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Comparison 1 Clinical outcomes, Outcome 1 Death or dependence (mRS 4 to 6) at day 90.
Figuras y tablas -
Analysis 1.1

Comparison 1 Clinical outcomes, Outcome 1 Death or dependence (mRS 4 to 6) at day 90.

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Comparison 1 Clinical outcomes, Outcome 2 Death or dependence (GOS‐E 1 to 4) at day 90.
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Analysis 1.2

Comparison 1 Clinical outcomes, Outcome 2 Death or dependence (GOS‐E 1 to 4) at day 90.

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Comparison 1 Clinical outcomes, Outcome 3 Death at day 90.
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Analysis 1.3

Comparison 1 Clinical outcomes, Outcome 3 Death at day 90.

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Comparison 2 Adverse events, Outcome 1 All serious adverse events.
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Analysis 2.1

Comparison 2 Adverse events, Outcome 1 All serious adverse events.

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Comparison 2 Adverse events, Outcome 2 Thromboembolic serious adverse events.
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Analysis 2.2

Comparison 2 Adverse events, Outcome 2 Thromboembolic serious adverse events.

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Comparison 3 Radiological outcomes, Outcome 1 Mean percentage increase in ICH volume on CT from baseline to 24 hours.
Figuras y tablas -
Analysis 3.1

Comparison 3 Radiological outcomes, Outcome 1 Mean percentage increase in ICH volume on CT from baseline to 24 hours.

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Comparison 3 Radiological outcomes, Outcome 2 Mean absolute increase in ICH volume on CT from baseline to 24 hours.
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Analysis 3.2

Comparison 3 Radiological outcomes, Outcome 2 Mean absolute increase in ICH volume on CT from baseline to 24 hours.

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Comparison 3 Radiological outcomes, Outcome 3 Mean percentage increase in ICH + IVH volume on CT from baseline to 24 hours.
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Analysis 3.3

Comparison 3 Radiological outcomes, Outcome 3 Mean percentage increase in ICH + IVH volume on CT from baseline to 24 hours.

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Comparison 3 Radiological outcomes, Outcome 4 Mean absolute increase in ICH + IVH volume on CT from baseline to 24 hours.
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Analysis 3.4

Comparison 3 Radiological outcomes, Outcome 4 Mean absolute increase in ICH + IVH volume on CT from baseline to 24 hours.

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Comparison 3 Radiological outcomes, Outcome 5 Participants without substantial ICH growth (> 33% or 12.5 ml) on CT at 1 hour.
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Analysis 3.5

Comparison 3 Radiological outcomes, Outcome 5 Participants without substantial ICH growth (> 33% or 12.5 ml) on CT at 1 hour.

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Comparison 3 Radiological outcomes, Outcome 6 Participants without substantial ICH growth (> 33% or 12.5 ml) on CT at 24 hours.
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Analysis 3.6

Comparison 3 Radiological outcomes, Outcome 6 Participants without substantial ICH growth (> 33% or 12.5 ml) on CT at 24 hours.

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Comparison 1. Clinical outcomes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Death or dependence (mRS 4 to 6) at day 90 Show forest plot

4

1305

Risk Ratio (IV, Random, 95% CI)

0.91 [0.72, 1.15]

2 Death or dependence (GOS‐E 1 to 4) at day 90 Show forest plot

3

486

Risk Ratio (M‐H, Fixed, 95% CI)

0.90 [0.81, 1.01]

3 Death at day 90 Show forest plot

6

1398

Risk Ratio (IV, Random, 95% CI)

0.85 [0.58, 1.25]
Figuras y tablas -
Comparison 1. Clinical outcomes
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Comparison 2. Adverse events

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 All serious adverse events Show forest plot

2

87

Risk Ratio (M‐H, Fixed, 95% CI)

1.47 [0.73, 2.95]

2 Thromboembolic serious adverse events Show forest plot

3

1310

Risk Ratio (IV, Random, 95% CI)

1.37 [0.74, 2.55]
Figuras y tablas -
Comparison 2. Adverse events
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Comparison 3. Radiological outcomes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mean percentage increase in ICH volume on CT from baseline to 24 hours Show forest plot

1

399

Mean Difference (IV, Fixed, 95% CI)

‐15.0 [‐27.61, ‐2.39]

2 Mean absolute increase in ICH volume on CT from baseline to 24 hours Show forest plot

1

399

Mean Difference (IV, Fixed, 95% CI)

‐4.50 [‐7.98, ‐1.02]

3 Mean percentage increase in ICH + IVH volume on CT from baseline to 24 hours Show forest plot

1

399

Mean Difference (IV, Fixed, 95% CI)

‐17.0 [‐29.61, ‐4.39]

4 Mean absolute increase in ICH + IVH volume on CT from baseline to 24 hours Show forest plot

1

399

Mean Difference (IV, Fixed, 95% CI)

‐5.4 [‐9.87, ‐0.93]

5 Participants without substantial ICH growth (> 33% or 12.5 ml) on CT at 1 hour Show forest plot

1

40

Risk Ratio (M‐H, Fixed, 95% CI)

0.82 [0.58, 1.15]

6 Participants without substantial ICH growth (> 33% or 12.5 ml) on CT at 24 hours Show forest plot

2

87

Risk Ratio (M‐H, Fixed, 95% CI)

0.84 [0.68, 1.03]
Figuras y tablas -
Comparison 3. Radiological outcomes
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