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Cochrane Database of Systematic Reviews

Derivados del tiol nebulizados y por vía oral para la enfermedad pulmonar en la fibrosis quística

Información

DOI:
https://doi.org/10.1002/14651858.CD007168.pub3Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 12 julio 2013see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:

  1. Grupo Cochrane de Fibrosis quística y enfermedades genéticas

Copyright:
  1. Copyright © 2015 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Cifras del artículo

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Contraer

Autores

  • Julian Tam

    Correspondencia a: Division of Respirology, Critical Care, and Sleep Medicine. Department of Medicine, University of Saskatchewan, Saskatoon, Canada

    [email protected]

  • Edward F Nash

    Department of Respiratory Medicine, Birmingham Heartlands Hospital, Birmingham, UK

  • Felix Ratjen

    Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada

  • Elizabeth Tullis

    Division of Respirology, St Michael's Hospital, Toronto, Canada

  • Anne Stephenson

    Division of Respirology, St Michael's Hospital, Toronto, Canada

Contributions of authors

Dr Anne Stephenson conceived of the idea for the review. Dr Edward Nash and Dr Anne Stephenson jointly wrote the original review. Dr Julian Tam, Dr Edward Nash, and Dr Anne Stephenson wrote the updated review.

Dr Elizabeth Tullis and Prof Felix Ratjen supervised, gave comments and offered advice on the review.

Dr Nash acts as guarantor for the review.

Sources of support

Internal sources

  • Division of Respirology, St. Michael's Hospital, Canada.

External sources

  • No sources of support supplied

Declarations of interest

One of the co‐authors of this review, Professor Felix Ratjen, is lead investigator on one of the included trials.

Acknowledgements

We would like to acknowledge the helpful advice and constructive criticism offered by Professor Bruce K Rubin in the preparation of this review. We would also like to thank Jan Tecklin for helping us in obtaining data.

Version history

Published

Title

Stage

Authors

Version

2013 Jul 12

Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis

Review

Julian Tam, Edward F Nash, Felix Ratjen, Elizabeth Tullis, Anne Stephenson

https://doi.org/10.1002/14651858.CD007168.pub3

2009 Jan 21

Nebulized and oral thiol derivatives for pulmonary disease in cystic fibrosis

Review

Edward F Nash, Anne Stephenson, Felix Ratjen, Elizabeth Tullis

https://doi.org/10.1002/14651858.CD007168.pub2

2008 Apr 23

Thiol derivatives for pulmonary disease in cystic fibrosis

Protocol

Edward F Nash, Anne Stephenson, Felix Ratjen, Elizabeth Tullis

https://doi.org/10.1002/14651858.CD007168

Keywords

MeSH

Medical Subject Headings (MeSH) Keywords

Medical Subject Headings Check Words

Humans;

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 1 Change in forced expiratory volume in 1 second.
Figuras y tablas -
Analysis 1.1

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 1 Change in forced expiratory volume in 1 second.

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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 2 Change in forced vital capacity.
Figuras y tablas -
Analysis 1.2

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 2 Change in forced vital capacity.

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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 3 Peak expiratory flow.
Figuras y tablas -
Analysis 1.3

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 3 Peak expiratory flow.

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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 4 Vmax50% Vital capacity.
Figuras y tablas -
Analysis 1.4

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 4 Vmax50% Vital capacity.

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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 5 Forced expiratory flow 25‐75.
Figuras y tablas -
Analysis 1.5

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 5 Forced expiratory flow 25‐75.

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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 6 RV/TLC.
Figuras y tablas -
Analysis 1.6

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 6 RV/TLC.

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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 7 Six‐minute walk test [metres].
Figuras y tablas -
Analysis 1.7

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 7 Six‐minute walk test [metres].

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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 8 Sputum viscosity.
Figuras y tablas -
Analysis 1.8

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 8 Sputum viscosity.

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Comparison 2 Oral thiols versus placebo, Outcome 1 Change in forced expiratory volume in 1 second [% predicted].
Figuras y tablas -
Analysis 2.1

Comparison 2 Oral thiols versus placebo, Outcome 1 Change in forced expiratory volume in 1 second [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 2 Peak expiratory flow [L/min].
Figuras y tablas -
Analysis 2.2

Comparison 2 Oral thiols versus placebo, Outcome 2 Peak expiratory flow [L/min].

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Comparison 2 Oral thiols versus placebo, Outcome 3 Change in peak expiratory flow [% predicted].
Figuras y tablas -
Analysis 2.3

Comparison 2 Oral thiols versus placebo, Outcome 3 Change in peak expiratory flow [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 4 Change in total lung capacity [% predicted].
Figuras y tablas -
Analysis 2.4

Comparison 2 Oral thiols versus placebo, Outcome 4 Change in total lung capacity [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 5 Change in flow 75% FVC [% predicted].
Figuras y tablas -
Analysis 2.5

Comparison 2 Oral thiols versus placebo, Outcome 5 Change in flow 75% FVC [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 6 Change in flow 50% FVC [% predicted].
Figuras y tablas -
Analysis 2.6

Comparison 2 Oral thiols versus placebo, Outcome 6 Change in flow 50% FVC [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 7 Change in flow 25% FVC [% predicted].
Figuras y tablas -
Analysis 2.7

Comparison 2 Oral thiols versus placebo, Outcome 7 Change in flow 25% FVC [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 8 Change in forced expiratory volume in 1 sec/vital capacity [% predicted].
Figuras y tablas -
Analysis 2.8

Comparison 2 Oral thiols versus placebo, Outcome 8 Change in forced expiratory volume in 1 sec/vital capacity [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 9 Change in total gas volume [% predicted].
Figuras y tablas -
Analysis 2.9

Comparison 2 Oral thiols versus placebo, Outcome 9 Change in total gas volume [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 10 Change in vital capacity [% predicted].
Figuras y tablas -
Analysis 2.10

Comparison 2 Oral thiols versus placebo, Outcome 10 Change in vital capacity [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 11 Change in residual volume/total lung capacity [% predicted].
Figuras y tablas -
Analysis 2.11

Comparison 2 Oral thiols versus placebo, Outcome 11 Change in residual volume/total lung capacity [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 12 Antibiotic treatment [weeks].
Figuras y tablas -
Analysis 2.12

Comparison 2 Oral thiols versus placebo, Outcome 12 Antibiotic treatment [weeks].

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Comparison 3 Oral thiols versus other oral agents, Outcome 1 Change in forced expiratory volume in 1 second [% predicted].
Figuras y tablas -
Analysis 3.1

Comparison 3 Oral thiols versus other oral agents, Outcome 1 Change in forced expiratory volume in 1 second [% predicted].

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Comparison 3 Oral thiols versus other oral agents, Outcome 2 Change in peak expiratory flow [% predicted].
Figuras y tablas -
Analysis 3.2

Comparison 3 Oral thiols versus other oral agents, Outcome 2 Change in peak expiratory flow [% predicted].

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Comparison 3 Oral thiols versus other oral agents, Outcome 3 Change in total lung capacity [% predicted].
Figuras y tablas -
Analysis 3.3

Comparison 3 Oral thiols versus other oral agents, Outcome 3 Change in total lung capacity [% predicted].

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 3 Oral thiols versus other oral agents, Outcome 4 Change in flow 75% FVC [% predicted].
Figuras y tablas -
Analysis 3.4

Comparison 3 Oral thiols versus other oral agents, Outcome 4 Change in flow 75% FVC [% predicted].

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Comparison 3 Oral thiols versus other oral agents, Outcome 5 Change in flow 50% FVC [% predicted].
Figuras y tablas -
Analysis 3.5

Comparison 3 Oral thiols versus other oral agents, Outcome 5 Change in flow 50% FVC [% predicted].

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 3 Oral thiols versus other oral agents, Outcome 6 Change in flow 25% FVC [% predicted].
Figuras y tablas -
Analysis 3.6

Comparison 3 Oral thiols versus other oral agents, Outcome 6 Change in flow 25% FVC [% predicted].

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Comparison 3 Oral thiols versus other oral agents, Outcome 7 Change in forced expiratory volume in 1 sec/vital capacity [% predicted].
Figuras y tablas -
Analysis 3.7

Comparison 3 Oral thiols versus other oral agents, Outcome 7 Change in forced expiratory volume in 1 sec/vital capacity [% predicted].

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Comparison 3 Oral thiols versus other oral agents, Outcome 8 Change in thoracic gas volume [% predicted].
Figuras y tablas -
Analysis 3.8

Comparison 3 Oral thiols versus other oral agents, Outcome 8 Change in thoracic gas volume [% predicted].

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 3 Oral thiols versus other oral agents, Outcome 9 Change in vital capacity [% predicted].
Figuras y tablas -
Analysis 3.9

Comparison 3 Oral thiols versus other oral agents, Outcome 9 Change in vital capacity [% predicted].

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 3 Oral thiols versus other oral agents, Outcome 10 Change in residual volume/total lung capacity [% predicted].
Figuras y tablas -
Analysis 3.10

Comparison 3 Oral thiols versus other oral agents, Outcome 10 Change in residual volume/total lung capacity [% predicted].

Ir a la figura de la revisiónAbrir en una pestaña nueva
Comparison 1. Nebulized thiols versus other nebulized medications

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in forced expiratory volume in 1 second Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Change in forced vital capacity Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.1 Up to 3 months (parallel)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.2 Up to 3 months (cross‐over)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Peak expiratory flow Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3.1 Up to 3 months (parallel)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.2 Up to 3 months (cross‐over)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Vmax50% Vital capacity Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Forced expiratory flow 25‐75 Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

5.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6 RV/TLC Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Six‐minute walk test [metres] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

7.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Sputum viscosity Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

8.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 1. Nebulized thiols versus other nebulized medications
Ir a la tabla de la revisión
Comparison 2. Oral thiols versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in forced expiratory volume in 1 second [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Peak expiratory flow [L/min] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Change in peak expiratory flow [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Change in total lung capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Change in flow 75% FVC [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

5.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6 Change in flow 50% FVC [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Change in flow 25% FVC [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

7.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Change in forced expiratory volume in 1 sec/vital capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

8.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

9 Change in total gas volume [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

9.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

10 Change in vital capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

10.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

11 Change in residual volume/total lung capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

11.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

12 Antibiotic treatment [weeks] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

12.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 2. Oral thiols versus placebo
Ir a la tabla de la revisión
Comparison 3. Oral thiols versus other oral agents

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in forced expiratory volume in 1 second [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Change in peak expiratory flow [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Change in total lung capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Change in flow 75% FVC [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Change in flow 50% FVC [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

5.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6 Change in flow 25% FVC [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Change in forced expiratory volume in 1 sec/vital capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

7.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Change in thoracic gas volume [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

8.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

9 Change in vital capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

9.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

10 Change in residual volume/total lung capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

10.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 3. Oral thiols versus other oral agents
Ir a la tabla de la revisión