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EMBASE = Excerpta Medica Database 
 MEDLINE = United States National Library of Medicine's bibliographic database 
 EBMZ = Evidence Based Medicine Reviews Multifile 
 Social Sci.= Social sciences database 
 CINAHL = Cumulative Index to Nursing & Allied Health Literature 
 EPOC = Effective Practice and Organisation of Care registry
Figuras y tablas -
Figure 1

EMBASE = Excerpta Medica Database
MEDLINE = United States National Library of Medicine's bibliographic database
EBMZ = Evidence Based Medicine Reviews Multifile
Social Sci.= Social sciences database
CINAHL = Cumulative Index to Nursing & Allied Health Literature
EPOC = Effective Practice and Organisation of Care registry

Comparison 1 Assertive community treatment versus standard community treatment, Outcome 1 Global assessment of function (symptomatology).
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Analysis 1.1

Comparison 1 Assertive community treatment versus standard community treatment, Outcome 1 Global assessment of function (symptomatology).

Comparison 1 Assertive community treatment versus standard community treatment, Outcome 2 Global assessment of function (Disability).
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Analysis 1.2

Comparison 1 Assertive community treatment versus standard community treatment, Outcome 2 Global assessment of function (Disability).

Comparison 1 Assertive community treatment versus standard community treatment, Outcome 3 Carer uplift/burden.
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Analysis 1.3

Comparison 1 Assertive community treatment versus standard community treatment, Outcome 3 Carer uplift/burden.

Comparison 1 Assertive community treatment versus standard community treatment, Outcome 4 Quality of life.
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Analysis 1.4

Comparison 1 Assertive community treatment versus standard community treatment, Outcome 4 Quality of life.

Table 1. Quality criteria results of protection against bias for randomised clinical trials

Author, year

Concealment of allocation

Follow up of study participants

Blinded assessment of outcome

Baseline measurement

Reliable primary outcome

Protection against contamination

Coelho, 1993

Not clear

Done

Not done

Done

Not clear

Not clear

Dowling, 2006

Done

Not done

Not done

Done

Done

Not done

Hassiotis, 2001

Not clear

Not clear

Not done

Done

Not Done

Done

Martin, 2005

Done

Done

Not clear

Done

Done

Not done

Oliver, 2005

Done

Done

Done

Done

Done

Not done

VanMinnen, 1997

Not clear

Done

Not clear

Done

Done

Done

Not clear: not reported in study

Not done: study authors specifically describe item and does not meet EPOC criteria

Done: study authors specifically describe item and it meets EPOC criteria

Scoring criteria provided by EPOC (Cochrane 2006b; Cochrane 2006a)

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Table 1. Quality criteria results of protection against bias for randomised clinical trials
Table 2. Results and Summary of Included Studies

Author, Year

Main results

Summary

Allen,
1998

I1 vs I2 Short term stays:

mean (SD): pre = 142.5 (42.0); post = 124.7 (20.7)

change: 17.8 less admission/year for I2
change in level: ‐3.3 (P = 0.94)
change in slope: ‐14.6 (P 0.49)

Long term stays:

mean (SD): pre = 16 (4.5); post = 9.0 (2.1)

change: 7 less admissions/year for I2
change in level: ‐43.5 (P = 0.07)
change in slope: 11.7 (P = 0.26)

I2 vs I3
Short term stays:

mean (SD): pre = 124.7 (20.7); post = 30.7 (30.7)

change: 94.0 less admissions/year for I3  
change in level : ‐6.1 (P = 0.21)
change in slope: ‐0.6 (P = 0.57)

Long term stays:

mean (SD): pre = 9 (2.1); post = 3.5 (2.4)

change: 5.5 less admissions/year for I3
change in level: 2.5 (P = 0.62)
change in slope: ‐0.3 (P = 0.90)

Reanalysis of results showed no evidence that community support teams alone or in combination with specialist services decreases short stay admissions

  

 

 

 

 

 

 

 

Reanalysis of results showed no evidence that community support teams alone or in combination with specialist services decreases long term stay admissions.

 

Coelho, 1993

Intervention with time shows significantly better results in all behaviour measures:
AMD‐ABS:

mean (SD) for I: pre = 199.4 (28.5); post = 211.9 (30.9)

mean (SD) for C: pre = 206.0 (30.0); post = 201.3 (29.0)
Adaptive behaviour increases more for I (P = 0.001)

AAMD‐ABS:

mean (SD) for I: pre = 53.7 (22.5); post = 40.1 (20.3)

mean (SD) for C: pre = 53.4 (27.5); post = 53.0 (29.0)

Maladaptive behaviour decreases more for I (P = 0.001)

MMBS:

mean (SD) for I: pre = 12.7 (7.0); post = 6.5 (4.6)

mean (SD) for C: pre = 12.0 (7.6); post = 11.5 (6.4)

Maladaptive behaviour decreases more for I (P = 0.001) 

Supports the use of decreased caseloads by professionals in a team and greater frequency of episodes of direct care with persons with dual diagnosis in their natural environment

Dowling, 2006

Improvements in behaviour for standard practice control group ONLY.  Significant difference in change in all measures except speech:

1) ABC irritability: mean change (SD) for I = ‐0.9 (5.8); for C = 6.1 (4.4); Greater improvement for C (P > 0.001)

2) ABC lethargy: mean change (SD) for I = ‐1.8 (4.5); for C = 5.7 (6.4); Greater improvement for C (P = 0.001)
3) ABC stereotypy: mean change (SD) for I = ‐0.8 (3.4); for C = 1.5 (2.0); Greater improvement for C (P = 0.020)
4) ABC hyperactivity: mean change (SD) for I = ‐0.3 (4.5); for C 6.2 (6.5); Greater improvement for C (P = 0.005)
5) ABC inappropriate speech: mean change (SD) for I = 0.4 (2.1); for C = ‐0.1 (5.5); NS difference (P = 0.781)
HoNOS‐LD: mean change (SD) for I = 0.4 (6.7); for C = 7.4 (7.0); Greater improvement for C (P = 0.009)

 

Supports mainstream bereavement counselling over grief work provided by carers at home and during day activities

Hassiotis, 2001

Persons with IQ of 85 or lower in intervention group were hospitalised for shorter lengths than those in control:

mean days in hospital (SD): I = 47.2 (98.0); C = 104.8 (159.5)

difference = 57.5 days; CI 110.9 to 4.2

Study reports no significant difference for quality of life scores for persons with IQ of 85 or less (results NR)

 

Supports intensive case management to decrease hospital length of stays for persons with a borderline or mild intellectual disability and psychotic illness

 

Lowe, 1996

DAS shows I group has significantly more behaviour problems (P < 0.05), but shows no difference in percentage rated severe + frequent (SD and P‐value NR)

ABC shows no difference in average score and no difference for number of problem behaviours (SD and P‐values NR)

No difference in ICI score (SD and P‐value NR)

MBI not used for this comparison

 

No evidence that specialist support services team is better than standard community treatment alone for persons with intellectual disability and challenging behaviour

Martin, 2005

No difference in GAF scores:
Symptoms (P = 0.263)
Disability (P = 0.209)

No difference in ABC score (P = 0.447)

Difference in QOLQ score favours C (P < 0.023)

No difference in Uplift/Burden score (P = 0.151)

(See figures 2‐5 for details)

No evidence that assertive community treatment is better than standard community treatment for persons with ID and mental health disorders

Oliver, 2005

No difference in GAF scores:

Symptomalogy (P = 0.080),

Social function and performance (P = 0.79)

No difference in any dimension of WHOQOL‐Bref or of Uplift/Burden Scale

(See figures 2‐5 for details)

No evidence that assertive community treatment is better than standard community treatment for persons with ID and mental health disorders

VanMinnen,

1997

No difference in psychiatric symptoms at endpoint:

PIMRA‐I mean: I = 15.6 (SD NR); C = 14.4 (SD NR)
difference = ‐1.2 (CI ‐4.9 to 2.6) (P = 0.53)

PIMRA‐SR mean: I = 16.7 (SD NR); C = 16.8 (SD NR); difference = 0.1 (CI ‐3.7 to 3.9) (P = 0.96)

Reiss mean: I = 12.7 (SD NR); C = 13.7 (SD NR)
difference = 1.0 (CI ‐4.4 to 6.4) (P = 0.71)

Carer burden not measured at endpoint for C group

Home based treatment of patients with dual diagnosis is as effective as hospital based treatment

* primary outcome was either identified by original study author or identified by review authors as best reflecting intervention
NR: not reported.

NS: not significant.

I: intervention.

C: control.

ID: intellectual disability.

SD: standard deviation.

CI 95% confidence interval.

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Table 2. Results and Summary of Included Studies
Comparison 1. Assertive community treatment versus standard community treatment

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Global assessment of function (symptomatology) Show forest plot

2

50

Mean Difference (IV, Fixed, 95% CI)

‐0.76 [‐6.07, 4.55]

2 Global assessment of function (Disability) Show forest plot

2

50

Mean Difference (IV, Fixed, 95% CI)

1.05 [‐4.05, 6.16]

3 Carer uplift/burden Show forest plot

2

50

Mean Difference (IV, Fixed, 95% CI)

0.03 [‐3.48, 3.54]

4 Quality of life Show forest plot

2

50

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.20 [‐0.75, 0.36]

Figuras y tablas -
Comparison 1. Assertive community treatment versus standard community treatment