Antibiotics for prolonged moist cough in children

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Figure 1

Children not cured or substantially improved at follow‐up

Analysis 1.1

Comparison 1 Clinical failure, Outcome 1 Children not cured or substantially improved at follow‐up (using 'intention to treat' analysis).

Analysis 1.2

Comparison 1 Clinical failure, Outcome 2 Children not cured or substantially improved at follow‐up (excluding those known to have B.Pertussis).

Analysis 1.3

Comparison 1 Clinical failure, Outcome 3 Children not cured or substantially improved at follow‐up (using available data only).

Analysis 2.1

Comparison 2 Illness progression, Outcome 1 Participants with progression of disease resulting in additional medical therapy required.

Analysis 3.1

Comparison 3 Adverse events (reaction to medications), Outcome 1 Reaction to medications (vomiting, diarrhoea, rash).

Comparison 1. Clinical failure

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Children not cured or substantially improved at follow‐up (using 'intention to treat' analysis) Show forest plot	2	140	Odds Ratio (M‐H, Fixed, 95% CI)	0.13 [0.06, 0.31]

2 Children not cured or substantially improved at follow‐up (excluding those known to have B.Pertussis) Show forest plot	2	128	Odds Ratio (M‐H, Fixed, 95% CI)	0.13 [0.05, 0.30]

3 Children not cured or substantially improved at follow‐up (using available data only) Show forest plot	2	124	Odds Ratio (M‐H, Fixed, 95% CI)	0.12 [0.05, 0.29]

Comparison 1. Clinical failure

Comparison 2. Illness progression

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Participants with progression of disease resulting in additional medical therapy required Show forest plot	2	125	Odds Ratio (M‐H, Fixed, 95% CI)	0.10 [0.03, 0.34]

Comparison 2. Illness progression

Comparison 3. Adverse events (reaction to medications)

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Reaction to medications (vomiting, diarrhoea, rash) Show forest plot	2	128	Odds Ratio (M‐H, Fixed, 95% CI)	1.38 [0.31, 6.08]

Comparison 3. Adverse events (reaction to medications)