Scolaris Content Display Scolaris Content Display

Cochrane Database of Systematic Reviews

Profilaxis con antibióticos para prevenir la endocarditis bacteriana tras intervenciones dentales

Información

DOI:
https://doi.org/10.1002/14651858.CD003813.pub5Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 10 mayo 2022see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:

  1. Grupo Cochrane de Salud oral

Copyright:
  1. Copyright © 2022 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Cifras del artículo

Altmetric:

Citado por:

Citado 0 veces por enlace Crossref Cited-by

Contraer

Autores

  • Samantha J Rutherford

    Scottish Dental Clinical Effectiveness Programme, NHS Education for Scotland, Dundee, UK

  • Anne-Marie Glenny

    Correspondencia a: Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK

    [email protected]

  • Graham Roberts

    King's College London Dental Institute, London, UK

  • Lee Hooper

    Norwich Medical School, University of East Anglia, Norwich, UK

  • Helen V Worthington

    Cochrane Oral Health, Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK

Contributions of authors

Samantha J Rutherford: revised the Background text for the 2021 update and screened updated search results.
Anne‐Marie Glenny: led the updates to the review, screened updated search results, amended background and discussion to reflect recent literature, added risk of bias tables and summary of findings tables in the 2013 update. 
Lee Hooper: was involved in the design of the first published version of the review, writing of the protocol, searching, duplication of assessment of titles and abstracts, inclusion and exclusion of full text papers, data extraction and quality assessment of included studies, data analysis and interpretation.
Graham Roberts: provided background information for the protocol and review and provided feedback on update.
Helen V Worthington: provided methodological and statistical support and screened updated search results.

Sources of support

Internal sources

  • Central Manchester and Manchester Children's University Hospitals NHS Trust, UK

  • School of Dentistry, The University of Manchester, UK

    Support to Cochrane Oral Health and Anne‐Marie Glenny

  • Eastman Dental Institute, UK

  • Manchester Academic Health Sciences Centre (MAHSC), UK

    Cochrane Oral Health is supported by MAHSC and the NIHR Manchester Biomedical Research Centre

External sources

  • Department of Health Cochrane Review Incentive Scheme 2007, UK

  • Cochrane Oral Health Global Alliance, UK

    The production of Cochrane Oral Health reviews has been supported financially by our Global Alliance since 2011 (oralhealth.cochrane.org/partnerships-alliances). Contributors in recent years have been the American Association of Public Health Dentistry, USA; AS‐Akademie, Germany; the British Association for the Study of Community Dentistry, UK; the British Society of Paediatric Dentistry, UK; the Canadian Dental Hygienists Association, Canada; the Centre for Dental Education and Research at All India Institute of Medical Sciences, India; the National Center for Dental Hygiene Research & Practice, USA; New York University College of Dentistry, USA; and Swiss Society of Endodontology, Switzerland.

  • National Institute for Health Research (NIHR), UK

    This project was supported by the NIHR, via Cochrane Infrastructure funding to Cochrane Oral Health. The views and opinions expressed herein are those of the review authors and do not necessarily reflect those of the Evidence Synthesis Programme, the NIHR, the NHS, or the Department of Health and Social Care.

Declarations of interest

Samantha J Rutherford: no interests to declare. I work for the Scottish Dental Clinical Effectiveness Programme and was involved in producing implementation guidance for the NICE guideline.
Anne‐Marie Glenny: no interests to declare. I am one of two Co‐ordinating Editors of Cochrane Oral Health.
Graham Roberts: no interests to declare.
Lee Hooper: no interests to declare.
Helen V Worthington: no interests to declare. I am an Editor with Cochrane Oral Health and was Co‐ordinating Editor until 2020.

Neither Anne‐Marie Glenny nor Helen V Worthington were involved in the editorial process for this review. 

Acknowledgements

For this update, we thank Laura MacDonald, Anne Littlewood and Jan Clarkson of Cochrane Oral Health and Julia Turner for copy editing. For contributions to previous versions of this review, our gratitude goes to Dr Van der Meer, Dr Imperiale, Luisa Fernandez Mauleffinch, Anne Littlewood, Margaret Burke, Vittoria Lutje, Marco Esposito, Sylvia Bickley, Jan Clarkson, Paul Coulthard, Jayne Harrison, David Rickard, Robin Richardson, Jan van der Meer, Robin Seymour, Jeremy Bagg and the Cochrane Non‐Randomised Methods Group, and the Harms subgroup. In particular, we are grateful to Richard Oliver for initiating the review and for his involvement as an author in the protocol and previous versions of the review. 

Version history

Published

Title

Stage

Authors

Version

2022 May 10

Antibiotic prophylaxis for preventing bacterial endocarditis following dental procedures

Review

Samantha J Rutherford, Anne-Marie Glenny, Graham Roberts, Lee Hooper, Helen V Worthington

https://doi.org/10.1002/14651858.CD003813.pub5

2013 Oct 09

Antibiotics for the prophylaxis of bacterial endocarditis in dentistry

Review

Anne‐Marie Glenny, Richard Oliver, Graham J Roberts, Lee Hooper, Helen V Worthington

https://doi.org/10.1002/14651858.CD003813.pub4

2008 Oct 08

Antibiotics for the prophylaxis of bacterial endocarditis in dentistry

Review

Richard Oliver, Graham J Roberts, Lee Hooper, Helen V Worthington

https://doi.org/10.1002/14651858.CD003813.pub3

2004 Apr 19

Penicillins for the prophylaxis of bacterial endocarditis in dentistry

Review

Richard J Oliver, Graham J Roberts, Lee Hooper

https://doi.org/10.1002/14651858.CD003813.pub2

2002 May 24

Penicillins for the prophylaxis of bacterial endocarditis in dentistry

Protocol

Richard J Oliver, Lee Hooper, GJ Roberts

https://doi.org/10.1002/14651858.CD003813

Differences between protocol and review

We modified the title from Antibiotics for the prophylaxis of bacterial endocarditis in dentistry to Antibiotic prophylaxis for preventing bacterial endocarditis following dental procedures. We updated the Background and added more detail of planned analyses under updated data analysis subheadings.

Keywords

MeSH

Medical Subject Headings (MeSH) Keywords

Medical Subject Headings Check Words

Humans;

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.

Study flow diagram

Figuras y tablas -
Figure 1

Study flow diagram

Ir a la figura de la revisiónAbrir en una pestaña nueva

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Figuras y tablas -
Figure 2

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Ir a la figura de la revisiónAbrir en una pestaña nueva
Summary of findings 1. Summary of findings: antibiotic prophylaxis versus no antibiotic prophylaxis for preventing bacterial endocarditis in dentistry

Antibiotic prophylaxis compared with no antibiotic prophylaxis for the prevention of bacterial endocarditis in dentistry

Population: adults or children at risk of endocarditis

Setting: dental setting

Intervention: antibiotic prophylaxis

Comparison: no antibiotic prophylaxis

Outcome

Results

No of participants
(studies)

Certainty of the evidence
(GRADE)

Comments

Mortality or serious adverse events requiring hospitalisation

No data reported

248

(1 study)

‐

‐

Development of endocarditis (in those with definite indication for prophylaxis)

There was no difference in the number of people (with a definitive indication for prophylaxis) who developed endocarditis between those receiving prophylaxis and those not receiving prophylaxis (OR 1.62; 95% CI 0.57 to 4.57).

248

(1 study)

⊕⊝⊝⊝
Very lowa

‐

Adverse effects of antibiotics

No data reported

248

(1 study)

‐

‐

CI: confidence interval; OR: odds ratio

GRADE Working Group grades of evidence
High certainty: we are very confident that the true effect lies close to that of the estimate of the effect.
Moderate certainty: we are moderately confident in the effect estimate; the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Low certainty: our confidence in the effect estimate is limited; the true effect may be substantially different from the estimate of the effect.
Very low certainty: we have very little confidence in the effect estimate; the true effect is likely to be substantially different from the estimate of effect.

aDowngraded 3 levels for high risk of bias and serious imprecision.

Figuras y tablas -
Summary of findings 1. Summary of findings: antibiotic prophylaxis versus no antibiotic prophylaxis for preventing bacterial endocarditis in dentistry
Ir a la tabla de la revisión