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Cochrane Database of Systematic Reviews

Desescalamiento del tratamiento antimicrobiano para los adultos con sepsis, sepsis grave y shock séptico

Esta versión no es la más reciente

Información

DOI:
https://doi.org/10.1002/14651858.CD007934.pub2Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 08 diciembre 2010see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:
  1. Grupo Cochrane de Anestesia

Copyright:
  1. Copyright © 2012 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Cifras del artículo

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Contraer

Autores

  • Brenda Nazaré Gomes Silva

    Correspondencia a: Brazilian Cochrane Centre, Universidade Federal de São Paulo, São Paulo, Brazil

    [email protected]

  • Régis B Andriolo

    Department of Public Health, Universidade do Estado do Pará, Belém, Brazil

  • Álvaro N Atallah

    Brazilian Cochrane Centre, Universidade Federal de São Paulo / Escola Paulista de Medicina, São Paulo, Brazil

  • Reinaldo Salomão

    Department of Medicine, Universidade Federal de São Paulo, São Paulo, Brazil

Contributions of authors

Conceiving the review: Brenda NG Silva (BGNS), Reinaldo Salomão (RS)

Co‐ordinating the review: BNGS

Screening search results: BNGS, Régis B Andriolo (RBA)

Organizing retrieval of papers: BNGS

Screening retrieved papers against inclusion criteria: BNGS, RBA, RS

Appraising quality of papers: BNGS, RBA, Álvaro N Atallah (ANA)

Abstracting data from papers: BNGS, RBA

Writing to authors of papers for additional information: BNGS

Providing additional data about papers: BNGS

Obtaining and screening data on unpublished studies: BNGS, RS

Data management for the review: BNGS

Entering data into Review Manager (RevMan 5.0): BNGS, RBA

RevMan statistical data: BNGS, RA, ANA

Other statistical analysis not using RevMan: RBA

Interpretation of data: BNGS, RBA, ANA

Statistical inferences: BNGS, RBA

Writing the review: BNGS, RS, ANA

Guarantor for the review (one author): BNGS

Person responsible for reading and checking review before submission: BNGS, RS, ANA

Sources of support

Internal sources

  • CAPES ‐ Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil.

External sources

  • No sources of support supplied

Declarations of interest

None known

Acknowledgements

We would like to thank the Cochrane Anaesthesia Review Group for their support throughout the entire editorial process.

We would like to thank Nicola Petrucci (content editor), Marissa M Alejandria, Marc Leone (peer reviewers) and Ann E Fonfa (consumer representative) for their help and editorial advice during the preparation of this review. In addition we also thank Nicola Petrucci (content editor), Marya Zilberberg and Mical Paul (peer reviewers) and Janet Wale and Tracey Lloyd (Cochrane Consumer Network) for their help and editorial advice during the preparation of the protocol for the review.

Version history

Published

Title

Stage

Authors

Version

2013 Mar 28

De‐escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock

Review

Brenda NG Silva, Régis B Andriolo, Álvaro N Atallah, Reinaldo Salomão

https://doi.org/10.1002/14651858.CD007934.pub3

2010 Dec 08

De‐escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock

Review

Brenda Nazaré Gomes Silva, Régis B Andriolo, Álvaro N Atallah, Reinaldo Salomão

https://doi.org/10.1002/14651858.CD007934.pub2

2009 Jul 08

De‐escalation of antimicrobial treatment for adults with sepsis, severe sepsis or septic shock

Protocol

Brenda Nazaré Gomes Silva, Régis B Andriolo, Álvaro N Atallah, Reinaldo Salomão

https://doi.org/10.1002/14651858.CD007934

Differences between protocol and review

We inserted two new items of Assessment of risk of bias in included studies according to the updated Cochrane Handbook (Higgins 2009): selective reporting bias and other bias.

The comparison group was inserted into the objective. Thus, the objective was changed from 'To evaluate the effectiveness and safety of antimicrobial de‐escalation for adult patients diagnosed with sepsis, severe sepsis or septic shock caused by any micro‐organism'

to

'To evaluate the effectiveness and safety of antimicrobial de‐escalation when compared with the maintenance of broad‐spectrum therapy for adult patients diagnosed with sepsis, severe sepsis or septic shock caused by any micro‐organism'.

The filter for randomized controlled trials previously planned to be used in the LILACS database was removed from the search strategy.

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.