NSAID compared with placebo for pain in women with endometriosis

Patient or population: women with endometriosis
Setting: Finland
Intervention: nonsteroidal anti‐inflammatory drugs (NSAIDs)
Comparison: placebo

Pain relief assessed with: overall pain relief score follow‐up: median 2 months

OR 3.27
(0.61 to 17.69)

24
(1 RCT)

⊕⊝⊝⊝
Very low^a,b

Unintended effects from treatment follow‐up: median 2 months

OR 0.46
(0.09 to 2.47)

24
(1 RCT)

⊕⊝⊝⊝
Very low^a,b

Quality of life: not reported

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‐

‐

Effects on daily activities: not reported

‐

‐

‐

Absence from work or school: not reported

‐

‐

‐

Number of women requiring more invasive treatment: not reported

‐

‐

‐

Requirements for additional medication follow‐up: median 2 months

OR 0.12
(0.01 to 1.29)

24
(1 RCT)

⊕⊝⊝⊝
Very low^a,b

Participant satisfaction with treatment: not reported

*The risk in the intervention group (and its 95% confidence interval) is based on assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

CI: confidence interval; OR: odds ratio.

GRADE Working Group grades of evidence.
High quality: We are very confident that the true effect lies close to the estimate of effect.
Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of effect but may be substantially different.
Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of effect.
Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect.