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Funnel plot of comparison: 1 Antibiotic prophylaxis versus no‐prophylaxis, outcome: 1.1 Surgical site infection.
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Figure 1

Funnel plot of comparison: 1 Antibiotic prophylaxis versus no‐prophylaxis, outcome: 1.1 Surgical site infection.

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Funnel plot of comparison: 1 Antibiotic prophylaxis versus no‐prophylaxis, outcome: 1.2 Global infections.
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Figure 2

Funnel plot of comparison: 1 Antibiotic prophylaxis versus no‐prophylaxis, outcome: 1.2 Global infections.

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Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
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Figure 3

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

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Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
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Figure 4

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

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Comparison 1 Antibiotic prophylaxis versus placebo or no‐prophylaxis, Outcome 1 Surgical site infection.
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Analysis 1.1

Comparison 1 Antibiotic prophylaxis versus placebo or no‐prophylaxis, Outcome 1 Surgical site infection.

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Comparison 1 Antibiotic prophylaxis versus placebo or no‐prophylaxis, Outcome 2 Extra‐abdominal infections.
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Analysis 1.2

Comparison 1 Antibiotic prophylaxis versus placebo or no‐prophylaxis, Outcome 2 Extra‐abdominal infections.

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Comparison 1 Antibiotic prophylaxis versus placebo or no‐prophylaxis, Outcome 3 Surgical site infection (Intention‐to‐treat analysis worst‐best case scenario).
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Analysis 1.3

Comparison 1 Antibiotic prophylaxis versus placebo or no‐prophylaxis, Outcome 3 Surgical site infection (Intention‐to‐treat analysis worst‐best case scenario).

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Comparison 1 Antibiotic prophylaxis versus placebo or no‐prophylaxis, Outcome 4 Surgical site infection (Intention‐to‐treat analysis best‐worst case scenario).
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Analysis 1.4

Comparison 1 Antibiotic prophylaxis versus placebo or no‐prophylaxis, Outcome 4 Surgical site infection (Intention‐to‐treat analysis best‐worst case scenario).

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Comparison 1. Antibiotic prophylaxis versus placebo or no‐prophylaxis

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Surgical site infection Show forest plot

11

1664

Odds Ratio (M‐H, Fixed, 95% CI)

0.87 [0.49, 1.54]

1.1 Per protocol analysis (Intention‐to‐treat analysis not performed)

11

1664

Odds Ratio (M‐H, Fixed, 95% CI)

0.87 [0.49, 1.54]

2 Extra‐abdominal infections Show forest plot

7

1188

Odds Ratio (M‐H, Fixed, 95% CI)

0.66 [0.25, 1.74]

3 Surgical site infection (Intention‐to‐treat analysis worst‐best case scenario) Show forest plot

11

1756

Odds Ratio (M‐H, Fixed, 95% CI)

2.80 [1.75, 4.46]

4 Surgical site infection (Intention‐to‐treat analysis best‐worst case scenario) Show forest plot

11

1756

Odds Ratio (M‐H, Fixed, 95% CI)

0.34 [0.21, 0.54]
Figuras y tablas -
Comparison 1. Antibiotic prophylaxis versus placebo or no‐prophylaxis
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