Heparin for prolonging peripheral intravenous catheter use in neonates

Scolaris Content Display Scolaris Content Display

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Analysis 1.1

Comparison 1 Heparin versus control (normal saline or no treatment), Outcome 1 Duration of catheter patency (hours), first catheter.

Analysis 1.2

Comparison 1 Heparin versus control (normal saline or no treatment), Outcome 2 Catheter occlusion, first catheter.

Analysis 1.3

Comparison 1 Heparin versus control (normal saline or no treatment), Outcome 3 Phlebitis or thrombophlebitis, first catheter.

Analysis 1.4

Comparison 1 Heparin versus control (normal saline or no treatment), Outcome 4 Intracranial hemorrhage.

Analysis 1.5

Comparison 1 Heparin versus control (normal saline or no treatment), Outcome 5 Heparin induced thrombocytopenia.

Comparison 1. Heparin versus control (normal saline or no treatment)

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Duration of catheter patency (hours), first catheter Show forest plot	7		Mean Difference (IV, Fixed, 95% CI)	Totals not selected

2 Catheter occlusion, first catheter Show forest plot	4	475	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.85, 1.16]

3 Phlebitis or thrombophlebitis, first catheter Show forest plot	4	432	Risk Ratio (M‐H, Fixed, 95% CI)	0.74 [0.50, 1.10]

4 Intracranial hemorrhage Show forest plot	2	322	Risk Ratio (M‐H, Fixed, 95% CI)	0.37 [0.12, 1.17]

5 Heparin induced thrombocytopenia Show forest plot	2	300	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]

Comparison 1. Heparin versus control (normal saline or no treatment)