Prophylactic oral betamimetics for preventing preterm labour in singleton pregnancies

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Analysis 1.1

Comparison 1 Betamimetic versus placebo, Outcome 1 Perinatal mortality.

Analysis 1.2

Comparison 1 Betamimetic versus placebo, Outcome 2 Preterm labour.

Analysis 1.3

Comparison 1 Betamimetic versus placebo, Outcome 3 Side effects sufficient to stop therapy.

Analysis 1.4

Comparison 1 Betamimetic versus placebo, Outcome 4 Birth before 37 completed weeks.

Analysis 1.5

Comparison 1 Betamimetic versus placebo, Outcome 5 Birthweight less than 2500 grams.

Analysis 1.6

Comparison 1 Betamimetic versus placebo, Outcome 6 Neonatal death.

Analysis 1.7

Comparison 1 Betamimetic versus placebo, Outcome 7 Side effects and adverse effects of betamimetics not sufficient to stop medication.

Comparison 1. Betamimetic versus placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Perinatal mortality Show forest plot	1	64	Odds Ratio (M‐H, Fixed, 95% CI)	4.74 [0.50, 45.00]

2 Preterm labour Show forest plot	1	64	Odds Ratio (M‐H, Fixed, 95% CI)	1.07 [0.14, 8.09]

3 Side effects sufficient to stop therapy Show forest plot	1	64	Odds Ratio (M‐H, Fixed, 95% CI)	2.51 [0.59, 10.76]

4 Birth before 37 completed weeks Show forest plot	1	64	Odds Ratio (M‐H, Fixed, 95% CI)	1.07 [0.14, 8.09]

5 Birthweight less than 2500 grams Show forest plot	1	64	Odds Ratio (M‐H, Fixed, 95% CI)	1.74 [0.44, 6.87]

6 Neonatal death Show forest plot	1	64	Odds Ratio (M‐H, Fixed, 95% CI)	4.74 [0.50, 45.00]

7 Side effects and adverse effects of betamimetics not sufficient to stop medication Show forest plot	1	64	Odds Ratio (M‐H, Fixed, 95% CI)	2.5 [0.88, 7.08]

Comparison 1. Betamimetic versus placebo