Postnatal phenobarbital for the prevention of intraventricular hemorrhage in preterm infants

Andrew Whitelaw; David Odd

doi:10.1002/14651858.CD001691.pub2

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Analysis 1.1

Comparison 1 Phenobarbital v control, Outcome 1 All intraventricular hemorrhage.

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Analysis 1.2

Comparison 1 Phenobarbital v control, Outcome 2 Severe intraventricular hemorrhage.

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Analysis 1.3

Comparison 1 Phenobarbital v control, Outcome 3 Ventricular dilatation or hydrocephalus.

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Analysis 1.4

Comparison 1 Phenobarbital v control, Outcome 4 Hypotension.

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Analysis 1.5

Comparison 1 Phenobarbital v control, Outcome 5 Pneumothorax/interstitial emphysema.

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Analysis 1.6

Comparison 1 Phenobarbital v control, Outcome 6 Hypercapnia.

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Analysis 1.7

Comparison 1 Phenobarbital v control, Outcome 7 Acidosis.

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Analysis 1.8

Comparison 1 Phenobarbital v control, Outcome 8 Use of mechanical ventilation.

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Analysis 1.9

Comparison 1 Phenobarbital v control, Outcome 9 Mild neurodevelopmental impairment.

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Analysis 1.10

Comparison 1 Phenobarbital v control, Outcome 10 Severe neurodevelopmental impairment.

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Analysis 1.11

Comparison 1 Phenobarbital v control, Outcome 11 Death before discharge.

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Analysis 1.12

Comparison 1 Phenobarbital v control, Outcome 12 All deaths during study.

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Comparison 1. Phenobarbital v control

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All intraventricular hemorrhage Show forest plot	9	740	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.87, 1.25]

2 Severe intraventricular hemorrhage Show forest plot	10	817	Risk Ratio (M‐H, Fixed, 95% CI)	0.91 [0.66, 1.24]

3 Ventricular dilatation or hydrocephalus Show forest plot	3	219	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.38, 2.08]

4 Hypotension Show forest plot	3	382	Risk Ratio (M‐H, Fixed, 95% CI)	1.18 [0.97, 1.43]

5 Pneumothorax/interstitial emphysema Show forest plot	8	682	Risk Ratio (M‐H, Fixed, 95% CI)	1.28 [0.92, 1.77]

6 Hypercapnia Show forest plot	5	241	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.73, 1.37]

7 Acidosis Show forest plot	6	521	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.90, 1.51]

8 Use of mechanical ventilation Show forest plot	5	323	Risk Ratio (M‐H, Fixed, 95% CI)	1.18 [1.06, 1.32]

9 Mild neurodevelopmental impairment Show forest plot	1	101	Risk Ratio (M‐H, Fixed, 95% CI)	0.57 [0.15, 2.17]

10 Severe neurodevelopmental impairment Show forest plot	1	101	Risk Ratio (M‐H, Fixed, 95% CI)	1.44 [0.41, 5.04]

11 Death before discharge Show forest plot	9	740	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.64, 1.21]

12 All deaths during study Show forest plot	10	817	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.66, 1.21]

Comparison 1. Phenobarbital v control

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