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Study selection flow diagram
Figuras y tablas -
Figure 1

Study selection flow diagram

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies
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Figure 2

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies

Risk of bias summary: review authors' judgements about each risk of bias item for each included study
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Figure 3

Risk of bias summary: review authors' judgements about each risk of bias item for each included study

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 1 Total cholesterol.
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Analysis 1.1

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 1 Total cholesterol.

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 2 LDL cholesterol.
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Analysis 1.2

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 2 LDL cholesterol.

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 3 HDL cholesterol.
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Analysis 1.3

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 3 HDL cholesterol.

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 4 Triglyceride.
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Analysis 1.4

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 4 Triglyceride.

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 5 Serum creatinine.
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Analysis 1.5

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 5 Serum creatinine.

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 6 Blood urea nitrogen.
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Analysis 1.6

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 6 Blood urea nitrogen.

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 7 Proteinuria.
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Analysis 1.7

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 7 Proteinuria.

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 8 Serum albumin.
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Analysis 1.8

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 8 Serum albumin.

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 9 Total serum protein.
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Analysis 1.9

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 9 Total serum protein.

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 10 Apolipoprotein A.
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Analysis 1.10

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 10 Apolipoprotein A.

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 11 Apolipoprotein B.
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Analysis 1.11

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 11 Apolipoprotein B.

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 12 Elevated liver enzymes.
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Analysis 1.12

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 12 Elevated liver enzymes.

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 13 Alanine aminotransferase.
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Analysis 1.13

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 13 Alanine aminotransferase.

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 14 Aspartate aminotransferase.
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Analysis 1.14

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 14 Aspartate aminotransferase.

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 15 Creatine phosphokinase.
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Analysis 1.15

Comparison 1 Lipid‐lowering agents versus placebo or no treatment, Outcome 15 Creatine phosphokinase.

Comparison 1. Lipid‐lowering agents versus placebo or no treatment

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Total cholesterol Show forest plot

3

Mean Difference (IV, Random, 95% CI)

Subtotals only

1.1 Statins (3 months)

2

92

Mean Difference (IV, Random, 95% CI)

‐53.04 [‐159.53, 53.45]

1.2 Statins (6 months)

1

52

Mean Difference (IV, Random, 95% CI)

‐45.0 [‐144.57, 54.57]

1.3 Statins (1 year)

1

52

Mean Difference (IV, Random, 95% CI)

‐46.0 [‐144.26, 52.26]

1.4 Fibrates

1

12

Mean Difference (IV, Random, 95% CI)

42.0 [‐33.63, 117.63]

2 LDL cholesterol Show forest plot

2

Mean Difference (IV, Random, 95% CI)

Totals not selected

2.1 Statins

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

2.2 Fibrates

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

3 HDL cholesterol Show forest plot

2

Mean Difference (IV, Random, 95% CI)

Totals not selected

3.1 Statins

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

3.2 Fibrates

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

4 Triglyceride Show forest plot

2

Mean Difference (IV, Random, 95% CI)

Totals not selected

4.1 Statins

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

4.2 Fibrates

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

5 Serum creatinine Show forest plot

3

Mean Difference (IV, Random, 95% CI)

Totals not selected

5.1 Statins (3 months)

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

5.2 Statins (6 months)

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

5.3 Statins (1 year)

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

5.4 Fibrates

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

6 Blood urea nitrogen Show forest plot

2

Mean Difference (IV, Random, 95% CI)

Totals not selected

6.1 Statins

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

6.2 Fibrates

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

7 Proteinuria Show forest plot

2

Std. Mean Difference (IV, Random, 95% CI)

Totals not selected

7.1 Statins

1

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

7.2 Fibrates

1

Std. Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

8 Serum albumin Show forest plot

2

Mean Difference (IV, Random, 95% CI)

Totals not selected

8.1 Statins (6 months)

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

8.2 Statins (1 year)

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

8.3 Fibrates

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

9 Total serum protein Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

9.1 Fibrates

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

10 Apolipoprotein A Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

10.1 Fibrates

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

11 Apolipoprotein B Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

11.1 Fibrates

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

12 Elevated liver enzymes Show forest plot

1

Risk Ratio (M‐H, Random, 95% CI)

Totals not selected

12.1 Statins

1

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

13 Alanine aminotransferase Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

13.1 Fibrates

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

14 Aspartate aminotransferase Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

14.1 Fibrates

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

15 Creatine phosphokinase Show forest plot

1

Mean Difference (IV, Random, 95% CI)

Totals not selected

15.1 Fibrates

1

Mean Difference (IV, Random, 95% CI)

0.0 [0.0, 0.0]

Figuras y tablas -
Comparison 1. Lipid‐lowering agents versus placebo or no treatment