Retroperitoneal drainage versus no drainage after pelvic lymphadenectomy for the prevention of lymphocyst formation in patients with gynaecological malignancies
Appendices
Appendix 1. MEDLINE Search Strategy
1 genital neoplasm, female/ or pelvic neoplasm/
2 "gynecologic$ cancer" or "gynaecologic$ cancer"
3 "gynecologic$ malignan$" or "gynaecologic$ malignan$"
4 fallopian tube neoplasms/su [Surgery]
5 exp ovarian neoplasms/su [Surgery]
6 exp uterine neoplasms/su [Surgery]
7 "fallopian tube" AND (cancer OR cancers OR carcinoma OR carcinomas OR tumour OR tumours OR tumor OR tumors OR neoplasm OR neoplasms OR malignant OR malignancy)
8 (ovary OR ovarian) AND (cancer OR cancers OR carcinoma OR carcinomas OR tumour OR tumours OR tumor OR tumors OR neoplasm OR neoplasms OR malignant OR malignancy)
9 (uterine OR uterus) AND (cancer OR cancers OR carcinoma OR carcinomas OR tumour OR tumours OR tumor OR tumors OR neoplasm OR neoplasms OR malignant OR malignancy)
10 or/1‐9
11 lymphadenectom$
12 "lymph node dissection$"
13 "lymph node excision$"
14 lymphocyst
15 lymphocele/
16 "lymphatic cyst$"
17 or/11‐16
18 "suction drainage$"
19 "pelvic drain$" or "pelvic drainage$"
20 "retroperitoneal drainage$"
21 "pelvic reperitonealization"
22 or/18‐21
23 10 and 17 and 22
24 randomized controlled trial.pt.
25 controlled clinical trial.pt.
26 Randomized Controlled Trials/
27 Random allocation/
28 Double‐blind method/
29 Single‐blind method/
30 or/24‐29
31 clinical trial.pt.
32 exp clinical trials/
33 (clin$ adj25 trial$).ti,ab,sh.
34 ((singl$ or doubl$ or tripl$ or trebl$) adj25 (blind$ or mask$)).ti,ab,sh.
35 Placebos/
36 placebo$.ti,ab,sh.
37 random$.ti,ab,sh.
38 Research design/
39 or/31‐38
40 animal/ not (human/ and animal/)
41 30 or 39
42 41 not 40
43 23 and 42
Appendix 2. EMBASE Search Strategy
1 Female Genital Tract Tumor/
2 "gynecologic$ cancer" or "gynaecologic$ cancer"
3 "gynecologic$ malignan$" or "gynaecologic$ malignan$"
4 fallopian tube tumor/su [Surgery]
5 exp ovarian tumor/su [Surgery]
6 exp uterine tumor/su [Surgery]
7 "fallopian tube" AND (cancer OR cancers OR carcinoma OR carcinomas OR tumour OR tumours OR tumor OR tumors OR neoplasm OR neoplasms OR malignant OR malignancy)
8 (ovary OR ovarian) AND (cancer OR cancers OR carcinoma OR carcinomas OR tumour OR tumours OR tumor OR tumors OR neoplasm OR neoplasms OR malignant OR malignancy)
9 (uterine OR uterus) AND (cancer OR cancers OR carcinoma OR carcinomas OR tumour OR tumours OR tumor OR tumors OR neoplasm OR neoplasms OR malignant OR malignancy)
10 or/1‐9
11 lymphadenectom$
12 "lymph node dissection$"
13 "lymph node excision$"
14 lymphocyst
15 lymphocele/
16 "lymphatic cyst$"
17 or/11‐16
18 "suction drainage$"
19 "pelvic drain$" or "pelvic drainage$"
20 "retroperitoneal drainage$"
21 "pelvic reperitonealization"
22 or/18‐21
23 10 and 17 and 22
24 controlled study/ or randomized controlled trial/
25 double blind procedure/
26 single blind procedure/
27 crossover procedure/
28 drug comparison/
29 placebo/
30 random$.ti,ab,hw,tn,mf.
31 latin square.ti,ab,hw,tn,mf.
32 crossover.ti,ab,hw,tn,mf.
33 cross‐over.ti,ab,hw,tn,mf.
34 placebo$.ti,ab,hw,tn,mf.
35 ((doubl$ or singl$ or tripl$ or trebl$) adj5 (blind$ or mask$)).ti,ab,hw,tn,mf.
36 (comparative adj5 trial$).ti,ab,hw,tn,mf.
37 (clinical adj5 trial$).ti,ab,hw,tn,mf.
38 or/24‐37
39 nonhuman/
40 animal/ not (human/ and animal/)
41 or/39‐40
42 38 not 41
43 23 and 42
Appendix 3. Specific criteria for allocation concealment rating
Clearly yes: rate A
-
Some form of centralised randomisation scheme, such as having to provide participant details by phone to receive treatment group allocation
-
A scheme controlled by a pharmacy or nutritional unit
-
An on‐site computer system, given that allocations are in a locked unreadable file which can be accessed only after inputting participant details
-
Assignment envelopes, provided that they are sequentially numbered, sealed and opaque
-
Other combinations which appear to provide assurance of adequate concealment
Unclear: rate B
-
Assignment envelopes, without description of adequate safeguards
-
Use of a "list" or "table"
-
Flip of a coin
-
A trial in which the description suggests adequate concealment, but other features are suspicious‐ for example, markedly unequal controls and trial groups
-
Stated random, but unable to obtain further details
Clearly no: rate C
-
Alternation
-
Case record numbers, dates of birth, day of the week, or any other such approach
-
Any allocation procedure transparent before assignment, such as an open list of random numbers