Systemic antimicrobial prophylaxis for percutaneous endoscopic gastrostomy

Allyson Lipp; Gail Lusardi

doi:10.1002/14651858.CD005571.pub3

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Figure 1

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

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Figure 2

Methodological quality summary: review authors' judgements about each methodological quality item for each included study.

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Analysis 1.1

Comparison 1 Systemic antibiotic (IV) compared with placebo, Outcome 1 Peristomal infection.

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Analysis 2.1

Comparison 2 Systemic antibiotic (IV) compared with no intervention, Outcome 1 Peristomal infection.

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Analysis 3.1

Comparison 3 Systemic antibiotic (IV) compared with placebo/no intervention/skin antiseptic, Outcome 1 Peristomal infection.

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Analysis 3.2

Comparison 3 Systemic antibiotic (IV) compared with placebo/no intervention/skin antiseptic, Outcome 2 Allocation concealment.

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Analysis 3.3

Comparison 3 Systemic antibiotic (IV) compared with placebo/no intervention/skin antiseptic, Outcome 3 Sponsorship.

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Analysis 4.1

Comparison 4 Systemic antibiotic compared with systemic antibiotic, Outcome 1 Systemic antibiotic (IV) compared with systemic antibiotic (IV).

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Analysis 4.2

Comparison 4 Systemic antibiotic compared with systemic antibiotic, Outcome 2 Systemic antibiotic (PEG) compared with systemic antibiotic (IV).

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Analysis 5.1

Comparison 5 Systemic antibiotic (IV) compared with systemic antibiotic (IV) and skin antiseptic, Outcome 1 Peristomal infection.

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Analysis 6.1

Comparison 6 Skin antiseptic compared with systemic antibiotic (IV) and skin antiseptic, Outcome 1 Peristomal infection.

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Comparison 1. Systemic antibiotic (IV) compared with placebo

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Peristomal infection Show forest plot	8	586	Odds Ratio (M‐H, Fixed, 95% CI)	0.34 [0.22, 0.53]

Comparison 1. Systemic antibiotic (IV) compared with placebo

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Comparison 2. Systemic antibiotic (IV) compared with no intervention

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Peristomal infection Show forest plot	3	623	Odds Ratio (M‐H, Fixed, 95% CI)	0.30 [0.17, 0.53]

Comparison 2. Systemic antibiotic (IV) compared with no intervention

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Comparison 3. Systemic antibiotic (IV) compared with placebo/no intervention/skin antiseptic

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Peristomal infection Show forest plot	12	1271	Odds Ratio (M‐H, Fixed, 95% CI)	0.36 [0.26, 0.50]

2 Allocation concealment Show forest plot	12	1271	Odds Ratio (M‐H, Fixed, 95% CI)	0.47 [0.34, 0.65]

2.1 adequate allocation concealment	8	554	Odds Ratio (M‐H, Fixed, 95% CI)	0.58 [0.38, 0.88]
2.2 unclear/inadequate concealment	4	717	Odds Ratio (M‐H, Fixed, 95% CI)	0.34 [0.21, 0.58]
3 Sponsorship Show forest plot	12	1271	Odds Ratio (M‐H, Fixed, 95% CI)	0.36 [0.26, 0.50]

3.1 Trials with no sponsorship	10	962	Odds Ratio (M‐H, Fixed, 95% CI)	0.38 [0.25, 0.56]
3.2 Trials with sponsorship	2	309	Odds Ratio (M‐H, Fixed, 95% CI)	0.32 [0.18, 0.58]

Comparison 3. Systemic antibiotic (IV) compared with placebo/no intervention/skin antiseptic

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Comparison 4. Systemic antibiotic compared with systemic antibiotic

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Systemic antibiotic (IV) compared with systemic antibiotic (IV) Show forest plot	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected

1.1 Peristomal infection	1		Odds Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 Systemic antibiotic (PEG) compared with systemic antibiotic (IV) Show forest plot	1		Odds Ratio (M‐H, Fixed, 95% CI)	Totals not selected

Comparison 4. Systemic antibiotic compared with systemic antibiotic

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Comparison 5. Systemic antibiotic (IV) compared with systemic antibiotic (IV) and skin antiseptic

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Peristomal infection Show forest plot	1	68	Odds Ratio (M‐H, Fixed, 95% CI)	15.78 [1.90, 130.86]

Comparison 5. Systemic antibiotic (IV) compared with systemic antibiotic (IV) and skin antiseptic

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Comparison 6. Skin antiseptic compared with systemic antibiotic (IV) and skin antiseptic

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Peristomal infection Show forest plot	1	62	Odds Ratio (M‐H, Fixed, 95% CI)	15.63 [1.84, 133.09]

Comparison 6. Skin antiseptic compared with systemic antibiotic (IV) and skin antiseptic

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