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Referencias

Molnar 2004a {published data only}

Molnar JA, Heimbach DM, Tredget EE, Hickerson WL, Still JM, Luterman A, et al. Prospective randomized controlled mulitcenter trial applying subatmospheric pressure to acute hand burns: an interim report. 2nd World Union of Wound Healing Societies' Meeting July 18‐23; Paris, France. 2004.

Adamkova 2005 {published data only}

Adamkova M, Tymonova J, Zamecnikova I, Kadlcik M, Klosova H. First experience with the use of vacuum assisted closure in the treatment of skin defects at the burn center. Acta Chirurgiae Plasticae 2005;47(1):24‐7.

Banwell 2004b {published data only}

Banwell PE. Topical negative pressure wound therapy: advances in burn wound management. Ostomy/Wound Management 2004;50(11A Suppl):9S‐14S.

Haslik 2004 {published data only}

Haslik W, Kamolz LP, Andel H, Meissl G, Frey M. The use of subatmospheric pressure to prevent burn wound progression: first experiences in burn wound treatment. Zentralblatt fur Chirurgie 2004;129(Suppl 1):S62‐3.

Kamolz 2004 {published data only}

Kamolz LP, Andel H, Haslik W, Winter W, Meissl G, Frey M. Use of subatmospheric pressure therapy to prevent burn wound progression in human: first experiences. Burns 2004;30(3):253‐8.

Moisidis 2004 {published data only}

Moisidis E, Heath T, Boorer C, Ho K, Deva AK. A prospective, blinded, randomized, controlled clinical trial of topical negative pressure use in skin grafting. Plastic and Reconstructive Surgery 2004;114(4):917‐22.

Molnar 2004b {published data only}

Molnar JA. Applications of negative pressure wound therapy to thermal injury. Ostomy/Wound Management 2004;50(4A Suppl):17S‐19S.
Molnar JA. The science behind negative pressure wound therapy. Ostomy/Wound Management 2004;50(4A Suppl):2S‐5S.

Nugent 2005 {published data only}

Nugent N, Lannon D, O'Donnell M. Vacuum‐assisted closure ‐ a management option for the burns patient with exposed bone. Burns 2005;31(3):390‐3.

Schintler 2005 {published data only}

Schintler M, Marschitz I, Trop M. The use of topical negative pressure in a paediatric patient with extensive burns. Burns 2005;31(8):1050‐3.

Schrank 2004 {published data only}

Schrank C, Mayr M, Overesch M, Molnar J, Henkel V, Donnersmarck G, et al. Results of vacuum therapy (v.a.c.) of superficial and deep dermal burns. Zentralblatt fur Chirurgie 2004;129(Suppl 1):S59‐61.

Atiyeh 2005

Atiyeh BS, Gunn SW, Hayek SN. State of the art in burn treatment. World Journal of Surgery 2005;29(2):131‐48.

Banwell 1999

Banwell PE. Topical negative pressure therapy in wound care. Journal of Wound Care 1999;8(2):79‐84.

Banwell 2004a

Banwell PE, Musgrave M. Topical negative pressure therapy: mechanisms and indications. International Wound Journal 2004;1(2):95‐106.

Boykin 1980

Boykin JV, Eriksson E, Pittman RN. In vivo microcirculation of a scald burn and the progression of postburn dermal ischemia. Plastic and Reconstructive Surgery 1980;66(2):191‐8.

Brigham 1996

Brigham PA, McLoughlin E. Burn incidence and medical care use in the United States: Estimates, trends, and data sources. Journal of Burn Care Rehabilitation 1996;17(2):95‐107.

Deeks 2002

Deeks JJ. Issues in the selection of a summary statistic for meta‐analysis of clinical trials with binary outcomes. Statistics in Medicine 2002;21(1):575‐600.

Demling 1979

Demling RH, Niehaus G, Perea A, Will JA. Effect of burn‐induced hypoproteinemia on pulmonary transvascular fluid filtration rate. Surgery 1979;85(3):39‐43.

Demling 2005

Demling RH, DeSanti L. Managing the burn wound. http://www.burnsurgery.org/Modules/BurnWound%201/index.htm (accessed 11 Jan 2006).

Department of Health and Human Services 2009

Department of Health and Human Services. Comparison of prices for negative pressure wound therapy pumps. oig.hhs.gov/oei/reports/oei‐02‐07‐00660.pdf. OEI‐02‐07‐00660 2009.

Higgins 2003

Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta‐analyses. BMJ 2003;327(7414):557‐60.

Higgins 2011

Higgins JPT, Altman DG, on behalf of the Cochrane Statistical Methods Group and the Cochrane Bias Methods Group (Editors). Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane‐handbook.org.

Johnson 2003

Johnson MR, Richard R. Partial thickness burns: identification and management. Advances in Skin and Wound Care 2003;16(4):178‐87.

Lefebvre 2011

Lefebvre C, Manheimer E, Glanville J, on behalf of the Cochrane Information Retrieval Methods Group. Chapter 6: Searching for studies. In: Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane‐handbook.org.

Pham 2003

Pham CT, Middleton P, Maddern G. Vacuum‐assisted closure for the management of wounds: an accelerated systematic review. Australian Safety & Efficacy Register of New Interventional Procedures – Surgical (ASERNIPS‐S) 2003;Report No.37:1‐53.

RevMan 2011 [Computer program]

The Nordic Cochrane Centre. Review Manager (RevMan) Version 5.1. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, issue 2011.

Sheridan 2002

Sheridan RL. Burns. Critical Care Medicine 2002;30(11):S500‐S514.

SIGN 2012

Scottish Intercollegiate Guidelines Network (SIGN). Search filters. Available from http://www.sign.ac.uk/methodology/filters.html#random (accessed 23 August 2012).

Subrahmanyam 1998

Subrahmanyam M. A prospective randomised clinical and histological study of superficial burn wound healing with honey and silver sulfadiazine. Burns 1998;24(2):157‐61.

Tierney 2007

Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR. Practical methods for incorporating summary time‐to‐event data into meta‐analysis. Trials 2007;7(8):16.

Ubbink 2008

Ubbink DT, Westerbos SJ, Evans D, Land L, Vermeulen H. Topical negative pressure for treating chronic wounds. Cochrane Database of Systematic Reviews 2008, Issue 3. [DOI: 10.1002/14651858.CD001898.pub2]

Villanueva 2004

Villanueva E, Bennett MH, Wasiak J, Lehm JP. Hyperbaric oxygen therapy for thermal burns. Cochrane Database of Systematic Reviews 2004, Issue 2. [DOI: 10.1002/14651858.CD004727.pub2]

Wasiak 2005

Wasiak J, Cleland HJ. Burns (minor thermal). Clinical Evidence. BMJ Publishing Group Ltd, 2005.

Youn 1992

Youn YK, LaLonde C, Demling R. The role of mediators in the response to thermal injury. World Journal of Surgery 1992;16(1):30‐6.

Dumville 2012

Dumville JC, Munson C. Negative pressure wound therapy for partial‐thickness burns.. Cochrane Database of Systematic Reviews 2012, Issue 12. [DOI: 10.1002/14651858.CD006215.pub3.]

Wasiak 2007

Wasiak J, Cleland H. Topical negative pressure (TNP) for partial thickness burns. Cochrane Database of Systematic Reviews 2007, Issue 3. [DOI: 10.1002/14651858.CD006215.pub2]

Characteristics of studies

Characteristics of included studies [ordered by study ID]

Ir a:

Molnar 2004a

Methods

RCT: "the study design was prospective, randomised, controlled, blinded, multi‐center and web‐based".

Participants

23 patients (age range 20‐70 years, mean 46 years; TBSA 5%‐40%, mean TBSA 16%) with bilateral hand burns treated within 24 h of burn injury.

Interventions

NPWT (125 mmHg pressure) applied for 48 h or silver sulfadiazine (SSD).

Outcomes

Rate of burn healing, volume of hand as determined by fluid displacement, range of motion, grip and pinch strength.

Notes

Only conference abstract available, which was an interim report on first 23 patients recruited.

Risk of bias

Bias

Authors' judgement

Support for judgement

Random sequence generation (selection bias)

Unclear risk

Not specified, although participants were reported as "randomised" to either the treatment or control group.

Allocation concealment (selection bias)

Unclear risk

Not reported.

Blinding (performance bias and detection bias)
participants

High risk

Not possible due to nature of intervention.

Blinding (performance bias and detection bias)
personnel delivering intervention

High risk

Not possible due to nature of intervention.

Blinding (performance bias and detection bias)
outcome assessors

Low risk

Blinding of principal investigator used to determine rate of burn healing (personal communication with study author, information not available in abstract).

Incomplete outcome data (attrition bias)
All outcomes

Unclear risk

Interim report only; no attrition reported at this point in trial.

Selective reporting (reporting bias)

Low risk

All pre‐specified outcomes presented in interim report.

Other bias

Low risk

No other concerns.

Abbreviations

h = hour(s)
NPWT = negative pressure wound therapy
SSD = silver sulfadiazine
TBSA: total burn surface area

Characteristics of excluded studies [ordered by study ID]

Ir a:

Study

Reason for exclusion

Adamkova 2005

Not a randomised controlled trial.

Banwell 2004b

Not a randomised controlled trial.

Haslik 2004

Not a randomised controlled trial.

Kamolz 2004

Did not address a pre‐specified primary outcome measure.

Moisidis 2004

No separate data on burns.

Molnar 2004b

Not a randomised controlled trial.

Nugent 2005

Not a randomised controlled trial.

Schintler 2005

Not a randomised controlled trial.

Schrank 2004

Did not address a pre‐specified primary outcome measure.

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Figuras y tablas -
Figure 1

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

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