1 No. Exposed to Allogeneic Blood Show forest plot

99

10144

Risk Ratio (M‐H, Random, 95% CI)

0.66 [0.62, 0.71]

2 No. Exposed to Allogeneic Blood ‐ Type of Surgery Show forest plot

99

10144

Risk Ratio (M‐H, Random, 95% CI)

0.66 [0.62, 0.71]

2.1 Cardiac surgery

77

8837

Risk Ratio (M‐H, Random, 95% CI)

0.66 [0.61, 0.72]

2.2 Orthopaedic surgery

14

794

Risk Ratio (M‐H, Random, 95% CI)

0.69 [0.56, 0.85]

2.3 Thoracic surgery

2

62

Risk Ratio (M‐H, Random, 95% CI)

0.28 [0.11, 0.74]

2.4 Vascular surgery

2

188

Risk Ratio (M‐H, Random, 95% CI)

1.01 [0.72, 1.40]

2.5 Liver surgery

2

177

Risk Ratio (M‐H, Random, 95% CI)

0.58 [0.37, 0.90]

2.6 Neuro surgery

1

56

Risk Ratio (M‐H, Random, 95% CI)

0.73 [0.40, 1.35]

2.7 Orthognathic surgery

1

30

Risk Ratio (M‐H, Random, 95% CI)

0.11 [0.02, 0.77]

3 No. Exposed to Allogeneic Blood ‐ Transfusion Protocol Show forest plot

99

10144

Risk Ratio (M‐H, Random, 95% CI)

0.66 [0.62, 0.71]

3.1 Transfusion Protocol

79

8962

Risk Ratio (M‐H, Random, 95% CI)

0.65 [0.60, 0.70]

3.2 No Transfusion Protocol

20

1182

Risk Ratio (M‐H, Random, 95% CI)

0.73 [0.62, 0.86]

4 No. Exposed to Allogeneic Blood ‐ Dose Show forest plot

98

11088

Risk Ratio (M‐H, Random, 95% CI)

0.68 [0.64, 0.72]

4.1 Prime Dose

16

1251

Risk Ratio (M‐H, Random, 95% CI)

0.83 [0.71, 0.96]

4.2 Low Dose

46

3268

Risk Ratio (M‐H, Random, 95% CI)

0.66 [0.59, 0.74]

4.3 High Dose

56

6569

Risk Ratio (M‐H, Random, 95% CI)

0.65 [0.60, 0.71]

5 No. Exposed to Allogeneic Blood ‐ Dose (Cardiac Surgery) Show forest plot

76

9763

Risk Ratio (M‐H, Random, 95% CI)

0.68 [0.64, 0.73]

5.1 Prime Dose

15

1191

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.69, 0.96]

5.2 Low Dose

25

2039

Risk Ratio (M‐H, Random, 95% CI)

0.67 [0.58, 0.77]

5.3 High Dose

55

6533

Risk Ratio (M‐H, Random, 95% CI)

0.66 [0.60, 0.72]

6 Trial Quality (Allocation Concealment ‐ Cochrane Scale) Show forest plot

98

10100

Risk Ratio (M‐H, Random, 95% CI)

0.66 [0.62, 0.71]

6.1 Quality A

29

2264

Risk Ratio (M‐H, Random, 95% CI)

0.65 [0.54, 0.78]

6.2 Quality B

57

7037

Risk Ratio (M‐H, Random, 95% CI)

0.68 [0.63, 0.73]

6.3 Quality C

12

799

Risk Ratio (M‐H, Random, 95% CI)

0.60 [0.49, 0.73]

7 Units of Allogeneic Blood Transfused ‐ Transfused Patients Show forest plot

38

3388

Mean Difference (IV, Random, 95% CI)

‐0.96 [‐1.24, ‐0.68]

8 Units of Allogeneic Blood Transfused ‐ All Patients Show forest plot

63

6820

Mean Difference (IV, Random, 95% CI)

‐1.07 [‐1.31, ‐0.83]

9 Blood loss ‐ Intra‐operative Show forest plot

13

722

Mean Difference (IV, Random, 95% CI)

‐185.32 [‐280.23, ‐90.41]

9.1 Cardiac surgery

5

360

Mean Difference (IV, Random, 95% CI)

‐140.00 [‐244.42, ‐35.59]

9.2 Orthopaedic surgery

5

201

Mean Difference (IV, Random, 95% CI)

‐151.05 [‐317.63, 15.52]

9.3 Thoracic surgery

1

24

Mean Difference (IV, Random, 95% CI)

‐532.0 [‐863.00, ‐199.00]

9.4 Liver surgery

2

137

Mean Difference (IV, Random, 95% CI)

‐1200.40 [‐2943.39, 542.59]

10 Blood loss ‐ Post‐operative Show forest plot

79

7414

Mean Difference (IV, Random, 95% CI)

‐358.13 [‐403.64, ‐312.62]

10.1 Cardiac surgery

68

6948

Mean Difference (IV, Random, 95% CI)

‐385.43 [‐432.36, ‐338.50]

10.2 Orthopaedic surgery

7

318

Mean Difference (IV, Random, 95% CI)

‐113.58 [‐223.69, ‐3.46]

10.3 Thoracic surgery

1

24

Mean Difference (IV, Random, 95% CI)

‐441.0 [‐786.40, ‐95.60]

10.4 Orthognathic surgery

1

30

Mean Difference (IV, Random, 95% CI)

‐513.0 [‐717.21, ‐308.79]

10.5 LIver surgery

1

44

Mean Difference (IV, Random, 95% CI)

‐105.0 [‐194.36, ‐15.64]

10.6 Vascular surgery

1

50

Mean Difference (IV, Random, 95% CI)

‐203.00 [‐404.93, ‐1.07]

11 Blood loss ‐ Post‐operative ‐ Dose (Cardiac Surgery) Show forest plot

68

7758

Mean Difference (IV, Random, 95% CI)

‐380.30 [‐421.96, ‐338.63]

11.1 Prime Dose

15

1158

Mean Difference (IV, Random, 95% CI)

‐343.08 [‐458.13, ‐228.04]

11.2 Low Dose

21

1781

Mean Difference (IV, Random, 95% CI)

‐293.24 [‐348.67, ‐237.81]

11.3 High Dose

48

4819

Mean Difference (IV, Random, 95% CI)

‐428.09 [‐485.38, ‐370.80]

12 Blood loss ‐ Total Show forest plot

15

1577

Mean Difference (IV, Random, 95% CI)

‐414.48 [‐520.13, ‐308.82]

12.1 Cardiac surgery

5

1147

Mean Difference (IV, Random, 95% CI)

‐489.06 [‐571.32, ‐406.80]

12.2 Orthopaedic surgery

10

430

Mean Difference (IV, Random, 95% CI)

‐399.09 [‐562.81, ‐235.37]

1 No. Exposed to Allogeneic Blood Show forest plot

53

3836

Risk Ratio (M‐H, Random, 95% CI)

0.61 [0.54, 0.70]

2 No. Exposed to Allogeneic Blood ‐ Type of Surgery Show forest plot

53

3836

Risk Ratio (M‐H, Random, 95% CI)

0.61 [0.54, 0.70]

2.1 Cardiac surgery

29

2488

Risk Ratio (M‐H, Random, 95% CI)

0.69 [0.60, 0.79]

2.2 Orthopaedic surgery

21

993

Risk Ratio (M‐H, Random, 95% CI)

0.44 [0.33, 0.60]

2.3 Liver surgery

2

296

Risk Ratio (M‐H, Random, 95% CI)

0.16 [0.00, 32.47]

2.4 Vascular surgery

1

59

Risk Ratio (M‐H, Random, 95% CI)

0.56 [0.33, 0.96]

3 No. Exposed to Allogeneic Blood ‐ Transfusion Protocol Show forest plot

53

3836

Risk Ratio (M‐H, Random, 95% CI)

0.61 [0.54, 0.70]

3.1 Transfusion Protocol

46

3236

Risk Ratio (M‐H, Random, 95% CI)

0.57 [0.49, 0.66]

3.2 No Transfusion Protocol

7

600

Risk Ratio (M‐H, Random, 95% CI)

0.82 [0.63, 1.07]

4 No. Exposed to Allogeneic Blood ‐ Dose (Cardiac Surgery) Show forest plot

29

2542

Risk Ratio (M‐H, Random, 95% CI)

0.70 [0.61, 0.80]

4.1 Total dose < 2.0 grams

16

926

Risk Ratio (M‐H, Random, 95% CI)

0.72 [0.59, 0.88]

4.2 Total dose 2.0 ‐ 10.0 grams

14

1616

Risk Ratio (M‐H, Random, 95% CI)

0.67 [0.55, 0.83]

5 Trial Quality (Allocation Concealment ‐ Cochrane Scale) Show forest plot

53

3836

Risk Ratio (M‐H, Random, 95% CI)

0.61 [0.54, 0.70]

5.1 Quality A

21

1610

Risk Ratio (M‐H, Random, 95% CI)

0.60 [0.49, 0.72]

5.2 Quality B

21

1299

Risk Ratio (M‐H, Random, 95% CI)

0.55 [0.42, 0.73]

5.3 Quality C

11

927

Risk Ratio (M‐H, Random, 95% CI)

0.69 [0.56, 0.86]

6 Units Allogeneic Blood Transfused ‐ Transfused Patients Show forest plot

11

429

Mean Difference (IV, Random, 95% CI)

‐0.51 [‐1.06, 0.04]

7 Units of Allogeneic Blood Transfused ‐ All Patients Show forest plot

16

1071

Mean Difference (IV, Random, 95% CI)

‐1.12 [‐1.59, ‐0.64]

8 Blood loss ‐ Intra‐operative Show forest plot

10

553

Mean Difference (IV, Random, 95% CI)

‐54.89 [‐105.31, ‐4.48]

8.1 Cardiac surgery

3

144

Mean Difference (IV, Random, 95% CI)

‐287.16 [‐481.57, ‐92.75]

8.2 Orthopaedic surgery

7

409

Mean Difference (IV, Random, 95% CI)

‐29.52 [‐69.17, 10.14]

9 Blood loss ‐ Post‐operative Show forest plot

23

1423

Mean Difference (IV, Random, 95% CI)

‐247.90 [‐313.07, ‐182.73]

9.1 Cardiac surgery

17

1130

Mean Difference (IV, Random, 95% CI)

‐262.60 [‐318.62, ‐206.59]

9.2 Orthopaedic surgery

6

293

Mean Difference (IV, Random, 95% CI)

‐209.72 [‐384.28, ‐35.16]

10 Blood loss ‐ Post‐operative ‐ Dose (Cardiac Surgery) Show forest plot

17

1130

Mean Difference (IV, Random, 95% CI)

‐262.60 [‐318.62, ‐206.59]

10.1 Total dose < 2.0 grams

9

302

Mean Difference (IV, Random, 95% CI)

‐251.77 [‐352.27, ‐151.26]

10.2 Total dose 2.0 ‐ 10.0 grams

8

828

Mean Difference (IV, Random, 95% CI)

‐272.85 [‐340.79, ‐204.90]

11 Blood loss ‐ Total Show forest plot

18

955

Mean Difference (IV, Random, 95% CI)

‐443.53 [‐572.08, ‐314.98]

11.1 Cardiac surgery

3

245

Mean Difference (IV, Random, 95% CI)

‐439.82 [‐606.50, ‐273.15]

11.2 Orthopaedic surgery

14

690

Mean Difference (IV, Random, 95% CI)

‐439.51 [‐590.93, ‐288.09]

11.3 Liver surgery

1

20

Mean Difference (IV, Random, 95% CI)

‐6552.0 [‐14329.54, 1225.54]

1 No. Exposed to Allogeneic Blood Show forest plot

14

801

Risk Ratio (M‐H, Random, 95% CI)

0.75 [0.58, 0.96]

2 No. Exposed to Allogeneic Blood ‐ Type of Surgery Show forest plot

14

801

Risk Ratio (M‐H, Random, 95% CI)

0.75 [0.58, 0.96]

2.1 Cardiac Surgery

10

597

Risk Ratio (M‐H, Random, 95% CI)

0.65 [0.47, 0.91]

2.2 Orthopaedic Surgery

3

122

Risk Ratio (M‐H, Random, 95% CI)

0.96 [0.61, 1.50]

2.3 Liver Surgery

1

82

Risk Ratio (M‐H, Random, 95% CI)

0.93 [0.80, 1.08]

3 No. Exposed to Allogeneic Blood ‐ Transfusion Protocol Show forest plot

14

801

Risk Ratio (M‐H, Random, 95% CI)

0.75 [0.58, 0.96]

3.1 Transfusion Protocol

13

771

Risk Ratio (M‐H, Random, 95% CI)

0.73 [0.56, 0.95]

3.2 No Transfusion Protocol

1

30

Risk Ratio (M‐H, Random, 95% CI)

1.33 [0.36, 4.97]

4 Trial Quality (Allocation Concealment ‐ Cochrane Scale) Show forest plot

14

801

Risk Ratio (M‐H, Random, 95% CI)

0.75 [0.58, 0.96]

4.1 Quality A

3

218

Risk Ratio (M‐H, Random, 95% CI)

0.68 [0.44, 1.04]

4.2 Quality B

9

455

Risk Ratio (M‐H, Random, 95% CI)

0.68 [0.46, 1.03]

4.3 Quality C

2

128

Risk Ratio (M‐H, Random, 95% CI)

0.93 [0.81, 1.08]

5 Units of Allogeneic Blood Transfused ‐ Transfused Patients Show forest plot

3

119

Mean Difference (IV, Random, 95% CI)

0.22 [‐0.34, 0.79]

6 Units of Allogeneic Blood Transfused ‐ All Patients Show forest plot

4

198

Mean Difference (IV, Random, 95% CI)

‐1.77 [‐2.59, ‐0.95]

7 Blood loss ‐ Intra‐operative Show forest plot

4

171

Mean Difference (IV, Random, 95% CI)

‐142.02 [‐284.95, 0.92]

7.1 Cardiac surgery

2

79

Mean Difference (IV, Random, 95% CI)

‐213.58 [‐310.03, ‐117.13]

7.2 Orthopaedic surgery

2

92

Mean Difference (IV, Random, 95% CI)

10.94 [‐259.66, 281.54]

8 Blood loss ‐ Post‐operative Show forest plot

12

940

Mean Difference (IV, Random, 95% CI)

‐202.08 [‐273.64, ‐130.53]

8.1 Cardiac surgery

11

894

Mean Difference (IV, Random, 95% CI)

‐196.27 [‐271.75, ‐120.79]

8.2 Orthopaedic surgery

1

46

Mean Difference (IV, Random, 95% CI)

‐276.0 [‐448.83, ‐103.17]

9 Blood loss ‐ Total Show forest plot

2

92

Mean Difference (IV, Random, 95% CI)

‐299.69 [‐522.54, ‐76.84]

9.1 Orthopaedic surgery

2

92

Mean Difference (IV, Random, 95% CI)

‐299.69 [‐522.54, ‐76.84]

1 No. Exposed to Allogeneic Blood Show forest plot

17

2170

Risk Ratio (M‐H, Random, 95% CI)

0.90 [0.72, 1.12]

2 No. Exposed to Allogeneic Blood ‐ Type of Surgery Show forest plot

17

2170

Risk Ratio (M‐H, Random, 95% CI)

0.90 [0.72, 1.12]

2.1 Cardiac surgery

14

1968

Risk Ratio (M‐H, Random, 95% CI)

0.85 [0.66, 1.09]

2.2 Liver surgery

2

178

Risk Ratio (M‐H, Random, 95% CI)

1.07 [0.81, 1.41]

2.3 Orthopaedic surgery

1

24

Risk Ratio (M‐H, Random, 95% CI)

11.00 [0.67, 179.29]

3 No. Exposed to Allogeneic Blood ‐ Transfusion Protocol Show forest plot

17

2170

Risk Ratio (M‐H, Random, 95% CI)

0.90 [0.72, 1.12]

3.1 Transfusion Protocol

16

2140

Risk Ratio (M‐H, Random, 95% CI)

0.88 [0.69, 1.13]

3.2 No Transfusion Protocol

1

30

Risk Ratio (M‐H, Random, 95% CI)

0.92 [0.67, 1.27]

4 Trial Quality (Allocation Concealment ‐ Cochrane Scale) Show forest plot

17

2170

Risk Ratio (M‐H, Random, 95% CI)

0.90 [0.72, 1.12]

4.1 Quality A

3

157

Risk Ratio (M‐H, Random, 95% CI)

0.48 [0.21, 1.11]

4.2 Quality B

11

1726

Risk Ratio (M‐H, Random, 95% CI)

0.97 [0.78, 1.22]

4.3 Quality C

3

287

Risk Ratio (M‐H, Random, 95% CI)

0.97 [0.44, 2.11]

5 Units Allogeneic Blood Transfused ‐ Transfused Patients Show forest plot

6

207

Mean Difference (IV, Random, 95% CI)

‐0.07 [‐0.44, 0.30]

6 Units Allogeneic Blood Transfused ‐ All Patients Show forest plot

8

722

Mean Difference (IV, Random, 95% CI)

‐0.18 [‐0.39, 0.03]

7 Blood loss Show forest plot

13

991

Mean Difference (IV, Random, 95% CI)

‐123.05 [‐181.57, ‐64.53]

7.1 Cardiac surgery ‐ Post‐operative

12

781

Mean Difference (IV, Random, 95% CI)

‐131.54 [‐192.15, ‐70.94]

7.2 Cardiac surgery ‐ Total

1

210

Mean Difference (IV, Random, 95% CI)

6.0 [‐171.38, 183.38]

1 No. Exposed to Allogeneic Blood Show forest plot

9

529

Risk Ratio (M‐H, Random, 95% CI)

0.80 [0.63, 1.02]

2 No. Exposed to Allogeneic Blood ‐ Type of Surgery Show forest plot

9

529

Risk Ratio (M‐H, Random, 95% CI)

0.80 [0.63, 1.02]

2.1 Cardiac surgery

7

454

Risk Ratio (M‐H, Random, 95% CI)

0.80 [0.61, 1.04]

2.2 Orthopaedic surgery

2

75

Risk Ratio (M‐H, Random, 95% CI)

0.82 [0.48, 1.40]

3 No. Exposed to Allogeneic Blood ‐ Transfusion Protocol Show forest plot

9

529

Risk Ratio (M‐H, Random, 95% CI)

0.80 [0.63, 1.02]

3.1 Transfusion Protocol

6

343

Risk Ratio (M‐H, Random, 95% CI)

0.82 [0.61, 1.11]

3.2 No Transfusion Protocol

3

186

Risk Ratio (M‐H, Random, 95% CI)

0.78 [0.47, 1.31]

4 Trial Quality (Allocation Concealment ‐ Cochrane Scale) Show forest plot

8

473

Risk Ratio (M‐H, Random, 95% CI)

0.86 [0.66, 1.13]

4.1 Quality A

1

40

Risk Ratio (M‐H, Random, 95% CI)

0.75 [0.41, 1.37]

4.2 Quality B

6

388

Risk Ratio (M‐H, Random, 95% CI)

0.90 [0.63, 1.28]

4.3 Quality C

1

45

Risk Ratio (M‐H, Random, 95% CI)

0.88 [0.49, 1.55]

5 Units of Allogeneic Blood Transfused ‐ Transfused Patients Show forest plot

2

63

Mean Difference (IV, Random, 95% CI)

‐0.18 [‐0.63, 0.28]

6 Units of Allogeneic Blood Transfused ‐ All Patients Show forest plot

3

218

Mean Difference (IV, Random, 95% CI)

‐0.20 [‐0.49, 0.10]

7 Blood loss Show forest plot

6

388

Mean Difference (IV, Random, 95% CI)

‐112.55 [‐231.33, 6.23]

7.1 Cardiac surgery ‐ Post‐operative

5

343

Mean Difference (IV, Random, 95% CI)

‐119.54 [‐241.78, 2.70]

7.2 Orthopaedic surgery ‐ Total

1

45

Mean Difference (IV, Random, 95% CI)

100.0 [‐515.06, 715.06]

1 No. Exposed to Allogeneic Blood Show forest plot

7

453

Risk Ratio (M‐H, Random, 95% CI)

0.99 [0.67, 1.45]

2 No. Exposed to Allogeneic Blood ‐ Type of Surgery Show forest plot

7

453

Risk Ratio (M‐H, Random, 95% CI)

0.99 [0.67, 1.45]

2.1 Cardiac surgery

5

302

Risk Ratio (M‐H, Random, 95% CI)

1.16 [0.68, 1.98]

2.2 Orthopaedic surgery

1

67

Risk Ratio (M‐H, Random, 95% CI)

0.23 [0.03, 1.94]

2.3 Liver surgery

1

84

Risk Ratio (M‐H, Random, 95% CI)

0.81 [0.64, 1.02]

3 No. Exposed to Allogeneic Blood ‐ Transfusion Protocol Show forest plot

7

453

Risk Ratio (M‐H, Random, 95% CI)

0.99 [0.67, 1.45]

3.1 Transfusion Protocol

7

453

Risk Ratio (M‐H, Random, 95% CI)

0.99 [0.67, 1.45]

4 Trial Quality (Allocation Concealment ‐ Cochrane Scale) Show forest plot

7

453

Risk Ratio (M‐H, Random, 95% CI)

0.99 [0.67, 1.45]

4.1 Quality B

5

302

Risk Ratio (M‐H, Random, 95% CI)

1.16 [0.68, 1.98]

4.2 Quality C

2

151

Risk Ratio (M‐H, Random, 95% CI)

0.63 [0.22, 1.84]

5 Units of Allogeneic Blood Transfused ‐ Transfused Patients Show forest plot

4

133

Mean Difference (IV, Random, 95% CI)

‐0.34 [‐0.74, 0.07]

6 Units of Allogeneic Blood Transfused ‐ All Patients Show forest plot

3

268

Mean Difference (IV, Random, 95% CI)

‐0.28 [‐0.59, 0.03]

7 Blood loss Show forest plot

7

469

Mean Difference (IV, Random, 95% CI)

‐4.20 [‐147.29, 138.89]

7.1 Cardiac surgery ‐ Post‐operative

6

402

Mean Difference (IV, Random, 95% CI)

‐4.36 [‐163.35, 154.63]

7.2 Orthopaedic surgery ‐ Total

1

67

Mean Difference (IV, Random, 95% CI)

‐9.0 [‐270.16, 252.16]

1 Re‐operation for bleeding Show forest plot

69

7800

Risk Ratio (M‐H, Random, 95% CI)

0.52 [0.40, 0.69]

1.1 Aprotinin versus Control

51

5384

Risk Ratio (M‐H, Random, 95% CI)

0.48 [0.35, 0.68]

1.2 Tranexamic Acid versus Control

20

1676

Risk Ratio (M‐H, Random, 95% CI)

0.67 [0.41, 1.09]

1.3 Epsilon Aminocaproic Acid versus Control

7

740

Risk Ratio (M‐H, Random, 95% CI)

0.35 [0.11, 1.17]

2 Mortality Show forest plot

75

10685

Risk Ratio (M‐H, Random, 95% CI)

0.86 [0.67, 1.11]

2.1 Aprotinin versus Control

52

7721

Risk Ratio (M‐H, Random, 95% CI)

0.90 [0.67, 1.20]

2.2 Tranexamic Acid versus Control

24

2210

Risk Ratio (M‐H, Random, 95% CI)

0.60 [0.32, 1.12]

2.3 Epsilon Aminocaproic Acid versus Control

6

754

Risk Ratio (M‐H, Random, 95% CI)

1.17 [0.47, 2.93]

3 Myocardial Infarction (MI) Show forest plot

58

8487

Risk Ratio (M‐H, Random, 95% CI)

0.92 [0.73, 1.15]

3.1 Aprotinin versus Control

40

6107

Risk Ratio (M‐H, Random, 95% CI)

0.92 [0.72, 1.18]

3.2 Tranexamic Acid versus Control

17

1718

Risk Ratio (M‐H, Random, 95% CI)

0.96 [0.48, 1.90]

3.3 Epsilon aminocaproic Acid versus Control

5

662

Risk Ratio (M‐H, Random, 95% CI)

0.89 [0.37, 2.18]

4 Stroke (CVA) Show forest plot

34

4403

Risk Ratio (M‐H, Random, 95% CI)

0.89 [0.51, 1.54]

4.1 Aprotinin versus Control

16

2298

Risk Ratio (M‐H, Random, 95% CI)

0.78 [0.38, 1.62]

4.2 Tranexamic Acid versus Control

14

1403

Risk Ratio (M‐H, Random, 95% CI)

1.25 [0.47, 3.31]

4.3 Epsilon Aminocaproic Acid versus Control

6

702

Risk Ratio (M‐H, Random, 95% CI)

0.59 [0.10, 3.44]

5 Deep Vein Thrombosis (DVT) Show forest plot

33

2335

Risk Ratio (M‐H, Random, 95% CI)

0.80 [0.53, 1.21]

5.1 Aprotinin versus Control

15

1104

Risk Ratio (M‐H, Random, 95% CI)

0.79 [0.46, 1.34]

5.2 Tranexamic Acid versus Control

18

1109

Risk Ratio (M‐H, Random, 95% CI)

0.77 [0.37, 1.61]

5.3 Epsilon Aminocaproic Acid versus Control

3

122

Risk Ratio (M‐H, Random, 95% CI)

1.09 [0.25, 4.85]

6 Pulmonary Embolism (PE) Show forest plot

17

1271

Risk Ratio (M‐H, Random, 95% CI)

0.78 [0.31, 1.95]

6.1 Aprotinin versus Control

3

233

Risk Ratio (M‐H, Random, 95% CI)

1.98 [0.38, 10.46]

6.2 Tranexamic Acid versus Control

13

946

Risk Ratio (M‐H, Random, 95% CI)

0.55 [0.17, 1.76]

6.3 Epsilon Aminocaproic Acid versus Control

2

92

Risk Ratio (M‐H, Random, 95% CI)

0.36 [0.02, 8.46]

7 Other Thrombosis Show forest plot

16

1107

Risk Ratio (M‐H, Random, 95% CI)

1.04 [0.47, 2.30]

7.1 Aprotinin versus Control

9

736

Risk Ratio (M‐H, Random, 95% CI)

0.73 [0.25, 2.15]

7.2 Tranexamic Acid versus Control

7

289

Risk Ratio (M‐H, Random, 95% CI)

2.10 [0.49, 8.99]

7.3 Epsilon Aminocaproic Acid versus Control

1

82

Risk Ratio (M‐H, Random, 95% CI)

0.95 [0.14, 6.44]

8 Coronary artery graft occlusion Show forest plot

2

728

Risk Ratio (M‐H, Random, 95% CI)

0.76 [0.10, 5.67]

8.1 Aprotinin versus Control

2

728

Risk Ratio (M‐H, Random, 95% CI)

0.76 [0.10, 5.67]

9 Renal Failure / Dysfunction Show forest plot

24

4856

Risk Ratio (M‐H, Random, 95% CI)

1.13 [0.77, 1.64]

9.1 Aprotinin versus Control

21

4412

Risk Ratio (M‐H, Random, 95% CI)

1.16 [0.79, 1.70]

9.2 Tranexamic Acid versus Control

5

444

Risk Ratio (M‐H, Random, 95% CI)

0.73 [0.16, 3.32]

10 Hospital Length of Stay Show forest plot

20

1792

Mean Difference (IV, Random, 95% CI)

‐0.10 [‐0.48, 0.29]

10.1 Aprotinin versus Control

17

1570

Mean Difference (IV, Random, 95% CI)

‐0.01 [‐0.50, 0.48]

10.2 Tranexamic Acid versus Control

4

176

Mean Difference (IV, Random, 95% CI)

‐0.30 [‐0.71, 0.10]

10.3 Epsilon Aminocaproic Acid versus Control

1

46

Mean Difference (IV, Random, 95% CI)

2.90 [‐0.96, 6.76]

1 Re‐operation for bleeding ‐ Aprotinin versus Tranexamic Acid Show forest plot

13

2005

Risk Ratio (M‐H, Random, 95% CI)

0.87 [0.50, 1.54]

2 Re‐operation for bleeding ‐ Aprotinin versus Epsilon Aminocaproic Acid Show forest plot

5

515

Risk Ratio (M‐H, Random, 95% CI)

1.03 [0.33, 3.18]

3 Re‐operation for bleeding ‐ Tranexamic Acid versus Epsilon Aminocaproic Acid Show forest plot

4

303

Risk Ratio (M‐H, Random, 95% CI)

1.37 [0.39, 4.84]

4 Mortality ‐ Aprotinin versus Tranexamic Acid Show forest plot

14

2167

Risk Ratio (M‐H, Random, 95% CI)

0.94 [0.49, 1.81]

5 Mortality ‐ Aprotinin versus Epsilon Aminocaproic Acid Show forest plot

3

281

Risk Ratio (M‐H, Random, 95% CI)

1.27 [0.30, 5.42]

6 Mortality ‐ Tranexamic Acid versus EACA Show forest plot

4

409

Risk Ratio (M‐H, Random, 95% CI)

0.64 [0.18, 2.24]

7 Myocardial Infarction ‐ Aprotinin versus Tranexamic Acid Show forest plot

11

1935

Risk Ratio (M‐H, Random, 95% CI)

0.82 [0.50, 1.35]

8 Myocardial Infarction ‐ Aprotinin versus Epsilon Aminocaproic Acid Show forest plot

2

173

Risk Ratio (M‐H, Random, 95% CI)

0.99 [0.26, 3.83]

9 Myocardial Infarction ‐ Tranexamic Acid versus Epsilon Aminocaproic Acid Show forest plot

2

225

Risk Ratio (M‐H, Random, 95% CI)

0.99 [0.29, 3.44]

10 Stroke (CVA) ‐ Aprotinin versus Tranexamic Acid Show forest plot

4

323

Risk Ratio (M‐H, Random, 95% CI)

2.97 [0.48, 18.50]

11 Stroke (CVA) ‐ Tranexamic Acid versus Epsilon Aminocaproic Acid Show forest plot

2

137

Risk Ratio (M‐H, Random, 95% CI)

3.20 [0.13, 76.60]

12 Deep Vein Thrombosis (DVT) ‐ Aprotinin versus Tranexamic Acid Show forest plot

3

265

Risk Ratio (M‐H, Random, 95% CI)

0.50 [0.05, 4.81]

13 Deep Vein Thrombosis (DVT) ‐ Aprotinin versus Epsilon Aminocaproic Acid Show forest plot

4

300

Risk Ratio (M‐H, Random, 95% CI)

0.14 [0.01, 2.51]

14 Deep Vein Thrombosis (DVT) ‐ Tranexamic Acid versus Epsilon Aminocaproic Acid Show forest plot

3

303

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

15 Pulmonary Embolism (PE) ‐ Aprotinin versus Tranexamic Acid Show forest plot

2

241

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

16 Pulmonary Embolism (PE) ‐ Aprotinin versus Epsilon Aminocaproic Acid Show forest plot

3

270

Risk Ratio (M‐H, Random, 95% CI)

1.33 [0.10, 18.42]

17 Pulmonary Embolism (PE) ‐ Tranexamic Acid versus Epsilon Aminocaproic Acid Show forest plot

3

284

Risk Ratio (M‐H, Random, 95% CI)

0.31 [0.01, 7.59]

18 Other Thrombosis ‐ Aprotinin versus Tranexamic Acid Show forest plot

3

287

Risk Ratio (M‐H, Random, 95% CI)

0.51 [0.10, 2.68]

19 Other Thrombosis ‐ Aprotinin versus Epsilon Aminocaproic Acid Show forest plot

1

92

Risk Ratio (M‐H, Random, 95% CI)

0.0 [0.0, 0.0]

20 Other Thrombosis ‐ Tranexamic Acid versus Epsilon Aminocaproic Acid Show forest plot

2

184

Risk Ratio (M‐H, Random, 95% CI)

2.0 [0.39, 10.34]

21 Renal Failure / Dysfunction ‐ Aprotinin versus Tranexamic Acid Show forest plot

3

287

Risk Ratio (M‐H, Random, 95% CI)

0.46 [0.11, 2.01]

22 Hospital Length of Stay ‐ Aprotinin versus Tranexamic Acid Show forest plot

3

209

Mean Difference (IV, Random, 95% CI)

0.43 [‐1.08, 1.95]

23 Hospital Length of Stay ‐ Aprotinin versus Epsilon Aminocaproic Acid Show forest plot

1

45

Mean Difference (IV, Random, 95% CI)

‐2.10 [‐5.84, 1.64]

1 Re‐operation for bleeding Show forest plot

64

7511

Risk Ratio (M‐H, Random, 95% CI)

0.52 [0.40, 0.69]

1.1 Aprotinin versus Control

47

5153

Risk Ratio (M‐H, Random, 95% CI)

0.49 [0.34, 0.70]

1.2 Tranexamic Acid versus Control

19

1618

Risk Ratio (M‐H, Random, 95% CI)

0.65 [0.39, 1.08]

1.3 Epsilon Aminocaproic Acid versus Control

7

740

Risk Ratio (M‐H, Random, 95% CI)

0.35 [0.11, 1.17]

2 Mortality Show forest plot

62

9452

Risk Ratio (M‐H, Random, 95% CI)

0.92 [0.70, 1.21]

2.1 Aprotinin versus Control

45

7078

Risk Ratio (M‐H, Random, 95% CI)

0.95 [0.70, 1.28]

2.2 Tranexamic Acid versus Control

18

1702

Risk Ratio (M‐H, Random, 95% CI)

0.55 [0.24, 1.25]

2.3 Epsilon Aminocaproic Acid versus Control

5

672

Risk Ratio (M‐H, Random, 95% CI)

1.65 [0.50, 5.43]

3 Myocardial Infarction Show forest plot

53

7922

Risk Ratio (M‐H, Random, 95% CI)

0.94 [0.75, 1.18]

3.1 Aprotinin versus Control

37

5628

Risk Ratio (M‐H, Random, 95% CI)

0.95 [0.74, 1.22]

3.2 Tranexamic Acid versus Control

15

1632

Risk Ratio (M‐H, Random, 95% CI)

0.91 [0.44, 1.88]

3.3 Epsilon Aminocaproic Acid versus Control

5

662

Risk Ratio (M‐H, Random, 95% CI)

0.89 [0.37, 2.18]

4 Stroke Show forest plot

28

3350

Risk Ratio (M‐H, Random, 95% CI)

0.94 [0.49, 1.79]

4.1 Aprotinin versus Control

11

1303

Risk Ratio (M‐H, Random, 95% CI)

0.76 [0.30, 1.93]

4.2 Tranexamic Acid versus Control

13

1345

Risk Ratio (M‐H, Random, 95% CI)

1.52 [0.52, 4.41]

4.3 Epsilon Aminocaproic Acid versus Control

6

702

Risk Ratio (M‐H, Random, 95% CI)

0.59 [0.10, 3.44]

5 Deep Vein Thrombosis (DVT) Show forest plot

6

694

Risk Ratio (M‐H, Random, 95% CI)

1.18 [0.29, 4.83]

5.1 Aprotinin versus Control

2

272

Risk Ratio (M‐H, Random, 95% CI)

2.52 [0.41, 15.45]

5.2 Tranexamic Acid versus Control

4

422

Risk Ratio (M‐H, Random, 95% CI)

0.37 [0.04, 3.47]

6 Pulmonary Embolism Show forest plot

6

569

Risk Ratio (M‐H, Random, 95% CI)

0.33 [0.04, 3.15]

6.1 Tranexamic Acid versus Control

6

569

Risk Ratio (M‐H, Random, 95% CI)

0.33 [0.04, 3.15]

7 Other Thrombosis Show forest plot

4

426

Risk Ratio (M‐H, Random, 95% CI)

0.62 [0.11, 3.36]

7.1 Aprotinin versus Control

4

426

Risk Ratio (M‐H, Random, 95% CI)

0.62 [0.11, 3.36]

8 Renal Failure / Dysfunction Show forest plot

21

4618

Risk Ratio (M‐H, Random, 95% CI)

1.08 [0.73, 1.60]

8.1 Aprotinin versus Control

18

4174

Risk Ratio (M‐H, Random, 95% CI)

1.12 [0.74, 1.67]

8.2 Tranexamic Acid versus Control

5

444

Risk Ratio (M‐H, Random, 95% CI)

0.73 [0.16, 3.32]

9 Hospital Length of Stay Show forest plot

14

1528

Mean Difference (IV, Random, 95% CI)

‐0.11 [‐0.52, 0.31]

9.1 Aprotinin versus Control

13

1412

Mean Difference (IV, Random, 95% CI)

‐0.10 [‐0.64, 0.44]

9.2 Tranexamic Acid versus Control

2

116

Mean Difference (IV, Random, 95% CI)

‐0.23 [‐0.67, 0.21]