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Comparison 1 Diuretic versus placebo or no treatment, Outcome 1 Pre‐eclampsia.
Figuras y tablas -
Analysis 1.1

Comparison 1 Diuretic versus placebo or no treatment, Outcome 1 Pre‐eclampsia.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 2 Hypertension (new or worsening).
Figuras y tablas -
Analysis 1.2

Comparison 1 Diuretic versus placebo or no treatment, Outcome 2 Hypertension (new or worsening).

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 3 Severe pre‐eclampsia.
Figuras y tablas -
Analysis 1.3

Comparison 1 Diuretic versus placebo or no treatment, Outcome 3 Severe pre‐eclampsia.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 4 Eclampsia.
Figuras y tablas -
Analysis 1.4

Comparison 1 Diuretic versus placebo or no treatment, Outcome 4 Eclampsia.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 5 Caesarean section.
Figuras y tablas -
Analysis 1.5

Comparison 1 Diuretic versus placebo or no treatment, Outcome 5 Caesarean section.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 6 Use of antihypertensive drugs.
Figuras y tablas -
Analysis 1.6

Comparison 1 Diuretic versus placebo or no treatment, Outcome 6 Use of antihypertensive drugs.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 7 Maternal side‐effects.
Figuras y tablas -
Analysis 1.7

Comparison 1 Diuretic versus placebo or no treatment, Outcome 7 Maternal side‐effects.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 8 Intervention stopped due to side‐effects.
Figuras y tablas -
Analysis 1.8

Comparison 1 Diuretic versus placebo or no treatment, Outcome 8 Intervention stopped due to side‐effects.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 9 Intervention stopped due to side‐effects (by side‐effect).
Figuras y tablas -
Analysis 1.9

Comparison 1 Diuretic versus placebo or no treatment, Outcome 9 Intervention stopped due to side‐effects (by side‐effect).

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 10 Perinatal death.
Figuras y tablas -
Analysis 1.10

Comparison 1 Diuretic versus placebo or no treatment, Outcome 10 Perinatal death.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 11 Stillbirth.
Figuras y tablas -
Analysis 1.11

Comparison 1 Diuretic versus placebo or no treatment, Outcome 11 Stillbirth.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 12 Neonatal death.
Figuras y tablas -
Analysis 1.12

Comparison 1 Diuretic versus placebo or no treatment, Outcome 12 Neonatal death.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 13 Premature birth.
Figuras y tablas -
Analysis 1.13

Comparison 1 Diuretic versus placebo or no treatment, Outcome 13 Premature birth.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 14 Small‐for‐gestational age.
Figuras y tablas -
Analysis 1.14

Comparison 1 Diuretic versus placebo or no treatment, Outcome 14 Small‐for‐gestational age.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 15 Birthweight.
Figuras y tablas -
Analysis 1.15

Comparison 1 Diuretic versus placebo or no treatment, Outcome 15 Birthweight.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 16 Gestation at birth.
Figuras y tablas -
Analysis 1.16

Comparison 1 Diuretic versus placebo or no treatment, Outcome 16 Gestation at birth.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 17 Postmaturity greater than 42 weeks.
Figuras y tablas -
Analysis 1.17

Comparison 1 Diuretic versus placebo or no treatment, Outcome 17 Postmaturity greater than 42 weeks.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 18 Apgar score at 5 minutes less than 7.
Figuras y tablas -
Analysis 1.18

Comparison 1 Diuretic versus placebo or no treatment, Outcome 18 Apgar score at 5 minutes less than 7.

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Comparison 1 Diuretic versus placebo or no treatment, Outcome 19 Neonatal thrombocytopenia.
Figuras y tablas -
Analysis 1.19

Comparison 1 Diuretic versus placebo or no treatment, Outcome 19 Neonatal thrombocytopenia.

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Comparison 1. Diuretic versus placebo or no treatment

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Pre‐eclampsia Show forest plot

4

1391

Risk Ratio (M‐H, Fixed, 95% CI)

0.68 [0.45, 1.03]

2 Hypertension (new or worsening) Show forest plot

2

1475

Risk Ratio (M‐H, Fixed, 95% CI)

0.85 [0.68, 1.08]

3 Severe pre‐eclampsia Show forest plot

2

1297

Risk Ratio (M‐H, Fixed, 95% CI)

1.56 [0.26, 9.17]

4 Eclampsia Show forest plot

1

1030

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Caesarean section Show forest plot

1

20

Risk Ratio (M‐H, Fixed, 95% CI)

1.0 [0.26, 3.81]

6 Use of antihypertensive drugs Show forest plot

1

20

Risk Ratio (M‐H, Fixed, 95% CI)

2.0 [0.21, 18.69]

7 Maternal side‐effects Show forest plot

1

519

Risk Ratio (M‐H, Fixed, 95% CI)

8.70 [1.19, 63.60]

8 Intervention stopped due to side‐effects Show forest plot

2

1217

Risk Ratio (M‐H, Fixed, 95% CI)

1.85 [0.81, 4.22]

9 Intervention stopped due to side‐effects (by side‐effect) Show forest plot

2

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

9.1 Nausea and vomiting

2

1217

Risk Ratio (M‐H, Fixed, 95% CI)

5.81 [1.04, 32.46]

9.2 Pruritis or rash

1

1139

Risk Ratio (M‐H, Fixed, 95% CI)

0.50 [0.05, 5.53]

9.3 Weakness or dizziness

1

1139

Risk Ratio (M‐H, Fixed, 95% CI)

1.01 [0.25, 4.00]

9.4 Diuresis

1

1139

Risk Ratio (M‐H, Fixed, 95% CI)

2.01 [0.18, 22.11]

10 Perinatal death Show forest plot

5

1836

Risk Ratio (M‐H, Fixed, 95% CI)

0.72 [0.40, 1.27]

11 Stillbirth Show forest plot

5

1836

Risk Ratio (M‐H, Fixed, 95% CI)

0.60 [0.27, 1.34]

12 Neonatal death Show forest plot

4

1816

Risk Ratio (M‐H, Fixed, 95% CI)

0.88 [0.40, 1.97]

13 Premature birth Show forest plot

2

465

Risk Ratio (M‐H, Fixed, 95% CI)

0.67 [0.32, 1.41]

14 Small‐for‐gestational age Show forest plot

1

20

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

15 Birthweight Show forest plot

1

20

Mean Difference (IV, Fixed, 95% CI)

139.0 [‐484.40, 762.40]

16 Gestation at birth Show forest plot

1

20

Mean Difference (IV, Fixed, 95% CI)

0.70 [‐0.71, 2.11]

17 Postmaturity greater than 42 weeks Show forest plot

1

20

Risk Ratio (M‐H, Fixed, 95% CI)

7.0 [0.41, 120.16]

18 Apgar score at 5 minutes less than 7 Show forest plot

1

20

Risk Ratio (M‐H, Fixed, 95% CI)

3.0 [0.14, 65.90]

19 Neonatal thrombocytopenia Show forest plot

1

1030

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 1. Diuretic versus placebo or no treatment
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