Anticonceptivos orales para los quistes ováricos funcionales
Appendices
Appendix 1. Search 2014
PubMed (2011 to 25 Mar 2014)
((contraceptives, oral OR estrogens/therapeutic use OR progesterones/therapeutic use) AND ovarian cysts) NOT (polycystic[title] OR PCOS[Title] OR hirsutism[title]) AND Humans[Mesh]
POPLINE (2011 to 25 Mar 2014)
Keyword: Ovarian cysts AND
Keyword: Oral contraceptives
Filter by keywords: Research report
CENTRAL (2011 to 25 Mar 2014)
Title, abstract, keywords: cyst AND contraception
EMBASE (2011 to 25 Mar 2014)
'oral contraceptive agent'/exp AND 'ovary cyst'/exp NOT 'ovary polycystic disease'/exp AND ([article]/lim OR [article in press]/lim OR [conference abstract]/lim OR [conference paper]/lim) AND [humans]/lim
ClinicalTrials.gov (01 Jan 2011 to 27 Mar 2014)
Search terms: ovarian cysts
Condition: NOT (polycystic OR PCOS)
Intervention: contraception OR contraceptive
Study type: Interventional
ICTRP (01 Jan 2011 to 27 Mar 2014)
Condition: ovarian cysts
Intervention: contraception OR contraceptive
Recruitment status: all
Appendix 2. Previous search strategies
2011
MEDLINE via PubMed (Sep 2008 to 06 Jun 2011)
(((contraceptives, oral OR estrogens/therapeutic use OR progesterones/therapeutic use) AND ovarian cysts) NOT (polycystic OR PCOS[Title])
POPLINE (06 Jun 2011 and past years)
ovarian cysts & treat* & (oral contraceptives/ progestin*/progesterone*/estrogen*) !(polycystic/dermoid)
CENTRAL (2008 to 06 Jun 2011)
cyst and contraception
ClinicalTrials.gov (06 Jun 2011)
Search terms: ovarian cysts
Condition: NOT (polycystic OR PCOS)
Intervention: contraception OR contraceptive
Study type: interventional
ICTRP (06 Jun 2011)
Condition: ovarian cysts
Intervention: contraception OR contraceptive
2006 to 2009
MEDLINE via PubMed
(contraceptives, oral OR estrogens/therapeutic use OR progesterones/therapeutic use) AND functional ovarian cysts
POPLINE
ovarian cysts & treat* & (oral contraceptives/ progestin*/progesterone*/estrogen*) !(polycystic/dermoid)
EMBASE
(oral contraceptive agent AND ovary cyst) NOT polycystic
CENTRAL
cyst and contraception
ClinicalTrials.gov
Search terms: ovarian cysts
Condition: oral contraceptive
ICTRP
Title: ovarian cysts
Intervention or condition: contraception OR contraceptive
Comparison 1 Norethindrone 1 mg plus mestranol 50 μg daily versus expectant management, Outcome 1 Resolution of cyst within nine weeks.
Comparison 2 Desogestrel 150 μg plus ethinyl estradiol 30 μg taken cyclically versus expectant management, Outcome 1 Resolution of cyst by last follow up (10 or 12 weeks).
Comparison 3 Desogestrel 150 μg plus ethinyl estradiol 20 μg taken daily versus expectant management, Outcome 1 Resolution of cyst by six months.
Comparison 4 Levonorgestrel 100 μg plus ethinyl estradiol 20 μg taken cyclically versus expectant management, Outcome 1 Resolution of cyst by 12 weeks.
Comparison 5 Levonorgestrel 125 μg plus ethinyl estradiol 50 μg taken cyclically versus expectant management, Outcome 1 Resolution of cyst within one menstrual cycle.
Comparison 6 Levonorgestrel 150 μg plus ethinyl estradiol 30 μg taken cyclically versus expectant management, Outcome 1 Resolution of cyst by last follow up (second or third month).
Comparison 6 Levonorgestrel 150 μg plus ethinyl estradiol 30 μg taken cyclically versus expectant management, Outcome 2 Cyst volume after third month.
Comparison 7 Levonorgestrel 250 μg plus ethinyl estradiol 50 μg taken cyclically versus expectant management, Outcome 1 Resolution of cyst by 10 weeks.
Comparison 8 Levonorgestrel 50/75/125 μg plus ethinyl estradiol 30/40/30 μg taken cyclically versus expectant management, Outcome 1 Resolution of cyst by 10 weeks.
Comparison 9 Levonorgestrel 100 μg plus ethinyl estradiol 20 μg versus desogestrel 150 μg plus ethinyl estradiol 30 μg, Outcome 1 Regression of cyst by 4 weeks.
Comparison 9 Levonorgestrel 100 μg plus ethinyl estradiol 20 μg versus desogestrel 150 μg plus ethinyl estradiol 30 μg, Outcome 2 Regression of cyst by 12 weeks.
Comparison 10 Levonorgestrel 100 μg plus ethinyl estradiol 20 μg versus placebo, Outcome 1 Regression of cyst by 4 weeks.
Comparison 10 Levonorgestrel 100 μg plus ethinyl estradiol 20 μg versus placebo, Outcome 2 Regression of cyst by 12 weeks.
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Resolution of cyst within nine weeks Show forest plot | 1 | 41 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.0 [0.0, 0.0] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Resolution of cyst by last follow up (10 or 12 weeks) Show forest plot | 2 | 76 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.52 [0.46, 5.00] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Resolution of cyst by six months Show forest plot | 1 | 141 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.62 [0.27, 1.42] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Resolution of cyst by 12 weeks Show forest plot | 1 | 42 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.71 [0.45, 6.51] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Resolution of cyst within one menstrual cycle Show forest plot | 1 | 54 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.72 [0.14, 3.57] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Resolution of cyst by last follow up (second or third month) Show forest plot | 2 | 112 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.19 [0.54, 2.60] |
| 2 Cyst volume after third month Show forest plot | 1 | 45 | Mean Difference (IV, Fixed, 95% CI) | 3.20 [‐0.87, 7.27] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Resolution of cyst by 10 weeks Show forest plot | 1 | 34 | Odds Ratio (M‐H, Fixed, 95% CI) | 3.18 [0.12, 83.76] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Resolution of cyst by 10 weeks Show forest plot | 1 | 35 | Odds Ratio (M‐H, Fixed, 95% CI) | 3.36 [0.13, 88.39] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Regression of cyst by 4 weeks Show forest plot | 1 | 124 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.15 [0.55, 2.38] |
| 2 Regression of cyst by 12 weeks Show forest plot | 1 | 124 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.41 [0.55, 3.64] |
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
| 1 Regression of cyst by 4 weeks Show forest plot | 1 | 124 | Odds Ratio (M‐H, Fixed, 95% CI) | 0.93 [0.44, 1.95] |
| 2 Regression of cyst by 12 weeks Show forest plot | 1 | 124 | Odds Ratio (M‐H, Fixed, 95% CI) | 1.27 [0.49, 3.32] |
