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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 1 Change in forced expiratory volume in 1 second.
Figuras y tablas -
Analysis 1.1

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 1 Change in forced expiratory volume in 1 second.

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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 2 Change in forced vital capacity.
Figuras y tablas -
Analysis 1.2

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 2 Change in forced vital capacity.

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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 3 Peak expiratory flow.
Figuras y tablas -
Analysis 1.3

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 3 Peak expiratory flow.

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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 4 Vmax50% Vital capacity.
Figuras y tablas -
Analysis 1.4

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 4 Vmax50% Vital capacity.

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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 5 Forced expiratory flow 25‐75.
Figuras y tablas -
Analysis 1.5

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 5 Forced expiratory flow 25‐75.

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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 6 RV/TLC.
Figuras y tablas -
Analysis 1.6

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 6 RV/TLC.

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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 7 Six‐minute walk test [metres].
Figuras y tablas -
Analysis 1.7

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 7 Six‐minute walk test [metres].

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Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 8 Sputum viscosity.
Figuras y tablas -
Analysis 1.8

Comparison 1 Nebulized thiols versus other nebulized medications, Outcome 8 Sputum viscosity.

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Comparison 2 Oral thiols versus placebo, Outcome 1 Change in forced expiratory volume in 1 second [% predicted].
Figuras y tablas -
Analysis 2.1

Comparison 2 Oral thiols versus placebo, Outcome 1 Change in forced expiratory volume in 1 second [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 2 Peak expiratory flow [L/min].
Figuras y tablas -
Analysis 2.2

Comparison 2 Oral thiols versus placebo, Outcome 2 Peak expiratory flow [L/min].

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Comparison 2 Oral thiols versus placebo, Outcome 3 Change in peak expiratory flow [% predicted].
Figuras y tablas -
Analysis 2.3

Comparison 2 Oral thiols versus placebo, Outcome 3 Change in peak expiratory flow [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 4 Change in total lung capacity [% predicted].
Figuras y tablas -
Analysis 2.4

Comparison 2 Oral thiols versus placebo, Outcome 4 Change in total lung capacity [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 5 Change in flow 75% FVC [% predicted].
Figuras y tablas -
Analysis 2.5

Comparison 2 Oral thiols versus placebo, Outcome 5 Change in flow 75% FVC [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 6 Change in flow 50% FVC [% predicted].
Figuras y tablas -
Analysis 2.6

Comparison 2 Oral thiols versus placebo, Outcome 6 Change in flow 50% FVC [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 7 Change in flow 25% FVC [% predicted].
Figuras y tablas -
Analysis 2.7

Comparison 2 Oral thiols versus placebo, Outcome 7 Change in flow 25% FVC [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 8 Change in forced expiratory volume in 1 sec/vital capacity [% predicted].
Figuras y tablas -
Analysis 2.8

Comparison 2 Oral thiols versus placebo, Outcome 8 Change in forced expiratory volume in 1 sec/vital capacity [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 9 Change in total gas volume [% predicted].
Figuras y tablas -
Analysis 2.9

Comparison 2 Oral thiols versus placebo, Outcome 9 Change in total gas volume [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 10 Change in vital capacity [% predicted].
Figuras y tablas -
Analysis 2.10

Comparison 2 Oral thiols versus placebo, Outcome 10 Change in vital capacity [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 11 Change in residual volume/total lung capacity [% predicted].
Figuras y tablas -
Analysis 2.11

Comparison 2 Oral thiols versus placebo, Outcome 11 Change in residual volume/total lung capacity [% predicted].

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Comparison 2 Oral thiols versus placebo, Outcome 12 Antibiotic treatment [weeks].
Figuras y tablas -
Analysis 2.12

Comparison 2 Oral thiols versus placebo, Outcome 12 Antibiotic treatment [weeks].

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Comparison 3 Oral thiols versus other oral agents, Outcome 1 Change in forced expiratory volume in 1 second [% predicted].
Figuras y tablas -
Analysis 3.1

Comparison 3 Oral thiols versus other oral agents, Outcome 1 Change in forced expiratory volume in 1 second [% predicted].

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Comparison 3 Oral thiols versus other oral agents, Outcome 2 Change in peak expiratory flow [% predicted].
Figuras y tablas -
Analysis 3.2

Comparison 3 Oral thiols versus other oral agents, Outcome 2 Change in peak expiratory flow [% predicted].

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Comparison 3 Oral thiols versus other oral agents, Outcome 3 Change in total lung capacity [% predicted].
Figuras y tablas -
Analysis 3.3

Comparison 3 Oral thiols versus other oral agents, Outcome 3 Change in total lung capacity [% predicted].

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Comparison 3 Oral thiols versus other oral agents, Outcome 4 Change in flow 75% FVC [% predicted].
Figuras y tablas -
Analysis 3.4

Comparison 3 Oral thiols versus other oral agents, Outcome 4 Change in flow 75% FVC [% predicted].

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Comparison 3 Oral thiols versus other oral agents, Outcome 5 Change in flow 50% FVC [% predicted].
Figuras y tablas -
Analysis 3.5

Comparison 3 Oral thiols versus other oral agents, Outcome 5 Change in flow 50% FVC [% predicted].

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Comparison 3 Oral thiols versus other oral agents, Outcome 6 Change in flow 25% FVC [% predicted].
Figuras y tablas -
Analysis 3.6

Comparison 3 Oral thiols versus other oral agents, Outcome 6 Change in flow 25% FVC [% predicted].

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Comparison 3 Oral thiols versus other oral agents, Outcome 7 Change in forced expiratory volume in 1 sec/vital capacity [% predicted].
Figuras y tablas -
Analysis 3.7

Comparison 3 Oral thiols versus other oral agents, Outcome 7 Change in forced expiratory volume in 1 sec/vital capacity [% predicted].

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Comparison 3 Oral thiols versus other oral agents, Outcome 8 Change in thoracic gas volume [% predicted].
Figuras y tablas -
Analysis 3.8

Comparison 3 Oral thiols versus other oral agents, Outcome 8 Change in thoracic gas volume [% predicted].

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Comparison 3 Oral thiols versus other oral agents, Outcome 9 Change in vital capacity [% predicted].
Figuras y tablas -
Analysis 3.9

Comparison 3 Oral thiols versus other oral agents, Outcome 9 Change in vital capacity [% predicted].

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Comparison 3 Oral thiols versus other oral agents, Outcome 10 Change in residual volume/total lung capacity [% predicted].
Figuras y tablas -
Analysis 3.10

Comparison 3 Oral thiols versus other oral agents, Outcome 10 Change in residual volume/total lung capacity [% predicted].

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Comparison 1. Nebulized thiols versus other nebulized medications

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in forced expiratory volume in 1 second Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Change in forced vital capacity Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.1 Up to 3 months (parallel)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.2 Up to 3 months (cross‐over)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Peak expiratory flow Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3.1 Up to 3 months (parallel)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.2 Up to 3 months (cross‐over)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Vmax50% Vital capacity Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Forced expiratory flow 25‐75 Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

5.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6 RV/TLC Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Six‐minute walk test [metres] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

7.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Sputum viscosity Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

8.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 1. Nebulized thiols versus other nebulized medications
Ir a la tabla de la revisión
Comparison 2. Oral thiols versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in forced expiratory volume in 1 second [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Peak expiratory flow [L/min] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Change in peak expiratory flow [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Change in total lung capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Change in flow 75% FVC [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

5.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6 Change in flow 50% FVC [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Change in flow 25% FVC [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

7.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Change in forced expiratory volume in 1 sec/vital capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

8.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

9 Change in total gas volume [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

9.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

10 Change in vital capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

10.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

11 Change in residual volume/total lung capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

11.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

12 Antibiotic treatment [weeks] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

12.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 2. Oral thiols versus placebo
Ir a la tabla de la revisión
Comparison 3. Oral thiols versus other oral agents

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in forced expiratory volume in 1 second [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Change in peak expiratory flow [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Change in total lung capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Change in flow 75% FVC [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Change in flow 50% FVC [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

5.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6 Change in flow 25% FVC [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Change in forced expiratory volume in 1 sec/vital capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

7.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Change in thoracic gas volume [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

8.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

9 Change in vital capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

9.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

10 Change in residual volume/total lung capacity [% predicted] Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

10.1 Up to 3 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 3. Oral thiols versus other oral agents
Ir a la tabla de la revisión