Cochrane Central Register of Controlled Trials (CENTRAL, part of the Cochrane Library)

#1[mh "Vitamin A"]
#2"Vitamin A" or retinol* or "Aquasol A" or retinal
#3#1 or #2
#4MeSH descriptor: [Child] explode all trees
#5MeSH descriptor: [Infant] this term only
#6(baby or babies or infant* or toddler* or child* or (pre next school*) or preschool* or girl* or boy*)
#7#4 or #5 or #6
#8#3 and #7 Publication Year from 2010 to 2016, in Trials

Ovid MEDLINE(R)

1 exp Vitamin A/
2 (retinol$ or retinal$ or aquasol a or vitamin a).tw.
3 or/1‐2
4 Infant/
5 exp Child/
6 (baby or babies or infant$ or toddler$ or child$ or girl$ or boy$ or pre school$ or pre‐school$ or preschool$).tw.
7 or/4‐6
8 randomized controlled trial.pt.
9 controlled clinical trial.pt.
10 randomi#ed.ab.
11 placebo$.ab.
12 drug therapy.fs.
13 randomly.ab.
14 trial.ab.
15 groups.ab.
16 or/8‐15
17 exp animals/ not humans.sh.
18 16 not 17
19 3 and 7 and 18
20 limit 19 to ed=20100401‐20160218

Ovid MEDLINE(R) In‐Process & Other Non‐Indexed Citations

1 (retinol$ or retinal$ or aquasol a or vitamin a).tw.
2 (baby or babies or infant$ or toddler$ or child$ or girl$ or boy$ or pre school$ or pre‐school$ or preschool$).tw.
3 1 and 2
4 random$.tw.
5 placebo$.tw.
6 trial.tw.
7 groups.tw.
8 (crossover or cross‐over).tw.
9 ((singl$ or doubl$ or tripl$ or trebl$) adj1 (blind$ or mask$)).tw.
10 prospective.tw.
11 factorial$.tw.
12 assign$.ab.
13 allocat$.ab.
14 or/4‐13
15 3 and 14
16 remove duplicates from 15

Embase (Ovid)

1 retinol/
2 (retinol$ or retinal$ or aquasol a or vitamin a).tw.
3 or/1‐2
4 exp child/
5 (baby or babies or infant$ or toddler$ or child$ or girl$ or boy$ or pre school$ or pre‐school$ or preschool$).tw.
6 or/4‐5
7 Randomized controlled trial/
8 controlled clinical trial/
9 Single blind procedure/
10 Double blind procedure/
11 triple blind procedure/
12 Crossover procedure/
13 (crossover or cross‐over).tw.
14 ((singl$ or doubl$ or tripl$ or trebl$) adj1 (blind$ or mask$)).tw.
15 Placebo/
16 placebo.tw.
17 prospective.tw.
18 factorial$.tw.
19 random$.tw.
20 assign$.ab.
21 allocat$.tw.
22 volunteer$.ab.
23 or/7‐22
24 exp animals/ or exp invertebrate/ or animal experiment/ or animal model/ or animal tissue/ or animal cell/ or nonhuman/
25 human/ or normal human/ or human cell/
26 24 and 25
27 24 not 2
28 23 not 27
29 3 and 6 and 28
30 limit 29 to yr="2010 ‐Current"
31 remove duplicates from 30

Science Citation Index‐Expanded (SCI, Web of Science) and Conference Proceedings Citation Index‐Science (CPCI‐S, Web of Science)

#5 #4 AND #3
DocType=All document types; Language=All languages;
#4 TS=(random* or placebo* or trial )
DocType=All document types; Language=All languages;
#3 #2 AND #1
DocType=All document types; Language=All languages;
#2 TS=(baby or babies or infant* or toddler* or child* or girl* or boy* or "pre school*" or pre‐school* or preschool*)
DocType=All document types; Language=All languages;
#1 TS=(retinol or "vitamin a")
DocType=All document types; Language=All languages;

Cochrane Database of Systematic Reviews (CDSR, part of the Cochrane Library) and Database of Abstracts of Reviews of Effects (DARE, part of the Cochrane Library)

#1 [mh "Vitamin A"]
#2 ("Vitamin A" or retinol* or "Aquasol A"):ti,ab,kw
#3 #1 or #2
#4 MeSH descriptor: [Child] explode all trees
#5 MeSH descriptor: [Infant] 1 tree(s) exploded
#6 (baby or babies or infant* or toddler* or child* or (pre next school*) or preschool* or girl* or boy*):ti,ab,kw
#7 #4 or #5 or #6
#8 #3 and #7 in Cochrane Reviews (Reviews and Protocols) and Other Reviews

Latino Americana e do Caribe em Ciências da Saúde (LILACS, bases.bireme.br/cgi‐bin/wxislind.exe/iah/online/)

(Mh vitamin a or tw retinol$ or tw aquasol$ or tw retinal$ ) AND ( Mh Child OR Mh Infant or Mh Child,preschool or Tw baby or Tw babies or Tw child$ or Tw infant$ or Tw toddler$ or Tw girl$ or Tw boy$ or Tw prescshool$ or Tw pre‐school$ or Tw niño or Tw niños or Tw niña or Tw niñas or Tw bebé or Tw bebés or Tw preescolar or Tw prescolares) [Words] and ((Pt randomized controlled trial OR Pt controlled clinical trial OR Mh randomized controlled trials OR Mh random allocation OR Mh double‐blind method OR Mh single‐blind method) AND NOT (Ct animal AND NOT (Ct human and Ct animal)) OR (Pt clinical trial OR Ex E05.318.760.535$ OR (Tw clin$ AND (Tw trial$ OR Tw ensa$ OR Tw estud$ OR Tw experim$ OR Tw investiga$)) OR ((Tw singl$ OR Tw simple$ OR Tw doubl$ OR Tw doble$ OR Tw duplo$ OR Tw trebl$ OR Tw trip$) AND (Tw blind$ OR Tw cego$ OR Tw ciego$ OR Tw mask$ OR Tw mascar$)) OR Mh placebos OR Tw placebo$ OR (Tw random$ OR Tw randon$ OR Tw casual$ OR Tw acaso$ OR Tw azar OR Tw aleator$) OR Mh research design) AND NOT (Ct animal AND NOT (Ct human and Ct animal)) OR (Ct comparative study OR Ex E05.337$ OR Mh follow‐up studies OR Mh prospective studies OR Tw control$ OR Tw prospectiv$ OR Tw volunt$ OR Tw volunteer$) AND NOT (Ct animal AND NOT (Ct human and Ct animal))) [Words] and (2010 OR 2011 OR 2012 OR 2013 OR 2014 OR 2015 OR 2016) [Country, year publication]

African Index Medicus (indexmedicus.afro.who.int/cgi‐bin/wxis.exe/iah/)

Retinol$ or retinal$ or aquasol$ or vitamin a [Descriptor] and 2010 OR 2011 OR 2012 OR 2013 OR 2014 OR 2015 OR 2016 [Publication Year]

World Health Organization International Clinical Trials Registry Platform (WHO ICTRP, apps.who.int/trialsearch/)

Advanced search: Intervention : Vitamin A AND Clinical Trials in Children AND Recruitment status: all (105)
Standard search: Vitamin A AND child OR Vitamin A AND babies OR Vitamin A AND infants (46)

The records from each of these searches were imported and deduplicated in Excel (148 records)

ClinicalTrials.gov

Advanced search: Intervention : Vitamin A AND Age Group: child

CENTRAL

27 April 2010

#1 MeSH descriptor Child explode all trees
#2 MeSH descriptor Infant explode all trees
#3 MeSH descriptor Child, Preschool explode all trees
#4 (baby or babies or infant* or toddler* or child* or (pre next school*) or preschool* or girl* or boy*):ti,ab,kw
#5 (#1 OR #2 OR #3 OR #4)
#6 MeSH descriptor Vitamin A explode all trees
#7 retinol* or retinal$ or “aquasol a” or “vitamin a”
#8 (#6 OR #7)
#9 (#5 AND #8)

Ovid MEDLINE

1950 to April Week 2 2010

1     exp infant/ or exp child/ or exp child, preschool/
2     (baby or babies or infant$ or toddler$ or child$ or girl$ or boy$ or pre school$ or pre‐school$ or preschool$).tw.
3     1 or 2
4     exp Vitamin A/
5     (retinol$ or retinal$ or aquasol a or vitamin a).ab,ti.
6     4 or 5
7     randomised controlled trial.pt.
8     controlled clinical trial.pt.
9     randomized.ab.
10     placebo.ab.
11     drug therapy.fs.
12     randomly.ab.
13     trial.ab.
14     groups.ab.
15     7 or 8 or 9 or 10 or 11 or 12 or 13 or 14
16     exp animals/ not humans.sh.
17     15 not 16
18     3 and 6 and 17

Embase

1980 to 2010 Week 16

EMTREE index terms were used when possible. The UK Cochrane Centre suggested that a combination of EMTREE and free‐text words were used to search for randomized controlled trials.

1 exp infant/ or exp child/ or exp child, preschool/
2 (baby or babies or infant$ or toddler$ or child$ or girl$ or boy$ or pre school$ or pre‐school$ or preschool$).tw.
3 1 or 2
4 exp Vitamin A/
5 (retinol$ or retinal$ or aquasol a or vitamin a).ab,ti.
6 4 or 5
7 exp crossover‐procedure/ or exp double‐blind procedure/ or exp randomized controlled trial/ or exp single‐blind procedure/
8 (random$ or factorial$ or crossover$ or cross over$ or cross‐over$ or placebo$ or (doubl$ adj blind$) or (singl$ adj blind$) or assign$ or allocat$ or volunteer$).mp.
9 7 or 8
10 3 and 6 and 9

Global Health

1973 to March 2010

For the search of Global Health database, replacement subject headings mapped to the Global Health database were used when possible, otherwise the text was used similar to the MEDLINE searches conducted previously.

1     exp school children/ or exp children/ or exp preschool children/
2     (baby or babies or infant$ or toddler$ or child$ or girl$ or boy$ or pre school$ or pre‐school$ or preschool$).tw.
3     1 or 2
4     retinol.sh.
5     (retinol$ or retinal$ or aquasol a or vitamin a).ab,ti.
6     4 or 5
7     exp randomized controlled trials/ or exp clinical trials/
8     random*.mp.
9     placebo.mp.
10     trial.mp.
11     7 or 8 or 9 or 10
12     3 and 6 and 11

LILACS

27 April 2010

Mh vitamin a or tw retinol$ or tw aquasol$ or tw retinal$ [Words] AND [Tw baby or Tw babies or Tw child$ or Tw infant$ or Tw toddler$ or Tw girl$ or Tw boy$ or Tw prescshool$ or Tw pre‐school$ or Tw niño or Tw niños or Tw niña or Tw niñas or Tw bebé or Tw bebés or Tw preescolar or Tw prescolares [Words] AND ((Pt randomized controlled trial OR Pt controlled clinical trial OR Mh randomized controlled trials OR Mh random allocation OR Mh double‐blind method OR Mh single‐blind method) AND NOT (Ct animal AND NOT (Ct human and Ct animal)) OR (Pt clinical trial OR Ex E05.318.760.535$ OR (Tw clin$ AND (Tw trial$ OR Tw ensa$ OR Tw estud$ OR Tw experim$ OR Tw investiga$)) OR ((Tw singl$ OR Tw simple$ OR Tw doubl$ OR Tw doble$ OR Tw duplo$ OR Tw trebl$ OR Tw trip$) AND (Tw blind$ OR Tw cego$ OR Tw ciego$ OR Tw mask$ OR Tw mascar$)) OR Mh placebos OR Tw placebo$ OR (Tw random$ OR Tw randon$ OR Tw casual$ OR Tw acaso$ OR Tw azar OR Tw aleator$) OR Mh research design) AND NOT (Ct animal AND NOT (Ct human and Ct animal)) OR (Ct comparative study OR Ex E05.337$ OR Mh follow‐up studies OR Mh prospective studies OR Tw control$ OR Tw prospectiv$ OR Tw volunt$ OR Tw volunteer$) AND NOT (Ct animal AND NOT (Ct human and Ct animal))) [Words]

metaRegister of Controlled Trials

27 April 2010

(baby or babies or infant or child) and (vitamin a or aquasol or retinol or retinal)

African Index Medicus

27 April 2010

1. retinol$ or retinal$ or aquasol a or vitamin a [Descriptor]