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Cochrane Database of Systematic Reviews

Immediate‐release versus controlled‐release carbamazepine in the treatment of epilepsy

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ver la versión actual 09 diciembre 2016

Información

DOI:
https://doi.org/10.1002/14651858.CD007124.pub4Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 03 diciembre 2014see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:

  1. Grupo Cochrane de Epilepsia

Copyright:
  1. Copyright © 2014 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Cifras del artículo

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Contraer

Autores

  • Graham Powell

    Correspondencia a: The Walton Centre for Neurology & Neurosurgery NHS Foundation Trust, Liverpool, UK

    [email protected]

  • Matthew Saunders

    Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

  • Alexandra Rigby

    Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

  • Anthony G Marson

    Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK

Contributions of authors

Graham Powell identified the studies, assessed their methodological quality, extracted the data and composed the review.

Matthew Saunders identified the studies, assessed their methodological quality and extracted the data.

Declarations of interest

None known

Acknowledgements

Alison Beamond and Rachael Kelly provided invaluable help with the searches and administrative aspects of this review.

Version history

Published

Title

Stage

Authors

Version

2016 Dec 09

Immediate‐release versus controlled‐release carbamazepine in the treatment of epilepsy

Review

Graham Powell, Matthew Saunders, Alexandra Rigby, Anthony G Marson

https://doi.org/10.1002/14651858.CD007124.pub5

2014 Dec 03

Immediate‐release versus controlled‐release carbamazepine in the treatment of epilepsy

Review

Graham Powell, Matthew Saunders, Alexandra Rigby, Anthony G Marson

https://doi.org/10.1002/14651858.CD007124.pub4

2014 Feb 03

Immediate‐release versus controlled‐release carbamazepine in the treatment of epilepsy

Review

Graham Powell, Matthew Saunders, Anthony G Marson

https://doi.org/10.1002/14651858.CD007124.pub3

2010 Jan 20

Immediate‐release versus controlled‐release carbamazepine in the treatment of epilepsy

Review

Graham Powell, Matthew Saunders, Anthony G Marson

https://doi.org/10.1002/14651858.CD007124.pub2

2008 Apr 23

Immediate‐release versus controlled‐release carbamazepine in the treatment of epilepsy

Protocol

Graham Powell, Anthony G Marson, Matthew Saunders

https://doi.org/10.1002/14651858.CD007124

Differences between protocol and review

Many of the outcomes specified in the protocol of this review were not measured. The studies were predominantly designed as randomised crossover trials. The duration of treatment in each arm ranged from two weeks to three months. No trial reported follow up beyond study completion. Categorical data including the proportion that were seizure free and the proportion with treatment failure, both at six and 12 months, were therefore not reported. In addition, time‐to‐event data were not reported.

Detailed statistical analysis, including meta‐analysis, was not appropriate. Therefore, the analysis used in this review was largely narrative.

Keywords

MeSH

Medical Subject Headings (MeSH) Keywords

Medical Subject Headings Check Words

Humans;

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.

Study flow diagram.
Figuras y tablas -
Figure 1

Study flow diagram.

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Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Figuras y tablas -
Figure 2

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

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