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Comparison 1 CENTRAL ACTION BETA‐BLOCKER versus PLACEBO, Outcome 1 Akathisia: 1. Not remitted.
Figuras y tablas -
Analysis 1.1

Comparison 1 CENTRAL ACTION BETA‐BLOCKER versus PLACEBO, Outcome 1 Akathisia: 1. Not remitted.

Comparison 1 CENTRAL ACTION BETA‐BLOCKER versus PLACEBO, Outcome 2 Akathisia: 2. No change/worse (SAS scale).
Figuras y tablas -
Analysis 1.2

Comparison 1 CENTRAL ACTION BETA‐BLOCKER versus PLACEBO, Outcome 2 Akathisia: 2. No change/worse (SAS scale).

Study

Interventions

Mean

SD

N

IMEPS

Irwin 1988

Propranolol

3.5

1.4

6

Irwin 1988

Placebo

3.2

1.9

5

SAS

Adler 1989

ICI 118,551

0.8

1.8

6

Adler 1989

Placebo

1.7

2.4

4

Figuras y tablas -
Analysis 1.3

Comparison 1 CENTRAL ACTION BETA‐BLOCKER versus PLACEBO, Outcome 3 Akathisia: 3. Average score (skewed data).

Comparison 1 CENTRAL ACTION BETA‐BLOCKER versus PLACEBO, Outcome 4 Leaving the study early ‐ for any reason.
Figuras y tablas -
Analysis 1.4

Comparison 1 CENTRAL ACTION BETA‐BLOCKER versus PLACEBO, Outcome 4 Leaving the study early ‐ for any reason.

Comparison 1 CENTRAL ACTION BETA‐BLOCKER versus PLACEBO, Outcome 5 Adverse effects: Any adverse event.
Figuras y tablas -
Analysis 1.5

Comparison 1 CENTRAL ACTION BETA‐BLOCKER versus PLACEBO, Outcome 5 Adverse effects: Any adverse event.

Comparison 1. CENTRAL ACTION BETA‐BLOCKER versus PLACEBO

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Akathisia: 1. Not remitted Show forest plot

1

Risk Ratio (M‐H, Random, 95% CI)

Subtotals only

1.1 not in full remission (100% reduction in symptoms)

1

11

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

1.2 not in partial remission (50% reduction in symptoms)

1

11

Risk Ratio (M‐H, Random, 95% CI)

1.04 [0.59, 1.83]

2 Akathisia: 2. No change/worse (SAS scale) Show forest plot

1

10

Risk Ratio (M‐H, Random, 95% CI)

0.22 [0.03, 1.45]

3 Akathisia: 3. Average score (skewed data) Show forest plot

Other data

No numeric data

3.1 IMEPS

Other data

No numeric data

3.2 SAS

Other data

No numeric data

4 Leaving the study early ‐ for any reason Show forest plot

2

31

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

5 Adverse effects: Any adverse event Show forest plot

1

20

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

Figuras y tablas -
Comparison 1. CENTRAL ACTION BETA‐BLOCKER versus PLACEBO