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Programas de cribado y tratamiento de infecciones del aparato genital inferior para la prevención del parto prematuro

Appendices

Appendix 1. CENTRAL search strategy

#1 MeSH descriptor Pregnancy explode all trees in MeSH products
#2 MeSH descriptor Pregnancy Complications explode all trees in MeSH products
#3 pregnan* in All Fields in all products
#4 (preterm or premature) near (labour or labor) in All Fields in all products
#5 MeSH descriptor Infection explode all trees in MeSH products
#6 MeSH descriptor Mass Screening explode all trees in MeSH products
#7 screen* in All Fields in all products
#8 infect* in All Fields in all products
#9 (#1 OR #2 OR #3 OR #4)
#10 (#5 OR #8)
#11 (#6 OR #7)
#12 (#9 AND #10 AND #11)

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Figuras y tablas -
Figure 1

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

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Comparison 1 Lower genital tract infection screening versus no screening, Outcome 1 Preterm birth less than 37 weeks.
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Analysis 1.1

Comparison 1 Lower genital tract infection screening versus no screening, Outcome 1 Preterm birth less than 37 weeks.

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Comparison 1 Lower genital tract infection screening versus no screening, Outcome 2 Preterm very low birthweight (below or equal 1500 g).
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Analysis 1.2

Comparison 1 Lower genital tract infection screening versus no screening, Outcome 2 Preterm very low birthweight (below or equal 1500 g).

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Comparison 1 Lower genital tract infection screening versus no screening, Outcome 3 Preterm low birthweight (below or equal 2500 g).
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Analysis 1.3

Comparison 1 Lower genital tract infection screening versus no screening, Outcome 3 Preterm low birthweight (below or equal 2500 g).

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Summary of findings for the main comparison. Lower genital tract infection screening versus no screening for preventing preterm delivery

Lower genital tract infection screening versus no screening for preventing preterm delivery

Patient or population: pregnant women presenting for routine prenatal care
Settings: Vienna, Austria
Intervention: lower genital tract infection screening versus no screening

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of Participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

No screening

Lower genital tract infection screening

Preterm birth less than 37 weeks

Study population

RR 0.55
(0.41 to 0.75)

4155
(1 study)

⊕⊕⊕⊝
moderate1

53 per 1000

29 per 1000
(22 to 40)

Preterm low birthweight (below or equal 2500 g)

Study population

RR 0.48
(0.34 to 0.66)

4155
(1 study)

⊕⊕⊕⊝
moderate1

51 per 1000

24 per 1000
(17 to 34)

Preterm very low birthweight (below or equal 1500 g)

Study population

RR 0.34
(0.15 to 0.75)

4155
(1 study)

⊕⊕⊕⊝
moderate1

11 per 1000

4 per 1000
(2 to 9)

*The basis for the assumed risk is the median control group risk across studies. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
CI: Confidence interval; RR: Risk ratio

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1 One study with design limitations.

Figuras y tablas -
Summary of findings for the main comparison. Lower genital tract infection screening versus no screening for preventing preterm delivery
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Comparison 1. Lower genital tract infection screening versus no screening

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Preterm birth less than 37 weeks Show forest plot

1

4155

Risk Ratio (M‐H, Fixed, 95% CI)

0.55 [0.41, 0.75]

2 Preterm very low birthweight (below or equal 1500 g) Show forest plot

1

4155

Risk Ratio (M‐H, Fixed, 95% CI)

0.34 [0.15, 0.75]

3 Preterm low birthweight (below or equal 2500 g) Show forest plot

1

4155

Risk Ratio (M‐H, Fixed, 95% CI)

0.48 [0.34, 0.66]

4 Neonatal morbidity

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Duration of admission to neonatal intensive care unit/hospital

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6 Neonatal death

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Side‐effects of treatment (including drug resistance)

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Persistent infection

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

9 Recurrent infection

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

10 Women's satisfaction

0

0

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 1. Lower genital tract infection screening versus no screening
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