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Comparison 1 Alpha2 adrenergic agonist versus methadone, Outcome 1 Duration of treatment.
Figures and Tables -
Analysis 1.1

Comparison 1 Alpha2 adrenergic agonist versus methadone, Outcome 1 Duration of treatment.

Comparison 1 Alpha2 adrenergic agonist versus methadone, Outcome 2 Retention in treatment.
Figures and Tables -
Analysis 1.2

Comparison 1 Alpha2 adrenergic agonist versus methadone, Outcome 2 Retention in treatment.

Comparison 1 Alpha2 adrenergic agonist versus methadone, Outcome 3 Completion of withdrawal.
Figures and Tables -
Analysis 1.3

Comparison 1 Alpha2 adrenergic agonist versus methadone, Outcome 3 Completion of withdrawal.

Comparison 1 Alpha2 adrenergic agonist versus methadone, Outcome 4 Completion of withdrawal ‐ studies with low risk of selection bias.
Figures and Tables -
Analysis 1.4

Comparison 1 Alpha2 adrenergic agonist versus methadone, Outcome 4 Completion of withdrawal ‐ studies with low risk of selection bias.

Comparison 1. Alpha2 adrenergic agonist versus methadone

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Duration of treatment Show forest plot

3

311

Std. Mean Difference (IV, Random, 95% CI)

‐1.07 [‐1.31, ‐0.83]

2 Retention in treatment Show forest plot

3

210

Risk Ratio (M‐H, Random, 95% CI)

0.73 [0.54, 0.99]

3 Completion of withdrawal Show forest plot

9

612

Risk Ratio (M‐H, Fixed, 95% CI)

0.89 [0.77, 1.03]

4 Completion of withdrawal ‐ studies with low risk of selection bias Show forest plot

6

420

Risk Ratio (M‐H, Fixed, 95% CI)

1.05 [0.86, 1.27]

Figures and Tables -
Comparison 1. Alpha2 adrenergic agonist versus methadone