1 Positive respiratory culture for P. aeruginosa (300 mg 2x daily) Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1.1 At 1 month

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.2 At 2 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Positive respiratory culture for P. aeruginosa (80 mg 2x daily) Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2.1 At 1 month

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.2 At 2 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.3 At 3 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.4 At 6 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.5 At 12 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Positive respiratory culture for P. aeruginosa (combined available case analysis) Show forest plot

2

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

3.1 At 1 month

2

38

Odds Ratio (M‐H, Fixed, 95% CI)

0.06 [0.01, 0.33]

3.2 At 2 months

2

38

Odds Ratio (M‐H, Fixed, 95% CI)

0.15 [0.03, 0.65]

4 Positive respiratory culture for P. aeruginosa (combined) ‐ best case Show forest plot

2

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

4.1 At 1 month

2

39

Odds Ratio (M‐H, Fixed, 95% CI)

0.06 [0.01, 0.30]

4.2 At 2 months

2

39

Odds Ratio (M‐H, Fixed, 95% CI)

0.14 [0.03, 0.60]

4.3 At 3 months

1

18

Odds Ratio (M‐H, Fixed, 95% CI)

0.14 [0.02, 1.16]

4.4 At 6 months

1

18

Odds Ratio (M‐H, Fixed, 95% CI)

0.04 [0.00, 0.48]

4.5 At 12 months

1

18

Odds Ratio (M‐H, Fixed, 95% CI)

0.01 [0.00, 0.26]

5 Positive respiratory culture for P. aeruginosa (combined) ‐ worst case Show forest plot

2

Odds Ratio (M‐H, Fixed, 95% CI)

Subtotals only

5.1 At 1 month

2

39

Odds Ratio (M‐H, Fixed, 95% CI)

0.08 [0.02, 0.38]

5.2 At 2 months

2

39

Odds Ratio (M‐H, Fixed, 95% CI)

0.18 [0.04, 0.73]

5.3 At 3 months

1

18

Odds Ratio (M‐H, Fixed, 95% CI)

0.36 [0.05, 2.77]

5.4 At 6 months

1

18

Odds Ratio (M‐H, Fixed, 95% CI)

0.16 [0.01, 1.83]

5.5 At 12 months

1

18

Odds Ratio (M‐H, Fixed, 95% CI)

0.36 [0.05, 2.77]

6 Change in weight from baseline Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6.1 At 1 month

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6.2 At 2 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Adverse events Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

7.1 Cough

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Change in modified Shwachmann score from baseline Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

8.1 At 1 month

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

8.2 At 2 months

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

1 Proportion colonised with P. aeruginosa Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1.1 At 3 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.2 At 6 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.3 At 12 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.4 At 24 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1 Positive respiratory culture for P.aeruginosa Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1.1 In first 6 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.2 At 24 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Adverse events Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2.1 Severe cough

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1 Time to next isolation of P. aeruginosa from BAL, sputum or oropharyngeal cultures Show forest plot

1

Hazard Ratio (Fixed, 95% CI)

Totals not selected

2 Number of respiratory exacerbations Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2.1 Until recurrence of P. aeruginosa

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Adverse events (up to 3 months) Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3.1 Cough

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.2 Productive cough

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.3 Haemoptysis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.4 Rhinitis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.5 Sinusitis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.6 Nasopharyngitis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.7 Tonsilitis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.8 Oropharyngeal pain

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.9 Dysphonia

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.10 Headache

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.11 URTI

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.12 Lung disorder

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.13 Bronchitis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.14 P. aeruginosa infection

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.15 Influenza

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.16 Otitis media

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.17 Deafness

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.18 Drug level increased

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.19 Pyrexia

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.20 Vomiting

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.21 Varicella

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Adverse events (over 3 months) Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4.1 Cough

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.2 Productive cough

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.3 Haemoptysis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.4 Rhinitis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.5 Sinusitis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.6 Nasopharyngitis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.7 Tonsilitis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.8 Oropharyngeal pain

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.9 Dysphonia

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.10 Headache

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.11 URTI

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.12 Lung disorder

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.13 Bronchitis

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.14 P. aeruginosa infection

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.15 Influenza

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.16 Otitis media

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.17 Deafness

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.18 Drug level increased

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.19 Pyrexia

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.20 Vomiting

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.21 Varicella

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1 Positive respiratory culture for P. aeruginosa Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

1.1 In first 6 months

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.2 At end of follow up (median 16 months)

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Relative change in % predicted FEV₁ from baseline (to mean 54 days) Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3 Post‐trial microbiology status Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

3.1 Stenotrophomonas maltophilia

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.2 Achromobacter xylosoxidans

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

3.3 Aspergillus species

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Adverse events leading to trial discontinuation Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

4.1 Vomiting

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.2 Photosensitivity

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.3 Wheeze

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.4 Pulmonary exacerbation during early eradication treatment

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.5 Lack of compliance

1

Odds Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

1 Participants with one or more isolates of P. aeruginosa from respiratory tract Show forest plot

1

Odds Ratio (IV, Fixed, 95% CI)

Totals not selected

2 Mean 70‐week change in FEV₁ % predicted Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3 Mean 70‐week change in weight from baseline Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4 Mean 70‐week change in height from baseline Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

5 Time to severe pulmonary exacerbation Show forest plot

1

Hazard Ratio (Fixed, 95% CI)

Totals not selected

6 Participants with one or more severe pulmonary exacerbations Show forest plot

1

Odds Ratio (IV, Fixed, 95% CI)

Totals not selected

7 Time to pulmonary exacerbation (any severity) Show forest plot

1

Hazard Ratio (Fixed, 95% CI)

Totals not selected

8 Participants with one or more pulmonary exacerbations (any severity) Show forest plot

1

Odds Ratio (IV, Fixed, 95% CI)

Totals not selected

9 Participants with new isolates of Stenotrophomonas maltophilia Show forest plot

1

Odds Ratio (IV, Fixed, 95% CI)

Totals not selected

10 Participants with one or more serious adverse event Show forest plot

1

Odds Ratio (IV, Fixed, 95% CI)

Totals not selected

1 Participants with one or more isolates of P. aeruginosa from respiratory tract Show forest plot

1

Odds Ratio (IV, Fixed, 95% CI)

Totals not selected

2 Mean 70‐week change in FEV₁ % predicted Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3 Mean 70‐week change in weight from baseline Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4 Mean 70‐week change in height from baseline Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

5 Time to severe pulmonary exacerbation Show forest plot

1

Hazard Ratio (Fixed, 95% CI)

Totals not selected

6 Participants with one or more severe pulmonary exacerbations Show forest plot

1

Odds Ratio (IV, Fixed, 95% CI)

Totals not selected

7 Time to pulmonary exacerbation (any severity) Show forest plot

1

Hazard Ratio (Fixed, 95% CI)

Totals not selected

8 Participants with one of more pulmonary exacerbation (any severity) Show forest plot

1

Odds Ratio (IV, Fixed, 95% CI)

Totals not selected

9 Participants with new isolates of Stenotrophomonas maltophilia Show forest plot

1

Odds Ratio (IV, Fixed, 95% CI)

Totals not selected

10 Participants with one or more serious adverse event Show forest plot

1

Odds Ratio (IV, Fixed, 95% CI)

Totals not selected