1 Mortality Show forest plot

1

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

2 Number of pain crises

0

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

3 Number of other serious sickle‐related complications Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3.1 Overall

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Red cell dehydration

0

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4.1 Mean cell volume

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

4.2 Mean cell haemoglobin concentration

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Full blood count (1)

0

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

5.1 Haemoglobin (g/dl)

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

5.2 HbF (%)

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

6 Full blood count (2)

0

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

6.1 White blood cell count (x10e9/l)

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Quality of life measures Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

7.1 Hospital stay per crisis (days)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

7.2 Loss of work days/crisis

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

7.3 Number of hospitalisations per year

0

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Other sickle related events

0

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected

9 Adverse drug reactions

0

Odds Ratio (M‐H, Fixed, 95% CI)

Totals not selected