a. We did not calculate NNT as per protocol, as largely this has been superseded by the use of the Summary of Findings table.

Also, this review has been ongoing for some time. During this period Summary of Findings tables became possible. We did not pre‐state outcomes that should be the focus of this table, but have chosen these post‐hoc: These outcomes were chosen after the data were known.

1. Weight ‐ no clinically important change in body weight (as defined by individual studies)

2. Change in BMI

3. Presence of metabolic syndrome

4. Global state ‐ no clinically important change in global state (as defined by individual studies)

5. Mental state (with particular reference to the positive and negative symptoms of schizophrenia) ‐ no clinically important change in general mental state

6. Averse effects ‐ serious

7. Satisfaction with treatment ‐ recipient of care not satisfied with treatment

b. In the protocol, a random‐effects model was planned to be used for measuring treatment effect but the review has used a fixed‐effect model and the reasons for this have been detailed under data synthesis. The Methods section also had to be modified slightly to accommodate the requirements of RevMan 5 (published protocol used RevMan 4).

c. The original protocol states that we were to work independently in extraction of data. Time constraints precluded this so these data were only extracted by AM ‐ but the review has been checked by GF, TC and GR.