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Cepillos dentales manuales versus eléctricos para la salud oral

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Antecedentes

La eliminación de la placa dental puede desempeñar un papel clave en el mantenimiento de la salud oral. Hay evidencia contradictoria sobre los méritos relativos del cepillado manual y del eléctrico para lograr esto. Ésta es una actualización de una revisión Cochrane publicada por primera vez en 2003 y actualizada previamente en 2005.

Objetivos

Comparar los cepillos de dientes manuales y eléctricos de uso cotidiano, de cualquier edad, en relación con la eliminación de la placa, la salud de las encías, las manchas y el cálculo, la fiabilidad, los efectos adversos y el coste.

Métodos de búsqueda

Se hicieron búsquedas en las siguientes bases de datos electrónicas: el Registro de Ensayos del Grupo Cochrane de Salud Oral (Cochrane Oral Health Group's Trials Register) (hasta el 23 de enero de 2014), el Registro Cochrane Central de Ensayos Controlados (Cochrane Central Register of Controlled Trials) (CENTRAL) (The Cochrane Library 2014, número 1), MEDLINE vía OVID (1946 hasta el 23 de enero de 2014), EMBASE vía OVID (1980 hasta el 23 de enero de 2014) y CINAHL vía EBSCO (1980 hasta el 23 de enero de 2014). Se hicieron búsquedas en el registro de ensayos de los Institutos Nacionales de Salud de EE.UU. y en la Plataforma de Registro de Ensayos Clínicos de la OMS los ensayos en curso. No se impusieron restricciones de idioma ni de fecha de publicación en la búsqueda en las bases de datos electrónicas.

Criterios de selección

Ensayos controlados aleatorizados de al menos cuatro semanas de cepillado dental motorizado no supervisado versus cepillado dental manual para la salud oral en niños y adultos.

Obtención y análisis de los datos

Se utilizaron los procedimientos metodológicos estándar previstos por la Colaboración Cochrane. Se utilizaron modelos de efectos aleatorios siempre que se incluyeran cuatro o más estudios en el metanálisis, de lo contrario se utilizaron modelos de efectos fijos. Los datos se clasificaron como de corto plazo (de uno a tres meses) y de largo plazo (más de tres meses).

Resultados principales

Cincuenta y seis ensayos cumplieron los criterios de inclusión; 51 ensayos con 4624 participantes proporcionaron datos para el metanálisis. Cinco ensayos tuvieron un bajo riesgo de sesgo, cinco un riesgo alto y 46 un riesgo de sesgo poco claro.

Hay evidencia de calidad moderada de que los cepillos dentales eléctricos proporcionan un beneficio estadísticamente significativo en comparación con los cepillos dentales manuales con respecto a la reducción de la placa tanto a corto plazo (diferencia de medias estandarizada (DME) ‐0,50 (intervalo de confianza (IC) del 95%: ‐0,70 a ‐0,31); 40 ensayos, n = 2871) como a largo plazo (DME ‐0,47 (IC del 95%: ‐0,82 a ‐0,11; 14 ensayos, n = 978). Estos resultados corresponden a una reducción del 11% de la placa para el índice Quigley Hein (Turesky) a corto plazo y del 21% a largo plazo. Ambos meta‐análisis mostraron altos niveles de heterogeneidad (I2 = 83% y 86% respectivamente) que no se explicaba por los diferentes subgrupos de tipo de cepillos de dientes de potencia.

Con respecto a la gingivitis, hay evidencia de calidad moderada de que los cepillos de dientes eléctricos nuevamente proporcionan un beneficio estadísticamente significativo en comparación con los cepillos de dientes manuales, tanto a corto plazo (DME ‐0,43 (IC del 95%: ‐0,60 a ‐0,25); 44 ensayos, n = 3345) como a largo plazo (DME ‐0,21 (IC del 95%: ‐0,31 a ‐0,12); 16 ensayos, n = 1645). Esto corresponde a una reducción del 6% y del 11% de la gingivitis para el índice de Löe y Silness respectivamente. Ambos meta‐análisis mostraron altos niveles de heterogeneidad (I2 = 82% y 51% respectivamente) que no se explicaba por los diferentes subgrupos de tipo de cepillos de dientes de potencia.

El número de ensayos para cada tipo de cepillo de dientes motorizado varió: de lado a lado (10 ensayos), contra‐oscilación (cinco ensayos), rotación‐oscilación (27 ensayos), circular (dos ensayos), ultrasónico (siete ensayos), iónico (cuatro ensayos) y desconocido (cinco ensayos). El mayor conjunto de evidencia fue el de los cepillos de rotación‐oscilación que demostraron una reducción estadísticamente significativa de la placa y la gingivitis en ambos puntos temporales.

Conclusiones de los autores

Los cepillos de dientes eléctricos reducen la placa y la gingivitis más que el cepillado manual a corto y largo plazo. La importancia clínica de estos hallazgos sigue sin estar clara. El cumplimiento de guías metodológicas y una mayor estandarización de diseño beneficiarían tanto a futuros ensayos como a futuros metanálisis.

El coste, la fiabilidad y los efectos secundarios se comunicaron de manera inconsistente. Cualquier efecto secundario reportado fue localizado y sólo temporal.

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.

Cepillos de dientes eléctricos comparados con los cepillos de dientes manuales para mantener la salud oral

Pregunta de la revisión

Esta revisión se ha realizado para evaluar los efectos del uso de un cepillo de dientes eléctrico en comparación con el uso de un cepillo de dientes manual para mantener la salud bucal.

Antecedentes

Una buena higiene oral, mediante la eliminación de la placa (una película pegajosa que contiene bacterias) por medio de un cepillado dental eficaz, tiene un papel importante en la prevención de las enfermedades de las encías y la caries dental. La placa dental es la causa principal de la gingivitis (inflamación de las encías) y está implicada en la progresión a la periodontitis, una forma más grave de enfermedad de las encías que afecta a los tejidos que sostienen los dientes. La acumulación de placa también puede llevar a la caries dental. Las enfermedades de la encía y la caries dental son las razones principales de la pérdida de dientes.

Hay numerosos tipos diferentes de cepillos de dientes eléctricos disponibles para el público, que varían en precio y modo de acción. Los diferentes cepillos de dientes funcionan de diferentes maneras (como moviéndose de un lado a otro o en un movimiento circular). Los cepillos de dientes eléctricos también varían drásticamente en precio. Es importante saber si los cepillos de dientes eléctricos son más eficaces para eliminar la placa que los cepillos de dientes manuales, y si su uso reduce la inflamación de las encías (gingivitis) y previene o retrasa la progresión de la periodontitis.

Características de los estudios

Los autores del Grupo Cochrane de Salud Oral realizaron esta revisión de los estudios existentes y las evidencia está actualizada hasta el 23 de enero de 2014. Incluye 56 estudios publicados de 1964 a 2011 en los que se asignó al azar a 5.068 participantes para que recibieran un cepillo de dientes motorizado o un cepillo de dientes manual. La mayoría de los estudios incluyeron adultos, y más del 50% de los estudios utilizaron un tipo de cepillo de dientes motorizado que tenía un modo de acción de oscilación de rotación (en el que el cabezal del cepillo gira en una dirección y luego en la otra).

Resultados clave

La evidencia producida muestra los beneficios de usar un cepillo de dientes motorizado en comparación con un cepillo de dientes manual. Hubo una reducción del 11% de la placa al cabo de uno a tres meses de uso, y una reducción del 21% de la placa cuando se evaluó después de tres meses de uso. En el caso de la gingivitis, hubo una reducción del 6% a los tres meses de uso y del 11% cuando se evaluó después de tres meses de uso. Los beneficios a largo plazo para la salud dental de esto son poco claros.

Pocos estudios informaron sobre los efectos secundarios; cualquier efecto secundario informado fue localizado y sólo temporal.

Calidad de la evidencia

La evidencia relacionada con la placa y la gingivitis se consideró de calidad moderada.

Authors' conclusions

Implications for practice

This review has found that compared with manual toothbrushes, powered toothbrushes are more effective than manual brushes in reducing plaque and gingivitis in the long and short term. An 11% reduction in plaque (Quigley Hein (Turesky) index) was shown at one to three months and a 21% reduction in plaque at longer than three months. With regard to gingivitis a 6% reduction (Löe Silness index) was seen at one to three months and a greater reduction of 11% in the long term. The clinical importance of these findings remains unclear.

Cost, reliability and side effects were inconsistently reported. Any reported side effects were localised and only temporary.

Implications for research

Trials of longer duration are required to fully evaluate the effects of powered toothbrushes. There are few trials reporting data over more than three months. Data on the long‐term benefits of powered toothbrushes would be valuable in their own right and could be used to trial other outcomes such as the adverse effects and benefits in the prevention of periodontitis and dental caries.

This review continued to identify idiosyncrasies in the design of the trials and in some cases data could not be included for this reason. Whilst many of the trials were conducted before the current emphasis on experimental design, even recent trials lacked power calculations and had not been analysed on an intention‐to‐treat basis. Researchers in this field would be advised to study guidance on the design and reporting of clinical trials such as that provided in the CONSORT statement (http://www.consort‐statement.org/) and Robinson and colleagues (Robinson 2006). Specific guidance exists for trials in the treatment or prevention of periodontal diseases (Imrey 1994) but greater standardisation of both the follow‐up intervals and the indices used would benefit both trials and future meta‐analyses. Thought should also be given to when the mouth should be examined in relation to when the teeth were last cleaned. Authors might also seek guidance on the analysis and presentation of cross‐over trials.

Some research designs created an artificial research environment that may have undermined the generalis ability of the findings. In particular the external validity was questionable in trials with split‐mouth designs where participants were asked to clean each side of their mouth with a different brush, in trials where interventions were used in combination and those where toothbrushing was supervised. Hence their exclusion from this meta‐analysis.

More research with improved rigour is also needed on the relative benefits of powered and manual toothbrushes to prevent or remove extrinsic staining of the teeth and calculus.

Finally, empirical data on thresholds for clinically important differences in plaque and gingivitis levels would help to determine whether oral hygiene aids provide important health benefits.

Summary of findings

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Summary of findings for the main comparison.

Powered toothbrushes compared with manual toothbrushes for oral health

Patient or population: Individuals of any age with no reported disability that might affect toothbrushing

Intervention: Powered toothbrushes with any mode of action

Comparison: Manual toothbrushes

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

Manual toothbrush

Powered toothbrush

Plaque scores at 1 to 3 months

Scale from: 0 to 5

The mean plaque score in the control group was 2.16 points1

The mean plaque score in the intervention groups was
0.23 lower (0.32 lower to 0.14 lower)

2871 (40 studies)

⊕⊕⊕⊝
moderate3,4

This effect represents an 11% reduction in plaque at 1 to 3 months

Long‐term data (>3 months) also showed a statistically significant reduction in plaque for powered toothbrushes compared to manual toothbrushes

Gingival scores at 1 to 3 months

Scale from: 0 to 3

The mean gingivitis score in the control group was 1.1 points2

The mean gingivitis score in the intervention groups was
0.07 lower (0.10 lower to 0.04 lower)

3345
(44 studies)

⊕⊕⊕⊝
moderate3,4

This effect represents a 6% reduction in gingivitis at 1 to 3 months

Long‐term data (>3 months) also showed a statistically significant reduction in gingivitis for powered toothbrushes compared to manual toothbrushes

Adverse events

There was no apparent relationship between the use of powered toothbrushes and soft tissue trauma. In part this finding was due to the very small number of adverse events reported in the trials

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI)
CI: confidence interval

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate
Very low quality: We are very uncertain about the estimate

1. Based on median of control means for all trials presenting data using Quigley Hein index at 1 to 3 months

2. Based on median of control means for all trials presenting data using Löe and Silness index at 1 to 3 months

3. Downgraded due to statistically significant heterogeneity (I2 = 83% for plaque; I2 = 82% for gingivitis)

4. No downgrading was undertaken for risk of bias although 46/56 included trials were assessed as being at unclear risk of bias. Given that many of the studies were conducted over 10 years ago, it was felt much of the uncertainty may be due to poor reporting

Background

Description of the condition

Periodontal diseases

Periodontal diseases are a diverse family of oral health conditions affecting the periodontium. As the most prevalent periodontal diseases, gingivitis and periodontitis are of major public health importance. Dental plaque is the primary cause of gingivitis (gum inflammation), which is recognised by redness of the gums at the junction with the teeth, together with slight swelling and bleeding from the gingival margin (Farina 2013). Globally, 80% to 90% of adolescents between 15 and 19 years of age have mild to moderate gingivitis, rising to 92% to 97% in adults between 35 and 44 (Petersen 2012).

Gingivitis can progress to involve the periodontal membrane (periodontitis). A pocket between the gingiva and the tooth forms, and with further destruction bone supporting the tooth is eroded. Eventually the tooth becomes mobile and can be lost. This is a slow process and is related to the amount of plaque and calculus present on the tooth surface, mediated by genetic factors, age, and lifestyle choices such as smoking (British Society of Periodontology 2012). Severe periodontitis is the sixth most prevalent condition, affecting 11% of the global population (Marcenes 2013) and tooth loss as a result is found in 5% to 20% of most adult populations worldwide (Petersen 2005).

Dental caries

Caries (decay) in permanent teeth is the most prevalent disease worldwide, with a global prevalence of 35% for all ages combined (Marcenes 2013). Whilst in high‐income countries the prevalence of caries has decreased over the past decade, in lower‐ and middle‐income countries (LMICs) the incidence is increasing due to population growth, an aging population, changing diets and inadequate exposure to fluorides (Marcenes 2013). In the United Kingdom (UK), 85% of adults have at least one filling (Steele 2011) and 31% have obvious untreated caries (White 2011). 

The presence of plaque (biofilm) on the tooth is necessary for the development of caries. Like periodontal disease, caries has a complex aetiology, being an interaction between lifestyle, particularly diet and fluoride use, together with host factors. Although the relationship between the presence of plaque and caries is not as clear as with gingivitis, there is clear evidence that the presence of plaque makes teeth more at risk of caries. Zenkner 2013 demonstrated that on erupting teeth with visible plaque accumulation were 14.5 times more likely to have caries than teeth without the presence of visible plaque.

Over twice as many adults who reported not brushing their teeth have caries compared to those who report brushing their teeth twice a day (White 2011). Almost all people in industrialised countries use fluoride toothpaste. When teeth are brushed with a fluoride toothpaste there is clear evidence that this is effective at preventing caries (White 2011) and that this is overall more important than brushing per se (Chesters 1992).

Description of the intervention

Powered versus manual toothbrushing for oral health

Good oral hygiene (the removal of plaque or biofilm from the tooth and gums) by effective toothbrushing has a key role in oral health. In general, populations of high‐income countries have adopted regular toothbrushing (Albertsson 2010). There is, however, substantial within‐country variation correlating strongly with educational level (Chen 1997). Toothbrushing is much less frequent in LMICs but is again associated with social status indicators (McKittrick 2014).

Effective toothbrushing depends on a number of factors including motivation, knowledge and manual dexterity. Powered brushes simulate the manual motion of toothbrushes with lateral and rotary movements of the brush head. Brushes which operate at a higher frequency of vibration have also been introduced (Johnson 1994; Terezhalmy 1995b). Powered toothbrushes were first introduced commercially in the early 1960s (Chilton 1962a; Cross 1962; Elliot 1963; Hoover 1962) and have become established as an alternative to manual methods of toothbrushing. In the UK a quarter of adults report using a powered toothbrush (Chadwick 2011) and use by children may be even higher (White 2004). 

How the intervention might work

Dental plaque is the primary cause of gingivitis and is implicated in the progression of periodontitis. Therefore more effective removal of plaque by a powered toothbrush compared to a manual brush will reduce the inflammation of the gums (gingivitis), a benefit in itself, and in the long term may prevent or slow the progression of periodontitis and therefore maintain a functioning dentition for longer (Aspiras 2013). 

There is a potential to reduce caries incidence by the effective removal of plaque (Zenkner 2013) but previous reviews on the effectiveness of powered toothbrushes have not identified any studies reporting this outcome (Deacon 2010; Robinson 2005).

Why it is important to do this review

Powered toothbrushes are popular and expensive compared to manual toothbrushes. However, the question remains, which is better, powered or manual? This is an update of the Cochrane review first published in 2003 and previously updated in 2005 comparing powered and manual toothbrushes (Heanue 2003; Robinson 2005). There is also a related review comparing the effectiveness of different designs of powered toothbrushes (Deacon 2010). However, the previous review comparing powered and manual toothbrushes was published in 2005, and there is a requirement to update that review to identify new evidence, and to include any evaluations of new designs of powered toothbrush introduced to the market.

Objectives

To compare manual and powered toothbrushes in everyday use, by people of any age, in relation to the removal of plaque, the health of the gingivae, staining and calculus, dependability, adverse effects and cost.

Methods

Criteria for considering studies for this review

Types of studies

The review is confined to randomised controlled trials comparing manual and powered toothbrushes. It excludes trials only comparing different kinds of powered brushes or those comparing different kinds of manual brushes.

In the current update an agreement was made that cross‐over trials were eligible for inclusion if the wash‐out period length was more than two weeks. This was particularly important to diminish any carry‐over effects of the different toothbrushes on clinical gingivitis. Split‐mouth trials were excluded, as these were not considered representative of 'everyday use'.

Studies were included irrespective of publication status or language.

Types of participants

We included individuals of any age with no reported disability that might affect toothbrushing. We also included individuals wearing orthodontic appliances.

Types of interventions

The toothbrushes included in the review were all forms of manual brushes and all forms of powered brushes. Trials instituting combined interventions, e.g. brushing combined with the use of mouthrinse or irrigation, were excluded. However, trials where participants were permitted to continue with their usual adjuncts to oral hygiene, such as flossing, were included.

Trials were excluded where the brushing intervention was carried out or was supervised by a professional less than 28 days before a follow‐up assessment.

Trials of 28 days and over were eligible and a subgroup analysis was carried out on the duration of trials for the different outcome measures.

Powered toothbrushes were divided into seven groups according to their mode of action.

  1. Side to side action, indicates a brush head action that moves laterally from side to side.

  2. Counter oscillation, indicates a brush action in which adjacent tufts of bristles (usually six to 10 in number) rotate in one direction and then the other, independently. Each tuft rotating in the opposite direction to that adjacent to it.

  3. Rotation oscillation, indicates a brush action in which the brush head rotates in one direction and then the other.

  4. Circular, indicates a brush action in which the brush head rotates in one direction.

  5. Ultrasonic, indicates a brush action where the bristles vibrate at ultrasonic frequencies (> 20 kHz).

  6. Ionic, indicates a brush that aims to impart an electrical charge to the tooth surface with the intent of disrupting the attachment of dental plaque.

  7. Unknown, indicates a brush action that the review authors have been unable to establish based on the trial report or confirm with the manufacturers.

An additional group was added in a parallel review of the effectiveness of different powered brushes (Deacon 2010). This 'multidimensional group' included brushes with two of the above action types. Due to the limited number of trials conducted using this brush type, they were considered as part of the rotation oscillation group in this update.

It was agreed from the earlier reviews that analysis of filament arrangement, orientation, size, shape and flexibility, brush head size and shape along with presence or absence and characteristics of a timer would prove difficult to define across time and brush types.

Types of outcome measures

Primary outcomes

The primary outcome measures employed were quantified levels of plaque or gingivitis or both. Where possible, values recorded on arrival at the assessment were used. If necessary, measures of gingivitis taken after participants had been instructed or permitted to brush their teeth at the assessment visit were used as it was assumed that toothbrushing would not affect gingivitis within such a short period. However, measures of plaque taken after participants had been instructed or permitted to brush their teeth at the assessment visit were not used. It was assumed that plaque scores achieved during toothbrushing under these circumstances would not reflect scores achieved in normal home use.

Secondary outcomes

Secondary outcome measures sought were levels of calculus and staining; dependability and cost of the brush used, including mechanical deterioration; and adverse effects such as hard or soft tissue injury and damage to orthodontic appliances and prostheses.

Future updates of this review will include caries as an outcome.

Search methods for identification of studies

For the identification of studies included or considered for this review, we developed a detailed search strategy for each database, based on the strategy developed for MEDLINE (OVID) but revised accordingly. The search strategy used a combination of controlled vocabulary and free text terms and was linked with the Cochrane Highly Sensitive Search Strategy (CHSSS) for identifying randomised trials (RCTs) in MEDLINE: sensitivity maximising version (2008 revision) as referenced in Chapter 6.4.11.1 and detailed in box 6.4.c of the Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0 (updated March 2011) (Higgins 2011). Details of the MEDLINE search are provided in Appendix 3. The searches of EMBASE and CINAHL were linked to the Cochrane Oral Health Group filters for identifying RCTs.

Electronic searches

We searched the following electronic databases:

  • the Cochrane Oral Health Group's Trials Register (to 23 January 2014) (Appendix 1);

  • the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2014, Issue 1) (Appendix 2);

  • MEDLINE via OVID (1946 to 23 January 2014) (Appendix 3);

  • EMBASE via OVID (1980 to 23 January 2014) (Appendix 4);

  • CINAHL via EBSCO (1980 to 23 January 2014) (Appendix 5).

No restrictions were placed on the language or date of publication when searching the electronic databases.

Searching other resources

We searched the following databases for ongoing trials, seeAppendix 6 for details of the search strategy:

Only handsearching done as part of the Cochrane Worldwide Handsearching Programme and uploaded to CENTRAL was included (see the Cochrane Masterlist for details of journal issues searched to date).

All references cited in the included trials were checked for additional studies. Identified manufacturers were contacted and additional published or unpublished trial reports requested.

Data collection and analysis

Selection of studies

Two review authors independently reviewed the titles and abstracts identified in the search. If in the opinion of both authors an article clearly did not fulfil the defined inclusion criteria it was considered ineligible. We obtained full reports of all trials of possible relevance for assessment. On receipt of the full article, two review authors assessed each study independently using specifically designed data extraction forms. Disagreements were resolved by discussion with the review team.

Data extraction and management

For this update, piloting of data extraction was performed independently by two authors on eight pilot articles. However, all authors reported back on the design of the data extraction forms and their interpretation of the inclusion and exclusion criteria along with their understanding of the outcome measures and new risk of bias (ROB) assessment. On the basis of this feedback the data extraction forms were altered and the inclusion, exclusion, outcome measures and ROB assessment were redefined to avoid misinterpretation. All data extraction for the included studies was then undertaken independently and in duplicate.

The final data extraction protocol considered the following information.

  1. Bibliographic details of the study.

  2. Funding source for the trial. A trial was considered to have been funded by a brush manufacturer if it was reported that any material sponsorship from the manufacturer occurred, including the donation of brushes. It was considered unclear, if there was no statement on funding. A trial was only considered to be unsponsored by a manufacturer if it clearly stated so.

  3. Inclusion eligibility.

  4. Baseline characteristics of the participants in the study, including age, number of participants in the study and gender. Also, specific groups, such as dental students or orthodontic patients were noted, where mentioned.

  5. Intervention characteristics including type of brush and its mode of action, duration of use and delivery of instructions.

  6. Outcomes including plaque and gingivitis indices.

  7. Additional information on a priori calculation of sample size, duration of study, reliability and validity of outcomes measures and monitoring of compliance.

Trials were considered as 'short term' or 'long term'. 'Short‐term' data included follow‐up between 28 days and three months. 'Long‐term' data included follow‐up beyond three months. Within each category of long term and short term, where a trial reported multiple end points, only the latest data were extracted.

Data from trials that reported follow‐up before and after three months were included in the short‐ and long‐term meta‐analyses. Likewise, data from trials that reported both plaque and gingivitis would be included in meta‐analyses for both outcomes. These were the only circumstances when data from the same trial were considered more than once.

Many different indices of plaque and gingivitis were used across trials and some trials reported multiple indices. A frequencies table was prepared of the indices used and they were ranked based on common usage and simplicity. For plaque we extracted, where possible, data reported as the Turesky modification of the Quigley‐Hein plaque index (Quigley 1962; Turesky 1970). For gingival inflammation we extracted where possible data reported as the gingival index of Löe and Silness (Löe 1963) or, if unavailable, bleeding on probing (Ainamo 1975). Data for Russell's periodontal index were excluded because this index fails to distinguish between gingivitis and periodontitis (Russell 1967).

Where available, data were extracted for whole as opposed to part‐mouth scores. Where only part‐mouth scores were reported in a study, they were extracted and a sensitivity analysis carried out to consider their impact on the results of the review. Part‐mouth scoring was said to have occurred if plaque or gingivitis or both were not recorded around all erupted teeth, except third molars.

Completed data extraction forms were compared. Where there was disagreement between review authors with regard to any part of the extraction details it was resolved by discussion between the authors and a note made on the data collection forms. Any disagreement, unresolved between the two authors, was settled by majority vote of the entire panel of review authors. Authors were contacted for clarification where necessary.

Assessment of risk of bias in included studies

We conducted this assessment using the recommended approach for assessing risk of bias in included studies for Cochrane reviews (Higgins 2011). All included studies were assessed independently and in duplicate by two review authors as part of the data extraction process. The risk of bias tool evaluates six specific domains.

  • Sequence generation (selection bias).

  • Allocation concealment (selection bias).

  • Blinding of outcome assessment (detection bias).

  • Incomplete outcome data (attrition bias).

  • Selective outcome reporting (reporting bias).

  • Other sources of bias; comparability of groups at baseline.

Risk of bias assessment.

  • A trial was considered to have adequately generated a random sequence of allocation, if it fully reported the type of allocation generation and it satisfied the CONSORT guidelines as true randomisation (http://www.consort‐statement.org/).

  • A trial was considered to have adequate blinding, if the report indicated that the method of outcome assessment did not allow the recording clinician to know to which group the participants had been allocated, with no other contradicting statement.

  • Attrition was considered to have been adequately reported if there was a clear indication of how many withdrawals occurred in each group during the trial and an attempt made to give reasons why the withdrawals occurred.

The first part of the entry involved authors' describing what was reported in the study. The second part involved the authors' judgements of the adequacy of the study, that is, whether they are at low, high or unclear risk of bias. Numerical data extracted from the included trials were checked by a third author for accuracy and entered into Review Manager (RevMan) software (RevMan 2012).

Two risk of bias figures were generated to illustrate the findings of the assessment. A 'Risk of bias graph' illustrated the proportion of studies across the domain with each of the judgements ('low risk', 'high risk', 'unclear risk'). A 'Risk of bias summary' summarised all of the judgements for a study entry. We assumed that the risk of bias of outcomes was equally important both within and across studies. They were assessed as follows.

Low risk of bias

Interpretation

Within a study

Across studies

Low risk of bias

Plausible bias unlikely to seriously alter the results

Low risk of bias for all key domains

Most information is from studies at low risk of bias

Unclear risk of bias

Plausible bias that raises some doubt about the results

Unclear risk of bias for one or more key domains

Most information is from studies at low or unclear risk of bias

High risk of bias

Plausible bias that seriously weakens confidence in the results

High risk of bias for one or more key domains

The proportion of information from studies at high risk of bias is sufficient to affect the interpretation of results

Measures of treatment effect

The estimate of effect used was the mean difference (MD) and corresponding 95% confidence intervals (CI). However, different indices for plaque measure the same concept on different scales, with high correlation between the different indices. The same is true for gingivitis. As it is not possible to combine the results from different indices, the effects were expressed as standardised values, which have no units, before combining. The standardised mean difference (SMD) was therefore calculated along with the appropriate 95% CI and was used as the effect measure for each meta‐analysis where results were available for more than one index (Deeks 2001). Where only one index was presented in a comparison, the treatment effect was measured as the MD with 95% CI.

Unit of analysis issues

No units of analysis issues were anticipated other than cross‐over studies which were included using the generic inverse variance (GIV) approach (Elbourne 2002; Higgins 2011).

Dealing with missing data

Trial authors were contacted to retrieve missing data where necessary. Data remain excluded until further clarification becomes available. Standard deviations were imputed as in section 7.7.3 of the Cochrane Handbook for Systematic Reviews of interventions (Higgins 2011).

Assessment of heterogeneity

We assessed heterogeneity by inspection of a graphical display of the estimated treatment effects from the trials along with their 95% CI and by Cochran's test for heterogeneity undertaken before each meta‐analysis as described in the Cochrane Handbook for Systematic Reviews of interventions (Higgins 2011). The heterogeneity was quantified using the I2 statistic, where a guide for interpretation in the Cochrane Handbook for Systematic Reviews of interventions is (Higgins 2011):

  • 0% to 40%: might not be important;

  • 30% to 60%: may represent moderate heterogeneity;

  • 50% to 90%: may represent substantial heterogeneity;

  • 75% to 100%: considerable heterogeneity.

Assessment of reporting biases

A funnel plot (plots of effect estimates versus the inverse of their standard errors) was drawn. Asymmetry of the funnel plot may indicate publication bias and other biases related to sample size, though it may also represent a true relationship between trial size and effect size. A formal investigation of the degree of asymmetry was performed using the method proposed by Egger et al (Egger 1997). This was carried out using Stata version 12.0 (Stata Corporation, USA) using the program Metabias.

Data synthesis

Statistical values such as SMD have no inherent clinical meaning. Therefore we back‐translated key effect scores using the clinical indices from a study where the difference was similar to the SMD. Such examples are given in the Discussion. Random‐effects models were performed where four or more studies were to be combined, otherwise fixed‐effect models were used.

Data from cross‐over trials were included with that of similar parallel group trials, using the techniques described by Elbourne and colleagues (Elbourne 2002). This was done using the generic inverse variance method within RevMan (Higgins 2011).

Subgroup analysis and investigation of heterogeneity

Subgroup analyses were undertaken for assessments based on full mouth recording versus those based on a partial recording and to examine the effects of concealed allocation, randomisation generation and blinded outcome assessment on the overall estimates of effect for important outcomes.

Additional subgroup analyses were undertaken to explore heterogeneity. Evidence of variability in any subgroup was further explored by examining funnel plots.

Sensitivity analysis

Sensitivity analyses were conducted to test whether the assumptions involved in the design of this review affected the findings. These analyses were undertaken by repeating the meta‐analyses in the following cases: where a full mouth index had been used, where adequate concealment of randomisation occurred, where there was adequate generation of randomisation sequence, where there was blinding of the outcome assessor, if the trial was funded by a manufacturer, with adequate information about attrition and for trials that were not restricted to participants only wearing fixed orthodontic appliances.

Presentation of main results

A GRADE approach was used to interpret findings. A 'Summary of findings' table was developed for the primary outcomes of this review using GRADE Profiler software (version 3.6). These tables provide information concerning the overall quality of the evidence from the trials, the magnitude of effect of the interventions examined, and the sum of available data on the primary outcomes and secondary outcomes. The outcomes selected for inclusion in these tables were plaque and gingivitis at two time points.

Results

Description of studies

Results of the search

SeeFigure 1.


Flow chart of study selection in this update.

Flow chart of study selection in this update.

This review was originally published in 2003, updated in 2005 and again for this version. Since its first publication to January 2014 a total of 1195 articles have been identified through the search strategy. After removing duplicates, this number falls to 432; titles and abstracts of these 432 articles were screened for eligibility. A total of 200 full‐text articles were retrieved as potentially relevant trials. Of these, 134 were excluded (Characteristics of excluded studies table) leaving 56 trials, in 66 publications.

In the original review 29 trials, all providing data for meta‐analysis, were included. In the 2005 update, an additional 10 trials were identified as meeting the inclusion criteria (Galgut 1996; Garcia‐Godoy 2001; Hickman 2002; Pucher 1999; Sharma 2000; Soparkar 2000; Sowinski 2000; Toto 1966; Van Swol 1996; Zimmer 2002). Data for three trials identified in the original search was received from the authors allowing their inclusion (Haffajee 2001a; Lapiere unpublished; Singh unpublished). Thus 42 trials were included in the 2005 publication.

In the current update, an additional 15 trials were identified as being eligible (Biavati Silvestrini 2010; Biesbrock 2007; Costa 2007; Dorfer 2009; Goyal 2007; Gugerli 2007; Kallar 2011; McCracken 2004; McCracken 2009; Moreira 2007; Moritis 2008; Rosema 2008; Sharma 2010; Silverman 2004; Zimmer 2005). Fourteen were parallel group designs and there was one cross‐over trial (Moreira 2007). One trial included in the original review was excluded as it was not truly a randomised controlled trial (McAllan 1976), leaving a total of 56 trials included in this 2014 update. Of these 56 trials, five did not present data in a way that allowed for meta‐analysis (Costa 2007; Galgut 1996; Gugerli 2007; Moreira 2007; Zimmer 2005). The meta‐analyses are based on 51 trials with a parallel group design.

Included studies

Of the 56 included trials, 36 were conducted in North America (Baab 1989; Barnes 1993; Biesbrock 2007; Costa 2007; Cronin 1998; Dentino 2002; Emling 1991; Forgas‐B 1998; Garcia‐Godoy 2001; Glass 1965; Goyal 2007; Haffajee 2001a; Ho 1997; Johnson 1994; Khocht 1992; Lobene 1964a; Moreira 2007; O'Beirne 1996; Pucher 1999; Sharma 2000; Sharma 2010; Silverman 2004; Singh unpublished; Soparkar 1964; Soparkar 2000; Sowinski 2000; Terezhalmy 1995a; Toto 1966; Tritten 1996; Van Swol 1996; Walsh 1989; Warren 2001; Wilson 1993; Yankell 1996; Yankell 1997; Yukna 1993b); 18 in Europe (Ainamo 1997; Biavati Silvestrini 2010; Clerehugh 1998; Dorfer 2009; Galgut 1996; Gugerli 2007; Heasman 1999; Hickman 2002; Lapiere unpublished; Lazarescu 2003; McCracken 2004; McCracken 2009; Moritis 2008; Rosema 2008; Stoltze 1994; van der Weijden 1994; Zimmer 2002; Zimmer 2005), one each in Israel (Stabholz 1996) and in India (Kallar 2011).

Three trials remain unpublished (Lapiere unpublished; Lazarescu 2003; Singh unpublished). The remainder were published between 1964 and October 2011; four in the 1960s; one in the 1970s; two in the 1980s; 23 in the 1990s and 19 in the 20th century. At least 37 were funded in some part by the manufacturer of one of the powered toothbrushes, one was funded by government scholarship and the remainder were unclear about sponsorship.

The combined total number of participants included in the trials was 5068. The number of patients reported lost to follow‐up was 334 (6.6%).

Characteristics of participants

The characteristics of participants in each study are noted in the Characteristics of included studies table and in Additional Table 1. Out of the 56 included trials the four most frequently stated inclusion criteria were adults (77% of trials), no relevant medical history (55%), a stated minimum number of teeth (55%) and a criterion related to gingival or periodontal health or plaque at baseline (50%). Exclusion criteria used in the included trials were noted and are summarised in Additional Table 2. Only seven trials included orthodontic patients (Biavati Silvestrini 2010; Clerehugh 1998; Costa 2007; Hickman 2002; Ho 1997; Pucher 1999; Singh unpublished).

Open in table viewer
Table 1. Summary of inclusion criteria categories within included studies

Inclusion criteria

Number (n = 56)

Adults

43

Minimum number of teeth

31

Minimum periodontal baseline measures

28

Participants recruited from dental clinics

9

Concurrent fixed orthodontic treatment

8

Some participants aged less than 16 years

11

Volunteer university students

3

Dental students

2

School children

3

Open in table viewer
Table 2. Summary of exclusion criteria categories within included studies

Exclusion criteria1

Number (n = 56)

Exclusion criteria related to medical history

31

Pregnancy or lactation

5

Previous use of powered toothbrushes

6

Patients undergoing orthodontic treatment

9

Previous periodontal treatment

3

Dental students

2

Cervical restorations

1

Smoking

3

Maximum periodontal measure

8

Wearing partial denture

2

1 Not all trials explicitly stated exclusion criteria

Characteristics of interventions

The powered toothbrushes, included:

Braun, Interplak, Braun Plaque Remover with OD5 head, Braun Oral B Pro Care series, Oral B CrossAction, Braun Oral B Pro Care 8500, Braun Oral B D25, Braun Oral B 3D, Braun Oral B D9, PlaK Trac, Ultrasonex, GEC, Braun Oral B D7, Philips Jordan HP 735, Philips HP 550, Sonicare Ultrasonic, Philips Sonicare, Philips Sensiflex 2000, Philips Sonicare Elite, Epident, Braun Oral B D5, Philips 550, Touchtronic Teledyne Aqua Tec, Ronson, Dominion, Pulse Plaque Remover, Broxodent, Plaq and White, LPA/Broxo, Braun D17, Rowenta Dentiphant, Rowenta, Plaque Dentacontrol Plus, Sangi Co Electronic, Braun Oral B D10, Braun Oral B D15 Plaque Remover, Braun Plaque Remover 3D with orthodontic head, Oral B Mickey Mouse, Hukuba Ionic, Colgate Actibrush, HyG Ionic, unspecified ionic, Ultra Sonex Ultima, Ultreo, Sunbeam cordless. These are summarised in Additional Table 3.

Open in table viewer
Table 3. Summary of toothbrush modes of action, number of trials and participants

Mode of action

Trial ID

Number of trials

Number in trials

Side to side

Glass 1965, Ho 1997, Johnson 1994, Lobene 1964, McCracken 2009, Moritis 2008, O'Beirne 1996, Tritten 1996, Walsh 1989, Yankell 1997

10

988

Counter oscillation

Baab 1989, Khocht 1992, Stabholz 1996, Wilson 1993, Yukna 1993

5

267

Rotation oscillation

Ainamo 1997, Barnes 1993, Biavati Silvestrini 2010, Biesbrock 2007, Clerehugh 1998, Costa 2007, Cronin 1998, Dentino 2002, Dorfer 2009, Garcia‐Godoy 2001, Gugerli 2007, Haffajee 2001a, Heasman 1999, Hickman 2002, Lapiere unpublished, Lazarescu unpublished, McCracken 2004, Rosema 2008, Sharma 2000, Silverman 2004, Soparkar 2000, Sowinski 2000, Stoltze 1994, van der Weijden 1994, Warren 2001, Yankell 1997, Zimmer 2005

27

2159

Circular

Khocht 1992, Yankell 1996

2

162

Ultrasonic

Costa 2007, Forgas‐B 1998, Goyal 2007, Sharma 2010, Terezhalmy 1995, Zimmer 2002, Zimmer 2005

7

506

Unknown

Emling 1991, Kallar 2011, Singh unpublished, Soparkar 1964, Toto 1966

5

1130

Ionic

Galgut 1996, Moreira 2007, Pucher 1999, van Swol 1996

4

221

Four trials evaluated two powered toothbrushes

Powered toothbrush, mode of action

The powered toothbrushes were subdivided into the seven groups according to their mode of action.

Side to side action

Philips Sonicare, Philips Sonicare Elite and Sonicare brushes (Sonicare c/o Philips Oral Healthcare, 35301 SE Center Street, Snoqualmie, WA 98065; http://www.sonicare.com/); Philips 550 (Philips Jordan, PO Box 324, 5500 AH Veldhoven, The Netherlands; http://www.philips‐jordan.com/) and Philips Sensiflex 2000 (http://www.philips.co.uk/c/electric‐toothbrushes/sensiflex‐hx1610_05/prd/).

Counter oscillation

Interplak brush (Interplak Conair Corporation, 1 Cummings Point Road, Stamford, CT 06904; http://www.conair.com/products/).

Rotation oscillation

Oral B CrossAction, Braun Oral B 3D, D17, Plaque Remover with OD5 head, Oral B D9, Oral B D7, Oral B D5, Oral B D10, Oral B D25, Oral B Pro Care 8500, Oral B Mickey Mouse, Braun Plaque Remover 3D with orthodontic head, Braun Oral B D15 Plaque Remover (Braun Oral B Consumer Services, 1 Gillette Park, South Boston, MA; http://www.oralb.com/); Philips Jordan HP 735, Philips HP 550 (Philips Jordan PO Box 324, 5500 AH Veldhoven, The Netherlands; http://www.philips‐jordan.com/); Colgate Actibrush (Consumer Affairs, Colgate‐Palmolive (UK) Limited, Guildford Business Park, Middleton Road, Guildford, Surrey GU2 8JZ UK; http://www.colgate.co.uk/contact/index.shtml).

Circular

Rowenta Dentiphant, Rowenta, Plaque Dentacontrol Plus (Rowenta Werke GmbH, Franz Alban, Stützer, Germany; http://www.products.rowenta.de/row/index.html); Epident (EPI Products, Santa Monica, CA).

Ultrasonic

Ultrasonex brush, Ultra Sonex Ultima (Salton‐Maxim 1801 N Stadium Boulevard, Columbia, MO 65202; http://www.salton‐maxim.com/salton/ultrasonex/ultrasonex.asp) and Ultreo (http://www.ultreo.com/meet‐ultreo), Oral B Pulsonic.

Ionic

Sangi Co Electronic (Tokyo), Hukuba Ionic and the HyG Ionic (Hukuba Dental Corporation, 914‐1 Nazukari, Nagareyama, Chiba, 270‐01 Japan).

Unknown

Some companies are no longer trading or complete details of the relevant toothbrushes are not easily found. The following toothbrushes fall into this latter category: PlaK Trac, GEC, Epident, Touchtronic, Ronson, Dominion, Broxodent, Plaq and White, LPA/Broxo, Sunbeam cordless.

The names and addresses of the manufacturers have changed over the years and those quoted above are correct at the time of the present review. Some of the trials were conducted when another company made the powered toothbrush.

Ten trials recruiting 988 participants compared manual brushing versus side to side powered toothbrushing. Five trials recruited 267 participants and compared manual brushing versus counter oscillating toothbrushing. Twenty‐seven trials recruiting 2159 participants compared manual brushing versus rotation oscillation powered brushing. Two trials recruiting 162 participants compared manual brushing versus circular powered brushing and seven trials recruiting 506 participants compared manual brushing versus ultrasonic powered brushing. Four trials recruiting 221 participants compared manual brushing versus ionic brushing. Five trials recruiting 1130 participants compared manual brushing and a powered toothbrush with an unknown action. It should be noted that four trials evaluated two powered brushes (Costa 2007; Khocht 1992; Yankell 1997; Zimmer 2005).

Summary of trials by toothbrush action

See Additional Table 3 for list of trials by mode of action.

Characteristics of outcome measures

Forty trials (2871 participants at the end of the trials) provided data for analysis on plaque at one to three months and 14 trials (978 participants at the end of the trials) provided data at longer than three months. Forty‐four trials (3345 participants at the end of the trials) provided data for analysis on gingivitis at one to three months and 16 trials (1645 participants at the end of the trials) provided data at longer than three months.

If it was not stated that a full or partial mouth index was used, we assumed it was full mouth. Fifty‐four trials reported plaque data, and of these eight trials reported that a partial mouth assessment was used. Fifty‐two trials reported gingivitis data and 10 of these reported using a partial mouth index.

The following plaque indices were reported.

The following gingivitis indices were reported.

Excluded studies

The primary reason for the exclusion of each study is given in the Characteristics of excluded studies table. Many trials were ineligible for more than one reason, however the primary reason for exclusion was study duration of less than 28 days. Other reasons included a high potential for compromised self toothbrushing efficacy; combined interventions that did not allow for assessment of the effect of powered toothbrushing; split‐mouth design; or insufficient information to determine whether inclusion criteria were met (in these situations authors have been contacted and if further information is supplied to confirm criteria for inclusion are met, the studies will be included in subsequent updates).

Risk of bias in included studies

SeeFigure 2; Figure 3. Fifty‐six studies were assessed for risk of bias, including five that were not meta‐analysed (Costa 2007; Galgut 1996; Gugerli 2007; Moreira 2007; Zimmer 2005). Overall, only five were assessed as being at low risk of bias (Clerehugh 1998; Haffajee 2001a; McCracken 2009; Sharma 2010; Silverman 2004). Five trials were assessed as being at high risk of bias (Glass 1965; Kallar 2011; Lazarescu 2003; Walsh 1989; Wilson 1993).


Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.


Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Allocation

The generation of randomisation sequence was at low risk of bias for 18 trials (32.1%), unclear risk for 36 (64.3%) and at high risk of bias for two trials (3.6%) (Lazarescu 2003; Walsh 1989). The concealment of allocation was at low risk of bias in 13 trials (23.2%) and unclear risk of bias in all other trials.

Blinding

The outcome assessment was at low risk of bias in 47 trials (83.9%). The adequacy of blinding was unclear in nine trials (16.1%).

Incomplete outcome data

The reported drop‐out rate ranged from 1% to 34%. Forty‐one trials were at low risk of bias with regard to attrition bias, either due to no drop‐outs, or drop‐outs unlikely to influence findings. Thirteen trials were at unclear risk of bias due to insufficient data for assessment; two studies with high drop‐out rates that did not present reasons for the losses were assessed as at high risk of bias (Glass 1965; Wilson 1993).

Selective reporting

All of the trials apart from one reported important outcomes and were assessed as at low risk of bias. Kallar 2011 failed to report gingivitis and was assessed as at high risk of bias for this domain.

Other potential sources of bias

Two trials were at unclear risk of bias due to other potential sources (Kallar 2011; Yukna 1993b) due to lack of information on the methods or insufficient detail regarding baseline comparison. All other trials were assessed as at low risk of bias for this domain.

Effects of interventions

See: Summary of findings for the main comparison

As mentioned in the methods section, the differences in plaque and gingivitis reduction between the powered and manual brushes were expressed as standardised mean differences (SMDs) unless all the studies used the same index in which case mean difference (MD) was used. The results are presented for both short‐term and long‐term studies.

All powered toothbrushes versus manual toothbrushes (Comparison 1)

Analysis 1.1; Analysis 1.2; Analysis 1.3; Analysis 1.4.

This primary analysis compared all powered brush types with manual.

Plaque

The meta‐analyses for both short‐term (40 trials n = 2871) and long‐term (14 trials n = 978) plaque indices indicated that there was a reduction in plaque when the powered toothbrushes were used, short term (one to three months) SMD ‐0.50 (95% confidence interval (CI) ‐0.70 to ‐0.31) and long term (>3 months) SMD ‐0.47 (95% CI ‐0.82 to ‐0.11). Both meta‐analyses showed high levels of heterogeneity (I2 = 83% and 86% respectively). These were not explained by the different powered toothbrush type subgroups, and there was considerable heterogeneity within these.

Gingivitis

The meta‐analyses for both short‐term (44 trials n = 3345) and long‐term (16 trials n = 1645) gingival indices indicated that there was a reduction in gingivitis when the powered toothbrushes were used, short term (1‐3 months) SMD ‐0.43 (95% CI ‐0.60 to ‐0.25) and long term (>3 months) SMD ‐0.21 (95% CI ‐0.31 to ‐0.12). Both meta‐analyses showed high levels of heterogeneity (I2 = 82% and 51% respectively). These were not explained by the different powered toothbrush type subgroups, and there was considerable heterogeneity within these.

Side to side powered toothbrushes versus manual toothbrushes (Comparison 2)

Analysis 2.1; Analysis 2.2; Analysis 2.3; Analysis 2.4.

Ten studies (n = 988) compared side to side toothbrushes with manual, one of which was at low risk (McCracken 2009) and two at high risk of bias (Glass 1965; Walsh 1989), the remainder being unclear.

No significant differences were found between side to side action and manual brushes in the reduction of plaque or gingivitis in the long or short term.

Counter oscillation powered toothbrushes versus manual (Comparison 3)

Analysis 3.1; Analysis 3.2; Analysis 3.3; Analysis 3.4.

All five studies (n = 267) that compared counter oscillation powered toothbrushes with manual toothbrushes were at unclear (Baab 1989; Khocht 1992; Stabholz 1996; Yukna 1993b) or high risk of bias (Wilson 1993). There was no evidence that counter oscillation powered toothbrushes were more effective than manual brushes for the removal of plaque or reduction of gingivitis with the exception of being associated with less plaque in the long term, where the MD was ‐0.27 (95% CI ‐0.48 to ‐0.07; two trials, n = 69; I2=0) (Analysis 3.3).

Rotation oscillation powered toothbrushes versus manual (Comparison 4)

Analysis 4.1; Analysis 4.2; Analysis 4.3; Analysis 4.4.

Twenty‐seven trials (n = 2159) compared rotation oscillation powered with manual toothbrushes. Only three of these were at low risk of bias (Clerehugh 1998; Haffajee 2001a; Silverman 2004) and one at high risk of bias (Lazarescu 2003), the remainder being unclear. This comparison contained the greatest number of trials, with 20 (n = 1404) and 21 (n = 1479) trials included in the meta‐analyses for plaque and gingivitis respectively in the short term, and seven (n = 527) and eight (n = 684) trials included in the meta‐analyses for plaque and gingivitis in the long term. Brushes with a rotation oscillation action removed more plaque and reduced gingivitis more effectively than manual brushes in the short term. For plaque at one to three months the SMD was ‐0.53 (95% CI ‐0.74 to ‐0.31; I2 = 72%) (Analysis 4.1) and for gingivitis the SMD was ‐0.49 (95% CI ‐0.73 to ‐0.26; I2 = 78%) (Analysis 4.2). Rotation oscillation brushes also reduced plaque and gingivitis in the long term. The SMD for plaque over 3 months was ‐0.66 (95% CI ‐1.28 to ‐0.03; I2 = 91%) (Analysis 4.3) and for gingivitis was ‐0.35 (95% CI ‐0.50 to ‐0.20; I2 = 53%) (Analysis 4.4). There was heterogeneity between the trials in the meta‐analyses for both short‐term and long‐term follow‐up, which is reported later in this section.

Three studies examined both outcomes but did not include sufficient information for meta‐analysis (Costa 2007; Gugerli 2007; Zimmer 2005). Two suggested treatment benefits from using rotation oscillation toothbrushes (Analysis 4.5). All three were at unclear risk of bias.

Circular powered toothbrushes versus manual (Comparison 5)

Analysis 5.1; Analysis 5.2.

Two trials (n = 162) were included in this comparison, both were at unclear risk (Khocht 1992; Yankell 1996). Both trials were included in the analyses for plaque and gingivitis in the short term; there were no long‐term data. There was no evidence that brushes with a circular action removed plaque or reduced gingivitis more effectively than manual brushes in either time period.

Ionic toothbrushes versus manual (Comparison 6)

Analysis 6.1; Analysis 6.2; Analysis 6.3; Analysis 6.4.

Four trials (n = 221) compared an ionic toothbrush with a manual brush. All four trials were at unclear risk of bias (Galgut 1996; Moreira 2007; Pucher 1999; Van Swol 1996). One trial (Moreira 2007) did not present data in a form suitable for meta‐analysis (Analysis 6.5).

Three trials provided data for meta‐analysis (Galgut 1996; Pucher 1999; Van Swol 1996). The short‐term analyses (one to three months) indicated an effect on plaque in favour of the ionic brush (SMD ‐0.57 (95% CI ‐0.87 to ‐0.27)) but not gingivitis (MD ‐0.01 (95% CI ‐0.04 to 0.02)).

The single long‐term trial showed a difference in favour of the ionic toothbrush on both plaque (MD ‐0.50 (95% CI ‐0.74 to ‐0.26)) and gingivitis (MD ‐0.36 (95% CI ‐0.59 to ‐0.13)).

Ultrasonic toothbrushes versus manual (Comparison 7)

Analysis 7.1; Analysis 7.2; Analysis 7.3; Analysis 7.4.

Seven trials (n = 506) compared ultrasonic toothbrushes with manual. One of the seven trials in this comparison was at low risk of bias (Sharma 2010) and all others were at unclear risk of bias. There were four trials for the meta‐analysis for the short‐term assessment of plaque and five for gingivitis; two trials did not provide data for meta‐analysis (Analysis 7.5). Ultrasonic powered toothbrushes reduced plaque and gingivitis in the short term, with SMDs of ‐1.33 (95% CI ‐1.59 to ‐1.07; I2 = 93%) (Analysis 7.1) and ‐0.99 (95% CI ‐1.21 to ‐0.76; I2 = 84%) (Analysis 7.2) respectively. Only one trial presented long‐term data and showed no statistically significant difference between brushes for either plaque or gingivitis (Terezhalmy 1995a) (Analysis 7.3; Analysis 7.4).

Unknown versus manual (Comparison 8)

Analysis 8.1; Analysis 8.2; Analysis 8.3.

Five studies (n = 1130) compared powered brushes of unknown action against manual brushes. One was assessed as being at high risk of bias (Kallar 2011) and four were at unclear risk. The data are presented in forest plots however, due to the lack of clarity about the toothbrushes being compared it is difficult to draw any conclusions.

Investigation of heterogeneity

Heterogenity was present for both plaque at one to three months and plaque at >3 months and gingivitis at >3 months for the rotation oscillation brushes compared with manual. We were unable to put forward covariates other than those considered in the sensitivity analyses below to explain this.

Sensitivity analyses

Sensitivity analyses were limited to the data on all types of powered toothbrushes (Comparison 1: Analysis 1.1; Analysis 1.2; Analysis 1.3; Analysis 1.4) as this was the primary analysis for this review.

These were conducted for trials with (1) full mouth indices only, (2) low risk of bias trials, (3) manufacturer funded (reported) and (4) excluding orthodontic patients (Additional Table 4). The effect estimates were similar to those for all trials apart from those for the low risk of bias studies. There are only five low risk of bias trials in total and two to three included in the sensitivity analyses. Due to the lack of evidence none of these were statistically significant although the effect estimates for plaque and gingivitis at one to three months were higher than those for all trials.

Open in table viewer
Table 4. Sensitivity analyses of all trials for all indices

Index

Group selected

Number of trials

SMD

Effect P value

Het. P value

I2

Plaque

1‐3 months

All trials

40

‐0.50 (‐0.70 to ‐0.31)

<0.0001

<0.0001

88

Full mouth

34

‐0.58 (‐0.80 to ‐0.36)

<0.0001

<0.0001

85

Low risk of bias

3

‐0.83 (‐2.02 to 0.36)

0.17

<0.0001

94

Manufacturer funded

26

‐0.56 (‐0.82 to ‐0.29)

<0.0001

<0.0001

88

Trials excluding ortho patients

36

‐0.46 (‐0.66 to ‐0.27)

<0.0001

<0.0001

83

Plaque

>3 months

All trials

14

‐0.37 (‐0.50 to ‐0.24)

<0.0001

<0.0001

86

Full mouth

13

‐0.39 (‐0.53 to ‐0.26)

<0.0001

<0.0001

87

Low risk of bias

2

0.12 (‐0.27 to 0.52)

0.53

0.51

0

Manufacturer funded

9

‐0.41 (‐0.56 to ‐0.25)

<0.0001

<0.0001

91

Trials excluding ortho patients

14 (all)

‐0.37 (‐0.50 to ‐0.24)

<0.0001

<0.0001

86

Gingivitis

1‐3 months

All trials

44

‐0.43 (‐0.60 to ‐0.25)

<0.0001

<0.0001

82

Full mouth

35

‐0.47 (‐0.68 to ‐0.25)

<0.0001

<0.0001

85

Low risk of bias

3

‐0.96 (‐1.95 to 0.03)

0.06

<0.0001

93

Manufacturer funded

32

‐0.47 (‐0.68 to ‐0.26)

<0.0001

<0.0001

84

Trials excluding ortho patients

38

‐0.42 (‐0.61 to ‐0.23)

<0.0001

<0.0001

83

 

Gingivitis >3 months

All trials

16

‐0.21 (‐0.31 to ‐0.12)

<0.0001

<0.0001

51

Full mouth

14

‐0.25 (‐0.37 to ‐0.13)

<0.0001

0.006

56

Low risk of bias

2

‐0.12 (‐0.52 to 0.27)

0.54

0.52

0

Manufacturer funded

10

‐0.21 (‐0.35 to ‐0.07)

0.003

0.003

68

Trials excluding ortho patients

16 (all)

‐0.21 (‐0.31 to ‐0.12)

<0.0001

<0.0001

51

SMD = standardised mean difference

Converting SMDs back to original indices

As the results of both gingivitis and plaque meta‐analyses were calculated as SMDs, which are unit‐less and difficult to interpret, we re‐expressed them in Summary of findings table 1 by calculating SMDs back into the most commonly reported indices (Quigley Hein for plaque and Löe Silness for gingivitis). In order to back translate we calculated the mean difference by multiplying the median standard deviation of the control group (end of study mean) by the pooled SMD. The table below shows this for plaque and gingivitis in both the short and long term. The differences are also expressed as percentage reductions of the median control group mean.

Plaque index

Time

Pooled SMD

Control mean*

Control standard deviation*

Difference in mean scores (95% CI)

Difference as % of control mean

Quigley Hein

1‐3 months

‐0.50 (‐0.70 to ‐0.31)

2.16

0.46

‐0.23 (‐0.32 to ‐0.14)

11%

Quigley Hein

>3 months

‐0.47 (‐0.82 to ‐0.11)

1.05

0.46

‐0.22 (‐0.38 to ‐0.05)

21%

Gingivitis index

Time

Pooled SMD

Control mean*

Control standard deviation*

Difference in mean scores (95% CI)

Difference as % of control mean

Löe Silness

1‐3 months

‐0.43 (‐0.60 to ‐0.25)

1.1

0.16

‐0.07 (‐0.10 to ‐0.04)

6%

Löe Silness

>3 months

‐0.21 (‐0.31 to ‐0.12)

0.74

0.4

‐0.08 (‐0.12 to ‐0.05)

11%

*median values for all trials presenting data using chosen indices (i.e. Quigley Hein for plaque; Löe Silness for gingivitis).

Publication bias

Publication bias was assessed for the studies included in the meta‐analysis for all powered toothbrushes versus manual for the one to three month assessments. Both funnel plots appear asymmetrical in visual interpretation (Figure 4; Figure 5) with some evidence of publication bias. A formal test of small study effects (Egger test) was undertaken for the Quigley Hein (Turesky) index for plaque and the Löe Silness index for gingivitis. The slope was not significant for either index (P value = 0.203; 0.56) and the hypothesis of no small study effects was also not significant (P value = 0.748; 0.15). From the statistical tests there was no evidence of any publication bias.


Funnel plot of Comparison 1: All powered toothbrushes versus manual toothbrushes, Outcome 1.1: Plaque scores at 1 to 3 months at all sites.

Funnel plot of Comparison 1: All powered toothbrushes versus manual toothbrushes, Outcome 1.1: Plaque scores at 1 to 3 months at all sites.


Funnel plot of Comparison 1: All powered toothbrushes versus manual toothbrushes, Outcome 1.2: Gingival scores at 1 to 3 months at all sites.

Funnel plot of Comparison 1: All powered toothbrushes versus manual toothbrushes, Outcome 1.2: Gingival scores at 1 to 3 months at all sites.

Secondary outcomes

Cost

None of the included trials reported on the relative costs of manual compared with powered toothbrushes.

Reliability

One trial reported a mechanical failure of one of the 48 powered toothbrushes used (Clerehugh 1998) and one trial reported mechanical failure in four of 20 powered brushes (Yukna 1993b). No other mechanical failures were reported.

Calculus

Three trials (Dentino 2002; Glass 1965; van der Weijden 1994) reported on calculus, two reporting that there was no significant difference between the brush types (Glass 1965; van der Weijden 1994) and one reporting that, compared to the manual brush, the powered brush group showed a significant favourable difference in the accumulation of calculus at six months (P value < 0.01) (Dentino 2002).

Stain

Three trials reported that there was no difference in the degree of staining on the teeth between the brush types (Dentino 2002; Glass 1965; Walsh 1989).

Adverse events ‐ Tissue trauma

There was no apparent relationship between the use of powered toothbrushes and soft tissue trauma. In part this finding was due to the very small number of adverse events reported in the trials.

Sixteen trials did not report on adverse events (Biavati Silvestrini 2010; Costa 2007; Galgut 1996; Goyal 2007; Haffajee 2001a; Ho 1997; Lazarescu 2003; Lobene 1964a; Moritis 2008; Rosema 2008; Sharma 2010; Silverman 2004; Soparkar 1964; Van Swol 1996; Zimmer 2002; Zimmer 2005 ). Of the 40 trials that did report on adverse events, 27 reported no trauma to soft or hard tissues or both (Ainamo 1997; Biesbrock 2007; Clerehugh 1998; Dentino 2002; Dorfer 2009; Emling 1991; Forgas‐B 1998; Galgut 1996; Garcia‐Godoy 2001; Glass 1965; Heasman 1999; Hickman 2002; McCracken 2009; Moreira 2007; Pucher 1999; Sharma 2000; Singh unpublished; Soparkar 2000; Sowinski 2000; Stabholz 1996; Stoltze 1994; Toto 1966; Walsh 1989; Warren 2001; Wilson 1993; Yankell 1996; Yankell 1997) and six reported no significant differences between powered and manual toothbrushes, or that tissue trauma was negligible (Baab 1989; Barnes 1993; Cronin 1998; Lapiere unpublished; O'Beirne 1996; Terezhalmy 1995a).

Therefore, of the 56 studies, there were seven trials that described differences in tissue trauma between participants using manual and powered toothbrushes. One trial reported five cases of gingival abrasion in the manual and one case of abrasion in the powered group (Tritten 1996), another reported 12 cases of gingival abrasion in the manual and five cases of gingival abrasion in the powered group (van der Weijden 1994). One trial reported seven soft tissue abnormalities in six participants in the manual group and 10 abnormalities in seven participants in the powered group (Johnson 1994). In the trial by Yukna et al (Yukna 1993b) four cases of abrasion were reported in the powered toothbrush group and one in the manual group. Khocht 1992 reported soft tissue changes in four participants using the manual toothbrush, six using the experimental powered toothbrush and one participant using a control powered toothbrush. In the trial by McCracken 2004, soft tissue lesion which included abrasion and ulcer were reported in eight of manual toothbrushes group and five in powered toothbrushes group. Gugerli 2007 reported three cases of abrasion in both manual and powered toothbrushes. These soft tissue changes were seen as transient irritations that were possibly/probably due to the product.

Discussion

We brush our teeth for many reasons: to feel fresh and confident; to have a nice smile; to avoid bad breath and to avoid disease. The selection of one's toothbrush is largely a matter of personal preference, affordability, availability and professional recommendation. Powered toothbrushes may have a particular appeal to some because they represent a 'high tech' solution to an everyday task. There is overwhelming evidence that toothbrushing reduces gingivitis (Lang 1973). It may prevent periodontitis and certainly prevents tooth decay if carried out in conjunction with fluoride toothpaste. These benefits occur whether the brush is manual or powered and the results of this review do not indicate that toothbrushing is only worthwhile with a powered toothbrush.

Summary of main results

The results of this review demonstrate that powered toothbrushes remove statistically significantly more plaque and gingivitis than manual brushes in both the short and long term. The results of the meta‐analyses are presented as standardised mean differences (SMD), which do not relate to tangible differences in clinical indices. To help interpret the magnitude of the effect, the results of the 'all powered toothbrushes' meta‐analysis have been back‐translated to the most commonly reported plaque and gingivitis indices. An 11% reduction in plaque was shown at one to three months for the Quigley Hein (Turesky) index and a 21% reduction in plaque at longer than three months. The longer term result was based only on 14 trials, compared to 40 trials for the short‐term analysis. With regard to gingivitis a 6% reduction was seen at one to three months for the Löe Silness index, based on 44 trials, and a greater reduction of 11% in the long term (16 trials).

When looking at individual modes of action of powered brushes there are inconsistencies with regard to reductions of plaque and gingivitis. Rotation oscillation brushes showed statistically significant reductions in both plaque and gingivitis at both time points. All other brushes, apart from side to side, showed some statistically significant findings but not consistently across both outcomes and time points. It is difficult to explain this inconsistency that a particular toothbrush design could affect plaque or gingivitis at one time but not at another and so the findings of these analyses may warrant further research, particularly given the small number of trials for some modes of action.

Overall completeness and applicability of evidence

The effectiveness of powered toothbrushes in removing plaque and reducing gingivitis can be related to destructive periodontal disease (periodontitis) only with some difficulty. Many factors are associated with the occurrence of periodontitis including plaque, tobacco use and individual medical factors. Periodontitis takes many years to develop whereas the trials have much shorter follow‐up. There is little compelling evidence that plaque and gingivitis are reliable proxies for long‐term destructive disease and it is difficult to estimate a threshold for clinically important reductions in either. We conclude that powered brushes reduce plaque accumulation and gingivitis but the clinical importance of these reductions cannot be assessed. More high quality long‐term studies are required to investigate the effectiveness of rotation oscillation brushes in the treatment and prevention of periodontitis.

Some authorities have advocated the use of arbitrary thresholds to make superiority claims for a specific product. For example, Imrey has proposed that a product cannot be claimed to be superior unless it provides a 20% improvement in performance (which was not the case for any types of brush in this review, in terms of long‐term plaque removal) (Imrey 1992; Imrey 1994). However, other authors have criticised the use of arbitrary thresholds and prefer a threshold for clinical significance to be decided in advance and selected on clinical grounds (D'Agostino 1992).

Few data were reported on the costs or reliability of the brushes or the side effects of their use. When reported, injuries to the gums were minor and transient.

Many factors may influence the effectiveness of toothbrushes including filament arrangement, orientation, size, shape and flexibility, brush head size and shape along with presence or absence and characteristics of a timer, that not all of them could be isolated and analysed. Whether the brush has a battery or rechargeable power source may also be important. These factors could be considered in subgroup analyses in the parallel review of different powered toothbrushes by Deacon and colleagues (Deacon 2010). More recently powered toothbrushes have been introduced with multidimensional actions (for example the filaments on some rotation oscillation brushes now also move in and out towards the tooth). Trials of such designs are yet to be identified.

The funnel plots for the trials of all powered toothbrushes were skewed for both plaque and gingivitis. This observation suggests but does not conclusively demonstrate publication bias. In the review intervention effects were measured by SMDs, which are naturally correlated with their standard error, which can produce spurious asymmetry in funnel plots. Other potential factors that may contribute to asymmetry include poor methodological quality of studies, true heterogeneity and the play of chance.

Publication bias might be expected in the reporting of toothbrush trials as manufacturers would like to have scientific support for the effectiveness of their products. Studies sponsored by pharmaceutical companies are more likely to favour the sponsor (Lexchin 2003). There was no evidence of this when publication bias was examined statistically, and no evidence of a difference in effect estimates when a sensitivity analysis was conducted for trials which did not mention commercial funding. It should be noted that the methods for detecting publication bias relate effect size to sample size, and in this review the trials tend to be of similar size. Therefore other methods may be required to examine publication bias in short‐term, low cost studies.

Quality of the evidence

The current review focused purely on truly randomised trials. Five trials were assessed as at low risk of bias (8.9%), five at high risk of bias (8.9%) and the remaining 46 trials (82%) at unclear risk of bias. Only three trials were able to be used in the sensitivity analysis for trials at low risk of bias. These trials were unable to demonstrate statistically significant differences between powered and manual toothbrushes, although the effect estimates for plaque and gingivitis at one to three months were higher than those for all trials.

There was considerable unexplained heterogeneity in the meta‐analyses for plaque and gingivitis for the primary analysis of powered toothbrushes versus manual brushes, and for the meta‐analyses of individual modes of action. This heterogeneity could not be explained.

Flow chart of study selection in this update.
Figuras y tablas -
Figure 1

Flow chart of study selection in this update.

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
Figuras y tablas -
Figure 2

Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
Figuras y tablas -
Figure 3

Risk of bias summary: review authors' judgements about each risk of bias item for each included study.

Funnel plot of Comparison 1: All powered toothbrushes versus manual toothbrushes, Outcome 1.1: Plaque scores at 1 to 3 months at all sites.
Figuras y tablas -
Figure 4

Funnel plot of Comparison 1: All powered toothbrushes versus manual toothbrushes, Outcome 1.1: Plaque scores at 1 to 3 months at all sites.

Funnel plot of Comparison 1: All powered toothbrushes versus manual toothbrushes, Outcome 1.2: Gingival scores at 1 to 3 months at all sites.
Figuras y tablas -
Figure 5

Funnel plot of Comparison 1: All powered toothbrushes versus manual toothbrushes, Outcome 1.2: Gingival scores at 1 to 3 months at all sites.

Comparison 1 All powered toothbrushes versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 month at all sites.
Figuras y tablas -
Analysis 1.1

Comparison 1 All powered toothbrushes versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 month at all sites.

Comparison 1 All powered toothbrushes versus manual toothbrushes, Outcome 2 Gingival scores at 1 to 3 months at all sites.
Figuras y tablas -
Analysis 1.2

Comparison 1 All powered toothbrushes versus manual toothbrushes, Outcome 2 Gingival scores at 1 to 3 months at all sites.

Comparison 1 All powered toothbrushes versus manual toothbrushes, Outcome 3 Plaque scores at >3 months.
Figuras y tablas -
Analysis 1.3

Comparison 1 All powered toothbrushes versus manual toothbrushes, Outcome 3 Plaque scores at >3 months.

Comparison 1 All powered toothbrushes versus manual toothbrushes, Outcome 4 Gingival scores at >3 months.
Figuras y tablas -
Analysis 1.4

Comparison 1 All powered toothbrushes versus manual toothbrushes, Outcome 4 Gingival scores at >3 months.

Comparison 2 Side to side powered toothbrushes versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 month at all sites.
Figuras y tablas -
Analysis 2.1

Comparison 2 Side to side powered toothbrushes versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 month at all sites.

Comparison 2 Side to side powered toothbrushes versus manual toothbrushes, Outcome 2 Gingival scores at 1 to 3 months at all sites.
Figuras y tablas -
Analysis 2.2

Comparison 2 Side to side powered toothbrushes versus manual toothbrushes, Outcome 2 Gingival scores at 1 to 3 months at all sites.

Comparison 2 Side to side powered toothbrushes versus manual toothbrushes, Outcome 3 Plaque scores at >3 months.
Figuras y tablas -
Analysis 2.3

Comparison 2 Side to side powered toothbrushes versus manual toothbrushes, Outcome 3 Plaque scores at >3 months.

Comparison 2 Side to side powered toothbrushes versus manual toothbrushes, Outcome 4 Gingival scores at >3 months.
Figuras y tablas -
Analysis 2.4

Comparison 2 Side to side powered toothbrushes versus manual toothbrushes, Outcome 4 Gingival scores at >3 months.

Comparison 3 Counter oscillation powered toothbrushes versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 month at all sites.
Figuras y tablas -
Analysis 3.1

Comparison 3 Counter oscillation powered toothbrushes versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 month at all sites.

Comparison 3 Counter oscillation powered toothbrushes versus manual toothbrushes, Outcome 2 Gingivitis scores at 1 to 3 months at all sites.
Figuras y tablas -
Analysis 3.2

Comparison 3 Counter oscillation powered toothbrushes versus manual toothbrushes, Outcome 2 Gingivitis scores at 1 to 3 months at all sites.

Comparison 3 Counter oscillation powered toothbrushes versus manual toothbrushes, Outcome 3 Plaque scores at >3 months.
Figuras y tablas -
Analysis 3.3

Comparison 3 Counter oscillation powered toothbrushes versus manual toothbrushes, Outcome 3 Plaque scores at >3 months.

Comparison 3 Counter oscillation powered toothbrushes versus manual toothbrushes, Outcome 4 Gingival scores at >3 months.
Figuras y tablas -
Analysis 3.4

Comparison 3 Counter oscillation powered toothbrushes versus manual toothbrushes, Outcome 4 Gingival scores at >3 months.

Comparison 4 Rotation oscillation powered toothbrushes versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 month at all sites.
Figuras y tablas -
Analysis 4.1

Comparison 4 Rotation oscillation powered toothbrushes versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 month at all sites.

Comparison 4 Rotation oscillation powered toothbrushes versus manual toothbrushes, Outcome 2 Gingival scores at 1 to 3 months at all sites.
Figuras y tablas -
Analysis 4.2

Comparison 4 Rotation oscillation powered toothbrushes versus manual toothbrushes, Outcome 2 Gingival scores at 1 to 3 months at all sites.

Comparison 4 Rotation oscillation powered toothbrushes versus manual toothbrushes, Outcome 3 Plaque scores at >3 months.
Figuras y tablas -
Analysis 4.3

Comparison 4 Rotation oscillation powered toothbrushes versus manual toothbrushes, Outcome 3 Plaque scores at >3 months.

Comparison 4 Rotation oscillation powered toothbrushes versus manual toothbrushes, Outcome 4 Gingival scores at >3 months.
Figuras y tablas -
Analysis 4.4

Comparison 4 Rotation oscillation powered toothbrushes versus manual toothbrushes, Outcome 4 Gingival scores at >3 months.

Study

Plaque

Gingivitis

Costa 2007

No statistically significant pre‐post differences shown

No statistically significant pre‐post differences shown

Gugerli 2007

"Subjects using a power toothbrush during initial treatment reduced supragingival plaque to lower levels...than subjects using a manual brush"

"Subjects using a power toothbrush ...showed significantly less bleeding on probing than subjects using a manual brush"

Zimmer 2005

Median change in Quigely‐Hein at 4 weeks:

Powered (Cybersonic): 0.23

Powered (Braun 3D Excel): 0.07

Manual: 0.22

Median change in Quigely‐Hein at 8 weeks:

Powered (Cybersonic): 0.41

Powered (Braun 3D Excel): 0.08

Manual: 0.35

All indices showed statistically significant reductions for both power
toothbrushes which were superior to the manual brush

Median change in papillary bleeding index at 4 weeks:

Powered (Cybersonic): 0.25

Powered (Braun 3D Excel): 0.02

Manual: 0.39

Median change in papillary bleeding index at 8 weeks:

Powered (Cybersonic): 0.36

Powered (Braun 3D Excel): 0.10

Manual: 0.61

Figuras y tablas -
Analysis 4.5

Comparison 4 Rotation oscillation powered toothbrushes versus manual toothbrushes, Outcome 5 Rotation oscillation versus manual: data not suitable for meta‐analysis.

Comparison 5 Circular powered toothbrushes versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 month at all sites.
Figuras y tablas -
Analysis 5.1

Comparison 5 Circular powered toothbrushes versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 month at all sites.

Comparison 5 Circular powered toothbrushes versus manual toothbrushes, Outcome 2 Gingival scores at 1 to 3 months at all sites.
Figuras y tablas -
Analysis 5.2

Comparison 5 Circular powered toothbrushes versus manual toothbrushes, Outcome 2 Gingival scores at 1 to 3 months at all sites.

Comparison 6 Ionic toothbrushes versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 months.
Figuras y tablas -
Analysis 6.1

Comparison 6 Ionic toothbrushes versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 months.

Comparison 6 Ionic toothbrushes versus manual toothbrushes, Outcome 2 Plaque scores at >3 months at all sites.
Figuras y tablas -
Analysis 6.2

Comparison 6 Ionic toothbrushes versus manual toothbrushes, Outcome 2 Plaque scores at >3 months at all sites.

Comparison 6 Ionic toothbrushes versus manual toothbrushes, Outcome 3 Gingivitis at 1 to 3 months.
Figuras y tablas -
Analysis 6.3

Comparison 6 Ionic toothbrushes versus manual toothbrushes, Outcome 3 Gingivitis at 1 to 3 months.

Comparison 6 Ionic toothbrushes versus manual toothbrushes, Outcome 4 Gingival scores at >3 months at all sites.
Figuras y tablas -
Analysis 6.4

Comparison 6 Ionic toothbrushes versus manual toothbrushes, Outcome 4 Gingival scores at >3 months at all sites.

Study

Plaque

Gingivitis

Galgut 1996

The electrically active toothbrushes better plaque removal than the inactive toothbrushes (6.5% more plaque removal at final visit)

Not reported

Moreira 2007

Frequency distribution for plaque zero at baseline and 28 days was 9.27+/‐ 10.14/17.75+/‐9.60 and 8.42+/‐10.43/16.79+/‐8.93 for ionic and conventional toothbrushes respectively

Not reported

Figuras y tablas -
Analysis 6.5

Comparison 6 Ionic toothbrushes versus manual toothbrushes, Outcome 5 Ionic versus manual: data not suitable for meta‐analysis.

Comparison 7 Ultrasonic powered toothbrushes versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 month at all sites.
Figuras y tablas -
Analysis 7.1

Comparison 7 Ultrasonic powered toothbrushes versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 month at all sites.

Comparison 7 Ultrasonic powered toothbrushes versus manual toothbrushes, Outcome 2 Gingival scores at 1 to 3 months at all sites.
Figuras y tablas -
Analysis 7.2

Comparison 7 Ultrasonic powered toothbrushes versus manual toothbrushes, Outcome 2 Gingival scores at 1 to 3 months at all sites.

Comparison 7 Ultrasonic powered toothbrushes versus manual toothbrushes, Outcome 3 Plaque scores at >3 months at all sites.
Figuras y tablas -
Analysis 7.3

Comparison 7 Ultrasonic powered toothbrushes versus manual toothbrushes, Outcome 3 Plaque scores at >3 months at all sites.

Comparison 7 Ultrasonic powered toothbrushes versus manual toothbrushes, Outcome 4 Gingival scores at >3 months.
Figuras y tablas -
Analysis 7.4

Comparison 7 Ultrasonic powered toothbrushes versus manual toothbrushes, Outcome 4 Gingival scores at >3 months.

Study

Plaque

Gingivitis

Costa 2007

"There was a significant difference for the ultrasonic/buccal group indicating that the ultrasonic brush improved plaque reduction on the buccal surfaces (p=0.007, Wilcoxon test)"

Marginal bleeding: "No significant differences were noted in the nine subgroups (p>0.05, Wilcoxon test)"

Zimmer 2005

"Improvements of the indices after 4 and 8 weeks were calculated for comparison between groups. After 4 and 8 weeks, with respect to all indices, the use of the power toothbrushes resulted in improvements which were statistically significant superior to what was found for the manual brush (p<0.001)." Results were presented as box‐plots with medians and 25, 75 percentiles. Non‐parametric tests have been used for the data analysis

"Improvements of the indices after 4 and 8 weeks were calculated for comparison between groups. After 4 and 8 weeks, with respect to all indices, the use of the power toothbrushes resulted in improvements which were statistically significant superior to what was found for the manual brush (p<0.001)." Results were presented as box‐plots with medians and 25, 75 percentiles. Non‐parametric tests have been used for the data analysis

Figuras y tablas -
Analysis 7.5

Comparison 7 Ultrasonic powered toothbrushes versus manual toothbrushes, Outcome 5 Ultrasonic versus manual: data not suitable for meta‐analysis.

Comparison 8 Unknown or other action versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 months at all sites.
Figuras y tablas -
Analysis 8.1

Comparison 8 Unknown or other action versus manual toothbrushes, Outcome 1 Plaque scores at 1 to 3 months at all sites.

Comparison 8 Unknown or other action versus manual toothbrushes, Outcome 2 Gingival scores at 1 to 3 months at all sites.
Figuras y tablas -
Analysis 8.2

Comparison 8 Unknown or other action versus manual toothbrushes, Outcome 2 Gingival scores at 1 to 3 months at all sites.

Comparison 8 Unknown or other action versus manual toothbrushes, Outcome 3 Gingival scores >3 months at all sites.
Figuras y tablas -
Analysis 8.3

Comparison 8 Unknown or other action versus manual toothbrushes, Outcome 3 Gingival scores >3 months at all sites.

Powered toothbrushes compared with manual toothbrushes for oral health

Patient or population: Individuals of any age with no reported disability that might affect toothbrushing

Intervention: Powered toothbrushes with any mode of action

Comparison: Manual toothbrushes

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect
(95% CI)

No of participants
(studies)

Quality of the evidence
(GRADE)

Comments

Assumed risk

Corresponding risk

Manual toothbrush

Powered toothbrush

Plaque scores at 1 to 3 months

Scale from: 0 to 5

The mean plaque score in the control group was 2.16 points1

The mean plaque score in the intervention groups was
0.23 lower (0.32 lower to 0.14 lower)

2871 (40 studies)

⊕⊕⊕⊝
moderate3,4

This effect represents an 11% reduction in plaque at 1 to 3 months

Long‐term data (>3 months) also showed a statistically significant reduction in plaque for powered toothbrushes compared to manual toothbrushes

Gingival scores at 1 to 3 months

Scale from: 0 to 3

The mean gingivitis score in the control group was 1.1 points2

The mean gingivitis score in the intervention groups was
0.07 lower (0.10 lower to 0.04 lower)

3345
(44 studies)

⊕⊕⊕⊝
moderate3,4

This effect represents a 6% reduction in gingivitis at 1 to 3 months

Long‐term data (>3 months) also showed a statistically significant reduction in gingivitis for powered toothbrushes compared to manual toothbrushes

Adverse events

There was no apparent relationship between the use of powered toothbrushes and soft tissue trauma. In part this finding was due to the very small number of adverse events reported in the trials

*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI)
CI: confidence interval

GRADE Working Group grades of evidence
High quality: Further research is very unlikely to change our confidence in the estimate of effect
Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate
Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate
Very low quality: We are very uncertain about the estimate

1. Based on median of control means for all trials presenting data using Quigley Hein index at 1 to 3 months

2. Based on median of control means for all trials presenting data using Löe and Silness index at 1 to 3 months

3. Downgraded due to statistically significant heterogeneity (I2 = 83% for plaque; I2 = 82% for gingivitis)

4. No downgrading was undertaken for risk of bias although 46/56 included trials were assessed as being at unclear risk of bias. Given that many of the studies were conducted over 10 years ago, it was felt much of the uncertainty may be due to poor reporting

Figuras y tablas -
Table 1. Summary of inclusion criteria categories within included studies

Inclusion criteria

Number (n = 56)

Adults

43

Minimum number of teeth

31

Minimum periodontal baseline measures

28

Participants recruited from dental clinics

9

Concurrent fixed orthodontic treatment

8

Some participants aged less than 16 years

11

Volunteer university students

3

Dental students

2

School children

3

Figuras y tablas -
Table 1. Summary of inclusion criteria categories within included studies
Table 2. Summary of exclusion criteria categories within included studies

Exclusion criteria1

Number (n = 56)

Exclusion criteria related to medical history

31

Pregnancy or lactation

5

Previous use of powered toothbrushes

6

Patients undergoing orthodontic treatment

9

Previous periodontal treatment

3

Dental students

2

Cervical restorations

1

Smoking

3

Maximum periodontal measure

8

Wearing partial denture

2

1 Not all trials explicitly stated exclusion criteria

Figuras y tablas -
Table 2. Summary of exclusion criteria categories within included studies
Table 3. Summary of toothbrush modes of action, number of trials and participants

Mode of action

Trial ID

Number of trials

Number in trials

Side to side

Glass 1965, Ho 1997, Johnson 1994, Lobene 1964, McCracken 2009, Moritis 2008, O'Beirne 1996, Tritten 1996, Walsh 1989, Yankell 1997

10

988

Counter oscillation

Baab 1989, Khocht 1992, Stabholz 1996, Wilson 1993, Yukna 1993

5

267

Rotation oscillation

Ainamo 1997, Barnes 1993, Biavati Silvestrini 2010, Biesbrock 2007, Clerehugh 1998, Costa 2007, Cronin 1998, Dentino 2002, Dorfer 2009, Garcia‐Godoy 2001, Gugerli 2007, Haffajee 2001a, Heasman 1999, Hickman 2002, Lapiere unpublished, Lazarescu unpublished, McCracken 2004, Rosema 2008, Sharma 2000, Silverman 2004, Soparkar 2000, Sowinski 2000, Stoltze 1994, van der Weijden 1994, Warren 2001, Yankell 1997, Zimmer 2005

27

2159

Circular

Khocht 1992, Yankell 1996

2

162

Ultrasonic

Costa 2007, Forgas‐B 1998, Goyal 2007, Sharma 2010, Terezhalmy 1995, Zimmer 2002, Zimmer 2005

7

506

Unknown

Emling 1991, Kallar 2011, Singh unpublished, Soparkar 1964, Toto 1966

5

1130

Ionic

Galgut 1996, Moreira 2007, Pucher 1999, van Swol 1996

4

221

Four trials evaluated two powered toothbrushes

Figuras y tablas -
Table 3. Summary of toothbrush modes of action, number of trials and participants
Table 4. Sensitivity analyses of all trials for all indices

Index

Group selected

Number of trials

SMD

Effect P value

Het. P value

I2

Plaque

1‐3 months

All trials

40

‐0.50 (‐0.70 to ‐0.31)

<0.0001

<0.0001

88

Full mouth

34

‐0.58 (‐0.80 to ‐0.36)

<0.0001

<0.0001

85

Low risk of bias

3

‐0.83 (‐2.02 to 0.36)

0.17

<0.0001

94

Manufacturer funded

26

‐0.56 (‐0.82 to ‐0.29)

<0.0001

<0.0001

88

Trials excluding ortho patients

36

‐0.46 (‐0.66 to ‐0.27)

<0.0001

<0.0001

83

Plaque

>3 months

All trials

14

‐0.37 (‐0.50 to ‐0.24)

<0.0001

<0.0001

86

Full mouth

13

‐0.39 (‐0.53 to ‐0.26)

<0.0001

<0.0001

87

Low risk of bias

2

0.12 (‐0.27 to 0.52)

0.53

0.51

0

Manufacturer funded

9

‐0.41 (‐0.56 to ‐0.25)

<0.0001

<0.0001

91

Trials excluding ortho patients

14 (all)

‐0.37 (‐0.50 to ‐0.24)

<0.0001

<0.0001

86

Gingivitis

1‐3 months

All trials

44

‐0.43 (‐0.60 to ‐0.25)

<0.0001

<0.0001

82

Full mouth

35

‐0.47 (‐0.68 to ‐0.25)

<0.0001

<0.0001

85

Low risk of bias

3

‐0.96 (‐1.95 to 0.03)

0.06

<0.0001

93

Manufacturer funded

32

‐0.47 (‐0.68 to ‐0.26)

<0.0001

<0.0001

84

Trials excluding ortho patients

38

‐0.42 (‐0.61 to ‐0.23)

<0.0001

<0.0001

83

 

Gingivitis >3 months

All trials

16

‐0.21 (‐0.31 to ‐0.12)

<0.0001

<0.0001

51

Full mouth

14

‐0.25 (‐0.37 to ‐0.13)

<0.0001

0.006

56

Low risk of bias

2

‐0.12 (‐0.52 to 0.27)

0.54

0.52

0

Manufacturer funded

10

‐0.21 (‐0.35 to ‐0.07)

0.003

0.003

68

Trials excluding ortho patients

16 (all)

‐0.21 (‐0.31 to ‐0.12)

<0.0001

<0.0001

51

SMD = standardised mean difference

Figuras y tablas -
Table 4. Sensitivity analyses of all trials for all indices
Comparison 1. All powered toothbrushes versus manual toothbrushes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Plaque scores at 1 to 3 month at all sites Show forest plot

40

2871

Std. Mean Difference (IV, Random, 95% CI)

‐0.50 [‐0.70, ‐0.31]

1.1 Quigley Hein (Turesky)

28

2000

Std. Mean Difference (IV, Random, 95% CI)

‐0.39 [‐0.56, ‐0.22]

1.2 Silness and Löe

6

431

Std. Mean Difference (IV, Random, 95% CI)

‐0.94 [‐1.83, ‐0.05]

1.3 Visible plaque index Ainamo Bay

1

111

Std. Mean Difference (IV, Random, 95% CI)

‐0.26 [‐0.63, 0.12]

1.4 Ortho modification of Silness and Löe

1

60

Std. Mean Difference (IV, Random, 95% CI)

0.0 [‐0.51, 0.51]

1.5 Navy plaque index mod Rustogi

3

249

Std. Mean Difference (IV, Random, 95% CI)

‐1.13 [‐1.94, ‐0.31]

1.6 O'Leary index

1

20

Std. Mean Difference (IV, Random, 95% CI)

‐1.81 [‐2.88, ‐0.73]

2 Gingival scores at 1 to 3 months at all sites Show forest plot

44

3345

Std. Mean Difference (IV, Random, 95% CI)

‐0.43 [‐0.60, ‐0.25]

2.1 Löe and Silness

30

2109

Std. Mean Difference (IV, Random, 95% CI)

‐0.46 [‐0.66, ‐0.25]

2.2 Lobene gingival index

8

907

Std. Mean Difference (IV, Random, 95% CI)

‐0.43 [‐0.88, 0.03]

2.3 BOP

3

159

Std. Mean Difference (IV, Random, 95% CI)

‐0.19 [‐0.50, 0.12]

2.4 Papillary bleeding index 0‐4 scale

2

95

Std. Mean Difference (IV, Random, 95% CI)

‐0.11 [‐1.55, 1.33]

2.5 BOMP 0‐2 scale

1

75

Std. Mean Difference (IV, Random, 95% CI)

‐0.58 [‐1.04, ‐0.12]

3 Plaque scores at >3 months Show forest plot

14

978

Std. Mean Difference (IV, Random, 95% CI)

‐0.47 [‐0.82, ‐0.11]

3.1 Quigley Hein (Turesky)

11

736

Std. Mean Difference (IV, Random, 95% CI)

‐0.51 [‐0.97, ‐0.04]

3.2 Silness and Löe

2

131

Std. Mean Difference (IV, Random, 95% CI)

‐0.38 [‐1.09, 0.34]

3.3 Visible plaque index Ainamo Bay

1

111

Std. Mean Difference (IV, Random, 95% CI)

‐0.28 [‐0.66, 0.09]

4 Gingival scores at >3 months Show forest plot

16

1645

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.21 [‐0.31, ‐0.12]

4.1 Löe and Silness

5

318

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.27 [‐0.49, ‐0.05]

4.2 Lobene gingival index

4

440

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.14 [‐0.33, 0.04]

4.3 BOP

4

270

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.46 [‐0.70, ‐0.22]

4.4 Papillary bleeding index 0‐4 scale

1

32

Std. Mean Difference (IV, Fixed, 95% CI)

0.65 [‐0.07, 1.36]

4.5 BOMP 0‐2 scale

1

75

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.24 [‐0.69, 0.22]

4.6 PMA

1

510

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.16 [‐0.34, 0.02]

Figuras y tablas -
Comparison 1. All powered toothbrushes versus manual toothbrushes
Comparison 2. Side to side powered toothbrushes versus manual toothbrushes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Plaque scores at 1 to 3 month at all sites Show forest plot

7

570

Std. Mean Difference (IV, Random, 95% CI)

‐0.27 [‐0.77, 0.23]

1.1 Quigley Hein (Turesky)

4

324

Std. Mean Difference (IV, Random, 95% CI)

‐0.14 [‐0.36, 0.08]

1.2 Silness and Löe

3

246

Std. Mean Difference (IV, Random, 95% CI)

‐0.78 [‐2.25, 0.68]

2 Gingival scores at 1 to 3 months at all sites Show forest plot

9

795

Std. Mean Difference (IV, Random, 95% CI)

‐0.32 [‐0.81, 0.17]

2.1 Löe and Silness

6

385

Std. Mean Difference (IV, Random, 95% CI)

‐0.28 [‐0.88, 0.32]

2.2 Lobene gingival index

3

410

Std. Mean Difference (IV, Random, 95% CI)

‐0.39 [‐1.24, 0.46]

3 Plaque scores at >3 months Show forest plot

3

272

Std. Mean Difference (IV, Fixed, 95% CI)

0.02 [‐0.21, 0.26]

3.1 Quigley Hein (Turesky)

2

218

Std. Mean Difference (IV, Fixed, 95% CI)

0.03 [‐0.24, 0.30]

3.2 Silness and Löe

1

54

Std. Mean Difference (IV, Fixed, 95% CI)

0.0 [‐0.53, 0.53]

4 Gingival scores at >3 months Show forest plot

3

272

Std. Mean Difference (IV, Fixed, 95% CI)

0.10 [‐0.14, 0.34]

4.1 Löe and Silness

1

54

Std. Mean Difference (IV, Fixed, 95% CI)

0.0 [‐0.53, 0.53]

4.2 Lobene gingival index

1

166

Std. Mean Difference (IV, Fixed, 95% CI)

0.16 [‐0.14, 0.47]

4.3 BOP

1

52

Std. Mean Difference (IV, Fixed, 95% CI)

0.0 [‐0.54, 0.54]

Figuras y tablas -
Comparison 2. Side to side powered toothbrushes versus manual toothbrushes
Comparison 3. Counter oscillation powered toothbrushes versus manual toothbrushes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Plaque scores at 1 to 3 month at all sites Show forest plot

4

Mean Difference (IV, Random, 95% CI)

Subtotals only

1.1 Quigley Hein (Turesky)

4

184

Mean Difference (IV, Random, 95% CI)

‐0.03 [‐0.15, 0.10]

2 Gingivitis scores at 1 to 3 months at all sites Show forest plot

4

172

Std. Mean Difference (IV, Fixed, 95% CI)

0.01 [‐0.30, 0.31]

2.1 Löe and Silness

2

103

Std. Mean Difference (IV, Fixed, 95% CI)

0.01 [‐0.39, 0.40]

2.2 Lobene gingival index

1

40

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.03 [‐0.65, 0.59]

2.3 BOP

1

29

Std. Mean Difference (IV, Fixed, 95% CI)

0.06 [‐0.68, 0.79]

3 Plaque scores at >3 months Show forest plot

2

Mean Difference (IV, Fixed, 95% CI)

Subtotals only

3.1 Quigley Hein (Turesky)

2

69

Mean Difference (IV, Fixed, 95% CI)

‐0.27 [‐0.48, ‐0.07]

4 Gingival scores at >3 months Show forest plot

2

69

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.19 [‐0.66, 0.29]

4.1 Lobene gingival index

1

40

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.18 [‐0.80, 0.44]

4.2 BOP

1

29

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.19 [‐0.93, 0.54]

Figuras y tablas -
Comparison 3. Counter oscillation powered toothbrushes versus manual toothbrushes
Comparison 4. Rotation oscillation powered toothbrushes versus manual toothbrushes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Plaque scores at 1 to 3 month at all sites Show forest plot

20

1404

Std. Mean Difference (IV, Random, 95% CI)

‐0.53 [‐0.74, ‐0.31]

1.1 Quigley Hein (Turesky)

13

979

Std. Mean Difference (IV, Random, 95% CI)

‐0.44 [‐0.69, ‐0.20]

1.2 Silness and Löe

2

115

Std. Mean Difference (IV, Random, 95% CI)

‐1.17 [‐2.74, 0.40]

1.3 Visible plaque index Ainamo Bay

1

111

Std. Mean Difference (IV, Random, 95% CI)

‐0.26 [‐0.63, 0.12]

1.4 Ortho modification of Silness and Löe

1

60

Std. Mean Difference (IV, Random, 95% CI)

0.0 [‐0.51, 0.51]

1.5 Navy plaque index mod Rustogi

2

119

Std. Mean Difference (IV, Random, 95% CI)

‐0.72 [‐1.09, ‐0.35]

1.6 O'Leary index

1

20

Std. Mean Difference (IV, Random, 95% CI)

‐1.81 [‐2.88, ‐0.73]

2 Gingival scores at 1 to 3 months at all sites Show forest plot

21

1479

Std. Mean Difference (IV, Random, 95% CI)

‐0.49 [‐0.73, ‐0.26]

2.1 Löe and Silness

14

952

Std. Mean Difference (IV, Random, 95% CI)

‐0.68 [‐0.99, ‐0.38]

2.2 Lobene gingival index

3

290

Std. Mean Difference (IV, Random, 95% CI)

‐0.11 [‐0.46, 0.24]

2.3 BOP

2

130

Std. Mean Difference (IV, Random, 95% CI)

‐0.25 [‐0.59, 0.10]

2.4 Papillary bleeding index

1

32

Std. Mean Difference (IV, Random, 95% CI)

0.65 [‐0.07, 1.36]

2.5 BOMP 0‐2 scale

1

75

Std. Mean Difference (IV, Random, 95% CI)

‐0.58 [‐1.04, ‐0.12]

3 Plaque scores at >3 months Show forest plot

7

527

Std. Mean Difference (IV, Random, 95% CI)

‐0.66 [‐1.28, ‐0.03]

3.1 Quigley Hein (Turesky)

5

339

Std. Mean Difference (IV, Random, 95% CI)

‐0.73 [‐1.69, 0.24]

3.2 Silness and Löe

1

77

Std. Mean Difference (IV, Random, 95% CI)

‐0.73 [‐1.19, ‐0.26]

3.3 Visible plaque index Ainamo Bay

1

111

Std. Mean Difference (IV, Random, 95% CI)

‐0.28 [‐0.66, 0.09]

4 Gingival scores at >3 months Show forest plot

8

684

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.35 [‐0.50, ‐0.20]

4.1 Lobene gingival index

2

234

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.36 [‐0.62, ‐0.10]

4.2 BOP

2

189

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.64 [‐0.93, ‐0.34]

4.3 Löe and Silness

2

154

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.25 [‐0.57, 0.07]

4.4 Papillary bleeding index 0‐4 scale

1

32

Std. Mean Difference (IV, Fixed, 95% CI)

0.65 [‐0.07, 1.36]

4.5 BOMP 0‐2 scale

1

75

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.24 [‐0.69, 0.22]

5 Rotation oscillation versus manual: data not suitable for meta‐analysis Show forest plot

Other data

No numeric data

Figuras y tablas -
Comparison 4. Rotation oscillation powered toothbrushes versus manual toothbrushes
Comparison 5. Circular powered toothbrushes versus manual toothbrushes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Plaque scores at 1 to 3 month at all sites Show forest plot

2

128

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.02 [‐0.37, 0.33]

1.1 Quigley Hein (Turesky)

2

128

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.02 [‐0.37, 0.33]

1.2 Silness and Löe

0

0

Std. Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Gingival scores at 1 to 3 months at all sites Show forest plot

2

128

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.18 [‐0.53, 0.17]

2.1 Löe and Silness

1

63

Std. Mean Difference (IV, Fixed, 95% CI)

0.13 [‐0.36, 0.63]

2.2 Lobene gingival index

1

65

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.50 [‐0.99, ‐0.00]

Figuras y tablas -
Comparison 5. Circular powered toothbrushes versus manual toothbrushes
Comparison 6. Ionic toothbrushes versus manual toothbrushes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Plaque scores at 1 to 3 months Show forest plot

3

186

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.57 [‐0.87, ‐0.27]

1.1 Quigley Hein (Turesky)

2

116

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.30 [‐0.67, 0.06]

1.2 Silness and Löe

1

70

Std. Mean Difference (IV, Fixed, 95% CI)

‐1.07 [‐1.57, ‐0.57]

2 Plaque scores at >3 months at all sites Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.1 Quigley Hein (Turesky)

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Gingivitis at 1 to 3 months Show forest plot

2

116

Mean Difference (IV, Fixed, 95% CI)

‐0.01 [‐0.04, 0.02]

3.1 Löe and Silness

2

116

Mean Difference (IV, Fixed, 95% CI)

‐0.01 [‐0.04, 0.02]

4 Gingival scores at >3 months at all sites Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4.1 Löe and Silness

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Ionic versus manual: data not suitable for meta‐analysis Show forest plot

Other data

No numeric data

Figuras y tablas -
Comparison 6. Ionic toothbrushes versus manual toothbrushes
Comparison 7. Ultrasonic powered toothbrushes versus manual toothbrushes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Plaque scores at 1 to 3 month at all sites Show forest plot

4

301

Std. Mean Difference (IV, Fixed, 95% CI)

‐1.33 [‐1.59, ‐1.07]

1.1 Quigley Hein (Turesky)

3

171

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.97 [‐1.30, ‐0.63]

1.2 Navy plaque index mod Rustogi

1

130

Std. Mean Difference (IV, Fixed, 95% CI)

‐1.89 [‐2.30, ‐1.47]

2 Gingival scores at 1 to 3 months at all sites Show forest plot

5

354

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.99 [‐1.21, ‐0.76]

2.1 Löe and Silness

3

161

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.56 [‐0.88, ‐0.25]

2.2 Lobene gingival index

1

130

Std. Mean Difference (IV, Fixed, 95% CI)

‐1.80 [‐2.21, ‐1.39]

2.3 Papillary bleeding index 0‐4 scale

1

63

Std. Mean Difference (IV, Fixed, 95% CI)

‐0.82 [‐1.34, ‐0.31]

3 Plaque scores at >3 months at all sites Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3.1 Quigley Hein

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

4 Gingival scores at >3 months Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

4.1 Löe and Silness

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

5 Ultrasonic versus manual: data not suitable for meta‐analysis Show forest plot

Other data

No numeric data

Figuras y tablas -
Comparison 7. Ultrasonic powered toothbrushes versus manual toothbrushes
Comparison 8. Unknown or other action versus manual toothbrushes

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Plaque scores at 1 to 3 months at all sites Show forest plot

2

Std. Mean Difference (IV, Fixed, 95% CI)

Totals not selected

1.1 Quigley Hein (Turesky)

2

Std. Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

2 Gingival scores at 1 to 3 months at all sites Show forest plot

3

Std. Mean Difference (IV, Fixed, 95% CI)

Totals not selected

2.1 Löe and Sillness

3

Std. Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

3 Gingival scores >3 months at all sites Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

3.1 PMA

1

Mean Difference (IV, Fixed, 95% CI)

0.0 [0.0, 0.0]

Figuras y tablas -
Comparison 8. Unknown or other action versus manual toothbrushes