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'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
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Figure 1

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

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'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
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Figure 2

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.

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Forest plot of comparison: 1 Quantitative versus qualitative culture, outcome: 1.1 Mortality.
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Figure 3

Forest plot of comparison: 1 Quantitative versus qualitative culture, outcome: 1.1 Mortality.

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Forest plot of comparison: 1 Quantitative versus qualitative culture, outcome: 1.2 Antibiotic change.
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Figure 4

Forest plot of comparison: 1 Quantitative versus qualitative culture, outcome: 1.2 Antibiotic change.

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Forest plot of comparison: 1 Quantitative versus qualitative culture, outcome: 1.3 Duration on mechanical ventilation (days).
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Figure 5

Forest plot of comparison: 1 Quantitative versus qualitative culture, outcome: 1.3 Duration on mechanical ventilation (days).

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Forest plot of comparison: 1 Quantitative versus qualitative culture, outcome: 1.4 ICU stay (days).
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Figure 6

Forest plot of comparison: 1 Quantitative versus qualitative culture, outcome: 1.4 ICU stay (days).

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Comparison 1 Quantitative versus qualitative culture, Outcome 1 Mortality.
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Analysis 1.1

Comparison 1 Quantitative versus qualitative culture, Outcome 1 Mortality.

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Comparison 1 Quantitative versus qualitative culture, Outcome 2 Antibiotic change.
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Analysis 1.2

Comparison 1 Quantitative versus qualitative culture, Outcome 2 Antibiotic change.

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Comparison 1 Quantitative versus qualitative culture, Outcome 3 Duration on mechanical ventilation (days).
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Analysis 1.3

Comparison 1 Quantitative versus qualitative culture, Outcome 3 Duration on mechanical ventilation (days).

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Comparison 1 Quantitative versus qualitative culture, Outcome 4 ICU stay (days).
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Analysis 1.4

Comparison 1 Quantitative versus qualitative culture, Outcome 4 ICU stay (days).

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Comparison 2 Invasive versus non‐invasive method, Outcome 1 Mortality.
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Analysis 2.1

Comparison 2 Invasive versus non‐invasive method, Outcome 1 Mortality.

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Comparison 2 Invasive versus non‐invasive method, Outcome 2 Antibiotic change.
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Analysis 2.2

Comparison 2 Invasive versus non‐invasive method, Outcome 2 Antibiotic change.

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Comparison 2 Invasive versus non‐invasive method, Outcome 3 Duration on mechanical ventilation (days).
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Analysis 2.3

Comparison 2 Invasive versus non‐invasive method, Outcome 3 Duration on mechanical ventilation (days).

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Comparison 2 Invasive versus non‐invasive method, Outcome 4 ICU stay (days).
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Analysis 2.4

Comparison 2 Invasive versus non‐invasive method, Outcome 4 ICU stay (days).

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Comparison 3 Invasive quantitative versus non‐invasive quantitative, Outcome 1 Mortality.
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Analysis 3.1

Comparison 3 Invasive quantitative versus non‐invasive quantitative, Outcome 1 Mortality.

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Comparison 1. Quantitative versus qualitative culture

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mortality Show forest plot

3

1240

Risk Ratio (M‐H, Fixed, 95% CI)

0.91 [0.75, 1.11]

2 Antibiotic change Show forest plot

2

827

Risk Ratio (M‐H, Random, 95% CI)

1.53 [0.54, 4.39]

3 Duration on mechanical ventilation (days) Show forest plot

2

827

Mean Difference (IV, Fixed, 95% CI)

0.58 [‐0.51, 1.68]

4 ICU stay (days) Show forest plot

3

1240

Mean Difference (IV, Fixed, 95% CI)

0.95 [‐0.14, 2.04]
Figuras y tablas -
Comparison 1. Quantitative versus qualitative culture
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Comparison 2. Invasive versus non‐invasive method

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mortality Show forest plot

5

1367

Risk Ratio (M‐H, Fixed, 95% CI)

0.93 [0.78, 1.11]

2 Antibiotic change Show forest plot

4

954

Risk Ratio (M‐H, Random, 95% CI)

1.67 [0.87, 3.21]

3 Duration on mechanical ventilation (days) Show forest plot

4

954

Mean Difference (IV, Fixed, 95% CI)

0.61 [‐0.47, 1.68]

4 ICU stay (days) Show forest plot

5

1367

Mean Difference (IV, Fixed, 95% CI)

0.94 [‐0.13, 2.01]
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Comparison 2. Invasive versus non‐invasive method
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Comparison 3. Invasive quantitative versus non‐invasive quantitative

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mortality Show forest plot

2

127

Risk Ratio (M‐H, Random, 95% CI)

1.14 [0.54, 2.41]
Figuras y tablas -
Comparison 3. Invasive quantitative versus non‐invasive quantitative
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