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Temas

Comparison 1 TOLCAPONE VERSUS ACTIVE COMPARATOR, Outcome 1 'Off' time reduction (hours).
Figuras y tablas -
Analysis 1.1

Comparison 1 TOLCAPONE VERSUS ACTIVE COMPARATOR, Outcome 1 'Off' time reduction (hours).

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Comparison 1 TOLCAPONE VERSUS ACTIVE COMPARATOR, Outcome 2 'On' time increase (hours).
Figuras y tablas -
Analysis 1.2

Comparison 1 TOLCAPONE VERSUS ACTIVE COMPARATOR, Outcome 2 'On' time increase (hours).

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Study

Tolcapone versus pergolide

Koller 1998

Week 12, 'on' state. Tolcapone mean change 1.9 (SD not calculable), pergolide mean change 1.6 (SD not calculable). Not significant.

Tolcapone versus bromocriptine

TSG 1999

Week 8, 'on' state. Tolcapone mean change ‐0.9 (SD 4.2); bromocriptine mean change ‐0.1 (SD 3.4). Not significant.

Figuras y tablas -
Analysis 1.3

Comparison 1 TOLCAPONE VERSUS ACTIVE COMPARATOR, Outcome 3 UPDRS ADL section (Part II).

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Study

Tolcapone versus pergolide

Koller 1998

Week 12, 'on' state. Tolcapone mean change 3.3 (SD not calculable), pergolide mean change 2.7 (SD not calculable). Not significant.

Tolcapone versus bromocriptine

TSG 1999

Week 8, 'on' state. Tolcapone mean change ‐3.1 (SD 8.5); pergolide mean change ‐3.3 (SD 8.6). Not significant.

Figuras y tablas -
Analysis 1.4

Comparison 1 TOLCAPONE VERSUS ACTIVE COMPARATOR, Outcome 4 UPDRS Motor section (Part III).

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Comparison 1 TOLCAPONE VERSUS ACTIVE COMPARATOR, Outcome 5 Adverse events ‐ Tolcapone versus Dopamine Agonist.
Figuras y tablas -
Analysis 1.5

Comparison 1 TOLCAPONE VERSUS ACTIVE COMPARATOR, Outcome 5 Adverse events ‐ Tolcapone versus Dopamine Agonist.

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Comparison 1 TOLCAPONE VERSUS ACTIVE COMPARATOR, Outcome 6 Adverse event withdrawal rate.
Figuras y tablas -
Analysis 1.6

Comparison 1 TOLCAPONE VERSUS ACTIVE COMPARATOR, Outcome 6 Adverse event withdrawal rate.

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Comparison 1 TOLCAPONE VERSUS ACTIVE COMPARATOR, Outcome 7 All cause withdrawal rate.
Figuras y tablas -
Analysis 1.7

Comparison 1 TOLCAPONE VERSUS ACTIVE COMPARATOR, Outcome 7 All cause withdrawal rate.

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Comparison 1. TOLCAPONE VERSUS ACTIVE COMPARATOR

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 'Off' time reduction (hours) Show forest plot

1

146

Mean Difference (IV, Fixed, 95% CI)

0.60 [‐0.67, 1.87]

1.1 Tolcapone versus bromocriptine

1

146

Mean Difference (IV, Fixed, 95% CI)

0.60 [‐0.67, 1.87]

2 'On' time increase (hours) Show forest plot

1

146

Mean Difference (IV, Fixed, 95% CI)

0.70 [‐0.53, 1.93]

2.1 Tolcapone versus bromocriptine

1

146

Mean Difference (IV, Fixed, 95% CI)

0.70 [‐0.53, 1.93]

3 UPDRS ADL section (Part II) Show forest plot

Other data

No numeric data

3.1 Tolcapone versus pergolide

Other data

No numeric data

3.2 Tolcapone versus bromocriptine

Other data

No numeric data

4 UPDRS Motor section (Part III) Show forest plot

Other data

No numeric data

4.1 Tolcapone versus pergolide

Other data

No numeric data

4.2 Tolcapone versus bromocriptine

Other data

No numeric data

5 Adverse events ‐ Tolcapone versus Dopamine Agonist Show forest plot

2

Peto Odds Ratio (Peto, Fixed, 95% CI)

Subtotals only

5.1 Adverse events ‐ Dyskinesia

2

349

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.63 [1.05, 2.54]

5.2 Adverse events ‐ Nausea

2

349

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.42 [0.26, 0.67]

5.3 Adverse events ‐ Vomiting

2

349

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.02 [0.41, 2.50]

5.4 Adverse events ‐ Diarrhoea

1

203

Peto Odds Ratio (Peto, Fixed, 95% CI)

2.27 [0.88, 5.82]

5.5 Adverse events ‐ Constipation

2

349

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.26 [0.14, 0.51]

5.6 Adverse events ‐ Confusion

1

203

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.40 [0.14, 1.19]

5.7 Adverse events ‐ Hallucinations

1

146

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.21 [0.05, 0.88]

5.8 Adverse events ‐ Orthostatic complaints (e.g. hypotension)

2

349

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.24 [0.11, 0.51]

6 Adverse event withdrawal rate Show forest plot

1

203

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.34 [0.13, 0.84]

6.1 Tolcapone versus Pergolide

1

203

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.34 [0.13, 0.84]

7 All cause withdrawal rate Show forest plot

2

349

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.68 [0.37, 1.27]

7.1 Tolcapone versus pergolide

1

203

Peto Odds Ratio (Peto, Fixed, 95% CI)

0.54 [0.25, 1.18]

7.2 Tolcapone versus bromocriptine

1

146

Peto Odds Ratio (Peto, Fixed, 95% CI)

1.03 [0.37, 2.90]
Figuras y tablas -
Comparison 1. TOLCAPONE VERSUS ACTIVE COMPARATOR
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