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Study flow diagram.
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Figure 1

Study flow diagram.

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Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.
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Figure 2

Methodological quality graph: review authors' judgements about each methodological quality item presented as percentages across all included studies.

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Methodological quality summary: review authors' judgements about each methodological quality item for each included study.
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Figure 3

Methodological quality summary: review authors' judgements about each methodological quality item for each included study.

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Comparison 1 HBOT compared with usual care, Outcome 1 Complete survival (defined as at least 95% take) at day 7.
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Analysis 1.1

Comparison 1 HBOT compared with usual care, Outcome 1 Complete survival (defined as at least 95% take) at day 7.

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Comparison 2 HBOT compared with sham HBOT, Outcome 1 Complete healing.
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Analysis 2.1

Comparison 2 HBOT compared with sham HBOT, Outcome 1 Complete healing.

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Comparison 2 HBOT compared with sham HBOT, Outcome 2 Time to healing (days).
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Analysis 2.2

Comparison 2 HBOT compared with sham HBOT, Outcome 2 Time to healing (days).

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Comparison 2 HBOT compared with sham HBOT, Outcome 3 Adverse effects (additional surgical procedures).
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Analysis 2.3

Comparison 2 HBOT compared with sham HBOT, Outcome 3 Adverse effects (additional surgical procedures).

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Comparison 2 HBOT compared with sham HBOT, Outcome 4 Adverse effects (tissue necrosis).
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Analysis 2.4

Comparison 2 HBOT compared with sham HBOT, Outcome 4 Adverse effects (tissue necrosis).

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Comparison 2 HBOT compared with sham HBOT, Outcome 5 Amputations.
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Analysis 2.5

Comparison 2 HBOT compared with sham HBOT, Outcome 5 Amputations.

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Comparison 2 HBOT compared with sham HBOT, Outcome 6 Length of hospital stay.
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Analysis 2.6

Comparison 2 HBOT compared with sham HBOT, Outcome 6 Length of hospital stay.

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Comparison 3 HBOT compared with dexamethasone or heparin, Outcome 1 Complete healing HBOT vs dexamethasone.
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Analysis 3.1

Comparison 3 HBOT compared with dexamethasone or heparin, Outcome 1 Complete healing HBOT vs dexamethasone.

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Comparison 3 HBOT compared with dexamethasone or heparin, Outcome 2 Complete healing HBOT vs heparin.
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Analysis 3.2

Comparison 3 HBOT compared with dexamethasone or heparin, Outcome 2 Complete healing HBOT vs heparin.

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Comparison 1. HBOT compared with usual care

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Complete survival (defined as at least 95% take) at day 7 Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 1. HBOT compared with usual care
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Comparison 2. HBOT compared with sham HBOT

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Complete healing Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Time to healing (days) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3 Adverse effects (additional surgical procedures) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4 Adverse effects (tissue necrosis) Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

5 Amputations Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

6 Length of hospital stay Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 2. HBOT compared with sham HBOT
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Comparison 3. HBOT compared with dexamethasone or heparin

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Complete healing HBOT vs dexamethasone Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Complete healing HBOT vs heparin Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected
Figuras y tablas -
Comparison 3. HBOT compared with dexamethasone or heparin
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