Steroid therapy for meconium aspiration syndrome in newborn infants

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Analysis 1.1

Comparison 1 Steroid vs placebo in the treatment of meconium aspiration syndrome, Outcome 1 Chronic lung disease (oxygen dependency at 28 days).

Analysis 1.2

Comparison 1 Steroid vs placebo in the treatment of meconium aspiration syndrome, Outcome 2 Mortality (before hospital discharge).

Analysis 1.3

Comparison 1 Steroid vs placebo in the treatment of meconium aspiration syndrome, Outcome 3 Duration of mechanical ventilation (days).

Analysis 1.4

Comparison 1 Steroid vs placebo in the treatment of meconium aspiration syndrome, Outcome 4 Duration of oxygen therapy (hours).

Analysis 1.5

Comparison 1 Steroid vs placebo in the treatment of meconium aspiration syndrome, Outcome 5 Pulmonary air leak syndrome.

Analysis 1.6

Comparison 1 Steroid vs placebo in the treatment of meconium aspiration syndrome, Outcome 6 Duration of hospital stay (days).

Comparison 1. Steroid vs placebo in the treatment of meconium aspiration syndrome

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Chronic lung disease (oxygen dependency at 28 days) Show forest plot	1	50	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]

2 Mortality (before hospital discharge) Show forest plot	2	85	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.20, 4.58]

3 Duration of mechanical ventilation (days) Show forest plot	1	50	Mean Difference (IV, Fixed, 95% CI)	‐1.10 [‐2.79, 0.59]

4 Duration of oxygen therapy (hours) Show forest plot	2	85	Mean Difference (IV, Fixed, 95% CI)	30.00 [8.40, 51.61]

5 Pulmonary air leak syndrome Show forest plot	1	35	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.18, 2.26]

6 Duration of hospital stay (days) Show forest plot	1	50	Mean Difference (IV, Fixed, 95% CI)	0.0 [‐3.09, 3.09]

Comparison 1. Steroid vs placebo in the treatment of meconium aspiration syndrome