Scolaris Content Display Scolaris Content Display

Cochrane Database of Systematic Reviews

Intervenciones para el tratamiento del cáncer de la cavidad bucal y orofaríngeo: radioterapia

Información

DOI:
https://doi.org/10.1002/14651858.CD006387.pub2Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 08 diciembre 2010see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:

  1. Grupo Cochrane de Salud oral

Copyright:
  1. Copyright © 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Cifras del artículo

Altmetric:

Citado por:

Citado 0 veces por enlace Crossref Cited-by

Contraer

Autores

  • Anne‐Marie Glenny

    Correspondencia a: Cochrane Oral Health Group, School of Dentistry, The University of Manchester, Manchester, UK

    [email protected]

  • Susan Furness

    Cochrane Oral Health Group, School of Dentistry, The University of Manchester, Manchester, UK

  • Helen V Worthington

    Cochrane Oral Health Group, School of Dentistry, The University of Manchester, Manchester, UK

  • David I Conway

    Glasgow Dental School, University of Glasgow, Glasgow, UK

  • Richard Oliver

    RED (Research and Education in Dentistry), Shrewsbury, UK

  • Jan E Clarkson

    Dental Health Services & Research Unit, University of Dundee, Dundee, Cochrane Oral Health Group, The University of Manchester, Manchester, UK

  • Michaelina Macluskey

    Unit of Oral Surgery and Medicine, University of Dundee, Dundee, UK

  • Sue Pavitt

    Clinical Trials Research Unit, University of Leeds, Leeds, UK

  • Kelvin KW Chan

    Princess Margaret Hospital, Toronto, Canada

  • Paul Brocklehurst

    School of Dentistry, The University of Manchester, Manchester, UK

  • The CSROC Expert Panel

    Cochrane Oral Health Group, School of Dentistry, The University of Manchester, Manchester, UK

Contributions of authors

  • Conceiving the review and writing of protocol: Helen Worthington (HW), Jan Clarkson (JC), Anne‐Marie Glenny (AMG), Richard Oliver (RO)

  • Designing the review: HW, JC, AMG, RO, Sue Pavitt (SP), Michaelina Macluskey (MM), David Conway (DC) and CSROC Expert Panel

  • Co‐ordinating the review: AMG, Susan Furness (SF)

  • Data collection for the review: AMG, HW, JC, SF, MM, DC

  • Designing search strategies: Anne Littlewood (AL) (Trials Seach Co‐ordinator, Cochrane Oral Health Group) in collaboration with SF and AMG

  • Undertaking searches: AL

  • Screening search results: SF, HW, AMG

  • Organizing retrieval of papers: AMG, SF, SP

  • Screening retrieved papers against eligibility criteria: AMG, SF, HW, JC, RO, SP, MM, DC

  • Appraising risk of bias: AMG, SF, Paul Brocklehurst (PB)

  • Extracting data from papers: AMG, HW, SF, PB

  • Writing to authors of papers for additional information: SP, SF

  • Data management for the review: AMG, SF, HW, SP

  • Entering data into RevMan: AMG, SF

  • Analysis of data: AMG, SF, HW

  • Interpretation of data: AMG, SF, HW, Kelvin KW Chan (KC)

  • Writing the review: AMG, SF, HW, KC.

The CSROC Expert Panel comprises:
Bertrand Baujat, Gerry Humphris, Iain Hutchison, Jean‐Pierre Pignon, Gerry Robertson, Simon Rogers, Jatin Shah, Nick Slevin, Phil Sloan, David Soutar, Erich Sturgis, Jan Vermorken, Steve Wardell, Saman Warnakulasuriya, Keith Webster.

Sources of support

Internal sources

  • School of Dentistry, The University of Manchester, UK.

  • Cochrane Oral Health Group, UK.

  • The University of Dundee, UK.

  • The University of Glasgow, UK.

  • Manchester Academic Health Sciences Centre (MAHSC) and NIHR Manchester Biomedical Research Centre, UK.

External sources

  • National Institute of Health, National Institute of Dental & Craniofacial Research, USA.

  • Central Manchester & Manchester Children's University Hospitals NHS Trust, UK.

Declarations of interest

None known.

Acknowledgements

Thanks to:

  • May Wong for her statistical input during data extraction

  • Emma Tavender for her contribution to the drafting of the original protocol for this review, and helping to secure funding for the review

  • Sylvia Bickley and Anne Littlewood ‐ Cochrane Oral Health Group, Trials Search Co‐ordinators

  • Phil Riley ‐ retrieval of papers

  • Chris O'Brien for his contribution to the CSROC Expert Panel

  • Dr KK Ang and Dr G Sanguineti for providing additional data.

Version history

Published

Title

Stage

Authors

Version

2010 Dec 08

Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy

Review

Anne‐Marie Glenny, Susan Furness, Helen V Worthington, David I Conway, Richard Oliver, Jan E Clarkson, Michaelina Macluskey, Sue Pavitt, Kelvin KW Chan, Paul Brocklehurst, The CSROC Expert Panel

https://doi.org/10.1002/14651858.CD006387.pub2

2007 Jan 24

Interventions for the treatment of oral cancer: radiotherapy

Protocol

Richard Oliver, Jan E Clarkson, David Conway, Anne‐Marie Glenny, Michaelina Macluskey, Sue Pavitt, Philip Sloan, The CSROC Expert Panel, Helen V Worthington

https://doi.org/10.1002/14651858.CD006387

Differences between protocol and review

Types of studies: As the primary outcome for this review is total mortality we have added a requirement that included studies have a minimum of 6 months of follow‐up of participants after the end of treatment.

Types of participants: We have only included studies where at least 50% of the participants have either oral cavity or oropharyngeal cancer, or where data for the oral cavity and oropharyngeal patients only are available.

Types of interventions: The intervention under evaluation must be radiotherapy. Trials where all participants receive the same radiotherapy regimen and are randomised to other treatments were excluded.

Types of outcomes: The protocol for this review stated that quality of life would be a primary outcome for this review. Quality of life is an important outcome, for both patients with oral cavity and oropharyngeal cancers and their doctors. However, quality of life is infrequently and inconsistently reported in trials which address a primary outcome of overall survival. Therefore we have opted to transfer this outcome to the list of secondary outcomes to be considered in future updates of this review as appropriate.

Search methods: The search strategy has been updated.

Quality assessment has been replaced by the new risk of bias tool.

Data synthesis has been updated. The primary outcome is total mortality expressed as a hazard ratio. A meta‐analysis of individual patient data (IPD) for altered fractionation versus conventional fractionation has previously been published (Bourhis 2006). For trials included in the Bourhis meta‐analysis, the IPD were used instead of data presented in the published reports. For dichotomous outcomes, the estimates of effect of an intervention were expressed as risk ratios together with 95% confidence intervals. Dichotomous data were only used for primary outcomes where hazard ratios were unavailable or could not be calculated.