2020 Feb 03

New citation required but conclusions have not changed

Contact author changed, and contact details updated.

2020 Feb 03

Amended

Arne Ohlsson deceased.

2018 Mar 22

New citation required and conclusions have changed

New citations, conclusions changed. For this update, we identified 6 new published studies. One study compared IV ibuprofen to placebo (Ding 2014); one study compared IV ibuprofen to IV indomethacin (Lin 2017); one study compared high versus standard dose of ibuprofen (Pourarian 2015); one study compared rectal versus oral ibuprofen (Demir 2017); one study compared IV ibuprofen to oral ibuprofen (Akar 2017) and one study compared IV ibuprofen to IV indomethacin( El‐Mashad 2017)

2018 Feb 11

New search has been performed

Thirty‐nine studies reporting on 2843 infants are included in this review.

Currently there are at least 11 ongoing studies relevant to this review.

2014 Aug 19

New search has been performed

This updates the review "Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants" (Ohlsson 2013).

2014 Aug 19

New citation required but conclusions have not changed

For this update we identified 6 new studies and one follow‐up study from a previously reported trial. One study compared ibuprofen to placebo (Bagnoli 2013); one study compared continuous infusion of ibuprofen vs. bolus administration (Lago 2014); one study compared oral vs. iv administration of ibuprofen (Pistulli 2014); one study compared a high dose of ibuprofen vs. a standard dose of ibuprofen (Fesharaki 2012); one study compared standard vs. echocardiographically guided ibuprofen treatment (Bravo 2014); and one study compared oral ibuprofen with oral indomethacin for patent ductus arteriosus closure in preterm infants (Yadav 2014). One study reported on long‐term follow‐up in a limited cohort of an earlier published study (Gokmen 2011);

Thirty‐three studies enrolling 2190 infants are included in this review.

Currently there are at least four ongoing trials (Gournay 2012; Su 2010; Sung 2014; Yeh 2012).

2012 Nov 16

New search has been performed

This updates the review "Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants" (Ohlsson 2010).

For this update six additional studies were included; one study compared oral ibuprofen with placebo (Lin 2012); three studies compared oral ibuprofen with iv ibuprofen (Cherif 2008; Erdeve 2012; Gokmen 2011, one study compared iv high dose of ibuprofen versus standard dose of ibuprofen (Dani 2012) and one study compared early versus expectant administration of iv ibuprofen (Sosenko 2012). Two studies are awaiting classification.

2012 Nov 16

New citation required and conclusions have changed

The results, as before, show that ibuprofen is as effective as indomethacin in closing a patent ductus arteriosus (PDA). There is no statistically significant increase in the risk of chronic lung disease with ibuprofen.

The incidence of necrotising enterocolitis is lowered by ibuprofen compared to indomethacin.

Kidney function is less affected by ibuprofen than indomethacin and less by oral compared to intravenous (iv) ibuprofen.

Oral ibuprofen may be more effective in closing a PDA than iv ibuprofen and reduces the risk of necrotising enterocolitis.

Ibuprofen is now recommended over indomethacin to close a PDA.

Additional studies are warranted to assess the effectiveness of high‐dose ibuprofen versus a standard dose regimen and early versus expectant administration of ibuprofen.

Long‐term follow‐up studies are still warranted.

2010 Feb 28

New citation required and conclusions have changed

Conclusions changed

2010 Feb 28

New search has been performed

This updates the review "Ibuprofen for the treatment of patent ductus arteriosus in preterm and/or low birth weight infants" (Ohlsson 2007).

This review was updated in February, 2010. One study comparing ibuprofen to placebo was identified and 5 new trials comparing ibuprofen to indomethacin were identified.

The results, as before, show that ibuprofen is as effective as indomethacin in closing a PDA. There is now clearly no statistically significant increase in the risk of chronic lung disease with ibuprofen. A new important finding is that ibuprofen reduces the risk of necrotizing enterocolitis.

Ibuprofen is now recommended over indomethacin to close a PDA.

Long‐term follow‐up studies are still warranted.

2008 Jun 26

Amended

Converted to new review format.

2017 May 10

Amended

Converted to new review format.

2017 May 10

Amended

Converted to new review format.