Clomiphene and anti‐oestrogens for ovulation induction in PCOS
Información
- DOI:
- https://doi.org/10.1002/14651858.CD002249.pub4Copiar DOI
- Base de datos:
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- Cochrane Database of Systematic Reviews
- Versión publicada:
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- 07 octubre 2009see what's new
- Tipo:
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- Intervention
- Etapa:
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- Review
- Grupo Editorial Cochrane:
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Grupo Cochrane de Ginecología y fertilidad
- Copyright:
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- Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Cifras del artículo
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Autores
Contributions of authors
Julie Brown: wrote the updated version of this review including identification of new trials, data extraction and analysis.
Cindy Farquhar: initiated and conceptualised the protocol, commented on drafts of the original and updated review and assisted in the identification of new trials and data extraction for the review update.
Clare Boothroyd: wrote the initial version of the protocol and commented on drafts of the review.
James Beck: updated the protocol and performed the primary literature search, initial assessment of trials and quality analysis, data collection, analysis and wrote the initial draft of the review.
Michelle Proctor: checked the literature search, reviewed quality analysis and data collection, checked and revised the initial draft of the review.
Edward Hughes: provided clinical input for the review and commented on drafts of the review.
Sources of support
Internal sources
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University of Newcastle Upon Tyne, School of Medicine, Newcastle Upon Tyne, UK.
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University of Auckland, School of Medicine, Auckland, New Zealand.
External sources
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No sources of support supplied
Declarations of interest
None known
Acknowledgements
This review includes work from a previous review on clomiphene for ovulation induction by E Hughes, J Collins and P Vandekerckhove (Hughes 1996).
The authors wish to thank Sue Hall and Jane Marjoribanks for their help and support. Thanks also to Ruth Buist for helping with the searches, Richmal Oates‐Whitehead and Anne Lethaby for translating and Neil Johnson and Ian Beck for their clinical input.
Version history
| Published | Title | Stage | Authors | Version |
| 2016 Dec 15 | Clomiphene and other antioestrogens for ovulation induction in polycystic ovarian syndrome | Review | Julie Brown, Cindy Farquhar | |
| 2009 Oct 07 | Clomiphene and anti‐oestrogens for ovulation induction in PCOS | Review | Julie Brown, Cindy Farquhar, James Beck, Clare Boothroyd, Edward Hughes | |
| 2009 Jul 08 | Oral anti‐oestrogens and medical adjuncts for subfertility associated with anovulation | Review | Julie Brown , Cindy Farquhar, James Beck, Clare Boothroyd, Michelle Proctor, Edward Hughes | |
| 2004 Jul 19 | Oral anti‐oestrogens and medical adjuncts for subfertility associated with polycystic ovary syndrome | Protocol | James I Beck, Clare Boothroyd, Cindy M Farquhar | |
| 2000 Jul 24 | Oral agents for ovulation induction in subfertility associated with PCOS | Protocol | C Boothroyd, C Farquhar | |
Differences between protocol and review
The inclusion criteria of this review were widened from that of the original protocol (participants with anovulation attributed to PCOS) to include all WHO group 2 causes of anovulation but excluding hyperprolactinaemia. Trials that were non‐specific but appeared to describe PCOS‐like anovulation (for example participants with progestin‐induced withdrawal bleeding) were included. Due to the age of many of the trials, particularly for clomiphene versus placebo, the most likely cause of anovulation was not described fully. In particular, the currently utilised diagnostic criteria for PCOS were not able to be met. These trials would have been excluded under the criteria of the protocol. It was felt that their results were valid and important and so the background and inclusion criteria sections were widened.
Aromatase inhibitor comparisons have been removed from this review as they will addressed within a separate protocol El Daly 2006.
Title changed from 'Oral anti‐oestrogens and medical adjuncts for subfertility associated with anovulation' to 'Clomiphene and anti‐oestrogens for ovulation induction in PCOS.
