Alpha2 adrenergic agonists for the management of opioid withdrawal

The Cochrane Library

Evidencia fiable. Decisiones informadas. Mejor salud.

Ir a:

Analysis 1.1

Comparison 1 Alpha2 adrenergic agonist versus methadone, Outcome 1 Duration of treatment.

Analysis 1.2

Comparison 1 Alpha2 adrenergic agonist versus methadone, Outcome 2 Retention in treatment.

Analysis 1.3

Comparison 1 Alpha2 adrenergic agonist versus methadone, Outcome 3 Completion of withdrawal.

Analysis 1.4

Comparison 1 Alpha2 adrenergic agonist versus methadone, Outcome 4 Completion of withdrawal ‐ studies with low risk of selection bias.

Comparison 1. Alpha2 adrenergic agonist versus methadone

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Duration of treatment Show forest plot	3	311	Std. Mean Difference (IV, Random, 95% CI)	‐1.07 [‐1.31, ‐0.83]

2 Retention in treatment Show forest plot	3	210	Risk Ratio (M‐H, Random, 95% CI)	0.73 [0.54, 0.99]

3 Completion of withdrawal Show forest plot	9	612	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.77, 1.03]

4 Completion of withdrawal ‐ studies with low risk of selection bias Show forest plot	6	420	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.86, 1.27]

Comparison 1. Alpha2 adrenergic agonist versus methadone