MEDLINE (OvidSP)

#1

deferasirox*.mp.

#2

(ICL670* or ICL 670*).mp.

#3

(CGP72670* or CGP 72670*).mp.

#4

exjade*.mp.

#5

2‐hydroxyphenyl.mp.

#6

triazol‐1‐yl.mp.

#7

benzoic acid.mp.

#8

5 and 6 and 7

#9

1 or 2 or 3 or 4 or 8

#10

(2010* or 2011* or 2012* or 2013* or 2014*).ed,ep,dc. or ("2010" or "2011" or "2012" or "2013" or "2014").yr.

#11

9 and 10

#12

randomized controlled trial.pt.

#13

controlled clinical trial.pt.

#14

randomi#ed.ab.

#15

placebo.ab.

#16

drug therapy.fs.

#17

randomly.ab.

#18

trial.ab.

#19

groups.ab.

#20

12 or 13 or 14 or 15 or 16 or 17 or 18 or 19

#21

exp animals/ not humans.sh.

#22

20 not 21

#23

11 and 22

Notes

.mp. = title, abstract, original title, name of substance word, subject heading word, protocol supplementary concept, rare disease supplementary concept, unique identifier.

.sh. or / = Medical Subject Heading

exp = explode

.ti. title

.ab. = abstract

.pt. = publication type

.yr. = year

.ed. = entry date

.ep. = electronic date of publication

.dc. = date created

MEDLINE Daily Update (OvidSP)

#1

deferasirox*.mp.

#2

(ICL670* or ICL 670*).mp.

#3

(CGP72670* or CGP 72670*).mp.

#4

exjade*.mp.

#5

2‐hydroxyphenyl.mp.

#6

triazol‐1‐yl.mp.

#7

benzoic acid.mp.

#8

5 and 6 and 7

#9

1 or 2 or 3 or 4 or 8

Notes

.mp. = title, abstract, original title, name of substance word, subject heading word, protocol supplementary concept, rare disease supplementary concept, unique identifier.

MEDLINE In‐Process & Other Non‐Indexed Citations (OvidSP)

#1

deferasirox*.mp.

#2

(ICL670* or ICL 670*).mp.

#3

(CGP72670* or CGP 72670*).mp.

#4

exjade*.mp.

#5

2‐hydroxyphenyl.mp.

#6

triazol‐1‐yl.mp.

#7

benzoic acid.mp.

#8

5 and 6 and 7

#9

1 or 2 or 3 or 4 or 8

Notes

.mp. = title, abstract, original title, name of substance word, subject heading word, protocol supplementary concept, rare disease supplementary concept, unique identifier.

PubMed – subset "supplied by publisher" (www.pubmed.gov)

#1

Search deferasirox*[tw]

#2

Search ICL670*[tw] OR ICL 670*[tw]

#3

Search CGP72670*[tw] OR CGP 72670*[tw]

#4

Search exjade*[tw]

#5

Search 2‐hydroxyphenyl[tw]

#6

Search triazol‐1‐yl[tw]

#7

Search benzoic acid[tw]

#8

Search #5 AND #6 AND #7

#9

Search #1 OR #2 OR #3 OR #4 OR #8

#10

Search #9 AND publisher[sb]

Notes

[tw] = textword: title, abstract, other abstract, MeSH terms, MeSH Subheadings, Publication Types, Substance Names, Personal Name as Subject, Corporate Author, Secondary Source, and Other Terms.

[sb] = subset

EMBASE and EMBASE Alert (DIMDI www.dimdi.de)

#1

EM05; EA08

#2

FT=DEFERASIROX*

#3

FT=ICL670* OR FT=ICL 670*

#4

FT=CGP72670* OR FT=CGP 72670*

#5

FT=EXJADE*

#6

FT=2‐HYDROXYPHENYL

#7

FT=TRIAZOL‐1‐YL

#8

FT=BENZOIC ACID

#9

6 AND 7 AND 8

#10

2 OR 3 OR 4 OR 5 OR 9

#11

10 AND PY>=2010

#12

(FT=RANDOM* OR FT=PLACEBO* ) OR FT=DOUBLE‐BLIND*

#13

11 AND 12

#14

13 NOT SU=MEDLINE

Notes

EM05 = EMBASE ab 2005; EA08 = EMBASE Alert

PY = Publication year

SU = subunit

The Cochrane Library (Wiley: www.thecochranelibrary.com)

#1

deferasirox*

#2

ICL670* OR (ICL next 670*)

#3

CGP72670* OR (CGP next 72670*)

#4

exjade*

#5

2 next hydroxyphenyl

#6

triazol next 1 next yl

#7

benzoic next acid

#8

(#5 AND #6 AND #7)

#9

(#1 OR #2 OR #3 OR #4 OR #8)

#10

#9 Publication Date from 2010 to 2014 (Word variations have been searched)

Biosis Previews (Thomson Reuters)

#1

ts=deferasirox*

#2

ts=(ICL670* or "ICL 670*")

#3

ts=(CGP72670* or "CGP 72670*")

#4

ts=exjade*

#5

ts="2‐hydroxyphenyl"

#6

ts="triazol‐1‐yl"

#7

ts="benzoic acid"

#8

#7 AND #6 AND #5

#9

#8 OR #4 OR #3 OR #2 OR #1

#10

ts=(rando* or placebo or trial or "single‐blind*" or "double‐blind*" or groups)

#11

#10 AND #9

Notes

Ts = topic:

• Title field

• Foreign Title field

• Abstract field

• Major Concepts field

• Concept Code(s) field

• Taxonomic Data table

• Disease Data table

• Chemical Data table

• Gene Name Data table

• Sequence Data table

• Geographic Data table

• Geologic Time Data table

• Methods and Equipment Data table

• Parts & Structure Data table

• Miscellaneous Descriptors field

Indexes = BIOSIS Previews

Timespan = 2010 to 2014

Web of Science via Web of Knowledge (Thomson Reuters)

#1

ts=deferasirox*

#2

ts=(ICL670* or "ICL 670*")

#3

ts=(CGP72670* or "CGP 72670*")

#4

ts=exjade*

#5

ts="2‐hydroxyphenyl"

#6

ts="triazol‐1‐yl"

#7

ts="benzoic acid"

#8

#7 AND #6 AND #5

#9

#8 OR #4 OR #3 OR #2 OR #1

#10

ts=(rando* or placebo or trial or "single‐blind*" or "double‐blind*" or groups)

#11

#10 AND #9

Notes

TS = topic: Title, Abstract, Author Keywords, Keywords Plus^®

Indexes = SCI‐EXPANDED, SSCI, A&HCI, CPCI‐S, CPCI‐SSH

Timespan = 2010 to 2014

Derwent Drug file (DIMDI www.dimdi.de)

#1

DD83

#2

DEFERASIROX*

#3

FT=ICL670* OR FT=ICL 670*

#4

FT=CGP72670* OR FT=CGP 72670*

#5

FT=EXJADE*

#6

FT=2‐HYDROXYPHENYL

#7

FT=TRIAZOL‐1‐YL

#8

FT=BENZOIC ACID

#9

6 AND 7 AND 8

#10

2 OR 3 OR 4 OR 5 OR 9

#11

10 AND PY>=2010

#12

((((FT=RANDO* OR FT=PLACEBO ) OR FT=TRIAL ) OR (CT D "SINGLE‐BLIND"* OR UT="SINGLE‐BLIND"* OR IT="SINGLE‐BLIND"* OR SH="SINGLE‐BLIND"*)) OR FT=DOUBLE‐BLIND* ) OR FT=GROUPS

#13

11 AND 12

Notes

DD83 = Derwent Drug File

PY = Publication year

MEDLINE & MEDLINE In‐Process (Ovid)

#1

deferasirox*.mp

#2

(ICL670* or ICL 670*).mp

#3

(CGP72670* or CGP 72670*).mp

#4

exjade*.mp

#5

2‐hydroxyphenyl.mp

#6

triazol‐1‐yl.mp

#7

benzoic acid.mp

#8

and/5‐7

#9

or/1‐4,8

#10

remove duplicates from 9

Notes

.mp = title, original title, abstract, name of substance word, subject heading word, unique identifier

The chemical substance name "4‐(3,5‐bis(2‐hydroxyphenyl)‐(1,2,4)‐triazol‐1‐yl) benzoic acid" was searched by splitting it up in searchable terms (2‐hydroxyphenyl, triazol‐1‐yl, benzoic acid) and combining those by AND (lines #5 ‐ #8).

EMBASE (Ovid)

#1

deferasirox*.mp

#2

(ICL670* or ICL 670*).mp

#3

(CGP72670* or CGP 72670*).mp

#4

exjade*.mp

#5

2‐hydroxyphenyl.mp

#6

triazol‐1‐yl.mp

#7

benzoic acid.mp

#8

and/5‐7

#9

or/1‐4,8

#10

remove duplicates from 9

Notes

.mp = title, abstract, subject headings, heading word, drug trade name, original title, device manufacturer, drug manufacturer name

The chemical substance name "4‐(3,5‐bis(2‐hydroxyphenyl)‐(1,2,4)‐triazol‐1‐yl) benzoic acid" was searched by splitting it up in searchable terms (2‐hydroxyphenyl, triazol‐1‐yl, benzoic acid) and combining those by AND (lines #5 ‐ #8).

The Cochrane Library (Wiley Interscience)

#1

deferasirox*

#2

ICL670* or ICL next 670*

#3

CGP72670* or CGP next 72670*

#4

exjade*

#5

2‐hydroxyphenyl

#6

triazol‐1‐yl

#7

benzoic acid

#8

(#5 AND #6 AND #7)

#9

(#1 OR #2 OR #3 OR #4 OR #8)

Notes

The chemical substance name "4‐(3,5‐bis(2‐hydroxyphenyl)‐(1,2,4)‐triazol‐1‐yl) benzoic acid" was searched by splitting it up in searchable terms (2‐hydroxyphenyl, triazol‐1‐yl, benzoic acid) and combining those by AND (lines #5 ‐ #8).

Issues searched: Issue 6, 2010 for Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials and Issue 2, 2010 for Other Reviews (DARE), Methods Studies, Technology Assessments, Economic Evaluations

BIOSIS Previews (Ovid)

#1

deferasirox*.mp

#2

(ICL670* or ICL 670*).mp

#3

(CGP72670* or CGP 72670*).mp

#4

exjade*.mp

#5

2‐hydroxyphenyl.mp

#6

triazol‐1‐yl.mp

#7

benzoic acid.mp

#8

and/5‐7

#9

or/1‐4,8

#10

remove duplicates from 9

Notes

.mp = abstract, biosystematic codes, original language book title (non‐english), book title (english), chemicals & biochemicals, concept codes, diseases, geopolitical locations, gene name, major concepts, miscellaneous descriptors, methods & equipment, organisms, parts, structures & systems of organisms, sequence data, super taxa, title, time, taxa notes

The chemical substance name "4‐(3,5‐bis(2‐hydroxyphenyl)‐(1,2,4)‐triazol‐1‐yl) benzoic acid" was searched by splitting it up in searchable terms (2‐hydroxyphenyl, triazol‐1‐yl, benzoic acid) and combining those by AND (lines #5 ‐ #8).

Web of Science (Thomson Reuters)

#1

ts=deferasirox*

#2

ts=(ICL670* or "ICL 670*")

#3

ts=(CGP72670* or "CGP 72670*")

#4

ts=exjade*

#5

ts="2‐hydroxyphenyl"

#6

ts="triazol‐1‐yl"

#7

ts="benzoic acid"

#8

#5 AND #6 AND #7

#9

#1 OR #2 OR #3 OR #4 OR #8

Notes

ts = topic

The chemical substance name "4‐(3,5‐bis(2‐hydroxyphenyl)‐(1,2,4)‐triazol‐1‐yl) benzoic acid" was searched by splitting it up in searchable terms (2‐hydroxyphenyl, triazol‐1‐yl, benzoic acid) and combining those by AND (lines #5 ‐ #8).

Date searched: 27 June 2010

Derwent Drug File and XTOXLINE (DIMDI)

#1

deferasirox* (text field)

#2

ICL670* or ICL 670* (text field)

#3

CGP72670* or CGP 72670* (text field)

#4

exjade* (text field)

#5

2‐hydroxyphenyl (text field)

#6

triazol‐1‐yl (text field)

#7

benzoic acid (text field)

#8

#5 and #6 and #7

#9

#1 or #2 or #3 or #4 or #8

Notes

The chemical substance name "4‐(3,5‐bis(2‐hydroxyphenyl)‐(1,2,4)‐triazol‐1‐yl) benzoic acid" was searched by splitting it up in searchable terms (2‐hydroxyphenyl, triazol‐1‐yl, benzoic acid) and combining those by AND (lines #5 ‐ #8).

Current Controlled Trials

#1

"deferasirox" OR "ICL670" OR "ICL 670" OR "exjade"

Notes

Date searched: 28 June 2010

ClinicalTrials.gov

#1

"deferasirox" OR "ICL670" OR "ICL 670" OR "exjade"

Notes

Date searched: 28 June 2010

ICTRP

#1

"deferasirox" OR "ICL670" OR "ICL 670" OR "exjade"

Notes

Date searched: 28 June 2010