP (U/L)

86.1

89.7

‐3.6

74.3

73

1.3

TG (mg/dL)

388.7

490

‐101.3

335.3

361.7

‐26.4

ALT = alanine aminotransferase
AST = aspartate aminotransferase
ALP = alkaline phosphatase
TG = triglycerides

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Table 2. Baseline and after treatment laboratory variables in Nelson et al trial
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Table 3. Baseline and after treatment laboratory variables in Athyros et al trial

 

Statin (n = 63)

Fenofibrate  (n = 62)

Before treatment

After treatment

Mean decrease

Before treatment

After treatment

Mean decrease

ALT (U/L)

54

32

22

52

36

16

AST (U/L)

38

25

13

39

27

12

ALP (U/L)

110

75

35

108

78

30

TG (mg/dL)

203.8

142.2

61.6

194.9

115.6

79.3

ALT = alanine aminotransferase
AST = aspartate aminotransferase
ALP = alkaline phosphatases
TG = triglycerides

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Table 3. Baseline and after treatment laboratory variables in Athyros et al trial
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Table 4. Level of evidence for each outcome

Outcome

Biochemical improvement

 

Radiological improvement

No improvement in histology

Serious adverse effects

Evidence

Low‐quality systematic review

Low‐quality randomised clinical trial

Small sample size in low‐quality randomised clinical trial

Low‐quality systematic review

 

Level of evidence

2

2

2

2

Grade of recommendation

B

B

B

B
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Table 4. Level of evidence for each outcome
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