Scolaris Content Display Scolaris Content Display

Contenido relacionado

Ir a:

Revisiones y protocolos relacionados

Topics

Temas

Comparison 1 Children ‐ global assessment, Outcome 1 Not cured or not improved.
Figuras y tablas -
Analysis 1.1

Comparison 1 Children ‐ global assessment, Outcome 1 Not cured or not improved.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 1 Children ‐ global assessment, Outcome 2 Not improved.
Figuras y tablas -
Analysis 1.2

Comparison 1 Children ‐ global assessment, Outcome 2 Not improved.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 1 Children ‐ global assessment, Outcome 3 Not cured.
Figuras y tablas -
Analysis 1.3

Comparison 1 Children ‐ global assessment, Outcome 3 Not cured.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 2 Children ‐ cough score, Outcome 1 Mean cough score at day 3.
Figuras y tablas -
Analysis 2.1

Comparison 2 Children ‐ cough score, Outcome 1 Mean cough score at day 3.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 2 Children ‐ cough score, Outcome 2 Mean score at day 10.
Figuras y tablas -
Analysis 2.2

Comparison 2 Children ‐ cough score, Outcome 2 Mean score at day 10.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 3 Adults ‐ global assessment, Outcome 1 Not cured or not improved.
Figuras y tablas -
Analysis 3.1

Comparison 3 Adults ‐ global assessment, Outcome 1 Not cured or not improved.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 3 Adults ‐ global assessment, Outcome 2 Not improved.
Figuras y tablas -
Analysis 3.2

Comparison 3 Adults ‐ global assessment, Outcome 2 Not improved.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 3 Adults ‐ global assessment, Outcome 3 Not cured.
Figuras y tablas -
Analysis 3.3

Comparison 3 Adults ‐ global assessment, Outcome 3 Not cured.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 4 Combined children and adults, Outcome 1 Not cured or not improved.
Figuras y tablas -
Analysis 4.1

Comparison 4 Combined children and adults, Outcome 1 Not cured or not improved.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 4 Combined children and adults, Outcome 2 Not improved.
Figuras y tablas -
Analysis 4.2

Comparison 4 Combined children and adults, Outcome 2 Not improved.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Comparison 4 Combined children and adults, Outcome 3 Not cured.
Figuras y tablas -
Analysis 4.3

Comparison 4 Combined children and adults, Outcome 3 Not cured.

Ir a la figura de la revisiónAbrir en una pestaña nueva

Mucolytics as an adjunct to antibiotics to reduce cough in acute pneumonia in children and adults

Patient or population: children and adults with acute pneumonia

Settings: any

Intervention: mucolytics (and antibiotics)1

Comparision: antibiotics only

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of Participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

antibiotics only

mucolytics (and antibiotics)

Cough score
Scale from: 0 (absent) to 3 (very severe).
(follow‐up: 3 days)

The mean cough score in the control groups was
1.45

The mean Cough score in the intervention groups was
0.25 lower
(0.33 to 0.17 lower)

120
(1)

⊕⊕⊝⊝
low2,3,4

Data for children only.

Number of people who had not improved or had not been cured
(follow‐up: 7 to 10 days)

16 per 100

14 per 100
(7 to 26)

OR 0.85
(0.4 to 1.8)

221
(2)

⊕⊕⊝⊝
low2,5

Fewer people represents a benefit

Adverse events
(follow‐up: 10 days)

See comment

See comment

Not estimable

120
(1)

See comment

1 study in children provided data specific to participants with pneumonia ‐ there were no adverse events.

Complications (e.g. medication change)

See comment

See comment

Not estimable

0
(0)

See comment

Complications were not measured in the trials.

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

CI: Confidence interval; OR: Odds ratio;

GRADE Working Group grades of evidance
High quality: Further research is very unlikely to change our confidence in the estimate of effect.
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
Very low quality: We are very uncertain about the estimate.

1 In addition to antibiotics, people with pneumonia often use over‐the‐counter (OTC) cough medications when at home or request OTC cough medicaitons when in hospital to suppress an annoying cough. There is a question as to whether suppressing cough may prolong pneumonia. Over‐the‐counter cough medications can include anti‐tussives, expectorants, anti‐histamine‐decongestants, anti‐histamines and mucolytics (such as bromhexine, ambroxol and neltenexine).

2 Allocation concealment unclear.

3 Scale not validated.

4 Sparse data.

5 Sparse data; confidence interval does not rule out the potential for "more people" not improved or cured with mucolytics.

Figuras y tablas -
Ir a la tabla de la revisión
Comparison 1. Children ‐ global assessment

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Not cured or not improved Show forest plot

1

120

Odds Ratio (M‐H, Fixed, 95% CI)

0.40 [0.10, 1.62]

2 Not improved Show forest plot

1

120

Odds Ratio (M‐H, Fixed, 95% CI)

0.40 [0.10, 1.62]

3 Not cured Show forest plot

1

120

Odds Ratio (M‐H, Fixed, 95% CI)

0.36 [0.16, 0.77]
Figuras y tablas -
Comparison 1. Children ‐ global assessment
Ir a la tabla de la revisión
Comparison 2. Children ‐ cough score

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean cough score at day 3 Show forest plot

1

120

Mean Difference (IV, Fixed, 95% CI)

‐0.25 [‐0.33, ‐0.17]

2 Mean score at day 10 Show forest plot

1

120

Mean Difference (IV, Fixed, 95% CI)

‐0.15 [‐0.17, ‐0.13]
Figuras y tablas -
Comparison 2. Children ‐ cough score
Ir a la tabla de la revisión
Comparison 3. Adults ‐ global assessment

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Not cured or not improved Show forest plot

1

101

Odds Ratio (M‐H, Fixed, 95% CI)

1.21 [0.48, 3.04]

2 Not improved Show forest plot

1

101

Odds Ratio (M‐H, Fixed, 95% CI)

1.21 [0.48, 3.04]

3 Not cured Show forest plot

1

101

Odds Ratio (M‐H, Fixed, 95% CI)

0.32 [0.13, 0.75]
Figuras y tablas -
Comparison 3. Adults ‐ global assessment
Ir a la tabla de la revisión
Comparison 4. Combined children and adults

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Not cured or not improved Show forest plot

2

221

Odds Ratio (M‐H, Fixed, 95% CI)

0.85 [0.40, 1.80]

2 Not improved Show forest plot

2

221

Odds Ratio (M‐H, Fixed, 95% CI)

0.80 [0.38, 1.67]

3 Not cured Show forest plot

2

221

Odds Ratio (M‐H, Fixed, 95% CI)

0.34 [0.19, 0.60]
Figuras y tablas -
Comparison 4. Combined children and adults
Ir a la tabla de la revisión