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Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 1 Death from any cause.
Figuras y tablas -
Analysis 1.1

Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 1 Death from any cause.

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Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 2 Residual fluid at 4 weeks.
Figuras y tablas -
Analysis 1.2

Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 2 Residual fluid at 4 weeks.

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Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 3 Residual fluid at 8 weeks.
Figuras y tablas -
Analysis 1.3

Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 3 Residual fluid at 8 weeks.

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Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 4 Presence of pleural thickening.
Figuras y tablas -
Analysis 1.4

Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 4 Presence of pleural thickening.

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Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 5 Presence of pleural adhesions.
Figuras y tablas -
Analysis 1.5

Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 5 Presence of pleural adhesions.

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Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 6 Days to improvement in symptoms.
Figuras y tablas -
Analysis 1.6

Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 6 Days to improvement in symptoms.

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Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 7 Clinical symptoms after 7 days.
Figuras y tablas -
Analysis 1.7

Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 7 Clinical symptoms after 7 days.

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Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 8 Adverse events leading to treatment discontinuation.
Figuras y tablas -
Analysis 1.8

Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 8 Adverse events leading to treatment discontinuation.

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Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 9 HIV‐associated events.
Figuras y tablas -
Analysis 1.9

Comparison 1 Corticosteroids versus control (placebo or no steroids), Outcome 9 HIV‐associated events.

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Comparison 1. Corticosteroids versus control (placebo or no steroids)

Outcome or subgroup title

No. of studies

No. of participants

Statistical method

Effect size

1 Death from any cause Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Subtotals only

2 Residual fluid at 4 weeks Show forest plot

3

394

Risk Ratio (M‐H, Fixed, 95% CI)

0.76 [0.62, 0.94]

3 Residual fluid at 8 weeks Show forest plot

4

399

Risk Ratio (M‐H, Random, 95% CI)

0.72 [0.46, 1.12]

4 Presence of pleural thickening Show forest plot

4

309

Risk Ratio (M‐H, Fixed, 95% CI)

0.69 [0.51, 0.94]

5 Presence of pleural adhesions Show forest plot

2

123

Risk Ratio (M‐H, Fixed, 95% CI)

0.75 [0.51, 1.11]

6 Days to improvement in symptoms Show forest plot

2

123

Mean Difference (IV, Fixed, 95% CI)

‐4.32 [‐7.44, ‐1.20]

7 Clinical symptoms after 7 days Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

8 Adverse events leading to treatment discontinuation Show forest plot

6

586

Risk Ratio (M‐H, Fixed, 95% CI)

2.80 [1.12, 6.98]

9 HIV‐associated events Show forest plot

1

Risk Ratio (M‐H, Fixed, 95% CI)

Totals not selected

9.1 Cryptococcal meningitis

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

9.2 Oesophageal candidiasis

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

9.3 Gastroenteritis

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

9.4 Herpes simplex

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

9.5 Herpes zoster

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

9.6 Kaposi sarcoma

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]

9.7 Oral thrush

1

Risk Ratio (M‐H, Fixed, 95% CI)

0.0 [0.0, 0.0]
Figuras y tablas -
Comparison 1. Corticosteroids versus control (placebo or no steroids)
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