Granulocyte‐Colony Stimulating Factor (G‐CSF) as an adjunct to antibiotics in the treatment of pneumonia in adults

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Ir a:

Analysis 1.1

Comparison 1 Mortality, Outcome 1 28 day mortality.

Analysis 2.1

Comparison 2 Adverse events, Outcome 1 Any adverse event (including organ dysfunction).

Analysis 2.2

Comparison 2 Adverse events, Outcome 2 Adult respiratory distress syndrome.

Analysis 2.3

Comparison 2 Adverse events, Outcome 3 Disseminated intravascular coagulation.

Analysis 2.4

Comparison 2 Adverse events, Outcome 4 Acute renal failure.

Analysis 2.5

Comparison 2 Adverse events, Outcome 5 Septic shock.

Comparison 1. Mortality

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 28 day mortality Show forest plot	4	1955	Odds Ratio (M‐H, Fixed, 95% CI)	0.99 [0.77, 1.29]

Comparison 1. Mortality

Comparison 2. Adverse events

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Any adverse event (including organ dysfunction) Show forest plot	4	1955	Odds Ratio (M‐H, Fixed, 95% CI)	0.91 [0.73, 1.14]

2 Adult respiratory distress syndrome Show forest plot	3	1254	Odds Ratio (M‐H, Fixed, 95% CI)	0.91 [0.54, 1.54]

3 Disseminated intravascular coagulation Show forest plot	3	1254	Odds Ratio (M‐H, Fixed, 95% CI)	0.43 [0.15, 1.22]

4 Acute renal failure Show forest plot	3	1254	Odds Ratio (M‐H, Fixed, 95% CI)	0.66 [0.27, 1.63]

5 Septic shock Show forest plot	2	1236	Odds Ratio (M‐H, Fixed, 95% CI)	0.60 [0.34, 1.08]

Comparison 2. Adverse events