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Forest plot of comparison: 1 Rofecoxib 50 mg v placebo, outcome: 1.5 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Figure 1

Forest plot of comparison: 1 Rofecoxib 50 mg v placebo, outcome: 1.5 Participants with at least 50% pain relief over 4 to 6 hours.

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L'Abbé plot showing heterogeneity between studies in dental pain (yellow) and in other types of surgery (pink). Study size is proportional to size of circle (inset scale).
Figuras y tablas -
Figure 2

L'Abbé plot showing heterogeneity between studies in dental pain (yellow) and in other types of surgery (pink). Study size is proportional to size of circle (inset scale).

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Comparison 1 Rofecoxib 50 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Analysis 1.1

Comparison 1 Rofecoxib 50 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Comparison 1 Rofecoxib 50 mg versus placebo, Outcome 2 Participants using rescue medication at 6 to 8 hours.
Figuras y tablas -
Analysis 1.2

Comparison 1 Rofecoxib 50 mg versus placebo, Outcome 2 Participants using rescue medication at 6 to 8 hours.

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Comparison 1 Rofecoxib 50 mg versus placebo, Outcome 3 Participants using rescue medication at 12 hours.
Figuras y tablas -
Analysis 1.3

Comparison 1 Rofecoxib 50 mg versus placebo, Outcome 3 Participants using rescue medication at 12 hours.

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Comparison 1 Rofecoxib 50 mg versus placebo, Outcome 4 Participants using rescue medication at 24 hours.
Figuras y tablas -
Analysis 1.4

Comparison 1 Rofecoxib 50 mg versus placebo, Outcome 4 Participants using rescue medication at 24 hours.

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Comparison 1 Rofecoxib 50 mg versus placebo, Outcome 5 Any adverse events.
Figuras y tablas -
Analysis 1.5

Comparison 1 Rofecoxib 50 mg versus placebo, Outcome 5 Any adverse events.

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Comparison 2 Rofecoxib 500 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.
Figuras y tablas -
Analysis 2.1

Comparison 2 Rofecoxib 500 mg versus placebo, Outcome 1 Participants with at least 50% pain relief over 4 to 6 hours.

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Table 1. Summary of outcomes: analgesia and use of rescue medication

Analgesia

Rescue medication

Study ID

Treatment

PI or PR

Number with 50% PR

PGE: v good or excellent

Median time to use (hr)

% using

Chang 2001

(1) Rofecoxib 50 mg, n = 182

(2) Paracetamol 600 mg plus codeine 60 mg, n = 180

(3) Placebo, n = 31

TOTPAR 6:

(1) 12.4

(2) 7.0

(3) 3.4

(1) 98/182

(2) 23/180

(3) 2/31

At 6 h:

(1) 87/178

(2) 26/176

(3) 0/29

(1) 9.6

(2) 2.3

(3) 1.6

No data

Chang 2002

(1) Rofecoxib 50 mg, n = 121

(2) Diclofenac sodium 50 mg, n = 121

(3) Placebo, n = 63

TOTPAR 6:

(1) 14.5

(2) 6.9

(3) 4.5

(1) 83/121

(2) 32/121

(3) 8/63

At 8 h:

(1) 79/121

(2) 21/121

(3) 6/63

(1) >24:00

(2) 1.62

(3) 1.62

At 8 h:

(1) 19.8

(2) 66.9

(3) 76.2

Chang 2004

(1) Rofecoxib 50 mg, n = 121

(2) Oxycodone/acetaminophen 10/650 mg, n = 120

(3) Placebo, n = 30

TOTPAR 6:

(1) 12.9

(2) 11.3

(3) 3.1

(1) 73/121

(2) 61/120

(3) 2/30

At 6 h:

(1) 59/120

(2) 56/116

(3) 0/30

(1) >6

(2) 5:05

(3) 1:37

At 6 h:

(1) 33.9

(2) 53.3

(3) 90.0

Chang 2005

(1) Rofecoxib 50 mg, n = 180

(2) Codeine/acetaminophen 60/600 mg, n = 180

(3) Placebo, n = 30

TOTPAR 6:

(1) 15.5

(2) 10.7

(3) 6.7

(1) 134/180

(2) 86/180

(3) 8/30

At 6 h:

(1) 124/180

(2) 68/180

(3) 3/30

(1) >24

(2) 6.5

(3) 3.2

At 24 h:

(1) 43

(2) 86

(3) 73

Chelly 2007

(1) Rofecoxib 50 mg, n = 151

(2) Hydrocodone/acetaminophen 7.5/750 mg, n = 145

(3) Placebo, n = 147

TOTPAR 6:

(1) 9.3

(2) 10.7

(3) 8.4

(1) 60/151

(2) 69/145

(3) 51/147

At 6 h:

(1) 91/151

(2) 99/147

(3) 76/147

(1) 4.4

(2) 6.3

(3) 3.6

At 6 h:

(1) 58.3

(2) 47.9

(3) 67.1

Christensen 2004

(1) Rofecoxib 50 mg, n = 101

(2) Valdecoxib 40 mg, n = 99

(3) Placebo, n = 50

TOTPAR 6:

(1) 14.84

(2) 16.27

(3) 5.20

(1) 71/101

(2) 78/99

(3) 9/50

No usable data

(1) >24:00

(2) >24:00

(3) 2:10

At 24 h:

(1) 8.9

(2) 17.2

(3) 72.0

Daniels 2006 study 1

(1) Rofecoxib 50 mg, n = 200

(2) Valdecoxib 20 mg, n = 201

(3) Placebo, n = 49

TOTPAR 4:

(1) 9.4

(2) 9.0

(3) 1.8

(1) 133/200

(2) 127/201

(3) 2/49

No usable data

(1) >24:00

(2) 23:58

(3) 2:04

At 6 h:

(1) 12.3

(2) 15.8

(3) 82.5

At 12 h:

(1) 31.6

(2) 38.6

(3) 87.7

Daniels 2006 study 2

(1) Rofecoxib 50 mg, n = 51

(2) Valdecoxib 40 mg, n = 50

(3) Placebo, n = 24

TOTPAR 4:

(1) 8.0

(2) 8.7

(3) 2.4

(1) 28/51

(2) 30/50

(3) 2/24

No usable data

(1) >24:00

(2) >24:00

(3) 2:15

At 6 h:

(1) 17.5

(2) 21.1

(3) 84.2

At 12 h:

(1) 35.1

(2) 29.8

(3) 93.0

Desjardins 2004

(1) Rofecoxib 50 mg, n = 85

(2) Diclofenac 100 mg, n = 85

(3) Placebo, n = 82

TOTPAR 6:

(1) 7.28

(2) 4.81

(3) 2.87

(1) 24/85

(2) 13/85

(3) 4/82

no usable data

(1) 4:02

(2) 2:03

(3) 1:41

No data

Desjardins 2007

(1) Rofecoxib 50 mg, n = 118

(2) Oxycodone/acetaminophen 10/650 mg, n = 122

(3) Placebo, n = 30

TOTPAR 6:

(1) 14.6

(2) 12.8

(3) 3.9

(1) 82/118

(2) 72/122

(3) 3/30

No usable data

(1) >24:00

(2) >24:00

(3) 1:50

At 6 h:

(1) 20.3

(2) 37.7

(3) 73.3

Edwards 2004 trial 111 dental

(1) Rofecoxib 50 mg, n = 159

(2) Ibuprofen 400 mg, n = 53

(3) Placebo, n = 52

No data

(1) 109/159

(2) 38/53

(3) 1/45

No data

No data

No data

Edwards 2004 trial 154 dental

(1) Rofecoxib 50 mg, n = 91

(2) Acetaminophen/codeine 325/5 mg, n = 89

(3) Placebo, n = 30

No data

(1) 60/91

(2) 17/89

(3) 4/30

No data

No data

No data

Edwards 2004 trial 27 dental

(1) Rofecoxib 50 mg, n = 38

(2) Naproxen 550 mg, n = 39

(3) Placebo, n = 39

No data

(1) 26/38

(2) 28/39

(3) 6/39

No data

No data

No data

Edwards 2004 trial 51 dental

(1) Rofecoxib 50 mg, n = 72

(2) Naproxen 550 mg, n = 49

(3) Placebo, n = 48

No data

(1) 40/72

(2) 24/49

(3) 3/48

No data

No data

No data

Edwards 2004 trial 71 dental

(1) Rofecoxib 50 mg, n = 50

(2) Ibuprofen 400 mg, n = 52

(3) Placebo, n = 50

No data

(1) 27/50

(2) 19/52

(3) 4/50

No data

No data

No data

Edwards 2004 trial 84 dental

(1) Rofecoxib 50 mg, n = 56

(2) Ibuprofen 400 mg, n = 56

(3) Placebo, n = 56

No data

(1) 30/56

(2) 30/56

(3) 2/56

No data

No data

No data

Edwards 2004 all dental surgery

(1) Rofecoxib 50 mg

(2) Placebo

(1) 15.5

(2) 1.6

Edwards 2004 all other surgery

(1) Rofecoxib 50 mg

(2) Placebo

(1) 5.8

(2) 2.8

Ehrich 1999

(1) Rofecoxib 50 mg, n = 32

(2) Rofecoxib 500 mg, n = 20

(3) Ibuprofen 400 mg, n = 20

(4) Placebo, n = 32

TOTPAR 6:

(1) 15.05

(2) 14.31

(3) 16.25

(4) 2.70

(1) 23/32

(2) 14/20

(3) 16/20

(4) 1/32

No usable data

(1) >6

(2) >6

(3) >6

(4) 1.6

No usable data

Fricke 2002

(1) Rofecoxib 50 mg, n = 82

(2) Valdecoxib 40 mg, n = 80

(3) Placebo, n = 41

TOTPAR 6:

(1) 8.6

(2) No usable data

(3) 3.4

(1) 30/82

(2) No usable data

(3) 3/41

No usable data

No data

At 24 h:

(1) 58.5

(2) 40.0

(3) 85.4

Haglund 2006

(1) Rofecoxib 50 mg, n = 36

(2) Rofecoxib/acetaminophen 50 mg/1 g, n = 34

(3) Acetaminophen 1 g, n = 20

(4) Placebo, n = 17

TOTPAR 6:

(1) 14.5

(2) 16

(3) 11.5

(4) 0.25

(1) 25/36

(2) 26/34

(3) 10/20

(4) 0/17

No usable data

MEAN time to use of rescue medication (h)

(1) 4.5

(2) 3.9

(3) 3.8

(4) 2.1

At 8 h:

(1) 16.7

(2) 8.8

(3) 40.0

(4) 70.6

Jackson 2004

(1) Rofecoxib 50 mg, n = 37

(2) Dexketoprofen trometamol 25 mg, n = 42

(3) Placebo, n = 41

No usable data

No usable data

No usable data

(1) >24:00

(2) 6.6

(3) 2.5

At 24 h:

(1) 40.5

(2) 83.3

(3) 87.8

Kellstein 2004

(1) Rofecoxib 50 mg, n = 102

(2) Lumiracoxib 400 mg, n = 101

(3) Celecoxib 200 mg, n = 101

(4) Placebo, n = 51

TOTPAR 6:

(1) 8.64

(2) 10.68

(3) 6.13

(4) 1.4

(1) 37/102

(2) 48/101

(3) 23/101

(4) 0/51

Rated excellent at 24 h:

(1) 26/102

(2) 32/101

(3) 14/101

(4) 1/51

(1) 3.8

(2) 7.2

(3) 2.0

(4) 1.3

No usable data

Korn 2004

(1) Rofecoxib 50 mg, n = 90

(2) Oxycodone/acetaminophen 5/325 mg, n = 91

(3) Placebo, n = 31

TOTPAR 4:

(1) 7.2

(2) 4.0

(3) 1.2

TOTPAR 6:

(1) 11.7

(2) 5.9

(3) 1.9

(1) 48/90

(2) 13/91

(3) 1/31

At 6 h:

(1) 42/90

(2) 17/91

(3) 0/31

(1) 8.3

(2) 3.3

(3) 1.7

At 24 h:

(1) 72.2

(2) 94.5

(3) 96.8

Malmstrom 1999

(1) Rofecoxib 50 mg, n = 90

(2) Celecoxib 200 mg, n = 91

(3) Ibuprofen 400 mg, n = 46

(4) Placebo, n = 45

TOTPAR 6:

(1) 13.17

(2) 9.55

(3) 12.85

(4) 3.07

(1) 55/90

(2) 38/91

(3) 27/46

(4) 2/45

At 8 h:

(1) 50/90

(2) 26/91

(3) 23/46

(4) 3/45

(1) >24

(2) 5.1

(3) 8.9

(4) 1.5

At 24 h:

(1) 78

(2) 49

(3) 76

(4) 91

Malmstrom 2002

(1) Rofecoxib 50 mg, n = 151

(2) Celecoxib 400 mg, n = 151

(3) Celecoxib 200 mg, n = 90

(4) Ibuprofen 400 mg, n = 45

(5) Placebo, n = 45

TOTPAR 6:

(1) 12.60

(2) 11.00

(3) 8.56

(4) 11.67

(5) 1.05

(1) 88/151

(2) 75/151

(3) 32/90

(4) 24/45

(5) 0/45

No usable data

(1) 15.9

(2) 10.6

(3) 6.8

(4) 10.0

(5) 1.6

At 24 h:

(1) 51.3

(2) 65.6

(3) 68.9

(4) 86.7

(5) 97.8

Michael‐Hill 2006

(1) Rofecoxib 50 mg, n = 80

(2) AZD3582 500 mg, n = 78

(3) AZD3582 750 mg, n = 83

(4) Placebo, n = 41

No usable data

No usable data

No data

(1) 10.6

(2) 3.6

(3) 6.1

(4) 1.5

No usable data

Morrison 1999

(1) Rofecoxib 50 mg, n = 50

(2) Ibuprofen 400 mg, n = 51

(3) Placebo, n = 50

TOTPAR 6:

(1) 10.12

(2) 9.26

(3) 4.15

(1) 23/50

(2) 22/51

(3) 7/50

No usable data

(1) 9.5

(2) 6.1

(3) 2.4

At 24 h:

(1) 84

(2) 56

(3) 92

Reicin 2001

(1) Rofecoxib 50 mg, n = 110

(2) Naproxen sodium 550 mg, n = 55

(3) Placebo, n = 53

TOTPAR 6:

(1) 10.7

(2) 9.8

(3) 5.4

(1) 43/110

(2) 20/55

(3) 7/53

No usable data

No data

No data
Figuras y tablas -
Table 1. Summary of outcomes: analgesia and use of rescue medication
Ir a la tabla de la revisión
Table 2. Summary of outcomes: adverse events and withdrawals

Adverse events

Withdrawals

Study ID

Treatment

Any

Serious

Adverse event

Other/Exclusions

Chang 2001

(1) Rofecoxib 50 mg, n = 182

(2) Paracetamol 600 mg plus codeine 60 mg, n = 180

(3) Placebo, n = 31

At 10 d:

(1) 60/182

(2) 83/180

(3) 10/31

None

(1) None

(2) 1 vomited pill

(3) None

None

Chang 2002

(1) Rofecoxib 50 mg, n = 121

(2) Diclofenac sodium 50 mg, n = 121

(3) Placebo, n = 63

At 24 h:

(1) 53/121

(2) 71/121

(3) 31/63

(1) None

(2) None

(3) 1 asthma flare

(1) None

(2) None

(3) 1 asthma flare

None

Chang 2004

(1) Rofecoxib 50 mg, n = 121

(2) Oxycodone/acetaminophen 10/650 mg, n = 120

(3) Placebo, n = 30

No single dose data

No single dose data

None

None

Chang 2005

(1) Rofecoxib 50 mg, n = 180

(2) Codeine/acetaminophen 60/600 mg, n = 180

(3) Placebo, n = 30

At 24 h:

(1) 40/180

(2) 63/180

(3) 14/30

None

None

1 participant lost to follow‐up

Chelly 2007

(1) Rofecoxib 50 mg, n = 151

(2) Hydrocodone/acetaminophen 7.5/750 mg, n = 145

(3) Placebo, n = 147

At 14 d:

(1) 39/151

(2) 36/145

(3) 29/147

Up to 14 d:

(1) 2/151 both deep vein thrombosis

(2) None

(3) None

None

(1) 1 lost to follow‐up

(2) 2 lost to follow‐up; 1 withdrew consent; 2 protocol deviations; 1 other unspecified

(3) 4 withdrew consent

Christensen 2004

(1) Rofecoxib 50 mg, n = 101

(2) Valdecoxib 40 mg, n = 99

(3) Placebo, n = 50

At 24 h:

39‐44% of participants had ≥ 1

None

None

None

Daniels 2006 study 1

(1) Rofecoxib 50 mg, n = 200

(2) Valdecoxib 20 mg, n = 201

(3) Placebo, n = 49

At 24 h:

(1) 79/200

(2) 74/201

(3) 24/49

None

None

(1) 1 withdrew consent

(2) None

(3) None

Daniels 2006 study 2

(1) Rofecoxib 50 mg, n = 51

(2) Valdecoxib 40 mg, n = 50

(3) Placebo, n = 24

At 24 h:

(1) 18/51

(2) 25/50

(3) 17/24

None

None

(1) 1 withdrew consent

(2) None

(3) None

Desjardins 2004

(1) Rofecoxib 50 mg, n = 85

(2) Diclofenac 100 mg, n = 85

(3) Placebo, n = 82

No single dose data

None

(1) 3

(2) 1

(3) 4

(1) None

(2) 3 due to lack of efficacy

(3) 3 due to lack of efficacy

Desjardins 2007

(1) Rofecoxib 50 mg, n = 118

(2) Oxycodone/acetaminophen 10/650 mg, n = 122

(3) Placebo, n = 30

At 24 h:

(1) 49/118

(2) No single dose data

(3) 21/30

None

(1) None

(2) 1 due to syncope, headache, and vomiting

(3) None

(1) None

(2) 1 protocol deviation

(3) None

Edwards 2004 trial 111 dental

(1) Rofecoxib 50 mg, n = 159

(2) Ibuprofen 400 mg, n = 53

(3) Placebo, n = 52

Time unknown

(1) 52/159

(3) 28/52

None

No data

No data

Edwards 2004 trial 154 dental

(1) Rofecoxib 50 mg, n = 91

(2) Acetaminophen/codeine 325/5 mg, n = 89

(3) Placebo, n = 30

Time unknown

(1) 36/91

(3) 14/30

None

No data

No data

Edwards 2004 trial 27 dental

(1) Rofecoxib 50 mg, n = 38

(2) Naproxen 550 mg, n = 39

(3) Placebo, n = 39

Time unknown

(1) 17/38

(3) 12/39

None

No data

No data

Edwards 2004 trial 51 dental

(1) Rofecoxib 50 mg, n = 72

(2) Naproxen 550 mg, n = 49

(3) Placebo, n = 48

Time unknown

(1) 34/72

(3) 13/48

None

No data

No data

Edwards 2004 trial 71 dental

(1) Rofecoxib 50 mg, n = 50

(2) Ibuprofen 400 mg, n = 52

(3) Placebo, n = 50

Time unknown

(1) 21/50

(3) 25/50

None

No data

No data

Edwards 2004 trial 84 dental

(1) Rofecoxib 50 mg, n = 56

(2) Ibuprofen 400 mg, n = 56

(3) Placebo, n = 56

Time unknown

(1) 19/56

(3) 22/56

None

No data

No data

Ehrich 1999

(1) Rofecoxib 50 mg, n = 32

(2) Rofecoxib 500 mg, n = 20

(3) Ibuprofen 400 mg, n = 20

(4) Placebo, n = 32

No data

None reported

None

(1) 1 requested remedication before 90 min.

(4) 1 requested remedication before 90 min.

Fricke 2002

(1) Rofecoxib 50 mg, n = 82

(2) Valdecoxib 40 mg, n = 80

(3) Placebo, n = 41

At 24 h:

(1) 39/82

(2) 36/80

(3) 21/41

None reported

None

(1) 1 protocol violation

(2) None

(3) None

Haglund 2006

(1) Rofecoxib 50 mg, n = 36

(2) Rofecoxib/acetaminophen 50 mg/1 g, n = 34

(3) Acetaminophen 1 g, n = 20

(4) Placebo, n = 17

No usable data

None

None

1 protocol violation, 4 did not return questionnaire. Treatment groups not provided.

Jackson 2004

(1) Rofecoxib 50 mg, n = 37

(2) Dexketoprofen trometamol 25 mg, n = 42

(3) Placebo, n= 41

At 24 h:

(1) 6/37

(2) 5/42

(3) 4/41

None

None

(1) 1 not dosed due to nausea.

(2) 2 lost to follow‐up.

(3) None

Kellstein 2004

(1) Rofecoxib 50 mg, n = 102

(2) Lumiracoxib 400 mg, n = 101

(3) Celecoxib 200 mg, n = 101

(4) Placebo, n = 51

At 24 h:

(1) 12/102

(2) 21/101

(3) 20/101

(4) 9/51

None

None

None

Korn 2004

(1) Rofecoxib 50 mg, n = 90

(2) Oxycodone/acetaminophen 5/325 mg, n = 91

(3) Placebo, n = 31

At 14 d:

(1) 46/90

(2) 59/91

(3) 15/31

No data

None reported

None

Malmstrom 1999

(1) Rofecoxib 50 mg, n = 90

(2) Celecoxib 200 mg, n = 91

(3) Ibuprofen 400 mg, n = 46

(4) Placebo, n = 45

No data

No data

(1) None

(2) None

(3) None

(4) 1 bleeding

(1) None

(2) None

(3) None

(4) 4 did not return for post‐study visit

Malmstrom 2002

(1) Rofecoxib 50 mg, n = 151

(2) Celecoxib 400 mg, n = 151

(3) Celecoxib 200 mg, n = 90

(4) Ibuprofen 400 mg, n = 45

(5) Placebo, n = 45

At 24 h:

(1) 42/151

(2) 38/151

(3) 22/90

(4) 8/45

(5) 12/45

(1) 1 appendicitis 5 days after dosing

(2) None

(3) 1 pregnancy 6 days after dosing. Spontaneous abortion 45 days later

(4) None

(5) None

None

(1) 1 did not provide any efficacy data

(2) None

(3) None

(4) None

(5) None

Michael‐Hill 2006

(1) Rofecoxib 50 mg, n = 80

(2) AZD3582 500 mg, n = 78

(3) AZD3582 750 mg, n = 83

(4) Placebo, n = 41

At 8 h:

(1) 11/80

(2) 25/78

(3) 21/83

(4) 12/41

None

None

None

Morrison 1999

(1) Rofecoxib 50 mg, n = 50

(2) Ibuprofen 400 mg, n = 51

(3) Placebo, n = 50

At 24 h:

(1) 6/50

(2) 13/51

(3) 17/50

None

None

None

Reicin 2001

(1) Rofecoxib 50 mg, n = 110

(2) Naproxen sodium 550 mg, n = 55

(3) Placebo, n = 53

No single dose data

No single dose data

No single dose data

No single dose data
Figuras y tablas -
Table 2. Summary of outcomes: adverse events and withdrawals
Ir a la tabla de la revisión
Comparison 1. Rofecoxib 50 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

19

3688

Risk Ratio (M‐H, Fixed, 95% CI)

5.10 [4.29, 6.07]

1.1 Dental surgery

16

3060

Risk Ratio (M‐H, Fixed, 95% CI)

7.32 [5.86, 9.16]

1.2 Other surgery

3

628

Risk Ratio (M‐H, Fixed, 95% CI)

1.70 [1.30, 2.21]

2 Participants using rescue medication at 6 to 8 hours Show forest plot

6

1158

Risk Ratio (M‐H, Fixed, 95% CI)

0.43 [0.38, 0.48]

2.1 Dental surgery

5

860

Risk Ratio (M‐H, Fixed, 95% CI)

0.25 [0.21, 0.30]

2.2 Other surgery

1

298

Risk Ratio (M‐H, Fixed, 95% CI)

0.87 [0.73, 1.03]

3 Participants using rescue medication at 12 hours Show forest plot

1

324

Risk Ratio (M‐H, Fixed, 95% CI)

0.37 [0.30, 0.45]

3.1 Dental surgery

1

324

Risk Ratio (M‐H, Fixed, 95% CI)

0.37 [0.30, 0.45]

4 Participants using rescue medication at 24 hours Show forest plot

8

1115

Risk Ratio (M‐H, Fixed, 95% CI)

0.61 [0.57, 0.66]

4.1 Dental surgery

8

1115

Risk Ratio (M‐H, Fixed, 95% CI)

0.61 [0.57, 0.66]

5 Any adverse events Show forest plot

15

3404

Risk Ratio (M‐H, Fixed, 95% CI)

0.94 [0.85, 1.03]

5.1 Dental surgery

13

2939

Risk Ratio (M‐H, Fixed, 95% CI)

0.92 [0.83, 1.02]

5.2 Other surgery

2

465

Risk Ratio (M‐H, Fixed, 95% CI)

1.07 [0.82, 1.38]
Figuras y tablas -
Comparison 1. Rofecoxib 50 mg versus placebo
Ir a la tabla de la revisión
Comparison 2. Rofecoxib 500 mg versus placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Participants with at least 50% pain relief over 4 to 6 hours Show forest plot

1

52

Risk Ratio (M‐H, Fixed, 95% CI)

12.0 [3.06, 47.01]
Figuras y tablas -
Comparison 2. Rofecoxib 500 mg versus placebo
Ir a la tabla de la revisión