1 Primary outcome (response) at 2 weeks Show forest plot

8

1294

Odds Ratio (M‐H, Random, 95% CI)

0.85 [0.64, 1.13]

1.1 vs Amitriptyline

5

722

Odds Ratio (M‐H, Random, 95% CI)

0.77 [0.54, 1.12]

1.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

0.89 [0.46, 1.73]

1.3 vs Doxepin

1

163

Odds Ratio (M‐H, Random, 95% CI)

1.11 [0.58, 2.12]

1.4 vs Nortriptyline

1

235

Odds Ratio (M‐H, Random, 95% CI)

0.84 [0.22, 3.22]

2 Primary outcome (response) at end of the acute‐phase treatment Show forest plot

9

1501

Odds Ratio (M‐H, Random, 95% CI)

0.89 [0.72, 1.10]

2.1 vs Amitriptyline

6

929

Odds Ratio (M‐H, Random, 95% CI)

0.90 [0.69, 1.17]

2.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

0.90 [0.47, 1.71]

2.3 vs Doxepin

1

163

Odds Ratio (M‐H, Random, 95% CI)

0.85 [0.44, 1.63]

2.4 vs Nortriptyline

1

235

Odds Ratio (M‐H, Random, 95% CI)

0.91 [0.53, 1.55]

3 Secondary outcome (remission) at 2 weeks Show forest plot

8

1294

Odds Ratio (M‐H, Random, 95% CI)

0.85 [0.55, 1.32]

3.1 vs Amitriptyline

5

722

Odds Ratio (M‐H, Random, 95% CI)

0.67 [0.35, 1.29]

3.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

0.89 [0.34, 2.31]

3.3 vs Doxepin

1

163

Odds Ratio (M‐H, Random, 95% CI)

1.27 [0.54, 3.00]

3.4 vs Nortriptyline

1

235

Odds Ratio (M‐H, Random, 95% CI)

0.70 [0.12, 4.28]

4 Secondary outcome (remission) at end of the acute‐phase treatment Show forest plot

9

1501

Odds Ratio (M‐H, Random, 95% CI)

0.86 [0.69, 1.08]

4.1 vs Amitriptyline

6

929

Odds Ratio (M‐H, Random, 95% CI)

0.87 [0.65, 1.16]

4.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

0.77 [0.41, 1.45]

4.3 vs Doxepin

1

163

Odds Ratio (M‐H, Random, 95% CI)

0.94 [0.50, 1.74]

4.4 vs Nortriptyline

1

235

Odds Ratio (M‐H, Random, 95% CI)

0.85 [0.46, 1.56]

5 Secondary outcome (depression severity) at 2 weeks Show forest plot

2

361

Std. Mean Difference (IV, Random, 95% CI)

0.10 [‐0.11, 0.31]

5.1 vs Amitritpyline

2

361

Std. Mean Difference (IV, Random, 95% CI)

0.10 [‐0.11, 0.31]

6 Secondary outcome (depression severity) at end of the acute‐phase treatment Show forest plot

1

144

Std. Mean Difference (IV, Random, 95% CI)

0.12 [‐0.21, 0.45]

6.1 vs Amitritpyline

1

144

Std. Mean Difference (IV, Random, 95% CI)

0.12 [‐0.21, 0.45]

7 Secondary outcome (Social adjustment) at 2 weeks Show forest plot

1

138

Mean Difference (IV, Random, 95% CI)

1.60 [‐1.98, 5.18]

7.1 vs Amitriptyline

1

138

Mean Difference (IV, Random, 95% CI)

1.60 [‐1.98, 5.18]

8 Secondary outcome (Social adjustment) at end of the acute‐phase treatment Show forest plot

3

440

Std. Mean Difference (IV, Random, 95% CI)

0.02 [‐0.17, 0.21]

8.1 vs Amitriptyline

1

114

Std. Mean Difference (IV, Random, 95% CI)

0.03 [‐0.34, 0.40]

8.2 vs Clomipramine

1

163

Std. Mean Difference (IV, Random, 95% CI)

0.12 [‐0.19, 0.43]

8.3 vs Doxepin

1

163

Std. Mean Difference (IV, Random, 95% CI)

‐0.09 [‐0.39, 0.22]

9 Secondary outcome (withdrawal due to any reason) Show forest plot

7

1166

Odds Ratio (M‐H, Random, 95% CI)

0.83 [0.63, 1.10]

9.1 vs Amitriptyline

5

829

Odds Ratio (M‐H, Random, 95% CI)

0.90 [0.65, 1.25]

9.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

0.80 [0.42, 1.54]

9.3 vs Doxepin

1

163

Odds Ratio (M‐H, Random, 95% CI)

0.51 [0.22, 1.19]

10 Secondary outcome (withdrawal due to adverse events) Show forest plot

8

1266

Odds Ratio (M‐H, Random, 95% CI)

0.65 [0.41, 1.03]

10.1 vs Amitriptyline

6

929

Odds Ratio (M‐H, Random, 95% CI)

0.60 [0.35, 1.03]

10.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

1.14 [0.42, 3.10]

10.3 vs Doxepin

1

163

Odds Ratio (M‐H, Random, 95% CI)

0.30 [0.06, 1.56]

11 Secondary outcome (having some adverse events) Show forest plot

2

442

Odds Ratio (M‐H, Random, 95% CI)

1.06 [0.54, 2.10]

11.1 vs Amitriptyline

1

207

Odds Ratio (M‐H, Random, 95% CI)

0.74 [0.16, 3.37]

11.2 vs Nortriptyline

1

235

Odds Ratio (M‐H, Random, 95% CI)

1.17 [0.55, 2.49]

12 Hypertension/Tachycardia Show forest plot

4

522

Odds Ratio (M‐H, Random, 95% CI)

0.44 [0.24, 0.81]

12.1 vs Amitriptyline

4

522

Odds Ratio (M‐H, Random, 95% CI)

0.44 [0.24, 0.81]

13 Hypotension/Bradycardia Show forest plot

2

215

Odds Ratio (M‐H, Random, 95% CI)

0.46 [0.12, 1.81]

13.1 vs Amitriptyline

2

215

Odds Ratio (M‐H, Random, 95% CI)

0.46 [0.12, 1.81]

14 Sweating Show forest plot

2

458

Odds Ratio (M‐H, Random, 95% CI)

0.42 [0.05, 3.24]

14.1 vs Amitriptyline

2

458

Odds Ratio (M‐H, Random, 95% CI)

0.42 [0.05, 3.24]

15 Constipation Show forest plot

6

1003

Odds Ratio (M‐H, Random, 95% CI)

0.72 [0.46, 1.12]

15.1 vs Amitriptyline

5

829

Odds Ratio (M‐H, Random, 95% CI)

0.72 [0.40, 1.29]

15.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

0.62 [0.26, 1.48]

16 Dry mouth/Decreased salivation Show forest plot

8

1266

Odds Ratio (M‐H, Random, 95% CI)

0.52 [0.24, 1.14]

16.1 vs Amitriptyline

6

929

Odds Ratio (M‐H, Random, 95% CI)

0.36 [0.14, 0.92]

16.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

0.81 [0.39, 1.69]

16.3 vs Doxepin

1

163

Odds Ratio (M‐H, Random, 95% CI)

2.86 [1.18, 6.94]

17 Nausea/Vomiting/Gastric distress Show forest plot

4

581

Odds Ratio (M‐H, Random, 95% CI)

0.29 [0.05, 1.59]

17.1 vs Amitriptyline

3

407

Odds Ratio (M‐H, Random, 95% CI)

0.33 [0.04, 2.59]

17.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

0.16 [0.02, 1.33]

18 Weight gain/Increased appetite Show forest plot

3

463

Odds Ratio (M‐H, Random, 95% CI)

1.04 [0.58, 1.86]

18.1 vs Amitriptyline

3

463

Odds Ratio (M‐H, Random, 95% CI)

1.04 [0.58, 1.86]

19 Sexual dysfunction Show forest plot

2

351

Odds Ratio (M‐H, Random, 95% CI)

0.41 [0.06, 2.61]

19.1 vs Amitriptyline

2

351

Odds Ratio (M‐H, Random, 95% CI)

0.41 [0.06, 2.61]

20 Anxiety/Agitation Show forest plot

2

307

Odds Ratio (M‐H, Random, 95% CI)

0.87 [0.34, 2.19]

20.1 vs Amitriptyline

2

307

Odds Ratio (M‐H, Random, 95% CI)

0.87 [0.34, 2.19]

21 Dizziness/Vertigo/Faintness Show forest plot

7

1166

Odds Ratio (M‐H, Random, 95% CI)

0.75 [0.43, 1.28]

21.1 vs Amitriptyline

5

829

Odds Ratio (M‐H, Random, 95% CI)

0.64 [0.35, 1.17]

21.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

0.70 [0.21, 2.29]

21.3 vs Doxepin

1

163

Odds Ratio (M‐H, Random, 95% CI)

3.04 [0.59, 15.53]

22 Fatigue/Tiredness/Asthenia Show forest plot

4

673

Odds Ratio (M‐H, Random, 95% CI)

1.25 [0.71, 2.21]

22.1 vs Amitriptyline

4

673

Odds Ratio (M‐H, Random, 95% CI)

1.25 [0.71, 2.21]

23 Headache Show forest plot

4

522

Odds Ratio (M‐H, Random, 95% CI)

0.74 [0.31, 1.74]

23.1 vs Amitriptyline

4

522

Odds Ratio (M‐H, Random, 95% CI)

0.74 [0.31, 1.74]

24 Tremor Show forest plot

7

1103

Odds Ratio (M‐H, Random, 95% CI)

0.36 [0.22, 0.57]

24.1 vs Amitriptyline

6

929

Odds Ratio (M‐H, Random, 95% CI)

0.36 [0.20, 0.62]

24.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

0.36 [0.15, 0.88]

25 Sleep disturbance Show forest plot

1

207

Odds Ratio (M‐H, Random, 95% CI)

1.43 [0.69, 2.98]

25.1 vs Amitriptyline

1

207

Odds Ratio (M‐H, Random, 95% CI)

1.43 [0.69, 2.98]

26 Sleepiness/Drowsiness/Somnolence Show forest plot

6

841

Odds Ratio (M‐H, Random, 95% CI)

0.92 [0.66, 1.27]

26.1 vs Amitriptyline

5

678

Odds Ratio (M‐H, Random, 95% CI)

0.81 [0.58, 1.14]

26.2 vs Doxepin

1

163

Odds Ratio (M‐H, Random, 95% CI)

1.86 [0.82, 4.21]

27 Suicide attempt Show forest plot

5

935

Odds Ratio (M‐H, Random, 95% CI)

1.77 [0.47, 6.58]

27.1 vs Amitriptyline

2

363

Odds Ratio (M‐H, Random, 95% CI)

2.08 [0.27, 16.29]

27.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

1.0 [0.06, 16.25]

27.3 vs Doxepin

1

163

Odds Ratio (M‐H, Random, 95% CI)

0.32 [0.01, 7.91]

27.4 vs Nortriptyline

1

235

Odds Ratio (M‐H, Random, 95% CI)

9.90 [0.53, 185.90]

28 Subgroup analysis: Response at 2 weeks: Treatment settings: Psychiatric inpatients Show forest plot

2

425

Odds Ratio (M‐H, Random, 95% CI)

0.81 [0.50, 1.32]

28.1 vs Amitriptyline

1

251

Odds Ratio (M‐H, Random, 95% CI)

0.73 [0.36, 1.48]

28.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

0.89 [0.46, 1.73]

29 Subgroup analysis: Response at end of the acute‐phase treatment: Treatment settings: Psychiatric inpatients Show forest plot

3

632

Odds Ratio (M‐H, Random, 95% CI)

0.89 [0.64, 1.23]

29.1 vs Amitriptyline

2

458

Odds Ratio (M‐H, Random, 95% CI)

0.88 [0.60, 1.29]

29.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

0.90 [0.47, 1.71]

30 Sensitivity analysis: Response at 2 weeks: Studies without imputation Show forest plot

7

1179

Odds Ratio (M‐H, Random, 95% CI)

0.85 [0.64, 1.15]

30.1 vs Amitriptyline

4

607

Odds Ratio (M‐H, Random, 95% CI)

0.76 [0.51, 1.13]

30.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

0.89 [0.46, 1.73]

30.3 vs Doxepin

1

163

Odds Ratio (M‐H, Random, 95% CI)

1.11 [0.58, 2.12]

30.4 vs Nortriptyline

1

235

Odds Ratio (M‐H, Random, 95% CI)

0.84 [0.22, 3.22]

31 Sensitivity analysis: Response at end of the acute‐phase treatment: Studies without imputation Show forest plot

8

1386

Odds Ratio (M‐H, Random, 95% CI)

0.93 [0.74, 1.15]

31.1 vs Amitriptyline

5

814

Odds Ratio (M‐H, Random, 95% CI)

0.95 [0.72, 1.26]

31.2 vs Clomipramine

1

174

Odds Ratio (M‐H, Random, 95% CI)

0.90 [0.47, 1.71]

31.3 vs Doxepin

1

163

Odds Ratio (M‐H, Random, 95% CI)

0.85 [0.44, 1.63]

31.4 vs Nortriptyline

1

235

Odds Ratio (M‐H, Random, 95% CI)

0.91 [0.53, 1.55]

32 Secondary outcome (SKEWED DATA: depression severity) at 2 weeks Show forest plot

Other data

No numeric data

33 Secondary outcome (SKEWED DATA: depression severity) at end of the acute‐phase treatment Show forest plot

Other data

No numeric data

1 Primary outcome (response) at 2 weeks Show forest plot

12

2626

Odds Ratio (M‐H, Random, 95% CI)

1.57 [1.30, 1.88]

1.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

2.01 [0.93, 4.35]

1.2 vs Fluoxetine

5

622

Odds Ratio (M‐H, Random, 95% CI)

1.26 [0.86, 1.85]

1.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

2.39 [1.42, 4.02]

1.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

1.45 [1.04, 2.02]

1.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

1.38 [0.90, 2.13]

2 Primary outcome (response) at end of the acute‐phase treatment Show forest plot

12

2626

Odds Ratio (M‐H, Random, 95% CI)

1.19 [1.01, 1.39]

2.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

0.76 [0.38, 1.52]

2.2 vs Fluoxetine

5

622

Odds Ratio (M‐H, Random, 95% CI)

1.55 [1.07, 2.23]

2.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

1.27 [0.94, 1.70]

2.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

0.97 [0.70, 1.35]

2.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

1.14 [0.76, 1.70]

3 Primary outcome (response) at end of the continuation treatment Show forest plot

1

197

Odds Ratio (M‐H, Random, 95% CI)

1.60 [0.91, 2.81]

3.1 vs Paroxetine

1

197

Odds Ratio (M‐H, Random, 95% CI)

1.60 [0.91, 2.81]

4 Secondary outcome (remission) at 2 weeks Show forest plot

12

2626

Odds Ratio (M‐H, Random, 95% CI)

1.82 [1.36, 2.44]

4.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

2.48 [0.47, 13.02]

4.2 vs Fluoxetine

5

622

Odds Ratio (M‐H, Random, 95% CI)

1.63 [0.81, 3.27]

4.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

2.31 [1.04, 5.11]

4.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

1.94 [1.19, 3.15]

4.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

1.46 [0.77, 2.76]

5 Secondary outcome (remission) at end of the acute‐phase treatment Show forest plot

12

2626

Odds Ratio (M‐H, Random, 95% CI)

1.17 [0.98, 1.40]

5.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

0.92 [0.55, 1.52]

5.2 vs Fluoxetine

5

622

Odds Ratio (M‐H, Random, 95% CI)

1.12 [0.80, 1.57]

5.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

1.58 [1.16, 2.15]

5.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

1.18 [0.82, 1.71]

5.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

0.84 [0.57, 1.23]

6 Secondary outcome (remission) at end of the continuation treatment Show forest plot

1

197

Odds Ratio (M‐H, Random, 95% CI)

1.89 [1.01, 3.54]

6.1 vs Paroxetine

1

197

Odds Ratio (M‐H, Random, 95% CI)

1.89 [1.01, 3.54]

7 Secondary outcome (withdrawal due to any reason) Show forest plot

11

2327

Odds Ratio (M‐H, Random, 95% CI)

1.12 [0.89, 1.40]

7.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

2.36 [0.99, 5.64]

7.2 vs Fluoxetine

4

323

Odds Ratio (M‐H, Random, 95% CI)

1.09 [0.67, 1.78]

7.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

0.80 [0.58, 1.10]

7.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

1.47 [1.01, 2.13]

7.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

1.20 [0.75, 1.93]

8 Secondary outcome (withdrawal due to adverse events) Show forest plot

11

2604

Odds Ratio (M‐H, Random, 95% CI)

1.26 [0.85, 1.86]

8.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

2.0 [0.59, 6.81]

8.2 vs Fluoxetine

4

600

Odds Ratio (M‐H, Random, 95% CI)

1.05 [0.62, 1.78]

8.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

0.74 [0.45, 1.21]

8.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

2.88 [1.43, 5.77]

8.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

1.66 [0.86, 3.21]

9 Secondary outcome (having some adverse events) Show forest plot

7

1773

Odds Ratio (M‐H, Random, 95% CI)

1.01 [0.81, 1.26]

9.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

0.82 [0.49, 1.37]

9.2 vs Fluoxetine

2

431

Odds Ratio (M‐H, Random, 95% CI)

1.42 [0.97, 2.09]

9.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

0.94 [0.66, 1.32]

9.4 vs Sertraline

1

346

Odds Ratio (M‐H, Random, 95% CI)

0.86 [0.55, 1.34]

10 Hypotension/Bradycardia Show forest plot

1

133

Odds Ratio (M‐H, Random, 95% CI)

5.41 [0.61, 47.62]

10.1 vs Fluoxetine

1

133

Odds Ratio (M‐H, Random, 95% CI)

5.41 [0.61, 47.62]

11 Sweating Show forest plot

5

1342

Odds Ratio (M‐H, Random, 95% CI)

0.25 [0.15, 0.44]

11.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

0.13 [0.04, 0.44]

11.2 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

0.32 [0.17, 0.62]

11.3 vs Sertraline

1

346

Odds Ratio (M‐H, Random, 95% CI)

0.21 [0.04, 0.97]

12 Constipation Show forest plot

5

1109

Odds Ratio (M‐H, Random, 95% CI)

1.20 [0.79, 1.82]

12.1 vs Fluoxetine

2

168

Odds Ratio (M‐H, Random, 95% CI)

2.14 [0.81, 5.66]

12.2 vs Paroxetine

2

529

Odds Ratio (M‐H, Random, 95% CI)

1.07 [0.59, 1.95]

12.3 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

1.01 [0.48, 2.12]

13 Diarrhoea Show forest plot

8

2040

Odds Ratio (M‐H, Random, 95% CI)

0.57 [0.41, 0.80]

13.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

0.47 [0.14, 1.60]

13.2 vs Fluoxetine

1

36

Odds Ratio (M‐H, Random, 95% CI)

1.0 [0.06, 17.33]

13.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

0.89 [0.55, 1.46]

13.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

0.37 [0.21, 0.67]

13.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

0.34 [0.13, 0.87]

14 Dry mouth/Decreased salivation Show forest plot

10

2305

Odds Ratio (M‐H, Random, 95% CI)

1.80 [1.37, 2.36]

14.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

1.72 [0.81, 3.68]

14.2 vs Fluoxetine

3

301

Odds Ratio (M‐H, Random, 95% CI)

3.68 [1.52, 8.91]

14.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

1.73 [0.81, 3.70]

14.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

1.53 [0.92, 2.55]

14.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

1.48 [0.77, 2.85]

15 Nausea/Vomiting/Gastric distress Show forest plot

11

2604

Odds Ratio (M‐H, Random, 95% CI)

0.33 [0.26, 0.43]

15.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

0.45 [0.22, 0.90]

15.2 vs Fluoxetine

4

600

Odds Ratio (M‐H, Random, 95% CI)

0.34 [0.14, 0.81]

15.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

0.27 [0.16, 0.44]

15.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

0.27 [0.16, 0.48]

15.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

0.29 [0.16, 0.53]

16 Weight gain/Increased appetite Show forest plot

11

2604

Odds Ratio (M‐H, Random, 95% CI)

4.23 [2.93, 6.11]

16.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

3.83 [1.49, 9.82]

16.2 vs Fluoxetine

4

600

Odds Ratio (M‐H, Random, 95% CI)

5.23 [2.15, 12.76]

16.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

3.92 [1.19, 12.92]

16.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

6.67 [3.30, 13.49]

16.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

2.51 [0.87, 7.26]

17 Weight loss/Anorexia Show forest plot

4

576

Odds Ratio (M‐H, Random, 95% CI)

0.35 [0.10, 1.18]

17.1 vs Fluoxetine

3

301

Odds Ratio (M‐H, Random, 95% CI)

0.42 [0.11, 1.62]

17.2 vs Paroxetine

1

275

Odds Ratio (M‐H, Random, 95% CI)

0.14 [0.01, 2.67]

18 Sexual dysfunction Show forest plot

4

907

Odds Ratio (M‐H, Random, 95% CI)

0.31 [0.13, 0.74]

18.1 vs Fluoxetine

1

36

Odds Ratio (M‐H, Random, 95% CI)

0.15 [0.02, 1.47]

18.2 vs Paroxetine

1

275

Odds Ratio (M‐H, Random, 95% CI)

0.19 [0.06, 0.59]

18.3 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

0.43 [0.10, 1.82]

19 Anxiety/Agitation Show forest plot

4

1134

Odds Ratio (M‐H, Random, 95% CI)

1.46 [0.59, 3.65]

19.1 vs Paroxetine

2

472

Odds Ratio (M‐H, Random, 95% CI)

0.71 [0.32, 1.60]

19.2 vs Sertraline

1

250

Odds Ratio (M‐H, Random, 95% CI)

1.65 [0.69, 3.98]

19.3 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

5.76 [1.65, 20.07]

20 Dizziness/Vertigo/Faintness Show forest plot

10

2568

Odds Ratio (M‐H, Random, 95% CI)

1.04 [0.77, 1.41]

20.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

2.03 [0.74, 5.58]

20.2 vs Fluoxetine

3

564

Odds Ratio (M‐H, Random, 95% CI)

0.92 [0.54, 1.56]

20.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

0.84 [0.47, 1.50]

20.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

1.16 [0.36, 3.70]

20.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

1.31 [0.69, 2.48]

21 Fatigue/Tiredness/Asthenia Show forest plot

8

2137

Odds Ratio (M‐H, Random, 95% CI)

1.53 [1.08, 2.15]

21.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

0.91 [0.44, 1.84]

21.2 vs Fluoxetine

1

133

Odds Ratio (M‐H, Random, 95% CI)

1.38 [0.30, 6.40]

21.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

1.71 [0.94, 3.11]

21.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

2.31 [1.32, 4.04]

21.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

0.94 [0.44, 2.00]

22 Headache Show forest plot

11

2604

Odds Ratio (M‐H, Random, 95% CI)

0.69 [0.56, 0.86]

22.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

0.63 [0.30, 1.33]

22.2 vs Fluoxetine

4

600

Odds Ratio (M‐H, Random, 95% CI)

0.86 [0.54, 1.36]

22.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

0.57 [0.36, 0.89]

22.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

0.67 [0.44, 1.01]

22.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

0.84 [0.46, 1.53]

23 Tremor Show forest plot

5

996

Odds Ratio (M‐H, Random, 95% CI)

0.34 [0.18, 0.66]

23.1 vs Fluoxetine

3

467

Odds Ratio (M‐H, Random, 95% CI)

0.42 [0.17, 1.07]

23.2 vs Paroxetine

2

529

Odds Ratio (M‐H, Random, 95% CI)

0.27 [0.11, 0.70]

24 Sleep disturbance Show forest plot

5

1346

Odds Ratio (M‐H, Random, 95% CI)

0.52 [0.31, 0.86]

24.1 vs Fluoxetine

1

299

Odds Ratio (M‐H, Random, 95% CI)

0.53 [0.21, 1.38]

24.2 vs Paroxetine

2

451

Odds Ratio (M‐H, Random, 95% CI)

0.68 [0.25, 1.85]

24.3 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

0.37 [0.16, 0.85]

25 Sleepiness/Drowsiness/Somnolence Show forest plot

11

2604

Odds Ratio (M‐H, Random, 95% CI)

1.81 [1.39, 2.37]

25.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

1.36 [0.53, 3.51]

25.2 vs Fluoxetine

4

600

Odds Ratio (M‐H, Random, 95% CI)

1.59 [0.97, 2.61]

25.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

1.24 [0.84, 1.83]

25.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

3.07 [1.89, 4.99]

25.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

2.34 [1.45, 3.77]

26 Suicide attempt Show forest plot

1

346

Odds Ratio (M‐H, Random, 95% CI)

4.89 [0.23, 102.51]

26.1 vs Sertraline

1

346

Odds Ratio (M‐H, Random, 95% CI)

4.89 [0.23, 102.51]

27 Subgroup analysis: Response at 2 weeks: Treatment settings: Outpatients in primary care Show forest plot

1

197

Odds Ratio (M‐H, Random, 95% CI)

4.38 [1.69, 11.35]

27.1 vs Paroxetine

1

197

Odds Ratio (M‐H, Random, 95% CI)

4.38 [1.69, 11.35]

28 Subgroup analysis: Response at end of the acute‐phase treatment: Treatment settings: Outpatients in primary care Show forest plot

1

197

Odds Ratio (M‐H, Random, 95% CI)

1.17 [0.66, 2.10]

28.1 vs Paroxetine

1

197

Odds Ratio (M‐H, Random, 95% CI)

1.17 [0.66, 2.10]

29 Sensitivity analysis: Response at 2 weeks: Studies without imputation Show forest plot

11

2604

Odds Ratio (M‐H, Random, 95% CI)

1.58 [1.31, 1.90]

29.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

2.01 [0.93, 4.35]

29.2 vs Fluoxetine

4

600

Odds Ratio (M‐H, Random, 95% CI)

1.27 [0.86, 1.88]

29.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

2.39 [1.42, 4.02]

29.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

1.45 [1.04, 2.02]

29.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

1.38 [0.90, 2.13]

30 Sensitivity analysis: Response at end of the acute‐phase treatment: Studies without imputation Show forest plot

11

2604

Odds Ratio (M‐H, Random, 95% CI)

1.17 [1.00, 1.38]

30.1 vs Citalolpram

1

270

Odds Ratio (M‐H, Random, 95% CI)

0.76 [0.38, 1.52]

30.2 vs Fluoxetine

4

600

Odds Ratio (M‐H, Random, 95% CI)

1.46 [1.04, 2.04]

30.3 vs Paroxetine

3

726

Odds Ratio (M‐H, Random, 95% CI)

1.27 [0.94, 1.70]

30.4 vs Sertraline

2

596

Odds Ratio (M‐H, Random, 95% CI)

0.97 [0.70, 1.35]

30.5 vs Fluvoxamine

1

412

Odds Ratio (M‐H, Random, 95% CI)

1.14 [0.76, 1.70]

31 Secondary outcome (SKEWED DATA: depression severity) at 2 weeks Show forest plot

Other data

No numeric data

32 Secondary outcome (SKEWED DATA: depression severity) at end of the acute‐phase treatment Show forest plot

Other data

No numeric data

1 Primary outcome (response) at 2 weeks Show forest plot

2

415

Odds Ratio (M‐H, Random, 95% CI)

2.29 [1.45, 3.59]

1.1 vs Venlafaxine

2

415

Odds Ratio (M‐H, Random, 95% CI)

2.29 [1.45, 3.59]

2 Primary outcome (response) at end of the acute‐phase treatment Show forest plot

2

415

Odds Ratio (M‐H, Random, 95% CI)

1.53 [1.03, 2.25]

2.1 vs Venlafaxine

2

415

Odds Ratio (M‐H, Random, 95% CI)

1.53 [1.03, 2.25]

3 Secondary outcome (remission) at 2 weeks Show forest plot

2

415

Odds Ratio (M‐H, Random, 95% CI)

2.34 [1.07, 5.13]

3.1 vs Venlafaxine

2

415

Odds Ratio (M‐H, Random, 95% CI)

2.34 [1.07, 5.13]

4 Secondary outcome (remission) at end of the acute‐phase treatment Show forest plot

2

415

Odds Ratio (M‐H, Random, 95% CI)

1.55 [0.98, 2.47]

4.1 vs Venlafaxine

2

415

Odds Ratio (M‐H, Random, 95% CI)

1.55 [0.98, 2.47]

5 Secondary outcome (withdrawal due to any reason) Show forest plot

2

415

Odds Ratio (M‐H, Random, 95% CI)

0.65 [0.43, 0.99]

5.1 vs Venlafaxine

2

415

Odds Ratio (M‐H, Random, 95% CI)

0.65 [0.43, 0.99]

6 Secondary outcome (withdrawal due to adverse events) Show forest plot

2

415

Odds Ratio (M‐H, Random, 95% CI)

0.55 [0.24, 1.24]

6.1 vs Venlafaxine

2

415

Odds Ratio (M‐H, Random, 95% CI)

0.55 [0.24, 1.24]

7 Secondary outcome (having some adverse events) Show forest plot

1

157

Odds Ratio (M‐H, Random, 95% CI)

1.51 [0.76, 3.00]

7.1 vs Venlafaxine

1

157

Odds Ratio (M‐H, Random, 95% CI)

1.51 [0.76, 3.00]

8 Hypotension/Bradycardia Show forest plot

1

157

Odds Ratio (M‐H, Random, 95% CI)

0.19 [0.02, 1.68]

8.1 vs Venlafaxine

1

157

Odds Ratio (M‐H, Random, 95% CI)

0.19 [0.02, 1.68]

9 Sweating Show forest plot

1

157

Odds Ratio (M‐H, Random, 95% CI)

0.03 [0.00, 0.45]

9.1 vs Venlafaxine

1

157

Odds Ratio (M‐H, Random, 95% CI)

0.03 [0.00, 0.45]

10 Constipation Show forest plot

1

157

Odds Ratio (M‐H, Random, 95% CI)

0.22 [0.06, 0.83]

10.1 vs Venlafaxine

1

157

Odds Ratio (M‐H, Random, 95% CI)

0.22 [0.06, 0.83]

11 Dry mouth/Decreased salivation Show forest plot

2

415

Odds Ratio (M‐H, Random, 95% CI)

8.61 [0.35, 211.85]

11.1 vs Venlafaxine

2

415

Odds Ratio (M‐H, Random, 95% CI)

8.61 [0.35, 211.85]

12 Nausea/Vomiting/Gastric distress Show forest plot

2

415

Odds Ratio (M‐H, Random, 95% CI)

0.11 [0.00, 9.34]

12.1 vs Venlafaxine

2

415

Odds Ratio (M‐H, Random, 95% CI)

0.11 [0.00, 9.34]

13 Anxiety/Agitation Show forest plot

1

157

Odds Ratio (M‐H, Random, 95% CI)

1.01 [0.24, 4.20]

13.1 vs Venlafaxine

1

157

Odds Ratio (M‐H, Random, 95% CI)

1.01 [0.24, 4.20]

14 Fatigue/Tiredness/Asthenia Show forest plot

1

258

Odds Ratio (M‐H, Random, 95% CI)

2.43 [1.30, 4.55]

14.1 vs Venlafaxine

1

258

Odds Ratio (M‐H, Random, 95% CI)

2.43 [1.30, 4.55]

15 Headache Show forest plot

2

415

Odds Ratio (M‐H, Random, 95% CI)

0.95 [0.53, 1.72]

15.1 vs Venlafaxine

2

415

Odds Ratio (M‐H, Random, 95% CI)

0.95 [0.53, 1.72]

16 Sleep disturbance Show forest plot

1

258

Odds Ratio (M‐H, Random, 95% CI)

0.02 [0.00, 0.41]

16.1 vs Venlafaxine

1

258

Odds Ratio (M‐H, Random, 95% CI)

0.02 [0.00, 0.41]

17 Sleepiness/Drowsiness/Somnolence Show forest plot

1

157

Odds Ratio (M‐H, Random, 95% CI)

1.56 [0.42, 5.77]

17.1 vs Venlafaxine

1

157

Odds Ratio (M‐H, Random, 95% CI)

1.56 [0.42, 5.77]

18 Completed suicide Show forest plot

1

157

Odds Ratio (M‐H, Random, 95% CI)

0.33 [0.01, 8.31]

18.1 vs Venlafaxine

1

157

Odds Ratio (M‐H, Random, 95% CI)

0.33 [0.01, 8.31]

1 Primary outcome (response) at 2 weeks Show forest plot

2

300

Odds Ratio (M‐H, Random, 95% CI)

1.14 [0.64, 2.04]

1.1 vs Trazodone

2

300

Odds Ratio (M‐H, Random, 95% CI)

1.14 [0.64, 2.04]

2 Primary outcome (response) at end of the acute‐phase treatment Show forest plot

2

300

Odds Ratio (M‐H, Random, 95% CI)

1.50 [0.95, 2.37]

2.1 vs Trazodone

2

300

Odds Ratio (M‐H, Random, 95% CI)

1.50 [0.95, 2.37]

3 Secondary outcome (remission) at 2 weeks Show forest plot

2

300

Odds Ratio (M‐H, Random, 95% CI)

1.0 [0.36, 2.80]

3.1 vs Trazodone

2

300

Odds Ratio (M‐H, Random, 95% CI)

1.0 [0.36, 2.80]

4 Secondary outcome (remission) at end of the acute‐phase treatment Show forest plot

2

300

Odds Ratio (M‐H, Random, 95% CI)

1.38 [0.76, 2.52]

4.1 vs Trazodone

2

300

Odds Ratio (M‐H, Random, 95% CI)

1.38 [0.76, 2.52]

5 Secondary outcome (withdrawal due to any reason) Show forest plot

2

300

Odds Ratio (M‐H, Random, 95% CI)

0.90 [0.47, 1.72]

5.1 vs Trazodone

2

300

Odds Ratio (M‐H, Random, 95% CI)

0.90 [0.47, 1.72]

6 Secondary outcome (withdrawal due to adverse events) Show forest plot

2

300

Odds Ratio (M‐H, Random, 95% CI)

0.61 [0.25, 1.51]

6.1 vs Trazodone

2

300

Odds Ratio (M‐H, Random, 95% CI)

0.61 [0.25, 1.51]

7 Hypertension/Tachycardia Show forest plot

1

100

Odds Ratio (M‐H, Random, 95% CI)

0.31 [0.06, 1.59]

7.1 vs Trazodone

1

100

Odds Ratio (M‐H, Random, 95% CI)

0.31 [0.06, 1.59]

8 Hypotension/Bradycardia Show forest plot

2

300

Odds Ratio (M‐H, Random, 95% CI)

0.17 [0.03, 1.00]

8.1 vs Trazodone

2

300

Odds Ratio (M‐H, Random, 95% CI)

0.17 [0.03, 1.00]

9 Constipation Show forest plot

1

100

Odds Ratio (M‐H, Random, 95% CI)

0.70 [0.26, 1.83]

9.1 vs Trazodone

1

100

Odds Ratio (M‐H, Random, 95% CI)

0.70 [0.26, 1.83]

10 Dry mouth/Decreased salivation Show forest plot

2

300

Odds Ratio (M‐H, Random, 95% CI)

0.39 [0.11, 1.37]

10.1 vs Trazodone

2

300

Odds Ratio (M‐H, Random, 95% CI)

0.39 [0.11, 1.37]

11 Nausea/Vomiting/Gastric distress Show forest plot

1

100

Odds Ratio (M‐H, Random, 95% CI)

0.68 [0.20, 2.32]

11.1 vs Trazodone

1

100

Odds Ratio (M‐H, Random, 95% CI)

0.68 [0.20, 2.32]

12 Weight gain/Increased appetite Show forest plot

1

100

Odds Ratio (M‐H, Random, 95% CI)

4.95 [1.30, 18.81]

12.1 vs Trazodone

1

100

Odds Ratio (M‐H, Random, 95% CI)

4.95 [1.30, 18.81]

13 Weight loss/Anorexia Show forest plot

1

100

Odds Ratio (M‐H, Random, 95% CI)

0.33 [0.01, 8.21]

13.1 vs Trazodone

1

100

Odds Ratio (M‐H, Random, 95% CI)

0.33 [0.01, 8.21]

14 Anxiety/Agitation Show forest plot

2

300

Odds Ratio (M‐H, Random, 95% CI)

0.62 [0.19, 1.96]

14.1 vs Trazodone

2

300

Odds Ratio (M‐H, Random, 95% CI)

0.62 [0.19, 1.96]

15 Dizziness/Vertigo/Faintness Show forest plot

2

300

Odds Ratio (M‐H, Random, 95% CI)

0.64 [0.30, 1.39]

15.1 vs Trazodone

2

300

Odds Ratio (M‐H, Random, 95% CI)

0.64 [0.30, 1.39]

16 Headache Show forest plot

1

100

Odds Ratio (M‐H, Random, 95% CI)

0.65 [0.23, 1.87]

16.1 vs Trazodone

1

100

Odds Ratio (M‐H, Random, 95% CI)

0.65 [0.23, 1.87]

17 Sleep disturbance Show forest plot

1

200

Odds Ratio (M‐H, Random, 95% CI)

0.42 [0.13, 1.42]

17.1 vs Trazodone

1

200

Odds Ratio (M‐H, Random, 95% CI)

0.42 [0.13, 1.42]

18 Sleepiness/Drowsiness/Somnolence Show forest plot

2

300

Odds Ratio (M‐H, Random, 95% CI)

0.62 [0.29, 1.36]

18.1 vs Trazodone

2

300

Odds Ratio (M‐H, Random, 95% CI)

0.62 [0.29, 1.36]

19 Completed suicide Show forest plot

1

200

Odds Ratio (M‐H, Random, 95% CI)

3.03 [0.12, 75.28]

19.1 vs Trazodone

1

200

Odds Ratio (M‐H, Random, 95% CI)

3.03 [0.12, 75.28]

20 Suicide attempt Show forest plot

1

200

Odds Ratio (M‐H, Random, 95% CI)

2.02 [0.18, 22.65]

20.1 vs Trazodone

1

200

Odds Ratio (M‐H, Random, 95% CI)

2.02 [0.18, 22.65]

1 Primary outcome (response) at 2 weeks Show forest plot

1

40

Odds Ratio (M‐H, Random, 95% CI)

1.0 [0.18, 5.67]

1.1 vs Reboxetine

1

40

Odds Ratio (M‐H, Random, 95% CI)

1.0 [0.18, 5.67]

2 Primary outcome (response) at end of the acute‐phase treatment Show forest plot

1

40

Odds Ratio (M‐H, Random, 95% CI)

1.0 [0.27, 3.67]

2.1 vs Reboxetine

1

40

Odds Ratio (M‐H, Random, 95% CI)

1.0 [0.27, 3.67]

3 Secondary outcome (remission) at 2 weeks Show forest plot

1

40

Odds Ratio (M‐H, Random, 95% CI)

1.0 [0.06, 17.18]

3.1 vs Reboxetine

1

40

Odds Ratio (M‐H, Random, 95% CI)

1.0 [0.06, 17.18]

4 Secondary outcome (remission) at end of the acute‐phase treatment Show forest plot

1

40

Odds Ratio (M‐H, Random, 95% CI)

1.26 [0.33, 4.73]

4.1 vs Reboxetine

1

40

Odds Ratio (M‐H, Random, 95% CI)

1.26 [0.33, 4.73]

5 Secondary outcome (depression severity) at 2 weeks Show forest plot

1

40

Std. Mean Difference (IV, Random, 95% CI)

‐0.37 [‐1.00, 0.25]

5.1 vs Reboxetine

1

40

Std. Mean Difference (IV, Random, 95% CI)

‐0.37 [‐1.00, 0.25]

6 Secondary outcome (withdrawal due to any reason) Show forest plot

2

80

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

6.1 vs Reboxetine

2

80

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

7 Secondary outcome (withdrawal due to adverse events) Show forest plot

2

80

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

7.1 vs Reboxetine

2

80

Odds Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

8 Secondary outcome (SKEWED DATA: depression severity) at end of the acute‐phase treatment Show forest plot

Other data

No numeric data

1 vs all compounds Show forest plot

26

4882

Risk Ratio (M‐H, Fixed, 99% CI)

1.05 [0.99, 1.12]

1.1 vs Amitriptyline

6

929

Risk Ratio (M‐H, Fixed, 99% CI)

0.95 [0.82, 1.11]

1.2 vs Clomipramine

1

174

Risk Ratio (M‐H, Fixed, 99% CI)

0.97 [0.74, 1.26]

1.3 vs Doxepin

1

163

Risk Ratio (M‐H, Fixed, 99% CI)

0.95 [0.71, 1.26]

1.4 vs Nortriptyline

1

235

Risk Ratio (M‐H, Fixed, 99% CI)

0.94 [0.59, 1.49]

1.5 vs Citalolpram

1

270

Risk Ratio (M‐H, Fixed, 99% CI)

0.96 [0.85, 1.09]

1.6 vs Fluoxetine

5

622

Risk Ratio (M‐H, Fixed, 99% CI)

1.18 [1.00, 1.39]

1.7 vs Paroxetine

3

726

Risk Ratio (M‐H, Fixed, 99% CI)

1.13 [0.93, 1.38]

1.8 vs Sertraline

2

596

Risk Ratio (M‐H, Fixed, 99% CI)

0.99 [0.83, 1.17]

1.9 vs Fluvoxamine

1

412

Risk Ratio (M‐H, Fixed, 99% CI)

1.05 [0.86, 1.28]

1.10 vs Venlafaxine

2

415

Risk Ratio (M‐H, Fixed, 99% CI)

1.24 [0.96, 1.60]

1.11 vs Trazodone

2

300

Risk Ratio (M‐H, Fixed, 99% CI)

1.21 [0.91, 1.61]

1.12 vs Reboxetine

1

40

Risk Ratio (M‐H, Fixed, 99% CI)

1.0 [0.55, 1.82]