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Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 1 Mortality.
Figuras y tablas -
Analysis 1.1

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 1 Mortality.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 2 Major neurodevelopmental disability in survivors assessed.
Figuras y tablas -
Analysis 1.2

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 2 Major neurodevelopmental disability in survivors assessed.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 3 Death or major neurodevelopmental disability in survivors assessed.
Figuras y tablas -
Analysis 1.3

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 3 Death or major neurodevelopmental disability in survivors assessed.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 4 Cerebral palsy in survivors assessed.
Figuras y tablas -
Analysis 1.4

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 4 Cerebral palsy in survivors assessed.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 5 Developmental delay (more than 2 SD below mean) in survivors assessed.
Figuras y tablas -
Analysis 1.5

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 5 Developmental delay (more than 2 SD below mean) in survivors assessed.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 6 Blindness in survivors assessed.
Figuras y tablas -
Analysis 1.6

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 6 Blindness in survivors assessed.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 7 Deafness in survivors assessed.
Figuras y tablas -
Analysis 1.7

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 7 Deafness in survivors assessed.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 8 Sinus bradycardia.
Figuras y tablas -
Analysis 1.8

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 8 Sinus bradycardia.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 9 Hypotension requiring inotropic support.
Figuras y tablas -
Analysis 1.9

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 9 Hypotension requiring inotropic support.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 10 Developmental delay (BSID MDI) in survivors assessed.
Figuras y tablas -
Analysis 1.10

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 10 Developmental delay (BSID MDI) in survivors assessed.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 11 Arrhythmia requiring medical treatment.
Figuras y tablas -
Analysis 1.11

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 11 Arrhythmia requiring medical treatment.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 12 Anaemia requiring transfusion.
Figuras y tablas -
Analysis 1.12

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 12 Anaemia requiring transfusion.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 13 Leukopaenia.
Figuras y tablas -
Analysis 1.13

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 13 Leukopaenia.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 14 Thrombocytopaenia.
Figuras y tablas -
Analysis 1.14

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 14 Thrombocytopaenia.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 15 Coagulopathy resulting in major thrombosis or haemorrhage.
Figuras y tablas -
Analysis 1.15

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 15 Coagulopathy resulting in major thrombosis or haemorrhage.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 16 Hypoglycaemia.
Figuras y tablas -
Analysis 1.16

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 16 Hypoglycaemia.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 17 Hypokalaemia.
Figuras y tablas -
Analysis 1.17

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 17 Hypokalaemia.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 18 Oliguria.
Figuras y tablas -
Analysis 1.18

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 18 Oliguria.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 19 Sepsis.
Figuras y tablas -
Analysis 1.19

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 19 Sepsis.

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 20 Moderate or severe enecphalopathy (Sarnat).
Figuras y tablas -
Analysis 1.20

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 20 Moderate or severe enecphalopathy (Sarnat).

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 21 Seizures.
Figuras y tablas -
Analysis 1.21

Comparison 1 Therapeutic hypothermia versus normothermia, Outcome 21 Seizures.

Comparison 1. Therapeutic hypothermia versus normothermia

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Mortality Show forest plot

2

50

Risk Ratio (M‐H, Fixed, 95% CI)

0.73 [0.26, 2.09]

2 Major neurodevelopmental disability in survivors assessed Show forest plot

1

23

Risk Ratio (M‐H, Fixed, 95% CI)

3.08 [0.40, 23.44]

3 Death or major neurodevelopmental disability in survivors assessed Show forest plot

1

31

Risk Ratio (M‐H, Fixed, 95% CI)

1.26 [0.46, 3.44]

4 Cerebral palsy in survivors assessed Show forest plot

1

23

Risk Ratio (M‐H, Fixed, 95% CI)

2.31 [0.28, 18.99]

5 Developmental delay (more than 2 SD below mean) in survivors assessed Show forest plot

1

22

Risk Ratio (M‐H, Fixed, 95% CI)

5.0 [0.29, 86.43]

6 Blindness in survivors assessed Show forest plot

1

22

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

7 Deafness in survivors assessed Show forest plot

1

22

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

8 Sinus bradycardia Show forest plot

1

31

Risk Ratio (M‐H, Fixed, 95% CI)

2.21 [0.10, 50.32]

9 Hypotension requiring inotropic support Show forest plot

2

50

Risk Ratio (M‐H, Fixed, 95% CI)

2.41 [0.82, 7.08]

10 Developmental delay (BSID MDI) in survivors assessed Show forest plot

1

21

Mean Difference (IV, Fixed, 95% CI)

‐10.30 [‐23.91, 3.31]

11 Arrhythmia requiring medical treatment Show forest plot

1

31

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

12 Anaemia requiring transfusion Show forest plot

1

31

Risk Ratio (M‐H, Fixed, 95% CI)

3.68 [0.19, 70.87]

13 Leukopaenia Show forest plot

1

31

Risk Ratio (M‐H, Fixed, 95% CI)

2.21 [0.10, 50.32]

14 Thrombocytopaenia Show forest plot

1

31

Risk Ratio (M‐H, Fixed, 95% CI)

2.53 [0.62, 10.25]

15 Coagulopathy resulting in major thrombosis or haemorrhage Show forest plot

1

31

Risk Ratio (M‐H, Fixed, 95% CI)

3.68 [0.19, 70.87]

16 Hypoglycaemia Show forest plot

1

31

Risk Ratio (M‐H, Fixed, 95% CI)

1.81 [0.41, 7.90]

17 Hypokalaemia Show forest plot

1

31

Risk Ratio (M‐H, Fixed, 95% CI)

1.16 [0.49, 2.73]

18 Oliguria Show forest plot

2

50

Risk Ratio (M‐H, Fixed, 95% CI)

0.92 [0.72, 1.17]

19 Sepsis Show forest plot

1

31

Risk Ratio (M‐H, Fixed, 95% CI)

0.72 [0.05, 10.52]

20 Moderate or severe enecphalopathy (Sarnat) Show forest plot

1

31

Risk Ratio (M‐H, Fixed, 95% CI)

1.17 [0.70, 1.97]

21 Seizures Show forest plot

2

50

Risk Ratio (M‐H, Fixed, 95% CI)

1.37 [0.67, 2.80]

Figuras y tablas -
Comparison 1. Therapeutic hypothermia versus normothermia