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QUOROM flow diagram
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Figure 1

QUOROM flow diagram

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Number of included studies according to publication year
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Figure 2

Number of included studies according to publication year

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Number of included studies according to ACE inhibitor studied
Figuras y tablas -
Figure 3

Number of included studies according to ACE inhibitor studied

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Log dose‐response curve of benazepril 2 ‐ 80 mg/day 
 (Shaded area represents manufacturer's recommended dose range)
Figuras y tablas -
Figure 4

Log dose‐response curve of benazepril 2 ‐ 80 mg/day
(Shaded area represents manufacturer's recommended dose range)

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Log dose‐response curve of captopril 37.5 ‐ 200 mg/day 
 (Shaded area represents manufacturer's recommended dose range)
Figuras y tablas -
Figure 5

Log dose‐response curve of captopril 37.5 ‐ 200 mg/day
(Shaded area represents manufacturer's recommended dose range)

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Log dose‐response curve of cilazapril 0.5 ‐ 10 mg/day 
 (Shaded area represents manufacturer's recommended dose range)
Figuras y tablas -
Figure 6

Log dose‐response curve of cilazapril 0.5 ‐ 10 mg/day
(Shaded area represents manufacturer's recommended dose range)

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Log dose‐response curve of enalapril 5 ‐ 40 mg/day 
 (Shaded area represents manufacturer's recommended dose range)
Figuras y tablas -
Figure 7

Log dose‐response curve of enalapril 5 ‐ 40 mg/day
(Shaded area represents manufacturer's recommended dose range)

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Lose dose‐response curve of fosinopril 2.5 ‐ 40 mg/day 
 (Shaded area represents manufacturer's recommended dose range)
Figuras y tablas -
Figure 8

Lose dose‐response curve of fosinopril 2.5 ‐ 40 mg/day
(Shaded area represents manufacturer's recommended dose range)

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Log dose‐response curve of imidapril 5 ‐ 40 mg/day 
 (Shaded area represents manufacturer's recommended dose range)
Figuras y tablas -
Figure 9

Log dose‐response curve of imidapril 5 ‐ 40 mg/day
(Shaded area represents manufacturer's recommended dose range)

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Lose dose‐response curve of lisinopril 1.25 ‐ 80 mg/day 
 (Shaded area represents manufacturer's recommended dose range)
Figuras y tablas -
Figure 10

Lose dose‐response curve of lisinopril 1.25 ‐ 80 mg/day
(Shaded area represents manufacturer's recommended dose range)

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Log dose‐response curve of moexipril 7.5 ‐ 30 mg/day 
 (Shaded area represents manufacturer's recommended dose range)
Figuras y tablas -
Figure 11

Log dose‐response curve of moexipril 7.5 ‐ 30 mg/day
(Shaded area represents manufacturer's recommended dose range)

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Log dose‐response curve of perindopril 2 ‐ 16 mg/day 
 (Shaded area represents manufacturer's recommended dose range)
Figuras y tablas -
Figure 12

Log dose‐response curve of perindopril 2 ‐ 16 mg/day
(Shaded area represents manufacturer's recommended dose range)

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Log dose‐response curve of quinapril 10 ‐ 40 mg/day 
 (Shaded area represents manufacturer's recommended dose range)
Figuras y tablas -
Figure 13

Log dose‐response curve of quinapril 10 ‐ 40 mg/day
(Shaded area represents manufacturer's recommended dose range)

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Log dose‐response curve of ramipril 1.25 ‐ 20 mg/day 
 (Shaded area represents manufacturer's recommended dose range)
Figuras y tablas -
Figure 14

Log dose‐response curve of ramipril 1.25 ‐ 20 mg/day
(Shaded area represents manufacturer's recommended dose range)

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Log dose‐response curve of spirapril 3 ‐ 24 mg/day
Figuras y tablas -
Figure 15

Log dose‐response curve of spirapril 3 ‐ 24 mg/day

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Log dose‐response curve of temocapril 1 ‐ 20 mg/day 
 (Shaded area represents manufacturer's recommended dose range)
Figuras y tablas -
Figure 16

Log dose‐response curve of temocapril 1 ‐ 20 mg/day
(Shaded area represents manufacturer's recommended dose range)

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Log dose‐response curve of trandolapril 0.5 ‐ 16 mg/day 
 (Shaded area represents manufacturer's recommended dose range)
Figuras y tablas -
Figure 17

Log dose‐response curve of trandolapril 0.5 ‐ 16 mg/day
(Shaded area represents manufacturer's recommended dose range)

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Blood pressure lowering efficacy of ACE inhibitors according to proportions of Max
Figuras y tablas -
Figure 18

Blood pressure lowering efficacy of ACE inhibitors according to proportions of Max

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Blood pressure lowering efficacy of ACE inhibitors according to proportions of Max
Figuras y tablas -
Figure 19

Blood pressure lowering efficacy of ACE inhibitors according to proportions of Max

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Blood pressure lowering efficacy of ACE inhibitors according to proportions of Max
Figuras y tablas -
Figure 20

Blood pressure lowering efficacy of ACE inhibitors according to proportions of Max

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Blood pressure lowering efficacy of ACE inhibitors according to proportions of Max
Figuras y tablas -
Figure 21

Blood pressure lowering efficacy of ACE inhibitors according to proportions of Max

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Blood pressure lowering efficacy of ACE inhibitors according to proportions of Max
Figuras y tablas -
Figure 22

Blood pressure lowering efficacy of ACE inhibitors according to proportions of Max

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Blood pressure lowering efficacy of ACE inhibitors according to proportions of Max
Figuras y tablas -
Figure 23

Blood pressure lowering efficacy of ACE inhibitors according to proportions of Max

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Blood pressure lowering efficacy of ACE inhibitors according to proportions of Max
Figuras y tablas -
Figure 24

Blood pressure lowering efficacy of ACE inhibitors according to proportions of Max

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Log dose‐response curve of ACE inhibitors according to proportions of Max
Figuras y tablas -
Figure 25

Log dose‐response curve of ACE inhibitors according to proportions of Max

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Near maximal blood pressure lowering efficacy of ACE inhibitors
Figuras y tablas -
Figure 26

Near maximal blood pressure lowering efficacy of ACE inhibitors

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Funnel plot of near maximal change in trough SBP for ACE inhibitors at 1/2 Max and higher doses
Figuras y tablas -
Figure 27

Funnel plot of near maximal change in trough SBP for ACE inhibitors at 1/2 Max and higher doses

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Funnel plot of near maximal change in trough DBP for ACE inhibitors at 1/2 Max and higher doses
Figuras y tablas -
Figure 28

Funnel plot of near maximal change in trough DBP for ACE inhibitors at 1/2 Max and higher doses

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Post‐hoc tertile analysis of the effect of trial size on reported trough BP lowering
Figuras y tablas -
Figure 29

Post‐hoc tertile analysis of the effect of trial size on reported trough BP lowering

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Post‐hoc tertile analysis of the effect of publication year on reported trough BP lowering
Figuras y tablas -
Figure 30

Post‐hoc tertile analysis of the effect of publication year on reported trough BP lowering

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Log dose‐response curve of peak blood pressure lowering efficacy of ACE inhibitors according to proportions of Max
Figuras y tablas -
Figure 31

Log dose‐response curve of peak blood pressure lowering efficacy of ACE inhibitors according to proportions of Max

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Log dose‐response curve assessing the effect of ACE inhibitors on heart rate
Figuras y tablas -
Figure 32

Log dose‐response curve assessing the effect of ACE inhibitors on heart rate

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Log dose‐response curve assessing the effect of ACE inhibitors on withdrawals due to adverse effects
Figuras y tablas -
Figure 33

Log dose‐response curve assessing the effect of ACE inhibitors on withdrawals due to adverse effects

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Comparison 1 Benazepril vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 1.1

Comparison 1 Benazepril vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 1 Benazepril vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 1.2

Comparison 1 Benazepril vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 2 Captopril vs Placebo, Outcome 1 Change in SBP.
Figuras y tablas -
Analysis 2.1

Comparison 2 Captopril vs Placebo, Outcome 1 Change in SBP.

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Comparison 2 Captopril vs Placebo, Outcome 2 Change in DBP.
Figuras y tablas -
Analysis 2.2

Comparison 2 Captopril vs Placebo, Outcome 2 Change in DBP.

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Comparison 3 Cilazapril vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 3.1

Comparison 3 Cilazapril vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 3 Cilazapril vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 3.2

Comparison 3 Cilazapril vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 4 Enalapril vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 4.1

Comparison 4 Enalapril vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 4 Enalapril vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 4.2

Comparison 4 Enalapril vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 5 Fosinopril vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 5.1

Comparison 5 Fosinopril vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 5 Fosinopril vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 5.2

Comparison 5 Fosinopril vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 6 Imidapril vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 6.1

Comparison 6 Imidapril vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 6 Imidapril vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 6.2

Comparison 6 Imidapril vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 7 Lisinopril vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 7.1

Comparison 7 Lisinopril vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 7 Lisinopril vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 7.2

Comparison 7 Lisinopril vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 8 Moexipril vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 8.1

Comparison 8 Moexipril vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 8 Moexipril vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 8.2

Comparison 8 Moexipril vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 9 Perindopril vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 9.1

Comparison 9 Perindopril vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 9 Perindopril vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 9.2

Comparison 9 Perindopril vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 10 Quinapril vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 10.1

Comparison 10 Quinapril vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 10 Quinapril vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 10.2

Comparison 10 Quinapril vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 11 Ramipril vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 11.1

Comparison 11 Ramipril vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 11 Ramipril vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 11.2

Comparison 11 Ramipril vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 12 Spirapril vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 12.1

Comparison 12 Spirapril vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 12 Spirapril vs Placebo, Outcome 2 Change in trough DBP.
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Analysis 12.2

Comparison 12 Spirapril vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 13 Temocapril vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 13.1

Comparison 13 Temocapril vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 13 Temocapril vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 13.2

Comparison 13 Temocapril vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 14 Trandolapril vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 14.1

Comparison 14 Trandolapril vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 14 Trandolapril vs Placebo, Outcome 2 Change in trough DBP.
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Analysis 14.2

Comparison 14 Trandolapril vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 15 1/16 Max Dose vs Placebo, Outcome 1 Change in trough SBP.
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Analysis 15.1

Comparison 15 1/16 Max Dose vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 15 1/16 Max Dose vs Placebo, Outcome 2 Change in trough DBP.
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Analysis 15.2

Comparison 15 1/16 Max Dose vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 16 1/8 Max Dose vs Placebo, Outcome 1 Change in trough SBP.
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Analysis 16.1

Comparison 16 1/8 Max Dose vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 16 1/8 Max Dose vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 16.2

Comparison 16 1/8 Max Dose vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 17 1/4 Max Dose vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 17.1

Comparison 17 1/4 Max Dose vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 17 1/4 Max Dose vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 17.2

Comparison 17 1/4 Max Dose vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 18 1/2 Max Dose vs Placebo, Outcome 1 Change in trough SBP.
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Analysis 18.1

Comparison 18 1/2 Max Dose vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 18 1/2 Max Dose vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 18.2

Comparison 18 1/2 Max Dose vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 19 Max Dose vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 19.1

Comparison 19 Max Dose vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 19 Max Dose vs Placebo, Outcome 2 Change in trough DBP.
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Analysis 19.2

Comparison 19 Max Dose vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 20 2 Max and Higher Doses vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 20.1

Comparison 20 2 Max and Higher Doses vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 20 2 Max and Higher Doses vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 20.2

Comparison 20 2 Max and Higher Doses vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 21 1/2 Max and Higher Doses vs Placebo, Outcome 1 Change in trough SBP.
Figuras y tablas -
Analysis 21.1

Comparison 21 1/2 Max and Higher Doses vs Placebo, Outcome 1 Change in trough SBP.

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Comparison 21 1/2 Max and Higher Doses vs Placebo, Outcome 2 Change in trough DBP.
Figuras y tablas -
Analysis 21.2

Comparison 21 1/2 Max and Higher Doses vs Placebo, Outcome 2 Change in trough DBP.

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Comparison 22 ACE Inhibitors vs Placebo, Outcome 1 Change in peak SBP [1/2 Max and Higher Doses Only].
Figuras y tablas -
Analysis 22.1

Comparison 22 ACE Inhibitors vs Placebo, Outcome 1 Change in peak SBP [1/2 Max and Higher Doses Only].

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Comparison 22 ACE Inhibitors vs Placebo, Outcome 2 Change in peak DBP [1/2 Max and Higher Doses Only].
Figuras y tablas -
Analysis 22.2

Comparison 22 ACE Inhibitors vs Placebo, Outcome 2 Change in peak DBP [1/2 Max and Higher Doses Only].

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Comparison 22 ACE Inhibitors vs Placebo, Outcome 3 Change in peak SBP [All Doses].
Figuras y tablas -
Analysis 22.3

Comparison 22 ACE Inhibitors vs Placebo, Outcome 3 Change in peak SBP [All Doses].

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Comparison 22 ACE Inhibitors vs Placebo, Outcome 4 Change in peak DBP [All Doses].
Figuras y tablas -
Analysis 22.4

Comparison 22 ACE Inhibitors vs Placebo, Outcome 4 Change in peak DBP [All Doses].

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Comparison 22 ACE Inhibitors vs Placebo, Outcome 5 Change in trough heart rate.
Figuras y tablas -
Analysis 22.5

Comparison 22 ACE Inhibitors vs Placebo, Outcome 5 Change in trough heart rate.

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Comparison 22 ACE Inhibitors vs Placebo, Outcome 6 Total withdrawals due to adverse effects.
Figuras y tablas -
Analysis 22.6

Comparison 22 ACE Inhibitors vs Placebo, Outcome 6 Total withdrawals due to adverse effects.

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Table 1. Overview of the 92 included studies investigating ACE inhibitors as monotherapy

ACE inhibitor

Dose range (mg/day)

Number of studies

ACEI patients (n)

Placebo patients (n)

Mean duration (wks)

Mean age (yrs)

Baseline BP (mm Hg)

Baseline PP (mm Hg)

Benazepril

2 ‐ 80

7

591

335

6.0

56.3

159.5/103.5

56.0

Captopril

37.5 ‐ 200

6

660

383

6.5

54.9

155.0/100.1

54.9

Cilazapril

0.5 ‐ 10

14

1054

448

4.9

53.3

153.5/101.0

52.5

Enalapril

5 ‐ 20

19

1477

1331

6.5

54.2

157.5/100.5

57.0

Fosinopril

2.5 ‐ 40

6

481

168

5.0

52.5

152.1/101.2

50.9

Imidapril

5 ‐ 40

1

127

35

4.0

51.9

160.7/101.5

59.2

Lisinopril

1.25 ‐ 80

5

484

357

5.7

55.2

154.5/101.8

52.7

Moexipril

7.5 ‐ 15

4

274

159

10.7

60.5

160.4/101.7

58.7

Perindopril

2 ‐ 16

6

658

396

7.1

55.9

159.4/99.9

59.5

Quinapril

20

3

99

97

4.0

52.6

161.7/105.6

56.1

Ramipril

1.25 ‐ 10

6

548

199

6.6

51.2

156.6/100.9

55.7

Spirapril

3 ‐24

4

586

189

5.6

52.3

164.3/103.5

60.8

Temocapril

20

1

19

11

6.0

57.0

158.0/97.6

60.4

Trandolapril

0.25 ‐ 16

10

1152

636

6.1

53.4

155.4/100.7

54.7

TOTAL

92

8210

4744

6.2

54.4

157.1/101.2

55.9
Figuras y tablas -
Table 1. Overview of the 92 included studies investigating ACE inhibitors as monotherapy
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Table 2. Summary of the blood pressure lowering efficacy of ACE inhibitors

ACE Inhibitor

Lowest effective dose (mg/day)

Lowest dose with near maximal BP lowering (mg/day)

Near maximal trough SBP lowering (mm Hg), 95% CI

Near maximal trough DBP lowering (mm Hg), 95% CI

benazepril

20

20

‐8.70 (‐11.43, ‐5.97)

‐4.92 (‐6.47, ‐3.36)

captopril

37.5

37.5

‐9.68 (‐11.73, ‐7.63)

‐5.43 (‐6.47, ‐4.40)

cilazapril

2.5

2.5

‐5.58 (‐7.84, ‐3.32)

‐3.50 (‐4.40, ‐2.60)

enalapril

5

20

‐8.66 (‐10.48, ‐6.84)

‐4.80 (‐5.81, ‐3.79)

fosinopril

10‐20

20

‐7.62 (‐11.07, ‐4.17)

‐5.00 (‐6.94, ‐3.05)

imidapril

Not estimable

Not estimable

‐9.30 (‐14.83, ‐3.78)

‐5.76 (‐9.44, ‐2.07)

lisinopril

10

10

‐8.00 (‐10.14, ‐5.85)

‐4.76 (‐5.92, ‐3.60)

moexipril

15

Not estimable

‐8.45 (‐11.99, ‐4.91)

‐4.38 (‐6.29, ‐2.46)

perindopril

4

4

‐7.09 (‐9.56, ‐4.61)

‐5.02 (‐6.22, ‐3.82)

quinapril

Not estimable

Not estimable

‐7.05 (‐11.26, ‐2.84)

‐3.35 (‐5.98, ‐0.72)

ramipril

5

5

‐6.29 (‐9.26, ‐3.32)

‐4.14 (‐5.81, ‐2.48)

spirapril

3‐6

6

‐8.54 (‐11.18, ‐5.89)

‐6.08( ‐7.50, ‐4.66)

temocapril

Not estimable

Not estimable

‐10.00 (‐23.87, 3.87)

‐5.00 (‐13.34, 3.34)

trandolapril

1

1

‐7.31 (‐8.85, ‐5.77)

‐4.42 (‐5.24, ‐3.60)
Figuras y tablas -
Table 2. Summary of the blood pressure lowering efficacy of ACE inhibitors
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Table 3. Variability of SBP and DBP at end of treatment

ACE Inhibitor

Placebo

SBP

Weighted mean SD

16.6

16.8

SD of weighted mean SD

3.1

3.0

Weighted mean SBP

146.0

152.9

Weighted mean coefficient of variation (CV)

11.2

11.0

SD of weighted mean CV

2.1

2.0

Number of observations

22

19

DBP

Weighted mean SD

9.0

8.9

SD of weighted mean SD

1.7

1.8

Weighted mean DBP

91.8

96.4

Weighted mean coefficient of variation (CV)

9.8

9.2

SD of weighted mean CV

1.8

1.9

Number of observations

20

18

t‐test

SD of SBP vs SD of DBP

p < 0.0001

p < 0.0001

t‐test

CV SBP vs CV DBP

p = 0.0227

p = 0.0045
Figuras y tablas -
Table 3. Variability of SBP and DBP at end of treatment
Ir a la tabla de la revisión
Table 4. SD of BP at baseline vs endpoint in trials with DBP entry criteria

ACE Inhibitor

Placebo

Weighted mean SD of SBP

At baseline (SD)

14.8 (3.0)

14.9 (2.8)

At endpoint (SD)

16.6 (3.1)

16.8 (3.0)

t‐test

baseline vs endpoint

p = 0.06

p = 0.05

Weighted mean SD of DBP

At baseline (SD)

5.1 (1.5)

5.1 (1.6)

At endpoint (SD)

9.0 (1.7)

8.9 (1.8)

t‐test

baseline vs endpoint

p < 0.0001

p < 0.0001
Figuras y tablas -
Table 4. SD of BP at baseline vs endpoint in trials with DBP entry criteria
Ir a la tabla de la revisión
Table 5. Change in pulse pressure according to proportions of Max

Proportion of recommended maximum dose (Max)

Number of studies

Weighted mean change from baseline in pulse pressure (95% CI)

ACE inhibitors

1/8 Max

18

‐1.2 (‐2.0, ‐0.4)

1/4 Max

40

‐1.8 (‐2.6, ‐0.9)

1/2 Max

50

‐2.5 (‐3.2, ‐1.9)

Max

16

‐3.7 (‐5.5, ‐1.9)

2 Max

6

‐4.1 (‐6.3, ‐1.9)

1/2 Max and above

54

‐2.9 (‐3.5, ‐2.3)

Placebo

74

0.6 (0.1, 1.1)
Figuras y tablas -
Table 5. Change in pulse pressure according to proportions of Max
Ir a la tabla de la revisión
Table 6. Comparison of manufacturers' dosage recommendations and findings of this review

ACE Inhibitor

Lowest effective dose (mg/day)

Manufacturer's recommended starting dose (mg/day)

Lowest dose with near maximal BP lowering (mg/day)

Manufacturer's recommended maximum dose (mg/day)

benazepril

20

10

20

40

captopril

37.5

50

37.5

150

cilazapril

2.5

2.5

2.5

10

enalapril

5

5

20

40

fosinopril

10‐20

10

20

40

imidapril

Not estimable

5

Not estimable

30

lisinopril

10

10

10

80

moexipril

15

7.5

Not estimable

30

perindopril

4

4

4

8

quinapril

Not estimable

10

Not estimable

40

ramipril

5

2.5

5

20

temocapril

Not estimable

1

Not estimable

4

trandolapril

1

1

1

4
Figuras y tablas -
Table 6. Comparison of manufacturers' dosage recommendations and findings of this review
Ir a la tabla de la revisión
Comparison 1. Benazepril vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

7

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 2 mg

1

36

Mean Difference (IV, Fixed, 95% CI)

0.20 [‐11.87, 12.27]

1.2 4 mg

1

71

Mean Difference (IV, Fixed, 95% CI)

‐5.5 [‐12.17, 1.17]

1.3 5 mg

2

60

Mean Difference (IV, Fixed, 95% CI)

‐6.52 [‐16.09, 3.06]

1.4 10 mg

3

284

Mean Difference (IV, Fixed, 95% CI)

‐2.68 [‐5.98, 0.61]

1.5 20 mg

6

422

Mean Difference (IV, Fixed, 95% CI)

‐8.30 [‐11.14, ‐5.46]

1.6 40 mg (Max Dose)

2

74

Mean Difference (IV, Fixed, 95% CI)

‐8.68 [‐14.00, ‐1.35]

1.7 80 mg

1

50

Mean Difference (IV, Fixed, 95% CI)

‐11.40 [‐19.95, ‐2.85]

2 Change in trough DBP Show forest plot

7

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 2 mg

1

36

Mean Difference (IV, Fixed, 95% CI)

1.1 [‐6.54, 8.74]

2.2 4 mg

1

71

Mean Difference (IV, Fixed, 95% CI)

‐4.10 [‐7.95, ‐0.25]

2.3 5 mg

2

60

Mean Difference (IV, Fixed, 95% CI)

‐2.04 [‐8.60, 4.53]

2.4 10 mg

3

283

Mean Difference (IV, Fixed, 95% CI)

‐0.72 [‐2.67, 1.22]

2.5 20 mg

6

422

Mean Difference (IV, Fixed, 95% CI)

‐4.53 [‐6.14, ‐2.93]

2.6 40 mg (Max Dose)

2

74

Mean Difference (IV, Fixed, 95% CI)

‐4.73 [‐9.15, ‐0.31]

2.7 80 mg

1

51

Mean Difference (IV, Fixed, 95% CI)

‐6.80 [‐11.60, 0.00]
Figuras y tablas -
Comparison 1. Benazepril vs Placebo
Ir a la tabla de la revisión
Comparison 2. Captopril vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in SBP Show forest plot

5

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 37.5 mg

1

111

Mean Difference (IV, Fixed, 95% CI)

‐8.6 [‐14.95, ‐2.25]

1.2 50 mg

3

324

Mean Difference (IV, Fixed, 95% CI)

‐8.25 [‐11.34, ‐5.16]

1.3 75 mg

2

124

Mean Difference (IV, Fixed, 95% CI)

‐9.16 [‐15.09, ‐3.23]

1.4 100 mg

1

96

Mean Difference (IV, Fixed, 95% CI)

‐12.0 [‐18.17, ‐5.83]

1.5 150 mg (Max Dose)

1

117

Mean Difference (IV, Fixed, 95% CI)

‐12.0 [‐18.06, ‐5.94]

1.6 200 mg

1

94

Mean Difference (IV, Fixed, 95% CI)

‐12.20 [‐18.32, ‐6.08]

2 Change in DBP Show forest plot

6

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 37.5 mg

1

111

Mean Difference (IV, Fixed, 95% CI)

‐5.40 [‐8.74, ‐2.06]

2.2 50 mg

4

500

Mean Difference (IV, Fixed, 95% CI)

‐4.58 [‐6.02, ‐3.15]

2.3 75 mg

2

124

Mean Difference (IV, Fixed, 95% CI)

‐5.92 [‐9.16, ‐2.68]

2.4 100 mg

1

97

Mean Difference (IV, Fixed, 95% CI)

‐6.4 [‐9.91, ‐2.89]

2.5 150 mg (Max Dose)

1

117

Mean Difference (IV, Fixed, 95% CI)

‐7.3 [‐10.43, ‐4.17]

2.6 200 mg

1

94

Mean Difference (IV, Fixed, 95% CI)

‐6.70 [‐10.23, ‐3.17]
Figuras y tablas -
Comparison 2. Captopril vs Placebo
Ir a la tabla de la revisión
Comparison 3. Cilazapril vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

9

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 2.5 mg

9

361

Mean Difference (IV, Fixed, 95% CI)

‐5.16 [‐8.32, 0.00]

1.2 5 mg

5

277

Mean Difference (IV, Fixed, 95% CI)

‐5.75 [‐9.38, ‐2.12]

1.3 10 mg (Max Dose)

1

67

Mean Difference (IV, Fixed, 95% CI)

‐7.0 [‐14.07, 0.07]

2 Change in trough DBP Show forest plot

14

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 0.5 mg

1

129

Mean Difference (IV, Fixed, 95% CI)

‐0.5 [‐3.45, 2.45]

2.2 1 mg

1

56

Mean Difference (IV, Fixed, 95% CI)

1.1 [‐3.66, 5.86]

2.3 2.5 mg

13

558

Mean Difference (IV, Fixed, 95% CI)

‐3.32 [‐4.70, ‐1.94]

2.4 5 mg

9

569

Mean Difference (IV, Fixed, 95% CI)

‐3.49 [‐4.87, ‐2.11]

2.5 10 mg (Max Dose)

2

190

Mean Difference (IV, Fixed, 95% CI)

‐4.06 [‐6.44, ‐1.67]
Figuras y tablas -
Comparison 3. Cilazapril vs Placebo
Ir a la tabla de la revisión
Comparison 4. Enalapril vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

17

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 5 mg

4

552

Mean Difference (IV, Fixed, 95% CI)

‐5.56 [‐7.95, ‐3.18]

1.2 10 mg

8

1122

Mean Difference (IV, Fixed, 95% CI)

‐5.42 [‐5.00, ‐3.84]

1.3 20 mg

8

911

Mean Difference (IV, Fixed, 95% CI)

‐9.61 [‐11.35, ‐7.86]

2 Change in trough DBP Show forest plot

19

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 5 mg

5

702

Mean Difference (IV, Fixed, 95% CI)

‐2.46 [‐3.67, ‐1.25]

2.2 10 mg

8

1122

Mean Difference (IV, Fixed, 95% CI)

‐3.10 [‐3.99, ‐2.20]

2.3 20 mg

9

984

Mean Difference (IV, Fixed, 95% CI)

‐5.34 [‐6.29, ‐4.38]
Figuras y tablas -
Comparison 4. Enalapril vs Placebo
Ir a la tabla de la revisión
Comparison 5. Fosinopril vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

6

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 2.5 mg

1

38

Mean Difference (IV, Fixed, 95% CI)

‐2.9 [‐13.01, 7.21]

1.2 5 mg

1

94

Mean Difference (IV, Fixed, 95% CI)

‐3.70 [‐10.37, 2.97]

1.3 10 mg

3

151

Mean Difference (IV, Fixed, 95% CI)

‐3.86 [‐9.03, 1.30]

1.4 20 mg

5

208

Mean Difference (IV, Fixed, 95% CI)

‐9.26 [‐13.72, ‐4.79]

1.5 40 mg (Max Dose)

3

158

Mean Difference (IV, Fixed, 95% CI)

‐7.81 [‐12.91, ‐2.72]

2 Change in trough DBP Show forest plot

6

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 2.5 mg

1

39

Mean Difference (IV, Fixed, 95% CI)

‐0.70 [‐6.31, 4.91]

2.2 5 mg

1

93

Mean Difference (IV, Fixed, 95% CI)

‐3.20 [‐7.12, 0.72]

2.3 10 mg

3

151

Mean Difference (IV, Fixed, 95% CI)

‐3.45 [‐6.42, ‐0.47]

2.4 20 mg

5

209

Mean Difference (IV, Fixed, 95% CI)

‐7.79 [‐10.12, ‐5.46]

2.5 40 mg (Max Dose)

3

157

Mean Difference (IV, Fixed, 95% CI)

‐4.73 [‐7.69, ‐1.76]
Figuras y tablas -
Comparison 5. Fosinopril vs Placebo
Ir a la tabla de la revisión
Comparison 6. Imidapril vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 5 mg

1

41

Mean Difference (IV, Fixed, 95% CI)

‐4.90 [‐15.96, 6.16]

1.2 10 mg

1

40

Mean Difference (IV, Fixed, 95% CI)

‐8.90 [‐20.02, 2.22]

1.3 20 mg (Max Dose)

1

40

Mean Difference (IV, Fixed, 95% CI)

‐12.90 [‐24.22, ‐1.58]

1.4 40 mg

1

41

Mean Difference (IV, Fixed, 95% CI)

‐10.60 [‐21.36, 0.16]

2 Change in trough DBP Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 5 mg

1

42

Mean Difference (IV, Fixed, 95% CI)

‐3.2 [‐10.28, 3.88]

2.2 10 mg

1

39

Mean Difference (IV, Fixed, 95% CI)

‐7.40 [‐15.16, 0.36]

2.3 20 mg (Max Dose)

1

40

Mean Difference (IV, Fixed, 95% CI)

‐6.3 [‐13.60, 1.00]

2.4 40 mg

1

41

Mean Difference (IV, Fixed, 95% CI)

‐6.50 [‐13.89, 0.89]
Figuras y tablas -
Comparison 6. Imidapril vs Placebo
Ir a la tabla de la revisión
Comparison 7. Lisinopril vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

5

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 1.25 mg

1

46

Mean Difference (IV, Fixed, 95% CI)

3.2 [‐5.00, 13.40]

1.2 5 mg

1

47

Mean Difference (IV, Fixed, 95% CI)

‐2.0 [‐13.22, 9.22]

1.3 10 mg

4

648

Mean Difference (IV, Fixed, 95% CI)

‐7.75 [‐9.98, ‐5.51]

1.4 20 mg

1

50

Mean Difference (IV, Fixed, 95% CI)

‐7.80 [‐18.67, 3.07]

1.5 80 mg (Max Dose)

1

50

Mean Difference (IV, Fixed, 95% CI)

‐13.8 [‐24.46, ‐3.14]

2 Change in trough DBP Show forest plot

5

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 1.25 mg

1

46

Mean Difference (IV, Fixed, 95% CI)

2.8 [‐2.34, 7.94]

2.2 5 mg

1

47

Mean Difference (IV, Fixed, 95% CI)

0.0 [‐5.32, 5.32]

2.3 10 mg

4

648

Mean Difference (IV, Fixed, 95% CI)

‐4.71 [‐5.92, ‐3.50]

2.4 20 mg

1

51

Mean Difference (IV, Fixed, 95% CI)

‐4.6 [‐10.17, 0.97]

2.5 80 mg (Max Dose)

1

49

Mean Difference (IV, Fixed, 95% CI)

‐6.00 [‐11.72, ‐0.28]
Figuras y tablas -
Comparison 7. Lisinopril vs Placebo
Ir a la tabla de la revisión
Comparison 8. Moexipril vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

4

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 7.5 mg

3

168

Mean Difference (IV, Fixed, 95% CI)

‐1.83 [‐6.71, 3.05]

1.2 15 mg

4

265

Mean Difference (IV, Fixed, 95% CI)

‐8.45 [‐11.99, ‐4.91]

2 Change in trough DBP Show forest plot

4

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 7.5 mg

3

167

Mean Difference (IV, Fixed, 95% CI)

‐2.23 [‐4.63, 0.16]

2.2 15 mg

4

266

Mean Difference (IV, Fixed, 95% CI)

‐4.38 [‐6.29, ‐2.46]
Figuras y tablas -
Comparison 8. Moexipril vs Placebo
Ir a la tabla de la revisión
Comparison 9. Perindopril vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

6

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 2 mg

2

85

Mean Difference (IV, Fixed, 95% CI)

‐3.24 [‐13.20, 6.72]

1.2 4 mg

6

820

Mean Difference (IV, Fixed, 95% CI)

‐6.76 [‐9.41, ‐4.12]

1.3 8 mg (Max Dose)

2

82

Mean Difference (IV, Fixed, 95% CI)

‐9.81 [‐19.32, ‐0.31]

1.4 16 mg

1

67

Mean Difference (IV, Fixed, 95% CI)

‐8.9 [‐19.65, 1.85]

2 Change in trough DBP Show forest plot

6

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 2 mg

2

85

Mean Difference (IV, Fixed, 95% CI)

‐2.10 [‐6.40, 2.20]

2.2 4 mg

6

820

Mean Difference (IV, Fixed, 95% CI)

‐4.91 [‐6.21, ‐3.61]

2.3 8 mg (Max Dose)

2

82

Mean Difference (IV, Fixed, 95% CI)

‐5.81 [‐10.11, ‐1.52]

2.4 16 mg

1

67

Mean Difference (IV, Fixed, 95% CI)

‐5.50 [‐10.09, ‐0.91]
Figuras y tablas -
Comparison 9. Perindopril vs Placebo
Ir a la tabla de la revisión
Comparison 10. Quinapril vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

3

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 20 mg

3

196

Mean Difference (IV, Fixed, 95% CI)

‐5.87 [‐9.75, ‐1.99]

2 Change in trough DBP Show forest plot

3

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 20 mg

3

196

Mean Difference (IV, Fixed, 95% CI)

‐3.26 [‐5.85, ‐0.68]
Figuras y tablas -
Comparison 10. Quinapril vs Placebo
Ir a la tabla de la revisión
Comparison 11. Ramipril vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

6

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 1.25 mg

2

98

Mean Difference (IV, Fixed, 95% CI)

4.06 [‐1.97, 10.08]

1.2 2.5 mg

4

197

Mean Difference (IV, Fixed, 95% CI)

‐4.38 [‐9.71, 0.95]

1.3 5 mg

4

195

Mean Difference (IV, Fixed, 95% CI)

‐7.47 [‐12.76, ‐2.19]

1.4 10 mg

4

257

Mean Difference (IV, Fixed, 95% CI)

‐5.74 [‐9.33, ‐2.16]

2 Change in trough DBP Show forest plot

6

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 1.25 mg

2

97

Mean Difference (IV, Fixed, 95% CI)

1.78 [‐1.83, 5.39]

2.2 2.5 mg

4

195

Mean Difference (IV, Fixed, 95% CI)

‐2.39 [‐5.18, 0.39]

2.3 5 mg

4

197

Mean Difference (IV, Fixed, 95% CI)

‐3.70 [‐6.38, ‐1.02]

2.4 10 mg

4

258

Mean Difference (IV, Fixed, 95% CI)

‐4.42 [‐6.54, ‐2.30]
Figuras y tablas -
Comparison 11. Ramipril vs Placebo
Ir a la tabla de la revisión
Comparison 12. Spirapril vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

3

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 3 mg

2

130

Mean Difference (IV, Fixed, 95% CI)

‐4.09 [‐10.47, 2.29]

1.2 6 mg

3

210

Mean Difference (IV, Fixed, 95% CI)

‐7.66 [‐11.93, ‐3.40]

1.3 12 mg (Max Dose)

2

146

Mean Difference (IV, Fixed, 95% CI)

‐8.46 [‐13.27, ‐3.66]

1.4 24 mg

2

139

Mean Difference (IV, Fixed, 95% CI)

‐9.67 [‐14.39, ‐4.95]

2 Change in trough DBP Show forest plot

4

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 3 mg

2

130

Mean Difference (IV, Fixed, 95% CI)

‐3.91 [‐7.52, ‐0.29]

2.2 6 mg

4

359

Mean Difference (IV, Fixed, 95% CI)

‐6.52 [‐8.42, ‐4.62]

2.3 12 mg (Max Dose)

2

146

Mean Difference (IV, Fixed, 95% CI)

‐6.20 [‐9.20, ‐3.20]

2.4 24 mg

2

140

Mean Difference (IV, Fixed, 95% CI)

‐4.84 [‐7.86, ‐1.83]
Figuras y tablas -
Comparison 12. Spirapril vs Placebo
Ir a la tabla de la revisión
Comparison 13. Temocapril vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 20 mg

1

30

Mean Difference (IV, Fixed, 95% CI)

‐10.0 [‐23.87, 3.87]

2 Change in trough DBP Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 20 mg

1

30

Mean Difference (IV, Fixed, 95% CI)

‐5.0 [‐13.34, 3.34]
Figuras y tablas -
Comparison 13. Temocapril vs Placebo
Ir a la tabla de la revisión
Comparison 14. Trandolapril vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

10

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

1.1 0.25 mg

1

35

Mean Difference (IV, Fixed, 95% CI)

‐2.7 [‐13.26, 7.86]

1.2 0.5 mg

4

185

Mean Difference (IV, Fixed, 95% CI)

‐3.33 [‐6.00, 1.33]

1.3 1 mg

4

294

Mean Difference (IV, Fixed, 95% CI)

‐8.45 [‐11.84, ‐5.06]

1.4 2 mg

7

636

Mean Difference (IV, Fixed, 95% CI)

‐6.21 [‐8.76, ‐3.66]

1.5 4 mg (Max Dose)

3

430

Mean Difference (IV, Fixed, 95% CI)

‐8.15 [‐10.82, ‐5.49]

1.6 8 mg

2

111

Mean Difference (IV, Fixed, 95% CI)

‐5.74 [‐12.52, 1.05]

1.7 12 mg

1

49

Mean Difference (IV, Fixed, 95% CI)

‐5.7 [‐16.60, 5.20]

1.8 16 mg

1

48

Mean Difference (IV, Fixed, 95% CI)

‐7.10 [‐17.36, 3.16]

2 Change in trough DBP Show forest plot

10

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

2.1 0.25 mg

1

35

Mean Difference (IV, Fixed, 95% CI)

0.6 [‐4.46, 5.66]

2.2 0.5 mg

4

184

Mean Difference (IV, Fixed, 95% CI)

‐2.33 [‐4.90, 0.24]

2.3 1 mg

4

294

Mean Difference (IV, Fixed, 95% CI)

‐4.07 [‐5.89, ‐2.25]

2.4 2 mg

7

637

Mean Difference (IV, Fixed, 95% CI)

‐4.24 [‐5.55, ‐2.94]

2.5 4 mg (Max Dose)

3

431

Mean Difference (IV, Fixed, 95% CI)

‐4.62 [‐6.10, ‐3.13]

2.6 8 mg

2

110

Mean Difference (IV, Fixed, 95% CI)

‐4.41 [‐7.82, ‐1.01]

2.7 12 mg

1

49

Mean Difference (IV, Fixed, 95% CI)

‐6.2 [‐11.78, ‐0.62]

2.8 16 mg

1

48

Mean Difference (IV, Fixed, 95% CI)

‐6.2 [‐11.38, ‐1.02]
Figuras y tablas -
Comparison 14. Trandolapril vs Placebo
Ir a la tabla de la revisión
Comparison 15. 1/16 Max Dose vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

4

262

Mean Difference (IV, Fixed, 95% CI)

‐0.16 [‐3.78, 3.46]

1.1 Fosinopril 2.5 mg

1

58

Mean Difference (IV, Fixed, 95% CI)

‐2.9 [‐9.93, 4.13]

1.2 Lisinopril 5 mg

1

76

Mean Difference (IV, Fixed, 95% CI)

‐2.0 [‐9.79, 5.79]

1.3 Ramipril 1.25 mg

2

128

Mean Difference (IV, Fixed, 95% CI)

2.01 [‐3.02, 7.05]

2 Change in trough DBP Show forest plot

4

262

Mean Difference (IV, Fixed, 95% CI)

0.15 [‐1.86, 2.16]

2.1 Fosinopril 2.5 mg

1

58

Mean Difference (IV, Fixed, 95% CI)

‐0.70 [‐4.77, 3.37]

2.2 Lisinopril 5 mg

1

76

Mean Difference (IV, Fixed, 95% CI)

0.0 [‐3.68, 3.68]

2.3 Ramipril 1.25 mg

2

128

Mean Difference (IV, Fixed, 95% CI)

0.70 [‐2.28, 3.67]
Figuras y tablas -
Comparison 15. 1/16 Max Dose vs Placebo
Ir a la tabla de la revisión
Comparison 16. 1/8 Max Dose vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

18

2025

Mean Difference (IV, Fixed, 95% CI)

‐5.70 [‐6.95, ‐4.45]

1.1 Benazepril 5 mg

2

91

Mean Difference (IV, Fixed, 95% CI)

‐6.39 [‐12.32, ‐0.47]

1.2 Enalapril 5 mg

4

607

Mean Difference (IV, Fixed, 95% CI)

‐5.12 [‐7.33, ‐2.92]

1.3 Fosinopril 5 mg

1

151

Mean Difference (IV, Fixed, 95% CI)

‐3.7 [‐8.06, 0.66]

1.4 Lisinopril 10 mg

4

648

Mean Difference (IV, Fixed, 95% CI)

‐7.75 [‐9.98, ‐5.51]

1.5 Ramipril 2.5 mg

4

292

Mean Difference (IV, Fixed, 95% CI)

‐4.52 [‐8.05, ‐0.98]

1.6 Trandolapril 0.5 mg

3

236

Mean Difference (IV, Fixed, 95% CI)

‐4.19 [‐7.91, ‐0.46]

2 Change in trough DBP Show forest plot

19

2176

Mean Difference (IV, Fixed, 95% CI)

‐3.19 [‐3.88, ‐2.51]

2.1 Benazepril 5 mg

2

91

Mean Difference (IV, Fixed, 95% CI)

‐1.92 [‐5.89, 2.05]

2.2 Enalapril 5 mg

5

758

Mean Difference (IV, Fixed, 95% CI)

‐2.37 [‐3.52, ‐1.23]

2.3 Fosinopril 5 mg

1

151

Mean Difference (IV, Fixed, 95% CI)

‐3.20 [‐5.72, ‐0.68]

2.4 Lisinopril 10 mg

4

648

Mean Difference (IV, Fixed, 95% CI)

‐4.71 [‐5.92, ‐3.50]

2.5 Ramipril 2.5 mg

4

292

Mean Difference (IV, Fixed, 95% CI)

‐2.50 [‐4.50, ‐0.51]

2.6 Trandolapril 0.5 mg

3

236

Mean Difference (IV, Fixed, 95% CI)

‐2.46 [‐4.59, ‐0.33]
Figuras y tablas -
Comparison 16. 1/8 Max Dose vs Placebo
Ir a la tabla de la revisión
Comparison 17. 1/4 Max Dose vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

40

3523

Mean Difference (IV, Fixed, 95% CI)

‐5.14 [‐6.05, ‐4.22]

1.1 Benazepril 10 mg

3

314

Mean Difference (IV, Fixed, 95% CI)

‐2.88 [‐5.92, 0.15]

1.2 Cilazapril 2.5 mg

9

462

Mean Difference (IV, Fixed, 95% CI)

‐4.76 [‐7.34, ‐2.18]

1.3 Enalapril 10 mg

8

1138

Mean Difference (IV, Fixed, 95% CI)

‐5.40 [‐6.93, ‐3.87]

1.4 Fosinopril 10 mg

3

239

Mean Difference (IV, Fixed, 95% CI)

‐3.93 [‐7.39, ‐0.46]

1.5 Imidapril 5 mg

1

68

Mean Difference (IV, Fixed, 95% CI)

‐4.90 [‐11.31, 1.51]

1.6 Lisinopril 20 mg

1

80

Mean Difference (IV, Fixed, 95% CI)

‐7.8 [‐14.38, ‐1.22]

1.7 Moexipril 7.5 mg

3

223

Mean Difference (IV, Fixed, 95% CI)

‐1.86 [‐5.86, 2.14]

1.8 Perindopril 2 mg

2

134

Mean Difference (IV, Fixed, 95% CI)

‐3.02 [‐9.36, 3.31]

1.9 Ramipril 5 mg

4

291

Mean Difference (IV, Fixed, 95% CI)

‐7.19 [‐10.71, ‐3.67]

1.10 Spirapril 3 mg

2

184

Mean Difference (IV, Fixed, 95% CI)

‐4.02 [‐8.33, 0.28]

1.11 Trandolapril 1 mg

4

390

Mean Difference (IV, Fixed, 95% CI)

‐7.74 [‐10.34, ‐5.15]

2 Change in trough DBP Show forest plot

43

3758

Mean Difference (IV, Fixed, 95% CI)

‐3.04 [‐3.53, ‐2.54]

2.1 Benazepril 10 mg

3

314

Mean Difference (IV, Fixed, 95% CI)

‐0.89 [‐2.70, 0.93]

2.2 Cilazapril 2.5 mg

12

697

Mean Difference (IV, Fixed, 95% CI)

‐3.15 [‐4.29, 0.00]

2.3 Enalapril 10 mg

8

1138

Mean Difference (IV, Fixed, 95% CI)

‐3.11 [‐2.00, ‐2.23]

2.4 Fosinopril 10 mg

3

239

Mean Difference (IV, Fixed, 95% CI)

‐3.42 [‐5.43, ‐1.42]

2.5 Imidapril 5 mg

1

68

Mean Difference (IV, Fixed, 95% CI)

‐3.2 [‐7.41, 1.01]

2.6 Lisinopril 20 mg

1

80

Mean Difference (IV, Fixed, 95% CI)

‐4.6 [‐8.63, ‐0.57]

2.7 Moexipril 7.5 mg

3

223

Mean Difference (IV, Fixed, 95% CI)

‐2.18 [‐4.11, ‐0.24]

2.8 Perindopril 2 mg

2

134

Mean Difference (IV, Fixed, 95% CI)

‐2.31 [‐5.06, 0.45]

2.9 Ramipril 5 mg

4

291

Mean Difference (IV, Fixed, 95% CI)

‐3.65 [‐5.62, ‐1.67]

2.10 Spirapril 3 mg

2

184

Mean Difference (IV, Fixed, 95% CI)

‐4.20 [‐6.66, ‐1.74]

2.11 Trandolapril 1 mg

4

390

Mean Difference (IV, Fixed, 95% CI)

‐3.52 [‐4.92, ‐2.11]
Figuras y tablas -
Comparison 17. 1/4 Max Dose vs Placebo
Ir a la tabla de la revisión
Comparison 18. 1/2 Max Dose vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

51

4980

Mean Difference (IV, Fixed, 95% CI)

‐7.60 [‐8.40, ‐6.79]

1.1 Benazepril 20 mg

6

504

Mean Difference (IV, Fixed, 95% CI)

‐7.97 [‐10.41, ‐5.52]

1.2 Cilazapril 5 mg

5

379

Mean Difference (IV, Fixed, 95% CI)

‐5.92 [‐8.70, ‐3.14]

1.3 Enalapril 20 mg

8

967

Mean Difference (IV, Fixed, 95% CI)

‐9.54 [‐11.22, ‐7.86]

1.4 Fosinopril 20 mg

5

277

Mean Difference (IV, Fixed, 95% CI)

‐8.99 [‐12.35, ‐5.62]

1.5 Imidapril 10 mg

1

66

Mean Difference (IV, Fixed, 95% CI)

‐8.90 [‐16.26, ‐1.54]

1.6 Lisinopril 40 mg

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.7 Moexipril 15 mg

4

321

Mean Difference (IV, Fixed, 95% CI)

‐8.02 [‐11.16, ‐4.88]

1.8 Perindopril 4 mg

6

868

Mean Difference (IV, Fixed, 95% CI)

‐6.53 [‐9.04, ‐4.02]

1.9 Quinapril 20 mg

2

182

Mean Difference (IV, Fixed, 95% CI)

‐7.05 [‐11.26, ‐2.84]

1.10 Ramipril 10 mg

4

344

Mean Difference (IV, Fixed, 95% CI)

‐6.17 [‐9.07, ‐3.27]

1.11 Spirapril 6 mg

3

303

Mean Difference (IV, Fixed, 95% CI)

‐7.43 [‐10.41, ‐4.46]

1.12 Trandolapril 2 mg

7

769

Mean Difference (IV, Fixed, 95% CI)

‐6.17 [‐8.24, ‐4.10]

2 Change in trough DBP Show forest plot

57

5623

Mean Difference (IV, Fixed, 95% CI)

‐4.67 [‐5.09, ‐4.25]

2.1 Benazepril 20 mg

6

504

Mean Difference (IV, Fixed, 95% CI)

‐4.30 [‐5.70, ‐2.90]

2.2 Cilazapril 5 mg

9

800

Mean Difference (IV, Fixed, 95% CI)

‐3.40 [‐4.45, ‐2.36]

2.3 Enalapril 20 mg

9

1039

Mean Difference (IV, Fixed, 95% CI)

‐5.29 [‐6.22, ‐4.37]

2.4 Fosinopril 20 mg

5

277

Mean Difference (IV, Fixed, 95% CI)

‐6.86 [‐8.70, ‐5.02]

2.5 Imidapril 10 mg

1

66

Mean Difference (IV, Fixed, 95% CI)

‐7.40 [‐12.13, ‐2.67]

2.6 Lisinopril 40 mg

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.7 Moexipril 15 mg

4

321

Mean Difference (IV, Fixed, 95% CI)

‐4.26 [‐5.93, ‐2.60]

2.8 Perindopril 4 mg

6

868

Mean Difference (IV, Fixed, 95% CI)

‐4.81 [‐6.04, ‐3.58]

2.9 Quinapril 20 mg

2

182

Mean Difference (IV, Fixed, 95% CI)

‐3.35 [‐5.98, ‐0.72]

2.10 Ramipril 10 mg

4

344

Mean Difference (IV, Fixed, 95% CI)

‐4.47 [‐6.17, ‐2.76]

2.11 Spirapril 6 mg

4

453

Mean Difference (IV, Fixed, 95% CI)

‐5.92 [‐7.45, ‐4.39]

2.12 Trandolapril 2 mg

7

769

Mean Difference (IV, Fixed, 95% CI)

‐4.24 [‐5.35, ‐3.14]
Figuras y tablas -
Comparison 18. 1/2 Max Dose vs Placebo
Ir a la tabla de la revisión
Comparison 19. Max Dose vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

16

1450

Mean Difference (IV, Fixed, 95% CI)

‐8.48 [‐9.91, ‐7.06]

1.1 Benazepril 40 mg

2

112

Mean Difference (IV, Fixed, 95% CI)

‐8.67 [‐13.73, ‐3.62]

1.2 Cilazapril 10 mg

1

101

Mean Difference (IV, Fixed, 95% CI)

‐7.0 [‐11.99, ‐2.01]

1.3 Enalapril 40 mg

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.4 Fosinopril 40 mg

3

245

Mean Difference (IV, Fixed, 95% CI)

‐7.78 [‐11.20, ‐4.36]

1.5 Imidapril 20 mg

1

66

Mean Difference (IV, Fixed, 95% CI)

‐12.90 [‐20.56, ‐5.24]

1.6 Lisinopril 80 mg

1

79

Mean Difference (IV, Fixed, 95% CI)

‐13.8 [‐20.77, ‐6.83]

1.7 Moexipril 30 mg

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.8 Perindopril 8 mg

2

129

Mean Difference (IV, Fixed, 95% CI)

‐10.09 [‐16.14, ‐4.05]

1.9 Quinapril 40 mg

1

14

Mean Difference (IV, Fixed, 95% CI)

‐6.0 [‐20.16, 8.16]

1.10 Ramipril 20 mg

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

1.11 Spirapril 12 mg

2

226

Mean Difference (IV, Fixed, 95% CI)

‐8.23 [‐11.65, ‐4.82]

1.12 Trandolapril 4 mg

3

478

Mean Difference (IV, Fixed, 95% CI)

‐6.00 [‐10.41, ‐5.59]

2 Change in trough DBP Show forest plot

17

1636

Mean Difference (IV, Fixed, 95% CI)

‐4.95 [‐5.71, ‐4.20]

2.1 Benazepril 40 mg

2

112

Mean Difference (IV, Fixed, 95% CI)

‐4.76 [‐7.84, ‐1.69]

2.2 Cilazapril 10 mg

2

287

Mean Difference (IV, Fixed, 95% CI)

‐4.06 [‐5.74, ‐2.37]

2.3 Enalapril 40 mg

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.4 Fosinopril 40 mg

3

245

Mean Difference (IV, Fixed, 95% CI)

‐4.63 [‐6.61, ‐2.65]

2.5 Imidapril 20 mg

1

66

Mean Difference (IV, Fixed, 95% CI)

‐6.3 [‐10.88, ‐1.72]

2.6 Lisinopril 80 mg

1

79

Mean Difference (IV, Fixed, 95% CI)

‐6.00 [‐9.96, ‐2.04]

2.7 Moexipril 30 mg

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.8 Perindopril 8 mg

2

129

Mean Difference (IV, Fixed, 95% CI)

‐5.94 [‐8.81, ‐3.07]

2.9 Quinapril 40 mg

1

14

Mean Difference (IV, Fixed, 95% CI)

‐9.0 [‐17.78, ‐0.22]

2.10 Ramipril 20 mg

0

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2.11 Spirapril 12 mg

2

226

Mean Difference (IV, Fixed, 95% CI)

‐6.02 [‐8.09, ‐3.96]

2.12 Trandolapril 4 mg

3

478

Mean Difference (IV, Fixed, 95% CI)

‐4.71 [‐6.05, ‐3.37]
Figuras y tablas -
Comparison 19. Max Dose vs Placebo
Ir a la tabla de la revisión
Comparison 20. 2 Max and Higher Doses vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

7

738

Mean Difference (IV, Fixed, 95% CI)

‐8.81 [‐10.92, ‐6.70]

1.1 Benazepril 80 mg

1

77

Mean Difference (IV, Fixed, 95% CI)

‐11.40 [‐17.51, ‐5.29]

1.2 Imidapril 40 mg

1

67

Mean Difference (IV, Fixed, 95% CI)

‐10.60 [‐17.40, ‐3.80]

1.3 Perindopril 16 mg

1

108

Mean Difference (IV, Fixed, 95% CI)

‐8.9 [‐15.36, ‐2.44]

1.4 Spirapril 24 mg

2

220

Mean Difference (IV, Fixed, 95% CI)

‐9.40 [‐12.67, ‐6.12]

1.5 Trandolapril 8, 12, 16 mg

2

266

Mean Difference (IV, Fixed, 95% CI)

‐6.03 [‐10.14, ‐1.93]

2 Change in trough DBP Show forest plot

7

738

Mean Difference (IV, Fixed, 95% CI)

‐5.25 [‐6.45, ‐4.05]

2.1 Benazepril 80 mg

1

77

Mean Difference (IV, Fixed, 95% CI)

‐6.80 [‐10.34, ‐3.26]

2.2 Imidapril 40 mg

1

67

Mean Difference (IV, Fixed, 95% CI)

‐6.5 [‐11.22, ‐1.78]

2.3 Perindopril 16 mg

1

108

Mean Difference (IV, Fixed, 95% CI)

‐5.5 [‐8.48, ‐2.52]

2.4 Spirapril 24 mg

2

220

Mean Difference (IV, Fixed, 95% CI)

‐4.56 [‐6.66, ‐2.47]

2.5 Trandolapril 8, 12, 16 mg

2

266

Mean Difference (IV, Fixed, 95% CI)

‐5.02 [‐7.12, ‐2.93]
Figuras y tablas -
Comparison 20. 2 Max and Higher Doses vs Placebo
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Comparison 21. 1/2 Max and Higher Doses vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in trough SBP Show forest plot

53

6113

Mean Difference (IV, Fixed, 95% CI)

‐7.85 [‐8.60, ‐7.09]

1.1 Benazepril 20, 40, 80 mg

6

598

Mean Difference (IV, Fixed, 95% CI)

‐8.54 [‐10.87, ‐6.21]

1.2 Cilazapril 5, 10 mg

5

429

Mean Difference (IV, Fixed, 95% CI)

‐5.79 [‐8.46, ‐3.12]

1.3 Enalapril 20, (40) mg

8

967

Mean Difference (IV, Fixed, 95% CI)

‐9.54 [‐11.22, ‐7.86]

1.4 Fosinopril 20, 40 mg

4

359

Mean Difference (IV, Fixed, 95% CI)

‐7.44 [‐10.44, ‐4.44]

1.5 Imidapril 10, 20, 40 mg

1

129

Mean Difference (IV, Fixed, 95% CI)

‐10.8 [‐16.60, ‐5.00]

1.6 Lisinopril (40), 80 mg

1

50

Mean Difference (IV, Fixed, 95% CI)

‐13.8 [‐24.46, ‐3.14]

1.7 Moexipril 15, (30) mg

4

321

Mean Difference (IV, Fixed, 95% CI)

‐8.02 [‐11.16, ‐4.88]

1.8 Perindopril 4, 8, 16 mg

6

985

Mean Difference (IV, Fixed, 95% CI)

‐7.12 [‐9.55, ‐4.70]

1.9 Quinapril 20, (40) mg

2

182

Mean Difference (IV, Fixed, 95% CI)

‐7.05 [‐11.26, ‐2.84]

1.10 Ramipril 10, (20) mg

4

257

Mean Difference (IV, Fixed, 95% CI)

‐5.74 [‐9.33, ‐2.16]

1.11 Spirapril 6, 12, 24 mg

3

521

Mean Difference (IV, Fixed, 95% CI)

‐8.31 [‐10.80, ‐5.82]

1.12 Trandolapril 2, 4, 8, 12, 16 mg

9

1315

Mean Difference (IV, Fixed, 95% CI)

‐7.02 [‐8.70, ‐5.34]

2 Change in trough DBP Show forest plot

59

6861

Mean Difference (IV, Fixed, 95% CI)

‐4.73 [‐5.13, ‐4.34]

2.1 Benazepril 20, 40, 80 mg

6

598

Mean Difference (IV, Fixed, 95% CI)

‐4.56 [‐5.91, ‐3.22]

2.2 Cilazapril 5, 10 mg

9

942

Mean Difference (IV, Fixed, 95% CI)

‐3.58 [‐4.57, ‐2.60]

2.3 Enalapril 20, (40) mg

9

1039

Mean Difference (IV, Fixed, 95% CI)

‐5.29 [‐6.22, ‐4.37]

2.4 Fosinopril 20, 40 mg

4

359

Mean Difference (IV, Fixed, 95% CI)

‐5.15 [‐6.85, ‐3.45]

2.5 Imidapril 10, 20, 40 mg

1

129

Mean Difference (IV, Fixed, 95% CI)

‐6.7 [‐10.54, ‐2.86]

2.6 Lisinopril (40), 80 mg

1

79

Mean Difference (IV, Fixed, 95% CI)

‐6.00 [‐9.96, ‐2.04]

2.7 Moexipril 15, (30) mg

4

321

Mean Difference (IV, Fixed, 95% CI)

‐4.26 [‐5.93, ‐2.60]

2.8 Perindopril 4, 8, 16 mg

6

985

Mean Difference (IV, Fixed, 95% CI)

‐5.01 [‐6.18, ‐3.84]

2.9 Quinapril 20, (40) mg

2

182

Mean Difference (IV, Fixed, 95% CI)

‐3.35 [‐5.98, ‐0.72]

2.10 Ramipril 10, (20) mg

4

257

Mean Difference (IV, Fixed, 95% CI)

‐4.42 [‐6.55, ‐2.29]

2.11 Spirapril 6, 12, 24 mg

4

671

Mean Difference (IV, Fixed, 95% CI)

‐5.84 [‐7.19, ‐4.49]

2.12 Trandolapril 2, 4, 8, 12, 16 mg

9

1299

Mean Difference (IV, Fixed, 95% CI)

‐4.65 [‐5.55, ‐3.74]
Figuras y tablas -
Comparison 21. 1/2 Max and Higher Doses vs Placebo
Ir a la tabla de la revisión
Comparison 22. ACE Inhibitors vs Placebo

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Change in peak SBP [1/2 Max and Higher Doses Only] Show forest plot

11

1154

Mean Difference (IV, Fixed, 95% CI)

‐11.53 [‐13.27, ‐9.78]

1.1 1/2 Max Dose

11

783

Mean Difference (IV, Fixed, 95% CI)

‐11.06 [‐13.11, ‐9.02]

1.2 Max Dose

3

143

Mean Difference (IV, Fixed, 95% CI)

‐11.48 [‐17.37, ‐5.60]

1.3 2 Max Dose

3

228

Mean Difference (IV, Fixed, 95% CI)

‐13.36 [‐17.40, ‐9.31]

2 Change in peak DBP [1/2 Max and Higher Doses Only] Show forest plot

15

1485

Mean Difference (IV, Fixed, 95% CI)

‐6.37 [‐7.15, ‐5.58]

2.1 1/2 Max Dose

15

1103

Mean Difference (IV, Fixed, 95% CI)

‐6.02 [‐6.95, ‐5.08]

2.2 Max Dose

4

157

Mean Difference (IV, Fixed, 95% CI)

‐6.49 [‐8.81, ‐4.16]

2.3 2 Max Dose

3

225

Mean Difference (IV, Fixed, 95% CI)

‐7.69 [‐9.56, ‐5.82]

3 Change in peak SBP [All Doses] Show forest plot

11

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

3.1 1/8 Max Dose

1

11

Mean Difference (IV, Fixed, 95% CI)

‐11.3 [‐30.46, 7.86]

3.2 1/4 Max Dose

6

326

Mean Difference (IV, Fixed, 95% CI)

‐6.03 [‐9.93, ‐2.13]

3.3 1/2 Max Dose

11

724

Mean Difference (IV, Fixed, 95% CI)

‐10.97 [‐13.14, ‐8.80]

3.4 Max Dose

3

136

Mean Difference (IV, Fixed, 95% CI)

‐11.43 [‐17.69, ‐5.16]

3.5 2 Max Dose

3

211

Mean Difference (IV, Fixed, 95% CI)

‐13.58 [‐18.03, ‐9.13]

4 Change in peak DBP [All Doses] Show forest plot

15

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

4.1 1/8 Max Dose

3

154

Mean Difference (IV, Fixed, 95% CI)

‐9.51 [‐12.64, ‐6.38]

4.2 1/4 Max Dose

9

451

Mean Difference (IV, Fixed, 95% CI)

‐3.69 [‐5.24, ‐2.15]

4.3 1/2 Max Dose

15

981

Mean Difference (IV, Fixed, 95% CI)

‐5.98 [‐7.02, ‐4.94]

4.4 Max Dose

4

157

Mean Difference (IV, Fixed, 95% CI)

‐6.49 [‐8.81, ‐4.16]

4.5 2 Max Dose

3

212

Mean Difference (IV, Fixed, 95% CI)

‐7.78 [‐9.74, ‐5.83]

5 Change in trough heart rate Show forest plot

16

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

5.1 1/8 Max Dose

1

114

Mean Difference (IV, Fixed, 95% CI)

‐3.0 [‐6.62, 0.62]

5.2 1/4 Max Dose

10

587

Mean Difference (IV, Fixed, 95% CI)

‐0.47 [‐1.76, 0.81]

5.3 1/2 Max Dose

9

917

Mean Difference (IV, Fixed, 95% CI)

‐0.71 [‐1.99, 0.57]

5.4 Max Dose

2

89

Mean Difference (IV, Fixed, 95% CI)

1.31 [‐2.15, 4.76]

6 Total withdrawals due to adverse effects Show forest plot

56

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

6.1 1/16 Max Dose

4

282

Risk Ratio (M‐H, Fixed, 95% CI)

1.01 [0.39, 2.57]

6.2 1/8 Max Dose

9

842

Risk Ratio (M‐H, Fixed, 95% CI)

0.88 [0.42, 1.82]

6.3 1/4 Max Dose

32

3385

Risk Ratio (M‐H, Fixed, 95% CI)

0.65 [0.42, 1.00]

6.4 1/2 Max Dose

38

3568

Risk Ratio (M‐H, Fixed, 95% CI)

0.81 [0.55, 1.19]

6.5 Max Dose

8

840

Risk Ratio (M‐H, Fixed, 95% CI)

1.15 [0.56, 2.35]

6.6 2 Max Dose

5

567

Risk Ratio (M‐H, Fixed, 95% CI)

1.51 [0.68, 3.34]
Figuras y tablas -
Comparison 22. ACE Inhibitors vs Placebo
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