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Cochrane Database of Systematic Reviews

敷料处理浅表烧伤及深二度烧伤

Información

DOI:
https://doi.org/10.1002/14651858.CD002106.pub4Copiar DOI
Base de datos:
  1. Cochrane Database of Systematic Reviews
Versión publicada:
  1. 28 marzo 2013see what's new
Tipo:
  1. Intervention
Etapa:
  1. Review
Grupo Editorial Cochrane:
  1. Grupo Cochrane de Heridas

Copyright:
  1. Copyright © 2013 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

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Autores

  • Jason Wasiak

    Correspondencia a: Victorian Adult Burns Service and School of Public Health and Preventative Medicine, Monash University, The Alfred Hospital, Melbourne, Australia

    [email protected]

    [email protected]

  • Heather Cleland

    Victorian Adult Burns Service, The Alfred Hospital, Melbourne, Australia

  • Fiona Campbell

    School of Health and Related Research, University of Sheffield, Sheffield, UK

  • Anneliese Spinks

    School of Medicine, Griffith University, Meadowbrook, Australia

Contributions of authors

Jason Wasiak: designed and coordinated the review. Extracted data and checked quality of data extraction. Undertook and checked quality assessment. Performed statistical analysis, interpreted data and checked the analysis. Completed first draft of the review and advised on subsequent drafts. Made an intellectual contribution to the review. Approved final review prior to submission. Performed previous work that was the foundation of the current review. Is guarantor of the review. Appraised search, checked data extraction, contributed guidance on data and analyses, and reviewed changes to the text in the most recent update

Heather Cleland: designed the review. Checked quality of data extraction and interpreted data. Completed first draft of the review. Made an intellectual contribution to the review and approved final review prior to submission. Advised on the review. Performed previous work that was the foundation of the current review. Appraised search, checked data extraction, contributed guidance on data and analyses, and reviewed changes to the text in the most recent update.

Fiona Campbell: designed and coordinated the review. Examined all search results. Extracted data and checked quality of data extraction. Wrote to study author/experts/companies and handsearched journals. Undertook and checked quality assessment. Performed statistical analysis, interpreted data and checked the analysis. Completed first draft of the review and advised on subsequent drafts. Made an intellectual contribution to the review. Approved final review prior to submission. Performed previous work that was the foundation of the current review.

Anneliese Spinks: Made an intellectual contribution to the review and approved the overall review process prior to submission. Advised on the review and reviewed changes to the text in the most recent update.

Contributions of editorial base:

Nicky Cullum: edited the review, advised on methodology, interpretation and review content. Undertook extensive redrafting. Approved the final review prior to submission. Commented on and edited the review update.

Sally Bell‐Syer: co‐ordinated the editorial process. Checked data extraction and quality assessment. Performed part of data analysis and interpretation. Advised on methodology, interpretation and content. Undertook extensive redrafting, editing and copy editing of the review and of the review update.

Ruth Foxlee: designed the search strategy and edited the search methods section.

Rachel Richardson: edited and checked the updated review.

Sources of support

Internal sources

  • No sources of support supplied

External sources

  • Royal College of Nursing, UK.

Declarations of interest

None

Acknowledgements

Acknowledgements to Kate Seers for previous work that was the foundation of the current review and to Greg Duncan for his assistance in reading the first draft review. The authors would like to acknowledge the peer referees, Wounds Group Editors (Andrew Jull, Dirk Ubbink, Gill Worthy) and Catriona McDaid, Mary Mondozzi and Janet Yarrow. Acknowledgements to the Cochrane Editorial Unit (Toby Lasserson, John Hilton and Rachel Marshall), Karla‐Soares Weiser, for search appraisal, data extraction and updating the text, and Anne Lethaby for extracting risk of bias data in the most recent review update. This work was funded by the NIHR.

Version history

Published

Title

Stage

Authors

Version

2013 Mar 28

Dressings for superficial and partial thickness burns

Review

Jason Wasiak, Heather Cleland, Fiona Campbell, Anneliese Spinks

https://doi.org/10.1002/14651858.CD002106.pub4

2008 Oct 08

Dressings for superficial and partial thickness burns

Review

Jason Wasiak, Heather Cleland, Fiona Campbell

https://doi.org/10.1002/14651858.CD002106.pub3

2007 Jul 18

Dressings for superficial and partial thickness burns

Protocol

Jason Wasiak, Heather Cleland, Fiona Campbell

https://doi.org/10.1002/14651858.CD002106.pub2

2000 Apr 24

Dressing and topical agents for burns

Protocol

Fiona Campbell, Kate Seers

https://doi.org/10.1002/14651858.CD002106

Keywords

MeSH

PICO

Population
Intervention
Comparison
Outcome

El uso y la enseñanza del modelo PICO están muy extendidos en el ámbito de la atención sanitaria basada en la evidencia para formular preguntas y estrategias de búsqueda y para caracterizar estudios o metanálisis clínicos. PICO son las siglas en inglés de cuatro posibles componentes de una pregunta de investigación: paciente, población o problema; intervención; comparación; desenlace (outcome).

Para saber más sobre el uso del modelo PICO, puede consultar el Manual Cochrane.

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
Figuras y tablas -
Figure 1

'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
Figuras y tablas -
Figure 2

'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.

Comparison 1 Hydrocolloid dressing vs chlorhexidine‐impregnated gauze dressing, Outcome 1 Withdrawal due to wound infection.
Figuras y tablas -
Analysis 1.1

Comparison 1 Hydrocolloid dressing vs chlorhexidine‐impregnated gauze dressing, Outcome 1 Withdrawal due to wound infection.

Comparison 2 Hydrocolloid dressing vs silver sulphadiazine, Outcome 1 Number of dressing changes.
Figuras y tablas -
Analysis 2.1

Comparison 2 Hydrocolloid dressing vs silver sulphadiazine, Outcome 1 Number of dressing changes.

Comparison 2 Hydrocolloid dressing vs silver sulphadiazine, Outcome 2 Level of pain.
Figuras y tablas -
Analysis 2.2

Comparison 2 Hydrocolloid dressing vs silver sulphadiazine, Outcome 2 Level of pain.

Comparison 3 Polyurethane film dressing vs paraffin gauze dressing, Outcome 1 Wound infection.
Figuras y tablas -
Analysis 3.1

Comparison 3 Polyurethane film dressing vs paraffin gauze dressing, Outcome 1 Wound infection.

Comparison 4 Polyurethane film dressing vs chlorhexidine‐impregnated paraffin gauze dressing, Outcome 1 Wound infection.
Figuras y tablas -
Analysis 4.1

Comparison 4 Polyurethane film dressing vs chlorhexidine‐impregnated paraffin gauze dressing, Outcome 1 Wound infection.

Comparison 5 Hydrogel dressing vs usual care, Outcome 1 Wound healing: number of people healed at 6 days.
Figuras y tablas -
Analysis 5.1

Comparison 5 Hydrogel dressing vs usual care, Outcome 1 Wound healing: number of people healed at 6 days.

Comparison 5 Hydrogel dressing vs usual care, Outcome 2 Wound healing: number of people healed at 9 days.
Figuras y tablas -
Analysis 5.2

Comparison 5 Hydrogel dressing vs usual care, Outcome 2 Wound healing: number of people healed at 9 days.

Comparison 5 Hydrogel dressing vs usual care, Outcome 3 Wound healing: number of people healed at 21 days.
Figuras y tablas -
Analysis 5.3

Comparison 5 Hydrogel dressing vs usual care, Outcome 3 Wound healing: number of people healed at 21 days.

Comparison 5 Hydrogel dressing vs usual care, Outcome 4 Wound healing: number of people healed at 12 days.
Figuras y tablas -
Analysis 5.4

Comparison 5 Hydrogel dressing vs usual care, Outcome 4 Wound healing: number of people healed at 12 days.

Comparison 5 Hydrogel dressing vs usual care, Outcome 5 Wound healing: number of people healed at 15 days.
Figuras y tablas -
Analysis 5.5

Comparison 5 Hydrogel dressing vs usual care, Outcome 5 Wound healing: number of people healed at 15 days.

Comparison 5 Hydrogel dressing vs usual care, Outcome 6 Wound healing: number of people healed at 18 days.
Figuras y tablas -
Analysis 5.6

Comparison 5 Hydrogel dressing vs usual care, Outcome 6 Wound healing: number of people healed at 18 days.

Comparison 5 Hydrogel dressing vs usual care, Outcome 7 Assessment of pain at baseline.
Figuras y tablas -
Analysis 5.7

Comparison 5 Hydrogel dressing vs usual care, Outcome 7 Assessment of pain at baseline.

Comparison 5 Hydrogel dressing vs usual care, Outcome 8 Pain 30 minutes after treatment.
Figuras y tablas -
Analysis 5.8

Comparison 5 Hydrogel dressing vs usual care, Outcome 8 Pain 30 minutes after treatment.

Comparison 5 Hydrogel dressing vs usual care, Outcome 9 Overall assessment of pain at end of study.
Figuras y tablas -
Analysis 5.9

Comparison 5 Hydrogel dressing vs usual care, Outcome 9 Overall assessment of pain at end of study.

Comparison 5 Hydrogel dressing vs usual care, Outcome 10 Infection with Pseudomonas aeruginosa requiring antibiotic therapy.
Figuras y tablas -
Analysis 5.10

Comparison 5 Hydrogel dressing vs usual care, Outcome 10 Infection with Pseudomonas aeruginosa requiring antibiotic therapy.

Comparison 6 Silicon nylon dressing vs silver sulphadiazine, Outcome 1 Number of dressing changes.
Figuras y tablas -
Analysis 6.1

Comparison 6 Silicon nylon dressing vs silver sulphadiazine, Outcome 1 Number of dressing changes.

Comparison 7 Biosynthetic skin substitute (Biobrane) vs silver sulphadiazine, Outcome 1 Pain.
Figuras y tablas -
Analysis 7.1

Comparison 7 Biosynthetic skin substitute (Biobrane) vs silver sulphadiazine, Outcome 1 Pain.

Comparison 7 Biosynthetic skin substitute (Biobrane) vs silver sulphadiazine, Outcome 2 Need for surgery.
Figuras y tablas -
Analysis 7.2

Comparison 7 Biosynthetic skin substitute (Biobrane) vs silver sulphadiazine, Outcome 2 Need for surgery.

Comparison 8 Antimicrobial‐releasing biosynthetic dressings vs silver sulphadiazine, Outcome 1 Wound infection.
Figuras y tablas -
Analysis 8.1

Comparison 8 Antimicrobial‐releasing biosynthetic dressings vs silver sulphadiazine, Outcome 1 Wound infection.

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 1 Wound healing time (days).
Figuras y tablas -
Analysis 9.1

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 1 Wound healing time (days).

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 2 Wound healing: number of people healed at 7 days.
Figuras y tablas -
Analysis 9.2

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 2 Wound healing: number of people healed at 7 days.

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 3 Wound healing: number of people healed at 10 days.
Figuras y tablas -
Analysis 9.3

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 3 Wound healing: number of people healed at 10 days.

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 4 Wound healing: number of people healed at 15 days.
Figuras y tablas -
Analysis 9.4

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 4 Wound healing: number of people healed at 15 days.

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 5 Wound healing: number of people healed at 17 days.
Figuras y tablas -
Analysis 9.5

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 5 Wound healing: number of people healed at 17 days.

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 6 Wound healing: number of people healed at 21 days.
Figuras y tablas -
Analysis 9.6

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 6 Wound healing: number of people healed at 21 days.

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 7 Healing rate (% wound area).
Figuras y tablas -
Analysis 9.7

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 7 Healing rate (% wound area).

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 8 Pain.
Figuras y tablas -
Analysis 9.8

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 8 Pain.

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 9 Need for surgery.
Figuras y tablas -
Analysis 9.9

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 9 Need for surgery.

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 10 Number of infections.
Figuras y tablas -
Analysis 9.10

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 10 Number of infections.

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 11 Number of wound dressings.
Figuras y tablas -
Analysis 9.11

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 11 Number of wound dressings.

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 12 Nursing time (minutes).
Figuras y tablas -
Analysis 9.12

Comparison 9 Silver‐impregnated dressing vs silver sulphadiazine, Outcome 12 Nursing time (minutes).

Comparison 10 Fibre dressing vs silver sulphadiazine, Outcome 1 Wound healing time (days).
Figuras y tablas -
Analysis 10.1

Comparison 10 Fibre dressing vs silver sulphadiazine, Outcome 1 Wound healing time (days).

Comparison 10 Fibre dressing vs silver sulphadiazine, Outcome 2 Pain at day 1.
Figuras y tablas -
Analysis 10.2

Comparison 10 Fibre dressing vs silver sulphadiazine, Outcome 2 Pain at day 1.

Comparison 10 Fibre dressing vs silver sulphadiazine, Outcome 3 Pain at day 3.
Figuras y tablas -
Analysis 10.3

Comparison 10 Fibre dressing vs silver sulphadiazine, Outcome 3 Pain at day 3.

Comparison 10 Fibre dressing vs silver sulphadiazine, Outcome 4 Pain at day 7.
Figuras y tablas -
Analysis 10.4

Comparison 10 Fibre dressing vs silver sulphadiazine, Outcome 4 Pain at day 7.

Comparison 10 Fibre dressing vs silver sulphadiazine, Outcome 5 Number of dressing changes.
Figuras y tablas -
Analysis 10.5

Comparison 10 Fibre dressing vs silver sulphadiazine, Outcome 5 Number of dressing changes.

Comparison 10 Fibre dressing vs silver sulphadiazine, Outcome 6 Number of infections.
Figuras y tablas -
Analysis 10.6

Comparison 10 Fibre dressing vs silver sulphadiazine, Outcome 6 Number of infections.

Comparison 10 Fibre dressing vs silver sulphadiazine, Outcome 7 Need for surgery.
Figuras y tablas -
Analysis 10.7

Comparison 10 Fibre dressing vs silver sulphadiazine, Outcome 7 Need for surgery.

Comparison 1. Hydrocolloid dressing vs chlorhexidine‐impregnated gauze dressing

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Withdrawal due to wound infection Show forest plot

1

68

Risk Ratio (M‐H, Fixed, 95% CI)

2.53 [0.11, 59.90]

Figuras y tablas -
Comparison 1. Hydrocolloid dressing vs chlorhexidine‐impregnated gauze dressing
Comparison 2. Hydrocolloid dressing vs silver sulphadiazine

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Number of dressing changes Show forest plot

1

42

Mean Difference (IV, Fixed, 95% CI)

‐18.65 [‐22.54, ‐14.76]

2 Level of pain Show forest plot

1

42

Mean Difference (IV, Fixed, 95% CI)

‐1.19 [‐1.82, ‐0.56]

Figuras y tablas -
Comparison 2. Hydrocolloid dressing vs silver sulphadiazine
Comparison 3. Polyurethane film dressing vs paraffin gauze dressing

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Wound infection Show forest plot

1

55

Risk Ratio (M‐H, Fixed, 95% CI)

1.25 [0.23, 6.90]

Figuras y tablas -
Comparison 3. Polyurethane film dressing vs paraffin gauze dressing
Comparison 4. Polyurethane film dressing vs chlorhexidine‐impregnated paraffin gauze dressing

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Wound infection Show forest plot

1

51

Risk Ratio (M‐H, Fixed, 95% CI)

0.48 [0.05, 4.98]

Figuras y tablas -
Comparison 4. Polyurethane film dressing vs chlorhexidine‐impregnated paraffin gauze dressing
Comparison 5. Hydrogel dressing vs usual care

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Wound healing: number of people healed at 6 days Show forest plot

1

80

Risk Ratio (M‐H, Fixed, 95% CI)

1.5 [0.46, 4.91]

2 Wound healing: number of people healed at 9 days Show forest plot

1

80

Risk Ratio (M‐H, Fixed, 95% CI)

2.0 [1.08, 3.72]

3 Wound healing: number of people healed at 21 days Show forest plot

1

80

Risk Ratio (M‐H, Fixed, 95% CI)

1.0 [0.95, 1.05]

4 Wound healing: number of people healed at 12 days Show forest plot

1

80

Risk Ratio (M‐H, Fixed, 95% CI)

1.68 [1.17, 2.42]

5 Wound healing: number of people healed at 15 days Show forest plot

1

80

Risk Ratio (M‐H, Fixed, 95% CI)

1.16 [0.95, 1.41]

6 Wound healing: number of people healed at 18 days Show forest plot

1

80

Risk Ratio (M‐H, Fixed, 95% CI)

1.08 [0.97, 1.21]

7 Assessment of pain at baseline Show forest plot

1

Mean Difference (IV, Fixed, 95% CI)

Totals not selected

8 Pain 30 minutes after treatment Show forest plot

1

118

Mean Difference (IV, Fixed, 95% CI)

‐0.79 [‐1.64, 0.06]

9 Overall assessment of pain at end of study Show forest plot

1

98

Mean Difference (IV, Fixed, 95% CI)

‐1.31 [‐2.37, ‐0.25]

10 Infection with Pseudomonas aeruginosa requiring antibiotic therapy Show forest plot

1

80

Risk Ratio (M‐H, Fixed, 95% CI)

0.33 [0.01, 7.95]

Figuras y tablas -
Comparison 5. Hydrogel dressing vs usual care
Comparison 6. Silicon nylon dressing vs silver sulphadiazine

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Number of dressing changes Show forest plot

1

66

Mean Difference (IV, Fixed, 95% CI)

‐1.49 [‐2.64, ‐0.34]

Figuras y tablas -
Comparison 6. Silicon nylon dressing vs silver sulphadiazine
Comparison 7. Biosynthetic skin substitute (Biobrane) vs silver sulphadiazine

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Pain Show forest plot

2

106

Mean Difference (IV, Random, 95% CI)

‐1.63 [‐2.20, ‐1.06]

2 Need for surgery Show forest plot

1

50

Risk Ratio (M‐H, Fixed, 95% CI)

0.68 [0.21, 2.24]

Figuras y tablas -
Comparison 7. Biosynthetic skin substitute (Biobrane) vs silver sulphadiazine
Comparison 8. Antimicrobial‐releasing biosynthetic dressings vs silver sulphadiazine

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Wound infection Show forest plot

1

100

Risk Ratio (M‐H, Fixed, 95% CI)

1.88 [0.87, 4.02]

Figuras y tablas -
Comparison 8. Antimicrobial‐releasing biosynthetic dressings vs silver sulphadiazine
Comparison 9. Silver‐impregnated dressing vs silver sulphadiazine

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Wound healing time (days) Show forest plot

2

169

Mean Difference (IV, Fixed, 95% CI)

‐4.22 [‐5.92, ‐2.52]

2 Wound healing: number of people healed at 7 days Show forest plot

1

104

Risk Ratio (M‐H, Fixed, 95% CI)

1.5 [0.58, 3.91]

3 Wound healing: number of people healed at 10 days Show forest plot

1

104

Risk Ratio (M‐H, Fixed, 95% CI)

1.82 [0.97, 3.40]

4 Wound healing: number of people healed at 15 days Show forest plot

2

270

Risk Ratio (M‐H, Fixed, 95% CI)

1.17 [1.02, 1.35]

5 Wound healing: number of people healed at 17 days Show forest plot

1

104

Risk Ratio (M‐H, Fixed, 95% CI)

1.23 [0.98, 1.54]

6 Wound healing: number of people healed at 21 days Show forest plot

1

104

Risk Ratio (M‐H, Fixed, 95% CI)

1.21 [1.06, 1.37]

7 Healing rate (% wound area) Show forest plot

1

166

Mean Difference (IV, Fixed, 95% CI)

2.21 [‐2.37, 6.79]

8 Pain Show forest plot

3

135

Mean Difference (IV, Random, 95% CI)

‐2.84 [‐5.89, 0.21]

9 Need for surgery Show forest plot

1

50

Risk Ratio (M‐H, Fixed, 95% CI)

0.67 [0.21, 2.08]

10 Number of infections Show forest plot

4

348

Risk Ratio (M‐H, Fixed, 95% CI)

1.04 [0.64, 1.67]

11 Number of wound dressings Show forest plot

1

65

Mean Difference (IV, Fixed, 95% CI)

‐11.07 [‐19.58, ‐2.56]

12 Nursing time (minutes) Show forest plot

1

65

Mean Difference (IV, Fixed, 95% CI)

‐4.82 [‐19.42, 9.78]

Figuras y tablas -
Comparison 9. Silver‐impregnated dressing vs silver sulphadiazine
Comparison 10. Fibre dressing vs silver sulphadiazine

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Wound healing time (days) Show forest plot

1

70

Mean Difference (IV, Fixed, 95% CI)

‐3.70 [‐5.44, ‐1.96]

2 Pain at day 1 Show forest plot

1

70

Mean Difference (IV, Fixed, 95% CI)

‐2.0 [‐3.03, ‐0.97]

3 Pain at day 3 Show forest plot

1

70

Mean Difference (IV, Fixed, 95% CI)

‐3.1 [‐4.02, ‐2.18]

4 Pain at day 7 Show forest plot

1

70

Mean Difference (IV, Fixed, 95% CI)

‐2.4 [‐3.18, ‐1.62]

5 Number of dressing changes Show forest plot

1

82

Mean Difference (IV, Fixed, 95% CI)

‐11.40 [‐15.66, ‐7.14]

6 Number of infections Show forest plot

1

82

Risk Ratio (M‐H, Fixed, 95% CI)

1.27 [0.48, 3.34]

7 Need for surgery Show forest plot

1

82

Risk Ratio (M‐H, Fixed, 95% CI)

0.68 [0.24, 1.97]

Figuras y tablas -
Comparison 10. Fibre dressing vs silver sulphadiazine